Clinical Predictors of Engagement in Teleintegrated Care and Telereferral Care for Complex Psychiatric Disorders in Primary Care: a Randomized Trial

Jennifer Severe, Paul N Pfeiffer, Katherine Palm-Cruz, Theresa Hoeft, Rebecca Sripada, Matthew Hawrilenko, Shiyu Chen, John Fortney, Jennifer Severe, Paul N Pfeiffer, Katherine Palm-Cruz, Theresa Hoeft, Rebecca Sripada, Matthew Hawrilenko, Shiyu Chen, John Fortney

Abstract

Background: Telepsychiatry Collaborative Care (TCC) and Telepsychiatry/Telepsychology Enhanced Referral (TER) expand the reach of specialty mental health services to underserved populations.

Objective: Assess clinical predictors of treatment engagement for complex psychiatric conditions in TCC-in which remote specialists consult with primary care teams via an onsite care manager who also provides brief psychotherapy-and TER, in which remote specialists provide direct telehealth treatment.

Design: A randomized pragmatic trial from twenty-four primary care clinics without onsite psychiatrists or psychologists.

Participants: A total of 1,004 adult patients screened positive for posttraumatic stress disorder (PTSD)and/or bipolar disorder were randomized to receive TCC or TER for 1 year.

Main measures: Psychotherapy engagement was measured by the number of sessions completed, and pharmacotherapy engagement by the medication adherence item from the Schizophrenia Care and Assessment Program Health Questionnaire (SCAP-HQ).

Key results: Engagement in TCC psychotherapy visits was greater compared to TER. There was no association between the PTSD symptom severity and treatment engagement. The internal state scale (ISS) activation subscale, an indicator of mania, was associated with reduced odds of initiating psychotherapy (odds ratio [OR] = 0.70; 95% CI, 0.59 to 0.84) but not the number of sessions attended once psychotherapy started. The Drug Abuse Screening Test-10(DAST-10) score was associated with receipt of fewer psychotherapy sessions (incidence ratio rate [IRR] = 0.88; 95% CI, 0.81 to 0.95). The number of physical health comorbidities was associated with greater engagement in psychotherapy (IRR = 1.11, 95% CI, 1.03 to 1.19) and pharmacotherapy (OR = 1.54; 95% CI, 1.27 to 1.87). None of the findings varied by intervention group.

Conclusions: Both teleintegrated and telereferral care offer an opportunity to treat patients with complex psychiatric conditions. While there was no difference in clinical characteristics predicting engagement, onsite care managers engaged patients in more psychotherapy sessions than remote therapists.

Trial registration: ClinicalTrials.gov Identifier: NCT02738944.

Keywords: PTSD; bipolar disorder; collaborative care; federally qualified; health centers; primary care; psychiatric disorders; telehealth; treatment engagement.

Conflict of interest statement

The authors declare that they do not have a conflict of interest.

© 2022. The Author(s).

Figures

Figure 1
Figure 1
SPIRIT Sequential Multiple Assignment Randomized Trials (SMART).

