Thai traditional massage increases biochemical markers of bone formation in postmenopausal women: a randomized crossover trial

Sunee Saetung, La-Or Chailurkit, Boonsong Ongphiphadhanakul, Sunee Saetung, La-Or Chailurkit, Boonsong Ongphiphadhanakul

Abstract

Background: The effect of massage therapy on bone metabolism in adults has only scarcely been explored. In a randomized crossover trial, we investigated the skeletal effect of Thai traditional massage by examining the changes in biochemical markers of bone turnover.

Methods: Forty-eight postmenopausal women participated in the study. All volunteers were randomized to a 2-hour session of Thai traditional massage twice a week for 4 weeks and a 4-week control period after a 2-week washout, or vice versa. Twenty-one subjects were allocated to receiving Thai traditional massage first, followed by the control period, while 27 were initially allocated to the control period.

Results: Serum P1NP increased significantly after Thai traditional massage (P <0.01), while there was no change in serum osteocalcin or CTX. During the control period, there was no significant change in P1NP, osteocalcin or CTX compared to baseline. When age and height were taken into account, P1NP in postmenopausal women whose ages were in the middle and higher tertiles and whose heights were in the lower and middle tertiles (n = 22) had a 14.8 ± 3.3% increase in P1NP after massage (P <0.001), while no change in P1NP was found in the rest of the women (n = 26).

Conclusions: Thai traditional massage results in an increase in bone formation as assessed by serum P1NP, particularly in postmenopausal women who are older and have a smaller body build. Future studies with larger samples and additional design features are warranted.

Trial registration: ClinicalTrials.gov : NCT01627028.

