Perineural dexmedetomidine added to ropivacaine causes a dose-dependent increase in the duration of thermal antinociception in sciatic nerve block in rat
Chad M Brummett, Amrita K Padda, Francesco S Amodeo, Kathleen B Welch, Ralph Lydic, Chad M Brummett, Amrita K Padda, Francesco S Amodeo, Kathleen B Welch, Ralph Lydic
Abstract
Background: The current study was designed to test the hypothesis that dexmedetomidine added to ropivacaine would increase the duration of antinociception to a thermal stimulus in a dose-dependent fashion in a rat model of sciatic nerve blockade.
Methods: Fifty adult Sprague-Dawley rats (10 rats/group) received unilateral sciatic nerve blocks with 0.2 ml ropivacaine (0.5%) or 0.2 ml ropivacaine (0.5%) plus dexmedetomidine (2.7 microm [0.5 microg/kg], 11.7 microm [2 microg/kg], 34.1 microm [6 microg/kg], or 120.6 microm [20 microg/kg]) in a randomized, blinded fashion. Time to paw withdrawal latency to a thermal stimulus for both paws and an assessment of motor function were measured every 30 min after the nerve block until a return to baseline.
Results: Dexmedetomidine added to ropivacaine increased the duration of dense sensory blockade and time for return to normal sensory function in a dose-dependent fashion (P < 0.005). There was a significant time (P < 0.005), dose (P < 0.005), and time-by-dose effect (P < 0.005) on paw withdrawal latencies of the operative paws. There were no significant differences in paw withdrawal latencies of the control paws, indicating little systemic effect of the dexmedetomidine. The duration of motor blockade was also increased with dexmedetomidine. High-dose dexmedetomidine (120.6 mum) was not neurotoxic.
Conclusion: This is the first study showing that dexmedetomidine added to ropivacaine increases the duration of sensory blockade in a dose-dependent fashion in rats. The findings are an essential first step encouraging future efficacy studies in humans.
Figures
![Figure 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2770892/bin/nihms-149520-f0001.jpg)
Figure 2A-D
Increasing doses of dexmedetomidine prolonged…
Figure 2A-D
Increasing doses of dexmedetomidine prolonged the duration of paw withdrawal latency to a…
Figure 3A-F
Between group comparisons from 90-210…
Figure 3A-F
Between group comparisons from 90-210 min for the dexmedetomidine groups also found multiple…
Figure 4A-E
Paw withdrawal latency values of…
Figure 4A-E
Paw withdrawal latency values of the operative paw (color) versus the unblocked control…
Figure 5
There was a direct increase…
Figure 5
There was a direct increase in the duration of motor blockade with increasing…
Figure 6
The highest dose of dexmedetomidine…
Figure 6
The highest dose of dexmedetomidine (120.6 μM [20 μg/kg]) studied caused sedative effects…
- "Above all, do no harm": hippocrates.Gerner P. Gerner P. Anesthesiology. 2009 Nov;111(5):938-9. doi: 10.1097/ALN.0b013e3181bbcd2c. Anesthesiology. 2009. PMID: 19786859 No abstract available.
- Perineural dexmedetomidine provides an increased duration of analgesia to a thermal stimulus when compared with a systemic control in a rat sciatic nerve block.Brummett CM, Amodeo FS, Janda AM, Padda AK, Lydic R. Brummett CM, et al. Reg Anesth Pain Med. 2010 Sep-Oct;35(5):427-31. doi: 10.1097/AAP.0b013e3181ef4cf0. Reg Anesth Pain Med. 2010. PMID: 20814283
- Perineural dexmedetomidine added to ropivacaine for sciatic nerve block in rats prolongs the duration of analgesia by blocking the hyperpolarization-activated cation current.Brummett CM, Hong EK, Janda AM, Amodeo FS, Lydic R. Brummett CM, et al. Anesthesiology. 2011 Oct;115(4):836-43. doi: 10.1097/ALN.0b013e318221fcc9. Anesthesiology. 2011. PMID: 21666435 Free PMC article.
