Plasminogen activator inhibitor 1 and 2 are tumor necrosis factor/cachectin-responsive genes

R L Medcalf, E K Kruithof, W D Schleuning, R L Medcalf, E K Kruithof, W D Schleuning

Abstract

Human rTNF/Cachectin was shown to stimulate gene transcription of plasminogen activator inhibitor (PA1)-1 and PAI-2, and simultaneously suppress constitutive gene expression of tissue-type plasminogen activator (t-PA) in human fibrosarcoma cells. We propose that a TNF-mediated reprogramming of gene transcription induces, in appropriate target cells, an anti-fibrinolytic state, which may cooperate with the induction of procoagulant activity (tissue factor) to stabilize the fibrin deposits commonly found in inflamed tissue. PAI genes also provide a model system for a study of the molecular pathways underlying TNF-mediated signal transduction.

References

    1. Proc Natl Acad Sci U S A. 1980 Sep;77(9):5201-5
    1. Arch Biochem Biophys. 1952 Oct;40(2):346-51
    1. Proc Natl Acad Sci U S A. 1983 May;80(10):2956-60
    1. J Mol Biol. 1983 Jun 15;167(1):77-101
    1. Nature. 1984 Oct 4-10;311(5985):433-8
    1. Science. 1985 Aug 30;229(4716):867-9
    1. Science. 1985 Aug 30;229(4716):869-71
    1. J Biol Chem. 1985 Sep 15;260(20):11223-30
    1. Adv Cancer Res. 1985;44:139-266
    1. J Exp Med. 1985 Dec 1;162(6):2163-8
    1. Proc Natl Acad Sci U S A. 1985 Dec;82(24):8710-4
    1. Proc Natl Acad Sci U S A. 1986 Jan;83(2):446-50
    1. Immunol Lett. 1985;11(3-4):173-7
    1. J Exp Med. 1986 Mar 1;163(3):740-5
    1. Proc Natl Acad Sci U S A. 1986 Jun;83(12):4533-7
    1. Am J Pathol. 1986 Aug;124(2):179-85
    1. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6776-80
    1. EMBO J. 1986 Sep;5(9):2217-22
    1. Blood. 1987 Feb;69(2):460-6
    1. J Cell Biol. 1987 Mar;104(3):705-12
    1. J Exp Med. 1987 Feb 1;165(2):320-39
    1. Int J Cancer. 1988 Feb 15;41(2):243-7
    1. Mol Cell Biol. 1987 Dec;7(12):4564-7
    1. J Cell Biol. 1988 Mar;106(3):971-8
    1. J Biol Chem. 1988 Apr 25;263(12):5797-803
    1. Nature. 1982 Oct 28;299(5886):797-802

Source: PubMed

Sponsorit ja yhteistyökumppanit

Sairaudet

Huumeiden interventiot

3
Tilaa