Nutrition, Health, and Regulatory Aspects of Digestible Maltodextrins

Denise L Hofman, Vincent J van Buul, Fred J P H Brouns, Denise L Hofman, Vincent J van Buul, Fred J P H Brouns

Abstract

Digestible maltodextrins are low-sweet saccharide polymers consisting of D-glucose units linked primarily linearly with alpha-1,4 bonds, but can also have a branched structure through alpha-1,6 bonds. Often, maltodextrins are classified by the amount of reducing sugars present relative to the total carbohydrate content; between 3 and 20 percent in the case of digestible maltodextrins. These relatively small polymers are used as food ingredients derived by hydrolysis from crops naturally rich in starch. Through advances in production technology, the application possibilities in food products have improved during the last 20 years. However, since glucose from digested maltodextrins is rapidly absorbed in the small intestine, the increased use has raised questions about potential effects on metabolism and health. Therefore, up-to-date knowledge concerning production, digestion, absorption, and metabolism of maltodextrins, including potential effects on health, were reviewed. Exchanging unprocessed starch with maltodextrins may lead to an increased glycemic load and therefore post meal glycaemia, which are viewed as less desirable for health. Apart from beneficial food technological properties, its use should accordingly also be viewed in light of this. Finally, this review reflects on regulatory aspects, which differ significantly in Europe and the United States, and, therefore, have implications for communication and marketing.

Keywords: Maltodextrins; digestion; health implications; nutritional properties; regulatory aspects.

Figures

Figure 1.
Figure 1.
Physicochemical properties related to the level of dextrose equivalence (DE).

