Evaluating Machine Learning-Based Automated Personalized Daily Step Goals Delivered Through a Mobile Phone App: Randomized Controlled Trial

Mo Zhou, Yoshimi Fukuoka, Yonatan Mintz, Ken Goldberg, Philip Kaminsky, Elena Flowers, Anil Aswani, Mo Zhou, Yoshimi Fukuoka, Yonatan Mintz, Ken Goldberg, Philip Kaminsky, Elena Flowers, Anil Aswani

Abstract

Background: Growing evidence shows that fixed, nonpersonalized daily step goals can discourage individuals, resulting in unchanged or even reduced physical activity.

Objective: The aim of this randomized controlled trial (RCT) was to evaluate the efficacy of an automated mobile phone-based personalized and adaptive goal-setting intervention using machine learning as compared with an active control with steady daily step goals of 10,000.

Methods: In this 10-week RCT, 64 participants were recruited via email announcements and were required to attend an initial in-person session. The participants were randomized into either the intervention or active control group with a one-to-one ratio after a run-in period for data collection. A study-developed mobile phone app (which delivers daily step goals using push notifications and allows real-time physical activity monitoring) was installed on each participant's mobile phone, and participants were asked to keep their phone in a pocket throughout the entire day. Through the app, the intervention group received fully automated adaptively personalized daily step goals, and the control group received constant step goals of 10,000 steps per day. Daily step count was objectively measured by the study-developed mobile phone app.

Results: The mean (SD) age of participants was 41.1 (11.3) years, and 83% (53/64) of participants were female. The baseline demographics between the 2 groups were similar (P>.05). Participants in the intervention group (n=34) had a decrease in mean (SD) daily step count of 390 (490) steps between run-in and 10 weeks, compared with a decrease of 1350 (420) steps among control participants (n=30; P=.03). The net difference in daily steps between the groups was 960 steps (95% CI 90-1830 steps). Both groups had a decrease in daily step count between run-in and 10 weeks because interventions were also provided during run-in and no natural baseline was collected.

Conclusions: The results showed the short-term efficacy of this intervention, which should be formally evaluated in a full-scale RCT with a longer follow-up period.

Trial registration: ClinicalTrials.gov: NCT02886871; https://ichgcp.net/clinical-trials-registry/NCT02886871 (Archived by WebCite at http://www.webcitation.org/6wM1Be1Ng).

Keywords: cell phone; clinical trial; fitness tracker; physical activity.

Conflict of interest statement

Conflicts of Interest: None declared.

©Mo Zhou, Yoshimi Fukuoka, Yonatan Mintz, Ken Goldberg, Philip Kaminsky, Elena Flowers, Anil Aswani. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 25.01.2018.

Figures

Figure 1
Figure 1
The CalFit app interface. (a) The landing page; (b) The homepage showing the steps done today and today’s goal; (c) The "History" tab showing the performance of the past week. The black bar is the goal, and the bars are green for achieved goals and red for unachieved goals; (d) The "Contact Us" tab where participants can easily send messages to the study team.
Figure 2
Figure 2
Screening, randomization, and assessments of study participants.
Figure 3
Figure 3
Weekly average and moving average steps for the 2 groups over the course of the study for intention-to-treat analysis after run-in adjustment. Left panel: mean weekly steps for intention-to-treat; Right panel: weekly moving average for intention-to-treat.
Figure 4
Figure 4
Weekly average step goals and average fraction of goals achieved for the 2 groups for intention-to-treat analysis. Left panel: weekly average step goals for intention-to-treat; Right panel: weekly average fraction of achieved goals for intention-to-treat.
Figure 5
Figure 5
Weekly average and moving average steps for the 2 groups over the course of the study for per-protocol analysis after run-in adjustment. Left panel: mean weekly steps for per-protocol; Right panel: weekly moving average for per-protocol.
Figure 6
Figure 6
Weekly average step goals and average fraction of goals achieved for the 2 groups for per-protocol analysis. Left panel: weekly average step goals for per-protocol; Right panel: weekly average fraction of achieved goals for per-protocol.