- Perineural administration of dexmedetomidine in combination with bupivacaine enhances sensory and motor blockade in sciatic nerve block without inducing neurotoxicity in rat.Brummett CM, Norat MA, Palmisano JM, Lydic R. Brummett CM, et al. Anesthesiology. 2008 Sep;109(3):502-11. doi: 10.1097/ALN.0b013e318182c26b. Anesthesiology. 2008. PMID: 18719449 Free PMC article.
- Perineural Dexmedetomidine Is More Effective Than Clonidine When Added to Local Anesthetic for Supraclavicular Brachial Plexus Block: A Systematic Review and Meta-analysis.El-Boghdadly K, Brull R, Sehmbi H, Abdallah FW. El-Boghdadly K, et al. Anesth Analg. 2017 Jun;124(6):2008-2020. doi: 10.1213/ANE.0000000000002014. Anesth Analg. 2017. PMID: 28525514 Review.
- Additives to local anesthetics for peripheral nerve blocks: Evidence, limitations, and recommendations.Bailard NS, Ortiz J, Flores RA. Bailard NS, et al. Am J Health Syst Pharm. 2014 Mar 1;71(5):373-85. doi: 10.2146/ajhp130336. Am J Health Syst Pharm. 2014. PMID: 24534592 Review.
- Evaluation of a constant rate intravenous infusion of dexmedetomidine on the duration of a femoral and sciatic nerve block using lidocaine in dogs.Stabile M, Lacitignola L, Acquafredda C, Scardia A, Crovace A, Staffieri F. Stabile M, et al. Front Vet Sci. 2023 Jan 13;9:1061605. doi: 10.3389/fvets.2022.1061605. eCollection 2022. Front Vet Sci. 2023. PMID: 36713886 Free PMC article.
- Evidence basis for using dexmedetomidine to enhance the quality of paravertebral block: A systematic review and meta-analysis of randomized controlled trials.Tang R, Liu YQ, Zhong HL, Wu F, Gao SX, Liu W, Lu WS, Wang YB. Tang R, et al. Front Pharmacol. 2022 Sep 29;13:952441. doi: 10.3389/fphar.2022.952441. eCollection 2022. Front Pharmacol. 2022. PMID: 36249767 Free PMC article.
- Dexmedetomidine pretreatment alleviates ropivacaine-induced neurotoxicity via the miR-10b-5p/BDNF axis.Xu W, Li X, Chen L, Luo X, Shen S, Wang J. Xu W, et al. BMC Anesthesiol. 2022 Sep 26;22(1):304. doi: 10.1186/s12871-022-01810-6. BMC Anesthesiol. 2022. PMID: 36163004 Free PMC article.
- A Bioinformatics Study of Ropivacaine plus Dexamethasone Prolonging the Duration of Nerve Block.Chen Y, Wu J, Xu J, Chen Y, Huang C. Chen Y, et al. Comput Intell Neurosci. 2022 Aug 11;2022:5869103. doi: 10.1155/2022/5869103. eCollection 2022. Comput Intell Neurosci. 2022. PMID: 35990127 Free PMC article.
- Low-dose dexmedetomidine as a perineural adjuvant for postoperative analgesia: a randomized controlled trial.Liu W, Guo J, Zheng J, Zheng B, Ruan X; Addition of Dexmedetomidine to Ropivacaine-Induced supraclavicular Block (ADRIB) investigator. Liu W, et al. BMC Anesthesiol. 2022 Aug 5;22(1):249. doi: 10.1186/s12871-022-01791-6. BMC Anesthesiol. 2022. PMID: 35931989 Free PMC article. Clinical Trial.