References

    1. Chow RHJE, Notarius C. Effect of two randomised exercise programmes on bone mass of healthy postmenopausal women. Br Med J (Clin Res Ed) 1887;295:1441–1444.
    1. Rubin C, Recker R, Cullen D, Ryaby J, McCabe J, McLeod K. Prevention of postmenopausal bone loss by a low-magnitude, high-frequency mechanical stimuli: a clinical trial assessing compliance, efficacy, and safety. J Bone Miner Res. 2004;19(3):343–351.
    1. Jane SW, Chen SL, Wilkie DJ, Lin YC, Foreman SW, Beaton RD, Fan JY, Lu MY, Wang YY, Lin YH. Effects of massage on pain, mood status, relaxation, and sleep in Taiwanese patients with metastatic bone pain: a randomized clinical trial. Pain. 2011;152(10):2432–2442. doi: 10.1016/j.pain.2011.06.021.
    1. Chen H, Miller S, Shaw J, Moyer-Mileur L. Massage therapy during early postnatal life promotes greater lean mass and bone growth, mineralization, and strength in juvenile and young adult rats. J Musculoskelet Neuronal Interact. 2009;9(4):278–287.
    1. Aly H, Moustafa MF, Hassanein SM, Massaro AN, Amer HA, Patel K. Physical activity combined with massage improves bone mineralization in premature infants: a randomized trial. J Perinatol. 2004;24(5):305–309. doi: 10.1038/sj.jp.7211083.
    1. Saetung S, Chailurkit LO, Ongphiphadhanakul B. Acute changes in biochemical markers of bone resorption and formation after Thai traditional massage. J Med Assoc Thai. 2010;93(7):771–775.
    1. Buttagat V, Eungpinichpong W, Chatchawan U, Arayawichanon P. Therapeutic effects of traditional Thai massage on pain, muscle tension and anxiety in patients with scapulocostal syndrome: a randomized single-blinded pilot study. J Bodyw Mov Ther. 2012;16(1):57–63. doi: 10.1016/j.jbmt.2011.04.005.
    1. Bemben DA, Palmer IJ, Bemben MG, Knehans AW. Effects of combined whole-body vibration and resistance training on muscular strength and bone metabolism in postmenopausal women. Bone. 2010;47(3):650–656. doi: 10.1016/j.bone.2010.06.019.
    1. Quesada-Gomez JM, Muschitz C, Gomez-Reino J, Greisen H, Andersen HS, Dimai HP. The effect of PTH(1–84) or strontium ranelate on bone formation markers in postmenopausal women with primary osteoporosis: results of a randomized, open-label clinical trial. Osteoporos Int. 2011;22(9):2529–2537. doi: 10.1007/s00198-010-1460-6.
    1. Sikjaer T, Rejnmark L, Rolighed L, Heickendorff L, Mosekilde L. The effect of adding PTH(1–84) to conventional treatment of hypoparathyroidism: a randomized, placebo-controlled study. J Bone Miner Res. 2011;26(10):2358–2370. doi: 10.1002/jbmr.470.
    1. Padhi D, Jang G, Stouch B, Fang L, Posvar E. Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody. J Bone Miner Res. 2011;26(1):19–26. doi: 10.1002/jbmr.173.
    1. Moyer-Mileur LJ, Ball SD, Brunstetter VL, Chan GM. Maternal-administered physical activity enhances bone mineral acquisition in premature very low birth weight infants. J Perinatol. 2008;28(6):432–437. doi: 10.1038/jp.2008.17.
    1. Rubin CT, Lanyon LE. Regulation of bone mass by mechanical strain magnitude. Calcif Tissue Int. 1985;37(4):411–417. doi: 10.1007/BF02553711.
    1. Qin YX, Rubin CT, McLeod KJ. Nonlinear dependence of loading intensity and cycle number in the maintenance of bone mass and morphology. J Orthop Res. 1998;16(4):482–489. doi: 10.1002/jor.1100160414.
    1. Turner CH, Owan I, Takano Y. Mechanotransduction in bone: role of strain rate. Am J Physiol. 1995;269(3 Pt 1):E438–E442.
    1. Cullen DM, Smith RT, Akhter MP. Bone-loading response varies with strain magnitude and cycle number. J Appl Physiol. 2001;91(5):1971–1976.
    1. Nagatomi J, Arulanandam BP, Metzger DW, Meunier A, Bizios R. Frequency- and duration-dependent effects of cyclic pressure on select bone cell functions. Tissue Eng. 2001;7(6):717–728. doi: 10.1089/107632701753337672.
    1. Kaspar D, Seidl W, Neidlinger-Wilke C, Beck A, Claes L, Ignatius A. Proliferation of human-derived osteoblast-like cells depends on the cycle number and frequency of uniaxial strain. J Biomech. 2002;35(7):873–880. doi: 10.1016/S0021-9290(02)00058-1.
    1. Karsenty G, Oury F. The central regulation of bone mass, the first link between bone remodeling and energy metabolism. J Clin Endocrinol Metab. 2010;95(11):4795–4801. doi: 10.1210/jc.2010-1030.
    1. Haley S, O’Grady S, Gulliver K, Bowman B, Baldassarre R, Miller S, Lane RH, Moyer-Mileur LJ. Mechanical-tactile stimulation (MTS) intervention in a neonatal stress model improves long-term outcomes on bone. J Musculoskelet Neuronal Interact. 2011;11(3):234–242.
    1. Sliz D, Smith A, Wiebking C, Northoff G, Hayley S. Neural correlates of a single-session massage treatment. Brain Imaging Behav. 2012;6(1):77–87. doi: 10.1007/s11682-011-9146-z.
    1. Fukushima N, Hanada R, Teranishi H, Fukue Y, Tachibana T, Ishikawa H, Takeda S, Takeuchi Y, Fukumoto S, Kangawa K. Ghrelin directly regulates bone formation. J Bone Miner Res. 2005;20(5):790–798.
    1. Kim SHKE, Park SK. Effect of Massage Therapy on Growth of Preterm Infants: Relationship with Ghrelin, Leptin and Bone Specific Alkaline Phosphatase Levels. J Korean Soc Pediatr Endocrinol. 2005;10(2):169–175.

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