Demographic and clinical correlates of diabetes-related quality of life among youth with type 1 diabetes
Jean M Lawrence, Joyce P Yi-Frazier, Mary Helen Black, Andrea Anderson, Korey Hood, Giuseppina Imperatore, Georgeanna J Klingensmith, Michelle Naughton, Elizabeth J Mayer-Davis, Michael Seid, SEARCH for Diabetes in Youth Study Group, Jean M Lawrence, Kristi Reynolds, Jin-Wen Hsu, Mary Helen Black, Kim Holmquist, Harpreet S Takhar, Ann K Kershnar, David J Pettitt, Dana Dabelea, Richard F Hamman, Lisa Testaverde, Georgeanna J Klingensmith, Marian J Rewers, David Maahs, Paul Wadwa, Stephen Daniels, Kristen Nadeau, Clifford A Bloch, Carmelita Sorrelman, Alfreda Beartrack, Beatriz L Rodriguez, Beth Waitzfelder, Wilfred Fujimoto, J David Curb, Fiona Kennedy, Greg Uramoto, Sorrell Waxman, Teresa Hillier, Richard Chung, Lawrence M Dolan, Michael Seid, Elaine Urbina, Debra A Standiford, Elizabeth J Mayer-Davis, Joan Thomas, Anwar Merchant, Angela D Liese, Robert R Moran, Gladys Gaillard-McBride, Deborah Lawler, Malaka Jackson, Deborah Bowlby, James Amrhein, Pam Clark, Mark Parker, Catherine Pihoker, Maryam Afkarian, Angela Badaru, Lisa Gilliam, Irl Hirsch, Lenna L Liu, John Neff, Joyce Yi- Frazier, Beth Loots, Rebecca O'Connor, Sue Kearns, Sharla Semana, Mona Yaptangco, Carla Greenbaum, Giuseppina Imperatore, Desmond E Williams, Henry S Kahn, Bernice Moore, Gregg W Edward, Sharon H Saydah, Barbara Linder, Santica M Marcovina, Vinod P Gaur, Kathy Gadbois, Ronny Bell, Ralph D'Agostino Jr, Bettina Beech, Douglas Case, Timothy Morgan, Michelle J Naughton, Susan Moxley, Gena Hargis, Donna Kronner, Andrea Anderson, Cralen Davis, Jeanette Andrews, Jennifer W Talton, Jean M Lawrence, Joyce P Yi-Frazier, Mary Helen Black, Andrea Anderson, Korey Hood, Giuseppina Imperatore, Georgeanna J Klingensmith, Michelle Naughton, Elizabeth J Mayer-Davis, Michael Seid, SEARCH for Diabetes in Youth Study Group, Jean M Lawrence, Kristi Reynolds, Jin-Wen Hsu, Mary Helen Black, Kim Holmquist, Harpreet S Takhar, Ann K Kershnar, David J Pettitt, Dana Dabelea, Richard F Hamman, Lisa Testaverde, Georgeanna J Klingensmith, Marian J Rewers, David Maahs, Paul Wadwa, Stephen Daniels, Kristen Nadeau, Clifford A Bloch, Carmelita Sorrelman, Alfreda Beartrack, Beatriz L Rodriguez, Beth Waitzfelder, Wilfred Fujimoto, J David Curb, Fiona Kennedy, Greg Uramoto, Sorrell Waxman, Teresa Hillier, Richard Chung, Lawrence M Dolan, Michael Seid, Elaine Urbina, Debra A Standiford, Elizabeth J Mayer-Davis, Joan Thomas, Anwar Merchant, Angela D Liese, Robert R Moran, Gladys Gaillard-McBride, Deborah Lawler, Malaka Jackson, Deborah Bowlby, James Amrhein, Pam Clark, Mark Parker, Catherine Pihoker, Maryam Afkarian, Angela Badaru, Lisa Gilliam, Irl Hirsch, Lenna L Liu, John Neff, Joyce Yi- Frazier, Beth Loots, Rebecca O'Connor, Sue Kearns, Sharla Semana, Mona Yaptangco, Carla Greenbaum, Giuseppina Imperatore, Desmond E Williams, Henry S Kahn, Bernice Moore, Gregg W Edward, Sharon H Saydah, Barbara Linder, Santica M Marcovina, Vinod P Gaur, Kathy Gadbois, Ronny Bell, Ralph D'Agostino Jr, Bettina Beech, Douglas Case, Timothy Morgan, Michelle J Naughton, Susan Moxley, Gena Hargis, Donna Kronner, Andrea Anderson, Cralen Davis, Jeanette Andrews, Jennifer W Talton
Abstract
Objectives: To evaluate the reliability and cluster structure of the Pediatric Quality of Life Inventory Type 1 Diabetes Module 3.0 (PedsQL-T1DM) and associated subscales and to explore the associations between PedsQL-T1DM total score and demographic and clinical characteristics and clinical indicators among a large racially/ethnically diverse cohort of youth with type 1 diabetes.
Study design: Principal components analysis was conducted on responses from the PedsQL-T1DM child self-report forms completed by SEARCH for Diabetes in Youth study participants aged ≥ 5 years. Multivariate linear regression models were fit to examine the associations among PedsQL-T1DM total score, demographic and clinical characteristics, and clinical indicators.
Results: The sample comprised 2602 youth with a mean age of 13.6 ± 4.1 years and a mean T1DM duration of 62.1 ± 47.0 months. Principal components analysis did not support the 5 existing PedsQL-T1DM subscales. In multivariate analyses, the PedsQL-T1DM total score was negatively and significantly associated with younger age (5-7 years), female sex, receiving insulin by injection (vs pump), having parents without a college degree, Medicaid/Medicare insurance, and having a comorbid medical condition. Youth with poor glycemic control based on their age-specific hemoglobin A1c target values and those with depressive symptoms had significantly lower PedsQL-T1DM scores than their counterparts with good control and no or limited depressive symptoms.
Conclusion: This study has identified sociodemographic and clinical characteristics of youth with T1DM more likely to experience poor diabetes-specific quality of life. The association of lower PedsQL-T1DM scores with depressive symptoms and poor glycemic control is especially concerning and may be the focus of future interventions and studies.
Conflict of interest statement
The authors declare no conflicts of interest.
Copyright © 2012 Mosby, Inc. All rights reserved.
Source: PubMed