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
- Adrenergic alpha-Agonists / administration & dosage*
- Amides / administration & dosage*
- Anesthetics, Local / administration & dosage*
- Animals
- Clonidine / administration & dosage
- Dexmedetomidine / administration & dosage*
- Dose-Response Relationship, Drug
- Hypnotics and Sedatives / administration & dosage*
- Male
- Nerve Block / methods*
- Pain Management*
- Rats
- Rats, Sprague-Dawley
- Ropivacaine
- Sciatic Nerve* / drug effects
- Adrenergic alpha-Agonists
- Amides
- Anesthetics, Local
- Hypnotics and Sedatives
- Dexmedetomidine
- Ropivacaine
- Clonidine
- Full Text Sources
- Other Literature Sources
- Medical
NCBI Literature Resources
The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.
National Library of Medicine
8600 Rockville Pike
Bethesda, MD 20894
![Figure 2A-D](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2770892/bin/nihms-149520-f0002.jpg)
Figure 3A-F
Between group comparisons from 90-210…
Figure 3A-F
Between group comparisons from 90-210 min for the dexmedetomidine groups also found multiple…
Figure 4A-E
Paw withdrawal latency values of…
Figure 4A-E
Paw withdrawal latency values of the operative paw (color) versus the unblocked control…
Figure 5
There was a direct increase…
Figure 5
There was a direct increase in the duration of motor blockade with increasing…
Figure 6
The highest dose of dexmedetomidine…
Figure 6
The highest dose of dexmedetomidine (120.6 μM [20 μg/kg]) studied caused sedative effects…
- "Above all, do no harm": hippocrates.Gerner P. Gerner P. Anesthesiology. 2009 Nov;111(5):938-9. doi: 10.1097/ALN.0b013e3181bbcd2c. Anesthesiology. 2009. PMID: 19786859 No abstract available.
- Perineural dexmedetomidine provides an increased duration of analgesia to a thermal stimulus when compared with a systemic control in a rat sciatic nerve block.Brummett CM, Amodeo FS, Janda AM, Padda AK, Lydic R. Brummett CM, et al. Reg Anesth Pain Med. 2010 Sep-Oct;35(5):427-31. doi: 10.1097/AAP.0b013e3181ef4cf0. Reg Anesth Pain Med. 2010. PMID: 20814283
- Perineural dexmedetomidine added to ropivacaine for sciatic nerve block in rats prolongs the duration of analgesia by blocking the hyperpolarization-activated cation current.Brummett CM, Hong EK, Janda AM, Amodeo FS, Lydic R. Brummett CM, et al. Anesthesiology. 2011 Oct;115(4):836-43. doi: 10.1097/ALN.0b013e318221fcc9. Anesthesiology. 2011. PMID: 21666435 Free PMC article.
- Perineural administration of dexmedetomidine in combination with bupivacaine enhances sensory and motor blockade in sciatic nerve block without inducing neurotoxicity in rat.Brummett CM, Norat MA, Palmisano JM, Lydic R. Brummett CM, et al. Anesthesiology. 2008 Sep;109(3):502-11. doi: 10.1097/ALN.0b013e318182c26b. Anesthesiology. 2008. PMID: 18719449 Free PMC article.
- Perineural Dexmedetomidine Is More Effective Than Clonidine When Added to Local Anesthetic for Supraclavicular Brachial Plexus Block: A Systematic Review and Meta-analysis.El-Boghdadly K, Brull R, Sehmbi H, Abdallah FW. El-Boghdadly K, et al. Anesth Analg. 2017 Jun;124(6):2008-2020. doi: 10.1213/ANE.0000000000002014. Anesth Analg. 2017. PMID: 28525514 Review.
- Additives to local anesthetics for peripheral nerve blocks: Evidence, limitations, and recommendations.Bailard NS, Ortiz J, Flores RA. Bailard NS, et al. Am J Health Syst Pharm. 2014 Mar 1;71(5):373-85. doi: 10.2146/ajhp130336. Am J Health Syst Pharm. 2014. PMID: 24534592 Review.
