Effectiveness of Cash Transfer Delivered Along With Combination HIV Prevention Interventions in Reducing the Risky Sexual Behavior of Adolescent Girls and Young Women in Tanzania: Cluster Randomized Controlled Trial

Evodius Kuringe, Alice Christensen, Jacqueline Materu, Mary Drake, Esther Majani, Caterina Casalini, Deusdedit Mjungu, Gaspar Mbita, Esther Kalage, Albert Komba, Daniel Nyato, Soori Nnko, Amani Shao, John Changalucha, Mwita Wambura, Evodius Kuringe, Alice Christensen, Jacqueline Materu, Mary Drake, Esther Majani, Caterina Casalini, Deusdedit Mjungu, Gaspar Mbita, Esther Kalage, Albert Komba, Daniel Nyato, Soori Nnko, Amani Shao, John Changalucha, Mwita Wambura

Abstract

Background: Poverty and social inequality exacerbate HIV risk among adolescent girls and young women (AGYW) in sub-Saharan Africa. Cash transfers can influence the structural determinants of health, thereby reducing HIV risk.

Objective: This study assessed the effectiveness of cash transfer delivered along with combination HIV prevention (CHP) interventions in reducing the risky sexual behavior of AGYW in Tanzania. The incidence of herpes simplex virus type 2 (HSV-2) infection was used as a proxy for sexual risk behavior.

Methods: A cluster randomized controlled trial was conducted in 15 matched pairs of communities (1:1 intervention to control) across 3 strata (urban, rural high-risk, and rural low-risk populations) of the Shinyanga Region, Tanzania. The target population was out-of-school AGYW aged 15-23 years who had completed 10-hour sessions of social and behavior change communication. Eligible communities were randomly assigned to receive CHP along with cash transfer quarterly (intervention group) or solely CHP interventions (control group) with no masking. Study recruitment and baseline survey were conducted between October 30, 2017 and December 1, 2017. Participants completed an audio computer-assisted self-interview, HIV counselling and testing, and HSV-2 testing at baseline and during follow-up visits at 6, 12, and 18 months after the baseline survey. A Cox proportional hazards model with random effects specified at the level of clusters (shared frailty) adjusted for matching pairs and other baseline imbalances was fitted to assess the effects of cash transfer on the incidence of HSV-2 infection (primary outcome). Secondary outcomes included HIV prevalence at follow-up, self-reported intergenerational sex, and self-reported compensated sex. All secondary outcomes were measured at each study visit.

Results: Of the 3026 AGYW enrolled in the trial (1482 in the intervention and 1544 in the control), 2720 AGYW (1373 in the intervention and 1347 in the control) were included in the final analysis. Overall, HSV-2 incidence was not significantly different at all follow-up points between the study arms in the adjusted analysis (hazard ratio 0.96, 95% CI 0.67-1.38; P=.83). However, HSV-2 incidence was significantly lower in the rural low-risk populations who received the cash transfer intervention (hazard ratio 0.45, 95% CI 0.29-0.71; P=.001), adjusted for potential confounders.

Conclusions: Although this trial showed no significant impact of the cash transfer intervention on HSV-2 incidence among AGYW overall, the intervention significantly reduced HSV-2 incidence among AGYW in rural low-risk communities. Factors such as lesser poverty and more asset ownership in urban and rural high-risk communities may have undermined the impact of cash transfer.

Trial registration: ClinicalTrials.gov NCT03597243; https://ichgcp.net/clinical-trials-registry/NCT03597243.

Keywords: HIV infections/epidemiology; HIV infections/prevention and control; Tanzania; adolescent; female; herpes simplex virus type 2; incidence; motivation.

Conflict of interest statement

Conflicts of Interest: None declared.

©Evodius Kuringe, Alice Christensen, Jacqueline Materu, Mary Drake, Esther Majani, Caterina Casalini, Deusdedit Mjungu, Gaspar Mbita, Esther Kalage, Albert Komba, Daniel Nyato, Soori Nnko, Amani Shao, John Changalucha, Mwita Wambura. Originally published in JMIR Public Health and Surveillance (https://publichealth.jmir.org), 19.09.2022.

Figures

Figure 1
Figure 1
Trial profile for a cluster randomized trial among adolescent girls and young women in Shinyanga Region, Tanzania, in October 2017 to July 2019. AGYW: adolescent girls and young women; HSV-2: herpes simplex virus type 2.

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