References

    1. World Health Organization. Health topics: physical activity
    1. Knight J. Physical inactivity: associated diseases and disorders. Ann Clin Lab Sci. 2012;42(3):320–37.
    1. Thompson PD, Buchner D, Pina IL, Balady GJ, Williams MA, Marcus BH, Berra K, Blair SN, Costa F, Franklin B, Fletcher GF, Gordon NF, Pate RR, Rodriguez BL, Yancey AK, Wenger NK. Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease. Circulation. 2003 Jun 24;107(24):3109–16. doi: 10.1161/01.CIR.0000075572.40158.77.
    1. Sigal RJ, Kenny GP, Wasserman DH, Castaneda-Sceppa C, White RD. Physical activity/exercise and type 2 diabetes: a consensus statement from the American Diabetes Association. Diabetes Care. 2006 Jun;29(6):1433–8. doi: 10.2337/dc06-9910.
    1. Ströhle A. Physical activity, exercise, depression and anxiety disorders. J Neural Transm. 2009 Jun;116(6):777–84. doi: 10.1007/s00702-008-0092-x.
    1. . 2008 Physical activity guidelines for Americans .
    1. . Physical inactivity statistical fact sheet .
    1. State of Obesity. Physical inactivity in the United States
    1. Eakin EG, Glasgow RE, Riley KM. Review of primary care-based physical activity intervention studies: effectiveness and implications for practice and future research. J Fam Pract. 2000 Feb;49(2):158–68.
    1. Little P, Dorward M, Gralton S, Hammerton L, Pillinger J, White P, Moore M, McKenna J, Payne S. A randomised controlled trial of three pragmatic approaches to initiate increased physical activity in sedentary patients with risk factors for cardiovascular disease. Br J Gen Pract. 2004 Mar;54(500):189–95.
    1. Pahor M, Blair SN, Espeland M, Fielding R, Gill TM, Guralnik JM, Hadley EC, King AC, Kritchevsky SB, Maraldi C, Miller ME, Newman AB, Rejeski WJ, Romashkan S, Studenski S. Effects of a physical activity intervention on measures of physical performance: results of the lifestyle interventions and independence for elders pilot (LIFE-P) study. J Gerontol A Biol Sci Med Sci. 2006 Nov;61(11):1157–65.
    1. Fritz T, Huang E, Murphy G, Zimmermann T. Persuasive technology in the real world: a study of long-term use of activity sensing devices for fitness. SIGCHI Conference on Human Factors in Computing Systems; 2014; Toronto. 2014. pp. 487–96.
    1. Fjeldsoe B, Miller Y, Marshall A. MobileMums: a randomized controlled trial of an SMS-based physical activity intervention. Ann Behav Med. 2010 May;39(2):101–11. doi: 10.1007/s12160-010-9170-z.
    1. Fukuoka Y, Vittinghoff E, Jong SS, Haskell W. Innovation to motivation--pilot study of a mobile phone intervention to increase physical activity among sedentary women. Prev Med. 2010;51(3-4):287–9. doi: 10.1016/j.ypmed.2010.06.006.
    1. Hurling R, Catt M, De Boni M, Fairley BW, Hurst T, Murray P, Richardson A, Sodhi JS. Using internet and mobile phone technology to deliver an automated physical activity program: randomized controlled trial. J Med Internet Res. 2007 Apr 27;9(2):e7. doi: 10.2196/jmir.9.2.e7.
    1. King AC, Ahn DK, Oliveira BM, Atienza AA, Castro CM, Gardner CD. Promoting physical activity through hand-held computer technology. Am J Prev Med. 2008 Feb;34(2):138–42. doi: 10.1016/j.amepre.2007.09.025.
    1. O'Reilly GA, Spruijt-Metz D. Current mHealth technologies for physical activity assessment and promotion. Am J Prev Med. 2013 Oct;45(4):501–7. doi: 10.1016/j.amepre.2013.05.012.
    1. van den Berg MH, Schoones JW, Vliet Vlieland TP. Internet-based physical activity interventions: a systematic review of the literature. J Med Internet Res. 2007 Sep 30;9(3):e26. doi: 10.2196/jmir.9.3.e26.
    1. Stephens J, Allen J. Mobile phone interventions to increase physical activity and reduce weight: a systematic review. J Cardiovasc Nurs. 2013;28(4):320–9. doi: 10.1097/JCN.0b013e318250a3e7.
