Vitamin D exposure and Risk of Breast Cancer: a meta-analysis

Nuria Estébanez, Inés Gómez-Acebo, Camilo Palazuelos, Javier Llorca, Trinidad Dierssen-Sotos, Nuria Estébanez, Inés Gómez-Acebo, Camilo Palazuelos, Javier Llorca, Trinidad Dierssen-Sotos

Abstract

The relationship between vitamin D and breast cancer is still controversial. The present meta-analysis examines the effects of the 25(OH)D, 1,25(OH)2D and vitamin D intake on breast cancer risk. For this purpose, a PubMed, Scopus and Web of Science-databases search was conducted including all papers published with the keywords "breast cancer" and "vitamin D" with at least one reported relative risk (RR) or odds ratio (OR). In total sixty eight studies published between 1998 and 2018 were analyzed. Information about type of study, hormonal receptors and menopausal status was retrieved. Pooled OR or RR were estimated by weighting individual OR/RR by the inverse of their variance Our study showed a protective effect between 25 (OH) D and breast cancer in both cohort studies (RR = 0.85, 95%CI:0.74-0.98) and case-control studies (OR = 0.65, 95%CI: 0.56-0.76). However, analyzing by menopausal status, the protective vitamin D - breast cancer association persisted only in the premenopausal group (OR = 0.67, 95%CI: 0.49-0.92) when restricting the analysis to nested case-control studies. No significant association was found for vitamin D intake or 1,25(OH)2D.

Conclusion: This systematic review suggests a protective relationship between circulating vitamin D (measured as 25(OH) D) and breast cancer development in premenopausal women.

Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Flowchart which describes the methodology of selection of the articles.
Figure 2
Figure 2
(a) Forest plot for the relationship between 25(OH)D and breast cancer in case control studies. (b) Forest plot for the relationship between 25(OH)D and breast cancer in nested case control studies.
Figure 3
Figure 3
(a) Forest plot for the relationship between 25(OH)D and premenopausal breast cancer in case control studies. (b) Forest plot for the relationship between 25(OH)D and premenopausal breast cancer in nested case control studies.

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