Lack of H5N1 avian influenza transmission to hospital employees, Hanoi, 2004
Nguyen Thanh Liem, Willna Lim, World Health Organization International Avian Influenza Investigation Team, Vietnam, Bach Huy Anh, Philippe Barboza, Niranjan Bhat, Arnold Bosman, Sofia Boqvist, Rick Brown, Pascale Brudon, Philippe Calain, Maria Cheng, Aaron Curns, Valerie Delpech, Robert Dietz, Nguyen Cong Doan, Roger Doran, Mirna Du Ry van Beest Holle, Joel Francart, Keiji Fukuda, Amy Wolkin, Patrice Gautier, Futoshi Hasebe, Peter Horby, Shigeyuki Itamura, Veronique Jestin, Donna Mak, Noel Miranda, Hitoshi Oshitani, Takehiko Saito, Taronna Maines, Reiko Saito, James Mark Simmerman, Terry Tumpey, Timothy Uyeki, Nguyen Thanh Liem, Willna Lim, World Health Organization International Avian Influenza Investigation Team, Vietnam, Bach Huy Anh, Philippe Barboza, Niranjan Bhat, Arnold Bosman, Sofia Boqvist, Rick Brown, Pascale Brudon, Philippe Calain, Maria Cheng, Aaron Curns, Valerie Delpech, Robert Dietz, Nguyen Cong Doan, Roger Doran, Mirna Du Ry van Beest Holle, Joel Francart, Keiji Fukuda, Amy Wolkin, Patrice Gautier, Futoshi Hasebe, Peter Horby, Shigeyuki Itamura, Veronique Jestin, Donna Mak, Noel Miranda, Hitoshi Oshitani, Takehiko Saito, Taronna Maines, Reiko Saito, James Mark Simmerman, Terry Tumpey, Timothy Uyeki
Abstract
To establish whether human-to-human transmission of influenza A H5N1 occurred in the healthcare setting in Vietnam, we conducted a cross-sectional seroprevalence survey among hospital employees exposed to 4 confirmed and 1 probable H5N1 case-patients or their clinical specimens. Eighty-three (95.4%) of 87 eligible employees completed a questionnaire and provided a serum sample, which was tested for antibodies to influenza A H5N1. Ninety-five percent reported exposure to > or = 1 H5N1 case-patients; 59 (72.0%) reported symptoms, and 2 (2.4%) fulfilled the definition for a possible H5N1 secondary case-patient. No study participants had detectable antibodies to influenza A H5N1. The data suggest that the H5N1 viruses responsible for human cases in Vietnam in January 2004 are not readily transmitted from person to person. However, influenza viruses are genetically variable, and transmissibility is difficult to predict. Therefore, persons providing care for H5N1 patients should continue to take measures to protect themselves.
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Source: PubMed