    1. Fanning J, Mullen S, McAuley E. Increasing physical activity with mobile devices: a meta-analysis. J Med Internet Res. 2012 Nov 21;14(6):e161. doi: 10.2196/jmir.2171.
    1. Araiza P, Hewes H, Gashetewa C, Vella CA, Burge MR. Efficacy of a pedometer-based physical activity program on parameters of diabetes control in type 2 diabetes mellitus. Metabolism. 2006 Oct;55(10):1382–7. doi: 10.1016/j.metabol.2006.06.009.
    1. Hultquist CN, Albright C, Thompson DL. Comparison of walking recommendations in previously inactive women. Med Sci Sports Exerc. 2005 Apr;37(4):676–83.
    1. Schneider PL, Bassett DR, Thompson DL, Pronk NP, Bielak KM. Effects of a 10,000 steps per day goal in overweight adults. Am J Health Promot. 2006;21(2):85–9.
    1. Lindberg R. Active living: on the road with the 10,000 steps program. J Am Diet Assoc. 2000 Aug;100(8):878–9.
    1. Pila E, Tignor S, Gilchrist J, Sabiston C, Fombelle P, Sirianni N. Self-conscious emotions in response to physical activity success and failure: findings from a global 112-day pedometer intervention. Journal of Exercise, Movement, and Sport (SCAPPS refereed abstracts repository) 2016;48(1)
    1. Ryan J, Edney S, Maher C. Engagement, compliance and retention with a gamified online social networking physical activity intervention. Transl Behav Med. 2017 Dec;7(4):702–8. doi: 10.1007/s13142-017-0499-8.
    1. Ransdell L, Robertson L, Ornes L, Moyer-Mileur L. Generations exercising together to improve fitness (GET FIT): a pilot study designed to increase physical activity and improve health-related fitness in three generations of women. Women Health. 2004;40(3):77–94.
    1. Adams M, Hurley J, Todd M, Bhuiyan N, Jarrett C, Tucker W, Hollingshead KE, Angadi SS. Adaptive goal setting and financial incentives: a 2 × 2 factorial randomized controlled trial to increase adults' physical activity. BMC Public Health. 2017 Dec 29;17(1):286. doi: 10.1186/s12889-017-4197-8.
    1. Adams M, Sallis J, Norman G, Hovell M, Hekler E, Perata E. An adaptive physical activity intervention for overweight adults: a randomized controlled trial. PLoS One. 2013;8(12):e82901. doi: 10.1371/journal.pone.0082901.
    1. Shilts M, Horowitz M, Townsend M. Goal setting as a strategy for dietary and physical activity behavior change: a review of the literature. Am J Health Promot. 2004;19(2):81–93.
    1. Locke E, Latham G. Building a practically useful theory of goal setting and task motivation. A 35-year odyssey. Am Psychol. 2002 Sep;57(9):705–17.
    1. Bandura A. Self-efficacy: toward a unifying theory of behavioral change. Psychol Rev. 1977 Mar;84(2):191–215.
    1. Fukuoka Y, Gay C, Joiner K, Vittinghoff E. A novel diabetes prevention intervention using a mobile app: a randomized controlled trial with overweight adults at risk. Am J Prev Med. 2015 Aug;49(2):223–37. doi: 10.1016/j.amepre.2015.01.003.
    1. Jakicic JM, Davis KK, Rogers RJ, King WC, Marcus MD, Helsel D, Rickman AD, Wahed AS, Belle SH. Effect of wearable technology combined with a lifestyle intervention on long-term weight loss: the IDEA randomized clinical trial. JAMA. 2016 Sep 20;316(11):1161–71. doi: 10.1001/jama.2016.12858.
    1. Joseph R, Keller C, Adams M, Ainsworth B. Print versus a culturally-relevant facebook and text message delivered intervention to promote physical activity in African American women: a randomized pilot trial. BMC Womens Health. 2015 Mar 27;15:30. doi: 10.1186/s12905-015-0186-1.
    1. Sidman CL, Corbin CB, Le MG. Promoting physical activity among sedentary women using pedometers. Res Q Exerc Sport. 2004 Jun;75(2):122–9. doi: 10.1080/02701367.2004.10609143.
    1. Tudor-Locke C. Eric.ed. 2002. [2018-01-16]. Taking steps toward increased physical activity: using pedometers to measure and motivate .