- Evaluation of a constant rate intravenous infusion of dexmedetomidine on the duration of a femoral and sciatic nerve block using lidocaine in dogs.Stabile M, Lacitignola L, Acquafredda C, Scardia A, Crovace A, Staffieri F. Stabile M, et al. Front Vet Sci. 2023 Jan 13;9:1061605. doi: 10.3389/fvets.2022.1061605. eCollection 2022. Front Vet Sci. 2023. PMID: 36713886 Free PMC article.
- Evidence basis for using dexmedetomidine to enhance the quality of paravertebral block: A systematic review and meta-analysis of randomized controlled trials.Tang R, Liu YQ, Zhong HL, Wu F, Gao SX, Liu W, Lu WS, Wang YB. Tang R, et al. Front Pharmacol. 2022 Sep 29;13:952441. doi: 10.3389/fphar.2022.952441. eCollection 2022. Front Pharmacol. 2022. PMID: 36249767 Free PMC article.
- Dexmedetomidine pretreatment alleviates ropivacaine-induced neurotoxicity via the miR-10b-5p/BDNF axis.Xu W, Li X, Chen L, Luo X, Shen S, Wang J. Xu W, et al. BMC Anesthesiol. 2022 Sep 26;22(1):304. doi: 10.1186/s12871-022-01810-6. BMC Anesthesiol. 2022. PMID: 36163004 Free PMC article.
- A Bioinformatics Study of Ropivacaine plus Dexamethasone Prolonging the Duration of Nerve Block.Chen Y, Wu J, Xu J, Chen Y, Huang C. Chen Y, et al. Comput Intell Neurosci. 2022 Aug 11;2022:5869103. doi: 10.1155/2022/5869103. eCollection 2022. Comput Intell Neurosci. 2022. PMID: 35990127 Free PMC article.
- Low-dose dexmedetomidine as a perineural adjuvant for postoperative analgesia: a randomized controlled trial.Liu W, Guo J, Zheng J, Zheng B, Ruan X; Addition of Dexmedetomidine to Ropivacaine-Induced supraclavicular Block (ADRIB) investigator. Liu W, et al. BMC Anesthesiol. 2022 Aug 5;22(1):249. doi: 10.1186/s12871-022-01791-6. BMC Anesthesiol. 2022. PMID: 35931989 Free PMC article. Clinical Trial.
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
- Adrenergic alpha-Agonists / administration & dosage*
- Amides / administration & dosage*
- Anesthetics, Local / administration & dosage*
- Animals
- Clonidine / administration & dosage
- Dexmedetomidine / administration & dosage*
- Dose-Response Relationship, Drug
- Hypnotics and Sedatives / administration & dosage*
- Male
- Nerve Block / methods*
- Pain Management*
- Rats
- Rats, Sprague-Dawley
- Ropivacaine
- Sciatic Nerve* / drug effects
- Adrenergic alpha-Agonists
- Amides
- Anesthetics, Local
- Hypnotics and Sedatives
- Dexmedetomidine
- Ropivacaine
- Clonidine
- Full Text Sources
- Other Literature Sources
- Medical
NCBI Literature Resources
The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.
National Library of Medicine
8600 Rockville Pike
Bethesda, MD 20894
![Figure 3A-F](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2770892/bin/nihms-149520-f0003.jpg)
Figure 4A-E
Paw withdrawal latency values of…
Figure 4A-E
Paw withdrawal latency values of the operative paw (color) versus the unblocked control…
Figure 5
There was a direct increase…
Figure 5
There was a direct increase in the duration of motor blockade with increasing…
Figure 6
The highest dose of dexmedetomidine…
Figure 6
The highest dose of dexmedetomidine (120.6 μM [20 μg/kg]) studied caused sedative effects…
- "Above all, do no harm": hippocrates.Gerner P. Gerner P. Anesthesiology. 2009 Nov;111(5):938-9. doi: 10.1097/ALN.0b013e3181bbcd2c. Anesthesiology. 2009. PMID: 19786859 No abstract available.