References

    1. Olfson M, Kroenke K, Wang S, et al. Trends in office-based mental health care provided by psychiatrists and primary care physicians. J Clin Psychiatry. 2014;75(3):247–53. doi: 10.4088/JCP.13m08834.
    1. Wang PS, Demler O, Olfson M, et al. Changing profiles of service sectors used for mental health care in the United States. Am J Psychiatry. 2006;163(7):1187–98. doi: 10.1176/ajp.2006.163.7.1187.
    1. Cerimele JM, Chwastiak LA, Dodson S, Katon WJ. The prevalence of bipolar disorder in general primary care samples: a systematic review. Gen Hosp Psychiatry. 2014;36(1):19–25. doi: 10.1016/j.genhosppsych.2013.09.008.
    1. Spoont MR, Williams JW, Kehle-Forbes S, et al. Does This Patient Have Posttraumatic Stress Disorder? Rational Clinical Examination Systematic Review. JAMA. 2015;314(5):501–510. doi: 10.1001/jama.2015.7877.
    1. Liebschutz J, Saitz R, Brower V, et al. PTSD in urban primary care: high prevalence and low physician recognition. J Gen Intern Med. 2007;22(6):719–26. doi: 10.1007/s11606-007-0161-0.
    1. Cerimele JM, Bauer AM, Fortney JC, et al. Patients with co-occurring bipolar disorder and posttraumatic stress disorder: a rapid review of the literature. J Clin Psychiatry. 2017;78(5):e506–e514. doi: 10.4088/JCP.16r10897.
    1. Hossain S, Mainali P, Bhimanadham NN, et al. Medical and Psychiatric Comorbidities in Bipolar Disorder: Insights from National Inpatient Population-based Study. Cureus. 2019;11(9):e5636.
    1. Bauer MS, Altshuler L, Evans DR, et al. Veterans Affairs Cooperative Study #430 Team. Prevalence and distinct correlates of anxiety, substance, and combined comorbidity in a multi-site public sector sample with bipolar disorder. J Affect Disord. 2005;85(3):301–15. doi: 10.1016/j.jad.2004.11.009.
    1. Roberts AL, Kubzansky LD, Chibnik LB, et al. Association of Posttraumatic Stress and Depressive Symptoms With Mortality in Women. JAMA Netw Open. 2020;3(12):e2027935. doi: 10.1001/jamanetworkopen.2020.27935.
    1. Jacobsen LK, Southwick SM, Kosten TR. Substance use disorders in patients with posttraumatic stress disorder: a review of the literature. Am J Psychiatry. 2001;158(8):1184–90. doi: 10.1176/appi.ajp.158.8.1184.
    1. Cerullo MA, Strakowski SM. The prevalence and significance of substance use disorders in bipolar type I and II disorder. Subst Abuse Treat Prev Policy. 2007;2:29. doi: 10.1186/1747-597X-2-29.
    1. Crump C, Sundquist K, Winkleby MA, et al. Comorbidities and mortality in bipolar disorder: a Swedish national cohort study. JAMA Psychiatry. 2013;70(9):931–9. doi: 10.1001/jamapsychiatry.2013.1394.
    1. Fornaro M, Novello S, Fusco A, et al. Clinical features associated with early drop-out among outpatients with unipolar and bipolar depression. J Psychiatr Res. 2021;136:522–528. doi: 10.1016/j.jpsychires.2020.10.025.
    1. Grubbs KM, Fortney JC, Pyne JM, et al. Predictors of Initiation and Engagement of Cognitive Processing Therapy Among Veterans With PTSD Enrolled in Collaborative Care. J Trauma Stress. 2015;28(6):580–584. doi: 10.1002/jts.22049.
    1. Graff FS, Griffin ML, Weiss RD. Predictors of dropout from group therapy among patients with bipolar and substance use disorders. Drug Alcohol Depend. 2008;94(1-3):272–275. doi: 10.1016/j.drugalcdep.2007.11.002.
    1. Maguen S, Li Y, Madden E, et al. Factors associated with completing evidence-based psychotherapy for PTSD among veterans in a national healthcare system. Psychiatry Res. 2019;274:112–128. doi: 10.1016/j.psychres.2019.02.027.
    1. Schottenbauer MA, Glass CR, Arnkoff DB, et al. Nonresponse and dropout rates in outcome studies on PTSD: review and methodological considerations. Psychiatry. 2008;71(2):134–68. doi: 10.1521/psyc.2008.71.2.134.
    1. Li K, Wei Q, Li G. Time to lack of persistence with pharmacological treatment among patients with current depressive episodes: a natural study with 1-year follow-up. Patient Prefer Adherence. 2016;10:2209–2215. doi: 10.2147/PPA.S109941.
