Mycobacterium tuberculosis microbiologic and clinical treatment outcomes in a randomized trial of immediate versus CD4(+)-initiated antiretroviral therapy in HIV-infected adults with a high CD4(+) cell count
Gabriel Chamie, Edwin D Charlebois, Padmini Srikantiah, Maria Walusimbi-Nanteza, Roy D Mugerwa, Harriet Mayanja, Alphonse Okwera, Christopher C Whalen, Diane V Havlir, Gabriel Chamie, Edwin D Charlebois, Padmini Srikantiah, Maria Walusimbi-Nanteza, Roy D Mugerwa, Harriet Mayanja, Alphonse Okwera, Christopher C Whalen, Diane V Havlir
Abstract
In a prospective randomized, controlled trial in Uganda comparing the efficacy of antiretroviral therapy during tuberculosis therapy with the efficacy of tuberculosis therapy alone in HIV-infected patients with tuberculosis who have a CD4(+) cell count >350 cells/microL, it was found that antiretroviral therapy did not accelerate microbiologic, radiographic, or clinical responses to tuberculosis therapy: 18% of participants had sputum smears positive for Mycobacterium tuberculosis after 5 months of tuberculosis therapy, despite having had negative culture results. Trial registration. ClinicalTrials.gov identifier: NCT00078247 .
Figures
![Figure 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2919368/bin/nihms-203285-f0001.jpg)
Source: PubMed