- Perineural dexmedetomidine provides an increased duration of analgesia to a thermal stimulus when compared with a systemic control in a rat sciatic nerve block.Brummett CM, Amodeo FS, Janda AM, Padda AK, Lydic R. Brummett CM, et al. Reg Anesth Pain Med. 2010 Sep-Oct;35(5):427-31. doi: 10.1097/AAP.0b013e3181ef4cf0. Reg Anesth Pain Med. 2010. PMID: 20814283
- Perineural dexmedetomidine added to ropivacaine for sciatic nerve block in rats prolongs the duration of analgesia by blocking the hyperpolarization-activated cation current.Brummett CM, Hong EK, Janda AM, Amodeo FS, Lydic R. Brummett CM, et al. Anesthesiology. 2011 Oct;115(4):836-43. doi: 10.1097/ALN.0b013e318221fcc9. Anesthesiology. 2011. PMID: 21666435 Free PMC article.
- Perineural administration of dexmedetomidine in combination with bupivacaine enhances sensory and motor blockade in sciatic nerve block without inducing neurotoxicity in rat.Brummett CM, Norat MA, Palmisano JM, Lydic R. Brummett CM, et al. Anesthesiology. 2008 Sep;109(3):502-11. doi: 10.1097/ALN.0b013e318182c26b. Anesthesiology. 2008. PMID: 18719449 Free PMC article.
- Perineural Dexmedetomidine Is More Effective Than Clonidine When Added to Local Anesthetic for Supraclavicular Brachial Plexus Block: A Systematic Review and Meta-analysis.El-Boghdadly K, Brull R, Sehmbi H, Abdallah FW. El-Boghdadly K, et al. Anesth Analg. 2017 Jun;124(6):2008-2020. doi: 10.1213/ANE.0000000000002014. Anesth Analg. 2017. PMID: 28525514 Review.
- Additives to local anesthetics for peripheral nerve blocks: Evidence, limitations, and recommendations.Bailard NS, Ortiz J, Flores RA. Bailard NS, et al. Am J Health Syst Pharm. 2014 Mar 1;71(5):373-85. doi: 10.2146/ajhp130336. Am J Health Syst Pharm. 2014. PMID: 24534592 Review.
- Evaluation of a constant rate intravenous infusion of dexmedetomidine on the duration of a femoral and sciatic nerve block using lidocaine in dogs.Stabile M, Lacitignola L, Acquafredda C, Scardia A, Crovace A, Staffieri F. Stabile M, et al. Front Vet Sci. 2023 Jan 13;9:1061605. doi: 10.3389/fvets.2022.1061605. eCollection 2022. Front Vet Sci. 2023. PMID: 36713886 Free PMC article.
- Evidence basis for using dexmedetomidine to enhance the quality of paravertebral block: A systematic review and meta-analysis of randomized controlled trials.Tang R, Liu YQ, Zhong HL, Wu F, Gao SX, Liu W, Lu WS, Wang YB. Tang R, et al. Front Pharmacol. 2022 Sep 29;13:952441. doi: 10.3389/fphar.2022.952441. eCollection 2022. Front Pharmacol. 2022. PMID: 36249767 Free PMC article.
- Dexmedetomidine pretreatment alleviates ropivacaine-induced neurotoxicity via the miR-10b-5p/BDNF axis.Xu W, Li X, Chen L, Luo X, Shen S, Wang J. Xu W, et al. BMC Anesthesiol. 2022 Sep 26;22(1):304. doi: 10.1186/s12871-022-01810-6. BMC Anesthesiol. 2022. PMID: 36163004 Free PMC article.