    1. Ramanuj P, Ferenchik E, Docherty M, et al. Evolving Models of Integrated Behavioral Health and Primary Care. Curr Psychiatry Rep. 2019;21(1):4. doi: 10.1007/s11920-019-0985-4.
    1. Adaji A, Fortney J. Telepsychiatry in Integrated Care Settings. Focus (Am Psychiatr Publ). 2017;15(3):257–263.
    1. Fortney JC, Pyne JM, Mouden SB, et al. Practice-Based Versus Telemedicine-Based Collaborative Care for Depression in Rural Federally Qualified Health Centers: A Pragmatic Randomized Comparative Effectiveness Trial. Focus (Am Psychiatr Publ). 2017;15(3):361–372.
    1. Unützer J, Katon W, Callahan CM, et al. IMPACT Investigators. Improving Mood-Promoting Access to Collaborative Treatment. Collaborative care management of late-life depression in the primary care setting: a randomized controlled trial. JAMA. 2002;288(22):2836–45. doi: 10.1001/jama.288.22.2836.
    1. Zayfert C, DeViva JC, Becker, et al. Exposure utilization and completion of cognitive behavioral therapy for PTSD in a “real world” clinical practice. J Trauma Stress. 2005;18:637–645. doi: 10.1002/jts.20072.
    1. Bryant RA, Moulds ML, Guthrie RM, et al. Imaginal exposure alone and imaginal exposure with cognitive restructuring in treatment of posttraumatic stress disorder. J Consult Clin Psychol. 2003;71(4):706–12. doi: 10.1037/0022-006X.71.4.706.
    1. Sayer NA, Friedemann-Sanchez G, Spoont M, et al. A qualitative study of determinants of PTSD treatment initiation in veterans. Psychiatry. 2009;72(3):238–55. doi: 10.1521/psyc.2009.72.3.238.
    1. Patel SY, Mehrotra A, Huskamp HA, et al. Trends in Outpatient Care Delivery and Telemedicine During the COVID-19 Pandemic in the US. JAMA Intern Med. 2021;181(3):388–391. doi: 10.1001/jamainternmed.2020.5928.
    1. Fortney JC, Heagerty PJ, Bauer AM, et al. Study to promote innovation in rural integrated telepsychiatry (SPIRIT): Rationale and design of a randomized comparative effectiveness trial of managing complex psychiatric disorders in rural primary care clinics. Contemp Clin Trials. 2020;90:105873. doi: 10.1016/j.cct.2019.105873.
    1. Fortney J, Bauer A, Cerimele J, et al. Comparison of Teleintegrated Care and Telereferral Care for Treating Complex Psychiatric Disorders in Primary Care: A Pragmatic Randomized Comparative Effectiveness Trial. JAMA Psychiatry. 2021 Nov 1;78(11):1189-1199.
    1. Xue Y, Greener E, Kannan V, et al. Federally qualified health centers reduce the primary care provider gap in health professional shortage counties. Nurs Outlook. 2018;66(3):263–272. doi: 10.1016/j.outlook.2018.02.003.
    1. Lang AJ, Stein MB. An abbreviated PTSD checklist for use as a screening instrument in primary care. Behav Res Ther. 2005;43(5):585–594. doi: 10.1016/j.brat.2004.04.005.
    1. Kessler RC, Akiskal HS, Angst J, et al. Validity of the assessment of bipolar spectrum disorders in the WHO CIDI 3.0. J Affect Disord. 2006;96:259–269. doi: 10.1016/j.jad.2006.08.018.
    1. Levis B, Sun Y, He C, et al. Accuracy of the PHQ-2 Alone and in Combination With the PHQ-9 for Screening to Detect Major Depression: Systematic Review and Meta-analysis. JAMA. 2020;323(22):2290–2300. doi: 10.1001/jama.2020.6504.
    1. McFall M. Behavioral activation as a primary care-based treatment for PTSD and depression among returning veterans. J Trauma Stress. 2010;23(4):491–5. doi: 10.1002/jts.20543.
    1. Lehman AF, Fischer EP, Postrado L, et al. The Schizophrenia Care and Assessment Program Health Questionnaire (SCAP-HQ): an instrument to assess outcomes of schizophrenia care. Schizophr Bull. 2003;29(2):247–56. doi: 10.1093/oxfordjournals.schbul.a007001.
    1. Williams JW, Jr, Stellato CP, Cornell J, et al. The 13- and 20-item Hopkins Symptom Checklist Depression Scale: psychometric properties in primary care patients with minor depression or dysthymia. Int J Psychiatry Med. 2004;34(1):37–50. doi: 10.2190/U1B0-NKWC-568V-4MAK.