    1. Williams B, Bezner J, Chesbro S, Leavitt R. The effect of a behavioral contract on adherence to a walking program in postmenopausal African American women. Top Geriatr Rehabil. 2005;21(4):332–42.
    1. Chan CB, Ryan DAJ, Tudor-Locke C. Health benefits of a pedometer-based physical activity intervention in sedentary workers. Prev Med. 2004 Dec;39(6):1215–22. doi: 10.1016/j.ypmed.2004.04.053.
    1. Poirier J, Bennett W, Jerome G, Shah N, Lazo M, Yeh H-C, Clark JM, Cobb NK. Effectiveness of an activity tracker- and internet-based adaptive walking program for adults: a randomized controlled trial. J Med Internet Res. 2016 Feb 09;18(2):e34. doi: 10.2196/jmir.5295.
    1. Bravata D, Smith-Spangler C, Sundaram V, Gienger A, Lin N, Lewis R, Stave CD, Olkin I, Sirard JR. Using pedometers to increase physical activity and improve health: a systematic review. JAMA. 2007 Nov 21;298(19):2296–304. doi: 10.1001/jama.298.19.2296.
    1. Croteau KA. A preliminary study on the impact of a pedometer-based intervention on daily steps. Am J Health Promot. 2004;18(3):217–20.
    1. Mintz Y, Aswani A, Kaminsky P, Flowers E, Fukuoka Y. Arxiv. 2017. [2018-01-16]. Behavioral analytics for myopic agents .
    1. Finkelstein EA, Brown DS, Brown DR, Buchner DM. A randomized study of financial incentives to increase physical activity among sedentary older adults. Prev Med. 2008 Aug;47(2):182–7. doi: 10.1016/j.ypmed.2008.05.002.
    1. Mitchell MS, Goodman JM, Alter DA, John LK, Oh PI, Pakosh MT, Faulkner GE. Financial incentives for exercise adherence in adults: systematic review and meta-analysis. Am J Prev Med. 2013 Nov;45(5):658–67. doi: 10.1016/j.amepre.2013.06.017.
    1. Paul-Ebhohimhen V, Avenell A. Systematic review of the use of financial incentives in treatments for obesity and overweight. Obes Rev. 2008 Jul;9(4):355–67. doi: 10.1111/j.1467-789X.2007.00409.x.
    1. Aswani A, Kaminsky P, Mintz Y, Flowers E, Fukuoka Y. SSRN. 2016. [2018-01-16]. Behavioral modeling in weight loss interventions .
    1. CDC. Barriers to being active quiz .
    1. Craig C, Marshall A, Sjöström M, Bauman A, Booth M, Ainsworth B, Pratt M, Ekelund U, Yngve A, Sallis JF, Oja P. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc. 2003 Aug;35(8):1381–95. doi: 10.1249/01.MSS.0000078924.61453.FB.
    1. Bai Y, Welk GJ, Nam YH, Lee JA, Lee J, Kim Y, Meier NF, Dixon PM. Comparison of consumer and research monitors under semistructured settings. Med Sci Sports Exerc. 2016 Jan;48(1):151–8. doi: 10.1249/MSS.0000000000000727.
    1. Case M, Burwick H, Volpp K, Patel M. Accuracy of smartphone applications and wearable devices for tracking physical activity data. JAMA. 2015 Feb 10;313(6):625–6. doi: 10.1001/jama.2014.17841.
    1. Althoff T, Sosič R, Hicks JL, King AC, Delp SL, Leskovec J. Large-scale physical activity data reveal worldwide activity inequality. Nature. 2017 Dec 20;547(7663):336–9. doi: 10.1038/nature23018.
    1. El-Amrawy F, Nounou MI. Are currently available wearable devices for activity tracking and heart rate monitoring accurate, precise, and medically beneficial? Healthc Inform Res. 2015 Oct;21(4):315–20. doi: 10.4258/hir.2015.21.4.315.
    1. Lee J, Kim Y, Welk GJ. Validity of consumer-based physical activity monitors. Med Sci Sports Exerc. 2014 Sep;46(9):1840–8. doi: 10.1249/MSS.0000000000000287.
    1. Wen D, Zhang X, Liu X, Lei J. Evaluating the consistency of current mainstream wearable devices in health monitoring: a comparison under free-living conditions. J Med Internet Res. 2017 Mar 07;19(3):e68. doi: 10.2196/jmir.6874.
    1. Naumova E, Must A, Laird N. Tutorial in biostatistics: evaluating the impact of 'critical periods' in longitudinal studies of growth using piecewise mixed effects models. Int J Epidemiol. 2001 Dec;30(6):1332–41.
