Functional characteristics of patients with SARS-CoV-2 pneumonia at 30 days post-infection

Justine Frija-Masson, Marie-Pierre Debray, Marie Gilbert, François-Xavier Lescure, Florence Travert, Raphaël Borie, Antoine Khalil, Bruno Crestani, Marie-Pia d'Ortho, Catherine Bancal, Justine Frija-Masson, Marie-Pierre Debray, Marie Gilbert, François-Xavier Lescure, Florence Travert, Raphaël Borie, Antoine Khalil, Bruno Crestani, Marie-Pia d'Ortho, Catherine Bancal

Abstract

More than half of patients with COVID-19 pneumonia exhibit abnormal lung function 30 days after symptom onset, without clear relationship with pneumonia extent on chest CT. This pleads for systematic and long-term follow-up of patients with COVID-19. https://bit.ly/2TFMPqE

Conflict of interest statement

Conflict of interest: J. Frija-Masson has nothing to disclose. Conflict of interest: M-P. Debray has nothing to disclose. Conflict of interest: M. Gilbert has nothing to disclose. Conflict of interest: F-X. Lescure reports personal fees for development of presentations from Gilead and MSD, and personal fees for travel/accommodation and meeting expenses from Astellas, Eumedica and MSD, outside the submitted work. Conflict of interest: F. Travert has nothing to disclose. Conflict of interest: R. Borie reports grants and personal fees from Roche, Boehringer Ingelheim and Savara, outside the submitted work. Conflict of interest: A. Khalil has nothing to disclose. Conflict of interest: B. Crestani has nothing to disclose. Conflict of interest: M-P. d'Ortho has nothing to disclose. Conflict of interest: C. Bancal has nothing to disclose.

References

    1. Mo X, Jian W, Su Z, et al. . Abnormal pulmonary function in COVID-19 patients at time of hospital discharge. Eur Respir J 2020; 55: 2001217. doi:10.1183/13993003.01217-2020
    1. Dai H, Zhang X, Xia J, et al. . High-resolution chest CT features and clinical characteristics of patients infected with COVID-19 in Jiangsu, China. Int J Infect Dis 2020; 95: 106–112. doi:10.1016/j.ijid.2020.04.003
    1. Wang Y, Dong C, Hu Y, et al. . Temporal changes of CT findings in 90 patients with COVID-19 pneumonia: a longitudinal study. Radiology 2020; 296: E555–E64. doi:10.1148/radiol.2020200843
    1. Venkataraman T, Frieman MB. The role of epidermal growth factor receptor (EGFR) signaling in SARS coronavirus-induced pulmonary fibrosis. Antiviral Res 2017; 143: 142–150. doi:10.1016/j.antiviral.2017.03.022
    1. European Respiratory Society. Recommendation from ERS Group 9.1 (Respiratory Function Technologists/Scientists). Lung Function Testing during COVID-19 Pandemic and Beyond Date last accessed 6 May, 2020.
    1. Stanojevic S, Graham BL, Cooper BG, et al. . Official ERS technical standards: Global Lung Function Initiative reference values for the carbon monoxide transfer factor for Caucasians. Eur Respir J 2017; 50: 1700010. doi:10.1183/13993003.00010-2017
    1. Revel MP, Parkar AP, Prosch H, et al. . COVID-19 patients and the radiology department – advice from the European Society of Radiology (ESR) and the European Society of Thoracic Imaging (ESTI). Eur Radiol 2020; in press []. doi:10.1007/s00330-020-06865-y
    1. Ziegler CGK, Allon SJ, Nyquist SK, et al. . SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues. Cell 2020; 181: 1016–1035.
    1. Guzik TJ, Mohiddin SA, Dimarco A, et al. . COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options. Cardiovasc Res 2020; 116: 1666–1687.doi:10.1093/cvr/cvaa106
    1. Copin MC, Parmentier E, Duburcq T, et al. . Time to consider histologic pattern of lung injury to treat critically ill patients with COVID-19 infection. Intensive Care Med 2020; 46: 1124–1126.

Source: PubMed

3
Tilaa