    1. Shirinbayan P, Salavati M, Soleimani F, et al. The Psychometric Properties of the Drug Abuse Screening Test. Addict Health. 2020;12(1):25–33.
    1. Dawson DA, Grant BF, Stinson FS, et al. Effectiveness of the derived Alcohol Use Disorders Identification Test (AUDIT-C) in screening for alcohol use disorders and risk drinking in the US general population. Alcohol Clin Exp Res. 2005;29(5):844–54. doi: 10.1097/01.ALC.0000164374.32229.A2.
    1. Rush AJ. Handbook of Psychiatric Measures. 1. Washington, DC: American Psychiatric Association; 2000. pp. 213–15.
    1. Bauer MS, Vojta C, Kinosian B, et al. The Internal State Scale: replication of its discriminating abilities in a multisite, public sector sample. Bipolar Disord. 2000;2(4):340–6. doi: 10.1034/j.1399-5618.2000.020409.x.
    1. Bauer MS, Crits-Christoph P, Ball WA, et al. Independent Assessment of Manic and Depressive Symptoms by Self-rating: Scale Characteristics and Implications for the Study of Mania. Arch Gen Psychiatry. 1991;48(9):807–812. doi: 10.1001/archpsyc.1991.01810330031005.
    1. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Series B Methodol. 1995;57(1):289–300.
    1. Jones D, Kazis L, Lee A, et al. Health status assessments using the Veterans SF-12 and SF-36: Methods for evaluating outcomes in the Veterans Health Administration. J Ambul Care Manage. 2001;24(3):68–86. doi: 10.1097/00004479-200107000-00011.
    1. Verdolini N, Hidalgo-Mazzei D, Murru A, et al. Mixed states in bipolar and major depressive disorders: systematic review and quality appraisal of guidelines. Acta Psychiatr Scand. 2018;138(3):196–222. doi: 10.1111/acps.12896.
    1. American Psychiatric Association Part A – Treatment Recommendations for Patients with Bipolar Disorder. Practice guideline for the treatment of patients with bipolar disorder (revision) Am J Psychiatry. 2002;159(4 Suppl):4–7.
    1. Miklowitz DJ, Efthimiou O, Furukawa TA, et al. Adjunctive Psychotherapy for Bipolar Disorder: A Systematic Review and Component Network Meta-analysis. JAMA Psychiatry. 2021;78(2):141–150. doi: 10.1001/jamapsychiatry.2020.2993.
    1. O'Brien B, Lee D, Swann AC, et al. Psychotherapy for Mixed Depression and Mixed Mania. Psychiatr Clin North Am. 2020 Mar;43(1):199-211. Epub 2019 Dec 18.
    1. French MT, Roebuck MC, McGeary KA, et al. Using the drug abuse screening test (DAST-10) to analyze health services utilization and cost for substance users in a community-based setting. Subst Use Misuse. 2001;36(6-7):927–46. doi: 10.1081/JA-100104096.
    1. Nordheim K, Walderhaug E, Alstadius S, et al. Young adults’ reasons for dropout from residential substance use disorder treatment. Qual Soc Work. 2018;17(1):24–40. doi: 10.1177/1473325016654559.
    1. King AC, Canada SA. Client-related predictors of early treatment drop-out in a substance abuse clinic exclusively employing individual therapy. J Subst Abuse Treat. 2004;26(3):189–95. doi: 10.1016/S0740-5472(03)00210-1.
    1. Sripada RK, Pfeiffer PN, Valenstein M, et al. Medical illness burden is associated with greater PTSD service utilization in a nationally representative survey. Gen Hosp Psychiatry. 2014;36(6):589–93. doi: 10.1016/j.genhosppsych.2014.09.007.
    1. Theis KA, Barker L, Shannon Self-Brown S et al. Chronic Disease Disparities by County Economic Status and Metropolitan Classification, Behavioral Risk Factor Surveillance System, 2013. Center for Chronic Disease (CDC). Prev Chronic Dis., Original Research, Volume 13, September 16. . Accessed 31 May 2021.
    1. Cohen BE, Gima K, Bertenthal D, et al. Mental health diagnoses and utilization of VA non-mental health medical services among returning Iraq and Afghanistan veterans. J Gen Intern Med. 2010;25(1):18–24. doi: 10.1007/s11606-009-1117-3.
    1. Levine DS, Sripada RK, Ganoczy D, et al. Poorer Physical Health is Associated With Greater Mental Health Service Utilization in a Sample of Depressed U.S. Army National Guard Soldiers. Mil Med. 2016;181(8):803–10. doi: 10.7205/MILMED-D-15-00287.

Source: PubMed

3
Tilaa