    1. Tabák AG, Jokela M, Akbaraly T, Brunner E, Kivimäki M, Witte D. Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study. Lancet. 2009 Jun 27;373(9682):2215–21. doi: 10.1016/S0140-6736(09)60619-X.
    1. Phillips SM, Bandini LG, Naumova EN, Cyr H, Colclough S, Dietz WH, Must A. Energy-dense snack food intake in adolescence: longitudinal relationship to weight and fatness. Obes Res. 2004 Mar;12(3):461–72. doi: 10.1038/oby.2004.52. doi: 10.1038/oby.2004.52.
    1. Verbeke G. Linear mixed models for longitudinal data. New York: Springer; 1997.
    1. Krueger C, Tian L. A comparison of the general linear mixed model and repeated measures ANOVA using a dataset with multiple missing data points. Biol Res Nurs. 2004 Oct;6(2):151–7. doi: 10.1177/1099800404267682.
    1. Mathworks. Natick, MA: The Mathworks Inc; 2016. [2018-01-16]. MATLAB and ttatistics toolbox release 2016a .
    1. R-project. Vienna, Austria: R Foundation for Statistical Computing; 2017. [2018-01-16]. R: A language and environment for statistical computing
    1. Tudor-Locke C, Johnson WD, Katzmarzyk PT. Accelerometer-determined steps per day in US adults. Med Sci Sports Exerc. 2009 Jul;41(7):1384–91. doi: 10.1249/MSS.0b013e318199885c.
    1. Stovitz SD, VanWormer JJ, Center BA, Bremer KL. Pedometers as a means to increase ambulatory activity for patients seen at a family medicine clinic. J Am Board Fam Pract. 2005;18(5):335–43.
    1. Annesi JJ. Goal-setting protocol in adherence to exercise by Italian adults. Percept Mot Skills. 2002 Apr;94(2):453–8. doi: 10.2466/pms.2002.94.2.453.
    1. Barz M, Lange D, Parschau L, Lonsdale C, Knoll N, Schwarzer R. Self-efficacy, planning, and preparatory behaviours as joint predictors of physical activity: a conditional process analysis. Psychol Health. 2016;31(1):65–78. doi: 10.1080/08870446.2015.1070157.
    1. Olander E, Fletcher H, Williams S, Atkinson L, Turner A, French D. What are the most effective techniques in changing obese individuals' physical activity self-efficacy and behaviour: a systematic review and meta-analysis. Int J Behav Nutr Phys Act. 2013 Mar 03;10:29. doi: 10.1186/1479-5868-10-29.
    1. Iwasaki Y, Honda S, Kaneko S, Kurishima K, Honda A, Kakinuma A, Jahng D. Exercise self-efficacy as a mediator between goal-setting and physical activity: developing the workplace as a setting for promoting physical activity. Saf Health Work. 2017 Mar;8(1):94–8. doi: 10.1016/j.shaw.2016.08.004.
    1. Clarke KK, Freeland-Graves J, Klohe-Lehman DM, Milani TJ, Nuss HJ, Laffrey S. Promotion of physical activity in low-income mothers using pedometers. J Am Diet Assoc. 2007 Jun;107(6):962–7. doi: 10.1016/j.jada.2007.03.010.
    1. Merom D, Rissel C, Phongsavan P, Smith BJ, Van KC, Brown WJ, Bauman AE. Promoting walking with pedometers in the community: the step-by-step trial. Am J Prev Med. 2007 Apr;32(4):290–7. doi: 10.1016/j.amepre.2006.12.007.
    1. Turner-McGrievy GM, Beets MW, Moore JB, Kaczynski AT, Barr-Anderson DJ, Tate DF. Comparison of traditional versus mobile app self-monitoring of physical activity and dietary intake among overweight adults participating in an mHealth weight loss program. J Am Med Inform Assoc. 2013 May 01;20(3):513–8. doi: 10.1136/amiajnl-2012-001510.
    1. Wang J, Cadmus-Bertram L, Natarajan L, White M, Madanat H, Nichols J, Ayala GX, Pierce JP. Wearable sensor/device (fitbit one) and SMS text-messaging prompts to increase physical activity in overweight and obese adults: a randomized controlled trial. Telemed J E Health. 2015 Oct;21(10):782–92. doi: 10.1089/tmj.2014.0176.
    1. Bandura A, Cervone D. Self-evaluative and self-efficacy mechanisms governing the motivational effects of goal systems. J Pers Soc Psychol. 1983;45(5):1017–28. doi: 10.1037/0022-3514.45.5.1017.
