A randomized feasibility pilot trial of hearing treatment for reducing cognitive decline: Results from the Aging and Cognitive Health Evaluation in Elders Pilot Study

Jennifer A Deal, Marilyn S Albert, Michelle Arnold, Shrikant I Bangdiwala, Theresa Chisolm, Sonia Davis, Ann Eddins, Nancy W Glynn, Adele M Goman, Melissa Minotti, Thomas Mosley, George W Rebok, Nicholas Reed, Elizabeth Rodgers, Victoria Sanchez, A Richey Sharrett, Josef Coresh, Frank R Lin, Jennifer A Deal, Marilyn S Albert, Michelle Arnold, Shrikant I Bangdiwala, Theresa Chisolm, Sonia Davis, Ann Eddins, Nancy W Glynn, Adele M Goman, Melissa Minotti, Thomas Mosley, George W Rebok, Nicholas Reed, Elizabeth Rodgers, Victoria Sanchez, A Richey Sharrett, Josef Coresh, Frank R Lin

Abstract

Introduction: Hearing loss (HL) is prevalent and independently related to cognitive decline and dementia. There has never been a randomized trial to test if HL treatment could reduce cognitive decline in older adults.

Methods: A 40-person (aged 70-84 years) pilot study in Washington County, MD, was conducted. Participants were randomized 1:1 to a best practices hearing or successful aging intervention and followed for 6 months. clinicaltrials.gov Identifier: NCT02412254.

Results: The Aging and Cognitive Health Evaluation in Elders Pilot (ACHIEVE-P) Study demonstrated feasibility in recruitment, retention, and implementation of interventions with no treatment-related adverse events. A clear efficacy signal of the hearing intervention was observed in perceived hearing handicap (mean of 0.11 to -1.29 standard deviation [SD] units; lower scores better) and memory (mean of -0.10 SD to 0.38 SD).

Discussion: ACHIEVE-P sets the stage for the full-scale ACHIEVE trial (N = 850, recruitment beginning November 2017), the first randomized trial to determine efficacy of a best practices hearing (vs. successful aging) intervention on reducing cognitive decline in older adults with HL.

Keywords: Clinical trials; Cognition; Dementia; Epidemiology; Hearing; Longitudinal study; Memory; Presbycusis.

Figures

Fig. 1
Fig. 1
Participant eligibility, randomization and follow-up, ACHIEVE-Pilot Study, Washington County, MD, N = 40. ∗Eligible but not enrolled because recruitment targets had been reached. †Unrelated to study intervention. Abbreviation: ACHIEVE, Aging and Cognitive Health Evaluation in Elders.

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