- A Bioinformatics Study of Ropivacaine plus Dexamethasone Prolonging the Duration of Nerve Block.Chen Y, Wu J, Xu J, Chen Y, Huang C. Chen Y, et al. Comput Intell Neurosci. 2022 Aug 11;2022:5869103. doi: 10.1155/2022/5869103. eCollection 2022. Comput Intell Neurosci. 2022. PMID: 35990127 Free PMC article.
- Low-dose dexmedetomidine as a perineural adjuvant for postoperative analgesia: a randomized controlled trial.Liu W, Guo J, Zheng J, Zheng B, Ruan X; Addition of Dexmedetomidine to Ropivacaine-Induced supraclavicular Block (ADRIB) investigator. Liu W, et al. BMC Anesthesiol. 2022 Aug 5;22(1):249. doi: 10.1186/s12871-022-01791-6. BMC Anesthesiol. 2022. PMID: 35931989 Free PMC article. Clinical Trial.
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
- Adrenergic alpha-Agonists / administration & dosage*
- Amides / administration & dosage*
- Anesthetics, Local / administration & dosage*
- Animals
- Clonidine / administration & dosage
- Dexmedetomidine / administration & dosage*
- Dose-Response Relationship, Drug
- Hypnotics and Sedatives / administration & dosage*
- Male
- Nerve Block / methods*
- Pain Management*
- Rats
- Rats, Sprague-Dawley
- Ropivacaine
- Sciatic Nerve* / drug effects
- Adrenergic alpha-Agonists
- Amides
- Anesthetics, Local
- Hypnotics and Sedatives
- Dexmedetomidine
- Ropivacaine
- Clonidine
- Full Text Sources
- Other Literature Sources
- Medical
NCBI Literature Resources
The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.
National Library of Medicine
8600 Rockville Pike
Bethesda, MD 20894
![Figure 4A-E](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2770892/bin/nihms-149520-f0004.jpg)
![Figure 5](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2770892/bin/nihms-149520-f0005.jpg)
Figure 6
The highest dose of dexmedetomidine…
Figure 6
The highest dose of dexmedetomidine (120.6 μM [20 μg/kg]) studied caused sedative effects…
- "Above all, do no harm": hippocrates.Gerner P. Gerner P. Anesthesiology. 2009 Nov;111(5):938-9. doi: 10.1097/ALN.0b013e3181bbcd2c. Anesthesiology. 2009. PMID: 19786859 No abstract available.
- Perineural dexmedetomidine provides an increased duration of analgesia to a thermal stimulus when compared with a systemic control in a rat sciatic nerve block.Brummett CM, Amodeo FS, Janda AM, Padda AK, Lydic R. Brummett CM, et al. Reg Anesth Pain Med. 2010 Sep-Oct;35(5):427-31. doi: 10.1097/AAP.0b013e3181ef4cf0. Reg Anesth Pain Med. 2010. PMID: 20814283
- Perineural dexmedetomidine added to ropivacaine for sciatic nerve block in rats prolongs the duration of analgesia by blocking the hyperpolarization-activated cation current.Brummett CM, Hong EK, Janda AM, Amodeo FS, Lydic R. Brummett CM, et al. Anesthesiology. 2011 Oct;115(4):836-43. doi: 10.1097/ALN.0b013e318221fcc9. Anesthesiology. 2011. PMID: 21666435 Free PMC article.
- Perineural administration of dexmedetomidine in combination with bupivacaine enhances sensory and motor blockade in sciatic nerve block without inducing neurotoxicity in rat.Brummett CM, Norat MA, Palmisano JM, Lydic R. Brummett CM, et al. Anesthesiology. 2008 Sep;109(3):502-11. doi: 10.1097/ALN.0b013e318182c26b. Anesthesiology. 2008. PMID: 18719449 Free PMC article.