References

    1. Al-Khatib G. R., Duggal M. S., Toumba K. J. An evaluation of the acidogenic potential of maltodextrins in vivo. J. Dent. 2001:409–414.
    1. Alexander R. Fat replacers based on starch. Cereal Foods World 1995
    1. Allison D. B. Liquid calories, energy compensation and weight: what we know and what we still need to learn. Brit. J. Nutr. 2013 111(3):384–386.
    1. Altschul A. M. Low-calorie foods—a scientific status summary by the Institute of Food Technologists' expert panel of food safety and nutrition. Food Techno. 1989:113.
    1. Anderson C., Curzon M., Van Loveren C., Tatsi C., Duggal M. Sucrose and dental caries: a review of the evidence. Obes. Rev. 2009:41–54.
    1. Astrup A. Macronutrient balances and obesity: the role of diet and physical activity. Public Health Nutr. 1999:341–347.
    1. Atkinson F. S., Foster-Powell K., Brand-Miller J. C. International tables of glycemic index and glycemic load values: 2008. Diabetes Care. 2008:2281–2283.
    1. BeMiller J. N., Whistler R. L. Starch: Chemistry and Technology. London: Academic Press; 2009.
    1. Booth D. A. Learnt reduction in the size of a meal. Measurement of the sensory-gastric inhibition from conditioned satiety. Appetite. 2009:745–749.
    1. Brouns F. Etiology of gastrointestinal disturbances during endurance events. Scand. J. Med. Sci. Sports. 1991:66–77.
    1. Brouns F. Gastric emptying as a regulatory factor in fluid uptake. Int. J. Sports Med. 1998:S125–128.
    1. Brouns F. Essentials of Sports Nutrition. West-Sussex, UK: Wiley; 2003.
    1. Brouns F., Arrigoni E., Langkilde A. M., Verkooijen I., Fassler C., Andersson H., Kettlitz B., van Nieuwenhoven M., Philipsson H., Amado R. Physiological and metabolic properties of a digestion-resistant maltodextrin, classified as type 3 retrograded resistant starch. J. Agr. Food Chem. 2007:1574–1581.
    1. Buléon A., Colonna P., Planchot V., Ball S. Starch granules: structure and biosynthesis. Int. J. Biol. Macromol. 1998:85–112.
    1. Cabre E., Gonzalez-Huix F., Abad-Lacruz A., Esteve M., Acero D., Fernandez-Bañares F., Xiol X., Gassull M. A. Effect of total enteral nutrition on the short-term outcome of severely malnourished cirrhotics. A randomized controlled trial. Gastroenterology. 1990:715–720.
    1. Cheng R., Yang H., Shao M., Hu T., Zhou X. Dental erosion and severe tooth decay related to soft drinks: a case report and literature review. J. Zhejiang Univ. Sci. B. 2009:395–399.
    1. Chevance F. F. V., Farmer L. J., Desmond E. M., Novelli E., Troy D. J., Chizzolini R. Effect of some fat replacers on the release of volatile aroma compounds from low-fat meat products. J. Agr. Food Chem. 2000:3476–3484.
    1. Chronakis I. S. On the molecular characteristics, compositional properties, and structural-functional mechanisms of maltodextrins: a review. Crit. Rev. Food Sci. Nutr. 1998:599–637.
    1. Coletta A., Thompson D. L., Raynor H. A. The influence of commercially-available carbohydrate and carbohydrate-protein supplements on endurance running performance in recreational athletes during a field trial. J. Int. Soc. Sports Nutr. 2013:17.
    1. Costill D. L., Hargreaves M. Carbohydrate nutrition and fatigue. Sports Med. 1992:86–92.
    1. Coultate T. Food: The Chemistry of its Components. 2009.
    1. Delzenne N., Blundell J., Brouns F., Cunningham K., De Graaf K., Erkner A., Lluch A., Mars M., Peters H., Westerterp-Plantenga M. Gastrointestinal targets of appetite regulation in humans. Obes. Rev. 2010:234–250.
    1. Dock-Nascimento D. B., de Aguilar-Nascimento J. E., Faria M. S. M., Caporossi C., Slhessarenko N., Waitzberg D. L. Evaluation of the effects of a preoperative 2-hour fast with maltodextrine and glutamine on insulin resistance, acute-phase response, nitrogen balance, and serum glutathione after laparoscopic cholecystectomy a controlled randomized trial. J. Parent. Enteral Nutr. 2012:43–52.
    1. EC Regulation (EC) No 1924/2006 of the European Parliament and of the council of 20 December 2006 on nutrition and health claims made on foods. Off. J. Eur. Union. 2006:9–25.
    1. EC Regulation (EC) No 1169/2011 of the European Parliament and of the council of 25 October 2011 on the provision of food information to consumers. Off. J. Eur. Union. 2011:18–63.
    1. EC Regulation (EC) No 1018/2013 of the European Parliament and of the council of 23 October 2013. Off. J. Eur. Union. 2013:43–44.
    1. El-Mougi M., Hendawi A., Koura H., Hegazi E., Fontaine O., Pierce N. Efficacy of standard glucose-based and reduced-osmolarity maltodextrin-based oral rehydration solutions: effect of sugar malabsorption. Bull. World Health Org. 1996:471.
    1. Englyst K. N., Englyst H. N. Carbohydrate bioavailability. Brit. J. Nutr. 2005:1–11.
    1. Febbraio M. A., Keenan J., Angus D. J., Campbell S. E., Garnham A. P. Preexercise carbohydrate ingestion, glucose kinetics, and muscle glycogen use: effect of the glycemic index. J. Appl. Physiol. 2000:1845–1851.
    1. Ferraris R. P. Dietary and developmental regulation of intestinal sugar transport. Biochem. J. 2001:265–276.
