Consideration of dornase alfa for the treatment of severe COVID-19 acute respiratory distress syndrome
A P Earhart, Z M Holliday, H V Hofmann, A G Schrum, A P Earhart, Z M Holliday, H V Hofmann, A G Schrum
Abstract
We propose a likely contribution to severe COVID-19 morbidity by extracellular DNA in neutrophil extracellular traps (NETs). Dornase alfa degrades extracellular DNA to reduce mucus rigidity and accumulation, and was associated with respiratory improvement in a first patient. Dornase alfa should be considered for clinical trials in treatment of severe COVID-19.
Keywords: COVID-19; DNAse 1; Neutrophil extracellular trap; acute respiratory distress syndrome; dornase alfa.
© 2020 The Author(s).
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Source: PubMed