    1. Anderson ES, Wojcik JR, Winett RA, Williams DM. Social-cognitive determinants of physical activity: the influence of social support, self-efficacy, outcome expectations, and self-regulation among participants in a church-based health promotion study. Health Psychol. 2006 Jul;25(4):510–20. doi: 10.1037/0278-6133.25.4.510.
    1. French DP, Olander EK, Chisholm A, Mc SJ. Which behaviour change techniques are most effective at increasing older adults' self-efficacy and physical activity behaviour? A systematic review. Ann Behav Med. 2014 Oct;48(2):225–34. doi: 10.1007/s12160-014-9593-z.
    1. Venditti EM, Wylie-Rosett J, Delahanty LM, Mele L, Hoskin MA, Edelstein SL, Diabetes Prevention Program Research Group Short and long-term lifestyle coaching approaches used to address diverse participant barriers to weight loss and physical activity adherence. Int J Behav Nutr Phys Act. 2014 Feb 12;11:16. doi: 10.1186/1479-5868-11-16.
    1. Cummins CO, Evers KE, Johnson JL, Paiva A, Prochaska JO, Prochaska JM. Assessing stage of change and informed decision making for Internet participation in health promotion and disease management. Manag Care Interface. 2004 Aug;17(8):27–32.
    1. Brug J, Oenema A, Kroeze W, Raat H. The internet and nutrition education: challenges and opportunities. Eur J Clin Nutr. 2005 Aug;59(Suppl 1):S130–9. doi: 10.1038/sj.ejcn.1602186.
    1. Wylie-Rosett J, Swencionis C, Ginsberg M, Cimino C, Wassertheil-Smoller S, Caban A, Segal-Isaacson CJ, Martin T, Lewis J. Computerized weight loss intervention optimizes staff time: the clinical and cost results of a controlled clinical trial conducted in a managed care setting. J Am Diet Assoc. 2001 Oct;101(10):1155–62.
    1. Atienza AA, King AC, Oliveira BM, Ahn DK, Gardner CD. Using hand-held computer technologies to improve dietary intake. Am J Prev Med. 2008 Jun;34(6):514–8. doi: 10.1016/j.amepre.2008.01.034.
    1. Carter MC, Burley VJ, Nykjaer C, Cade JE. Adherence to a smartphone application for weight loss compared to website and paper diary: pilot randomized controlled trial. J Med Internet Res. 2013 Apr 15;15(4):e32. doi: 10.2196/jmir.2283.
    1. Ahtinen A, Mattila E, Vaatanen A, Hynninen L, Salminen J, Koskinen E. User experiences of mobile wellness applications in health promotion: user study of wellness diary, mobile coach and selfrelax. Pervasive Computing Technologies for Healthcare; 2009; London. 2009.
    1. Kulavic K, Hultquist CN, McLester JR. A comparison of motivational factors and barriers to physical activity among traditional versus nontraditional college students. J Am Coll Health. 2013;61(2):60–6. doi: 10.1080/07448481.2012.753890.
    1. Sawchuk C, Russo J, Bogart A, Charles S, Goldberg J, Forquera R, Roy-Byrne P, Buchwald D. Barriers and facilitators to walking and physical activity among American Indian elders. Prev Chronic Dis. 2011 May;8(3):A63.
    1. Kim Y, Park I, Kang M. Convergent validity of the international physical activity questionnaire (IPAQ): meta-analysis. Public Health Nutr. 2013 Mar;16(3):440–52. doi: 10.1017/S1368980012002996.
    1. Bombardier C, Fann J, Ludman E, Vannoy S, Dyer J, Barber J, Temkin NR. The relations of cognitive, behavioral, and physical activity variables to depression severity in traumatic brain injury: reanalysis of data from a randomized controlled trial. J Head Trauma Rehabil. 2017;32(5):343–53. doi: 10.1097/HTR.0000000000000288.
    1. Sandroff B, Klaren R, Pilutti L, Dlugonski D, Benedict R, Motl R. Randomized controlled trial of physical activity, cognition, and walking in multiple sclerosis. J Neurol. 2014 Feb;261(2):363–72. doi: 10.1007/s00415-013-7204-8.

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