    1. Fetzer W., Crosby E., Engel C., Kirst L. Effect of acid and heat on dextrose and dextrose polymers. Ind. Eng. Chem. 1953:1075–1083.
    1. Gray G. M. Carbohydrate digestion and absorption. New England J. Med. 1975:1225–1230.
    1. Gregorio G. V., Gonzales M. L. M., Dans L. F., Martinez E. G. Cochrane review: Polymer-based oral rehydration solution for treating acute watery diarrhoea. Evid. Based Child Health: A Cochrane Rev. J. 2010:1612–1675.
    1. Grenby T., Mistry M. Properties of maltodextrins and glucose syrups in experiments in vitro and in the diets of laboratory animals, relating to dental health. Brit. J. Nutr. 2000:565–574.
    1. Gross L. S., Li L., Ford E. S., Liu S. Increased consumption of refined carbohydrates and the epidemic of type 2 diabetes in the United States: an ecologic assessment. Amer. J Clin. Nutr. 2004:774–779.
    1. Guyton A. C., Hall J. E. Medical Physiology. Saunders; Philadelphia, PA: 2000. p. 1064.
    1. Hadnađev M., Dokić L., Hadnađev T. D., Pajin B., Krstonošić V. The impact of maltodextrin-based fat mimetics on rheological and textural characteristics of edible vegetable fat. J. Texture Stud. 2011:404–411.
    1. Harger-Domitrovich S. G., McClaughry A. E., Gaskill S. E., Ruby B. C. Exogenous carbohydrate spares muscle glycogen in men and women during 10 h of exercise. Med. Sci. Sports Exer. 2007:2171.
    1. Hawley J. A., Dennis S. C., Noakes T. D. Oxidation of carbohydrate ingested during prolonged endurance exercise. Sports Med. 1992:27–42.
    1. Ivy J. L., Goforth H. W., Damon B. M., McCauley T. R., Parsons E. C., Price T. B. Early postexercise muscle glycogen recovery is enhanced with a carbohydrate-protein supplement. J. Appl. Physiol. 2002:1337–1344.
    1. Jeukendrup A. E. Carbohydrate intake during exercise and performance. Nutrition. 2004:669–677.
    1. Johnson R. K., Appel L. J., Brands M., Howard B. V., Lefevre M., Lustig R. H., Sacks F., Steffen L. M., Wylie-Rosett J. Dietary sugars intake and cardiovascular health a scientific statement from the american heart association. Circulation. 2009:1011–1020.
    1. Junsi M., Usawakesmanee W., Siripongvutikorn S. Effect of using starch on off-odors retention in tuna dark meat. Int. Food Res. J. 2012:709–714.
    1. Kellett G. L., Helliwell P. A. The diffusive component of intestinal glucose absorption is mediated by the glucose-induced recruitment of GLUT2 to the brush-border membrane. Biochem. J. 2000:155.
    1. Kerksick C., Harvey T., Stout J., Campbell B., Wilborn C., Kreider R., Kalman D., Ziegenfuss T., Lopez H., Landis10 J. International Society of Sports Nutrition position stand: Nutrient timing. J. Int. Soc. Sports Nutr. 2008:17.
    1. Klaauw A. A., Keogh J. M., Henning E., Trowse V. M., Dhillo W. S., Ghatei M. A., Farooqi I. S. High protein intake stimulates postprandial GLP1 and PYY release. Obesity21(8):1602–1607 2013
    1. Kuntz L. A.1997Making the most of maltodextrins Food Products Design8
    1. Lebenthal E. Role of salivary amylase in gastric and intestinal digestion of starch. Dig. Dis. Sci. 1987:1155–1157.
    1. Lecoultre V., Egli L., Theytaz F., Despland C., Schneiter P., Tappy L. Fructose-induced hyperuricemia is associated with a decreased renal uric acid excretion in humans. Diab. Care. 2013:e149–e150.
    1. Lee B.-H., Yan L., Phillips R. J., Reuhs B. L., Jones K., Rose D. R., Nichols B. L., Quezada-Calvillo R., Yoo S.-H., Hamaker B. R. Enzyme-synthesized highly branched maltodextrins have slow glucose generation at the mucosal α-glucosidase level and are slowly digestible in vivo. PloS One. 2013:e59745.
    1. Levine R. S. Briefing paper: maltodextrins and caries. Brit. Dental J. 1998:392.
    1. Livesey G.1991The energy value of carbohydrate and “fibre” for manIn:Proc. Nutr. Soc. Aust 79–87.
    1. Lustig R. H., Schmidt L. A., Brindis C. D. Public health: The toxic truth about sugar. Nature. 2012:27–29.
    1. Maldonado J., Gil A., Narbona E., Molina J. A. Special formulas in infant nutrition: a review. Early Hum. Dev. 1998;(Supplement 1):S23–S32.
    1. Man C., Camilleri M., Cobelli C. A system model of oral glucose absorption: validation on gold standard data. Biomed. Eng. IEEE Trans. on. 2006:2472–2478.
    1. Marchal L. M.1999Towards a rational design of commercial maltodextrins: a mechanistic approach Trends in Food Science & Technology10
    1. McCleave E. L., Ferguson-Stegall L., Ding Z., Doerner P. G., III, Wang B., Kammer L. M., Ivy J. L. A low carbohydrate–protein supplement improves endurance performance in female athletes. J. Strength Cond. Res. 2011:879–888.
    1. Moynihan P. J. Dietary advice in dental practice. Brit. Dental J. 2002:563–568.
    1. Moynihan P. J., Gould M. E., Huntley N., Thorman S. Effect of glucose polymers in water, milk and a milk substitute on plaque pH in vitro. Int. J. Paediat. Den. 1996:19–24.
    1. Nakhostin-Roohi B., Khorshidi M. The effect of glutamine and maltodextrin acute supplementation on anaerobic power. Asian J. Sports Med. 2013
