Novel soy germ pasta enriched in isoflavones ameliorates gastroparesis in type 2 diabetes: a pilot study

Kenneth D R Setchell, Elisabetta Nardi, Pier-Maria Battezzati, Stefania Asciutti, Danilo Castellani, Gabriele Perriello, Carlo Clerici, Kenneth D R Setchell, Elisabetta Nardi, Pier-Maria Battezzati, Stefania Asciutti, Danilo Castellani, Gabriele Perriello, Carlo Clerici

Abstract

Objective: To determine the effect of soy germ pasta enriched in biologically active isoflavone aglycons on gastric emptying in type 2 diabetic patients with gastroparesis.

Research design and methods: This randomized double-blind, placebo-controlled study compared soy germ pasta with conventional pasta for effects on gastric emptying. Patients (n = 10) with delayed gastric emptying consumed one serving per day of each pasta for 8 weeks, with a 4-week washout. Gastric emptying time (t1/2) was measured using the [(13)C]octanoic acid breath test at baseline and after each period, and blood glucose and insulin concentrations were determined after oral glucose load.

Results: Soy germ pasta significantly accelerated the t1/2 in these patients (161.2 ± 17.5 min at baseline vs. 112.6 ± 11.2 min after treatment, P = 0.009). Such change differed significantly (P = 0.009) from that for conventional pasta (153.6 ± 24.2 vs. 156.2 ± 27.4 min), without affecting glucose or insulin concentrations.

Conclusions: These findings suggest that soy germ pasta may offer a simple dietary approach to managing diabetic gastropathy.

Figures

Figure 1
Figure 1
Relationship between gastric emptying time (t1/2) in 10 patients with documented diabetic gastroparesis measured at baseline and after consuming soy germ pasta containing isoflavone aglycons and conventional pasta lacking isoflavones. The dotted line in the upper plots denotes no change after consuming pasta. Data points below this line indicate reduced gastric emptying time. The solid lines show the regression line of values after treatment on those before treatment during enriched pasta (Pasta+) or control pasta (Pasta−) feeding. Gray and hollow circles denote the data measured on entry into this crossover study and after the first pasta treatment (to be enrolled, these patients had to show a baseline emptying time >120 min); gray and hollow triangles denote values measured after the washout period, i.e., before and after the other pasta treatment. The lower plot (box plots) shows the distribution of gastric emptying times before and after 8-week treatment with the two pastas.

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Source: PubMed

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