- Perineural Dexmedetomidine Is More Effective Than Clonidine When Added to Local Anesthetic for Supraclavicular Brachial Plexus Block: A Systematic Review and Meta-analysis.El-Boghdadly K, Brull R, Sehmbi H, Abdallah FW. El-Boghdadly K, et al. Anesth Analg. 2017 Jun;124(6):2008-2020. doi: 10.1213/ANE.0000000000002014. Anesth Analg. 2017. PMID: 28525514 Review.
- Additives to local anesthetics for peripheral nerve blocks: Evidence, limitations, and recommendations.Bailard NS, Ortiz J, Flores RA. Bailard NS, et al. Am J Health Syst Pharm. 2014 Mar 1;71(5):373-85. doi: 10.2146/ajhp130336. Am J Health Syst Pharm. 2014. PMID: 24534592 Review.
- Evaluation of a constant rate intravenous infusion of dexmedetomidine on the duration of a femoral and sciatic nerve block using lidocaine in dogs.Stabile M, Lacitignola L, Acquafredda C, Scardia A, Crovace A, Staffieri F. Stabile M, et al. Front Vet Sci. 2023 Jan 13;9:1061605. doi: 10.3389/fvets.2022.1061605. eCollection 2022. Front Vet Sci. 2023. PMID: 36713886 Free PMC article.
- Evidence basis for using dexmedetomidine to enhance the quality of paravertebral block: A systematic review and meta-analysis of randomized controlled trials.Tang R, Liu YQ, Zhong HL, Wu F, Gao SX, Liu W, Lu WS, Wang YB. Tang R, et al. Front Pharmacol. 2022 Sep 29;13:952441. doi: 10.3389/fphar.2022.952441. eCollection 2022. Front Pharmacol. 2022. PMID: 36249767 Free PMC article.
- Dexmedetomidine pretreatment alleviates ropivacaine-induced neurotoxicity via the miR-10b-5p/BDNF axis.Xu W, Li X, Chen L, Luo X, Shen S, Wang J. Xu W, et al. BMC Anesthesiol. 2022 Sep 26;22(1):304. doi: 10.1186/s12871-022-01810-6. BMC Anesthesiol. 2022. PMID: 36163004 Free PMC article.
- A Bioinformatics Study of Ropivacaine plus Dexamethasone Prolonging the Duration of Nerve Block.Chen Y, Wu J, Xu J, Chen Y, Huang C. Chen Y, et al. Comput Intell Neurosci. 2022 Aug 11;2022:5869103. doi: 10.1155/2022/5869103. eCollection 2022. Comput Intell Neurosci. 2022. PMID: 35990127 Free PMC article.
- Low-dose dexmedetomidine as a perineural adjuvant for postoperative analgesia: a randomized controlled trial.Liu W, Guo J, Zheng J, Zheng B, Ruan X; Addition of Dexmedetomidine to Ropivacaine-Induced supraclavicular Block (ADRIB) investigator. Liu W, et al. BMC Anesthesiol. 2022 Aug 5;22(1):249. doi: 10.1186/s12871-022-01791-6. BMC Anesthesiol. 2022. PMID: 35931989 Free PMC article. Clinical Trial.
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
- Adrenergic alpha-Agonists / administration & dosage*
- Amides / administration & dosage*
- Anesthetics, Local / administration & dosage*
- Animals
- Clonidine / administration & dosage
- Dexmedetomidine / administration & dosage*
- Dose-Response Relationship, Drug
- Hypnotics and Sedatives / administration & dosage*
- Male
- Nerve Block / methods*
- Pain Management*
- Rats
- Rats, Sprague-Dawley
- Ropivacaine
- Sciatic Nerve* / drug effects
- Adrenergic alpha-Agonists
- Amides
- Anesthetics, Local
- Hypnotics and Sedatives
- Dexmedetomidine
- Ropivacaine
- Clonidine
- Full Text Sources
- Other Literature Sources
- Medical
![Figure 6](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2770892/bin/nihms-149520-f0006.jpg)
Source: PubMed