    1. Nedergaard M., Ransom B., Goldman S. A. New roles for astrocytes: Redefining the functional architecture of the brain. Trends Neurosci. 2003:523–530.
    1. O'Brien-Nabors L. Alternative Sweeteners. Boca Raton, Florida, USA: CRC Press; 2011.
    1. Ogden C. L., Carroll M. D., Kit B. K., Flegal K. M. Prevalence of obesity and trends in body mass index among US children and adolescents, 1999–2010. Jama. 2012:483–490.
    1. Parker K., Salas M., Nwosu V. C. High fructose corn syrup: Production, uses and public health concerns. Biotechnol. Mol. Biol. Rev. 2010:71–78.
    1. Pexe-Machado P. A., de Oliveira B. D., Dock-Nascimento D. B., de Aguilar-Nascimento J. E. Shrinking preoperative fast time with maltodextrin and protein hydrolysate in gastrointestinal resections due to cancer. Nutrition. 2013:1054–1059.
    1. Regulations, C. o. F. Code of Federal Regulations. Washington DC: ProStar Publications; 2009.
    1. Rehrer N., Brouns F., Beckers E., Saris W. The influence of beverage composition and gastrointestinal function on fluid and nutrient availability during exercise. Scand. J. Med. Sci. Sports. 1994:159–172.
    1. Rodin J. Effects of pure sugar vs. mixed starch fructose loads on food intake. Appetite. 1991:213–219.
    1. Rolls B. J., Hetherington M., Burley V. J. The specificity of satiety: the influence of foods of different macronutrient content on the development of satiety. Physiol. Behavior. 1988:145–153.
    1. Sajilata M., Singhal R. S. Specialty starches for snack foods. Carbohydr. Polym. 2005:131–151.
    1. Sandhu B. K., Jones B., Brook C., Silk D. Oral rehydration in acute infantile diarrhoea with a glucose-polymer electrolyte solution. Arch. Disease Childhood. 1982:152–154.
    1. Shi X., Passe D. H. Water and solute absorption from carbohydrate-electrolyte solutions in the human proximal small intestine: a review and statistical analysis. Int. J. Sport Nutr. Exer. Metabol. 2010:427–442.
    1. Shi X., Summers R. W., Schedl H. P., Flanagan S. W., Chang R., Gisolfi C. V. Effects of carbohydrate type and concentration and solution osmolality on water absorption. Med. Sci. Sports Exer. 1995:1607.
    1. Siddiqui Z., Osayande A. S. Selected disorders of malabsorption. Primary Care. 2011:395–414. vii.
    1. Stephen M. S., Philips G. O., Williams P. A. Food Polysaccharides and Their Applications. CRC Press; Boca Raton: 2006.
    1. Stewart S. L., Black R. M., Wolever T., Anderson G. H. The relationship between the glycaemic response to breakfast cereals and subjective appetite and food intake. Nutr. Res. 1997:1249–1260.
    1. Stubbs J., Ferres S., Horgan G. Energy density of foods: effects on energy intake. Crit. Rev. Food Sci. Nutr. 2000:481–515.
    1. Tahmassebi J. F., Duggal M. S., Malik-Kotru G., Curzon M. E. Soft drinks and dental health: a review of the current literature. J. Dent. 2006:2–11.
    1. Takeiti C., Kieckbusch T., Collares-Queiroz F. Morphological and physicochemical characterization of commercial maltodextrins with different degrees of dextrose-equivalent. Int. J. Food Propert. 2010:411–425.
    1. Tester R. F., Karkalas J., Qi X. Starch—composition, fine structure and architecture. J. Cereal Sci. 2004:151–165.
    1. Topping D. L., Gooden J. M., Brown I. L., Biebrick D. A., McGrath L., Trimble R. P., Choct M., Illman R. J. A high amylose (amylomaize) starch raises proximal large bowel starch and increases colon length in pigs. J. Nutr. 1997:615–622.
    1. Urashima T., Fukuda K., Messer M. Evolution of milk oligosaccharides and lactose: a hypothesis. Animal. 2011:369.
    1. Vist G. E., Maughan R. J. The effect of osmolality and carbohydrate content on the rate of gastric emptying of liquids in man. J. Physiol. 1995:523–531.
    1. Wagenmakers A. J., Brouns F., Saris W. H., Halliday D. Oxidation rates of orally ingested carbohydrates during prolonged exercise in men. J. Appl. Physiol. 1993:2774–2780.
    1. Wallis G. A., Dawson R., Achten J., Webber J., Jeukendrup A. E. Metabolic response to carbohydrate ingestion during exercise in males and females. American J. Physiol.-Endocrinol. Metabol. 2006:E708–E715.
    1. Wallis G. A., Rowlands D. S., Shaw C., Jentjens R., Jeukendrup A. E. Oxidation of combined ingestion of maltodextrins and fructose during exercise. Med. Sci. Sports Exerc. 2005:426–432.
    1. Welsh J. A., Sharma A., Abramson J. L., Vaccarino V., Gillespie C., Vos M. B. Caloric sweetener consumption and dyslipidemia among US adults. JAMA:J Amer. Med. Assoc. 2010:1490–1497.
    1. Westman E. C. Is dietary carbohydrate essential for human nutrition? Amer. J. Clin. Nutr. 2002:951–953.
    1. Whelan W. J. The wars of the carbohydrates, Part 6: What a name. IUBMB Life. 2008:555–556.
    1. Yeomans M. R., Gray R. W., Conyers T. H. B. Maltodextrin preloads reduce food intake without altering the appetiser effect. Physiol. Behav. 1998:501–506.
    1. Zhang G., Hamaker B. R. Slowly digestible starch: concept, mechanism, and proposed extended glycemic index. Crit. Rev. Food Sci. Nutr. 2009:852–867.

Source: PubMed

3
Tilaa