High intensity interval running enhances measures of physical fitness but not metabolic measures of cardiovascular disease risk in healthy adolescents

Duncan S Buchan, Stewart Ollis, John D Young, Stephen-Mark Cooper, Julian P H Shield, Julien S Baker, Duncan S Buchan, Stewart Ollis, John D Young, Stephen-Mark Cooper, Julian P H Shield, Julien S Baker

Abstract

Background: With accumulating evidence suggesting that CVD has its origins in childhood, the purpose of this study was to examine whether a high intensity training (HIT) intervention could enhance the CVD risk profile of secondary school aged adolescents in a time efficient manner.

Methods: Participants in the study were adolescent school children (64 boys, 25 girls, 16.7 ± 0.6 years). The intervention group (30 boys, 12 girls) performed three weekly exercise sessions over 7 weeks with each session consisting of either four to six repeats of maximal sprint running within a 20 m area with 30 s recovery. The control group were instructed to continue their normal behaviour. All participants had indices of obesity, blood pressure and nine biochemical risk markers for cardiovascular disease recorded as well as four physical performance measures at baseline and post-intervention. Feedback was provided through informal discussion throughout the intervention period as well as post-intervention focus groups. Statistical differences between and within groups were determined by use of paired samples t-tests and ANCOVA.

Results: Significant enhancements (P ≤ 0.05) in vertical jump performance, 10 m sprint speed and cardiorespiratory fitness was evident in the intervention group whereas a significant decrease in both agility and vertical jump performance was evident in the control group. Participants in the intervention group also experienced a significant decrease in systolic blood pressure post-intervention. Limited changes occurred with respect to the biochemical markers although both groups did experience a significant increase in LDL post-intervention whilst the control group experienced a significant decrease in total cholesterol. No apparent differences were evident between groups post intervention for any of the biochemical markers. Feedback indicated that participants endorsed the use of the intervention as an effective means of exercise.

Conclusions: Our results demonstrate that high intensity exercise interventions may be used in the school setting for adolescents as a means of improving measures of physical fitness. Further investigations involving a larger cohort of participants, taken from different schools, is recommended.

Trial registration: NCT01027156.

References

    1. Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, De Simone G, Ferguson TB, Ford E, Furie K, Gillespie C. Heart disease and stroke statistics–2010 update: a report from the American Heart Association. Circulation. 2009;121(7):e46–e215.
    1. Freedman DS, Khan LK, Dietz WH, Srinivasan SR, Berenson GS. Relationship of childhood obesity to coronary heart disease risk factors in adulthood: the Bogalusa Heart Study. Pediatrics. 2001;108(3):712–718. doi: 10.1542/peds.108.3.712.
    1. Raitakari OT, Juonala M, Kahonen M, Taittonen L, Laitinen T, Maki-Torkko N, Jarvisalo MJ, Uhari M, Jokinen E, Ronnemaa T. Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study. J A M A. 2003;290(17):2277–2283. doi: 10.1001/jama.290.17.2277.
    1. Cook DG, Mendall MA, Whincup PH, Carey IM, Ballam L, Morris JE, Miller GJ, Strachan DP. C-reactive protein concentration in children: relationship to adiposity and other cardiovascular risk factors. Atherosclerosis. 2000;149(1):139–150. doi: 10.1016/S0021-9150(99)00312-3.
    1. Juhola J, Magnussen CG, Viikari JS, Kahonen M, Hutri-Kahonen N, Jula A, Lehtimaki T, Akerblom HK, Pietikainen M, Laitinen T. Tracking of serum lipid levels, blood pressure, and body mass index from childhood to adulthood: the Cardiovascular Risk in Young Finns Study. J Pediatr. 2011;159(4):584–590. doi: 10.1016/j.jpeds.2011.03.021.
    1. Punthakee Z, Delvin EE, O'Loughlin J, Paradis G, Levy E, Platt RW, Lambert M. Adiponectin, adiposity, and insulin resistance in children and adolescents. J Clin Endocrinol Metab. 2006;91(6):2119–2125. doi: 10.1210/jc.2005-2346.
    1. Ferreira I, van de Laar RJ, Prins MH, Twisk JW, Stehouwer CD. Carotid Stiffness in Young Adults: A Life-Course Analysis of its Early Determinants. Hypertension. 2012;59(1):54–61. doi: 10.1161/HYPERTENSIONAHA.110.156109.
    1. Ekelund U, Tomkinson G, Armstrong N. What proportion of youth are physically active? Measurement issues, levels and recent time trends. Br J Sports Med. 2011;45(11):859–865. doi: 10.1136/bjsports-2011-090190.
    1. Chief Medical Officers of England S, Wales, and Northern Ireland. Start Active, Stay Active. A report on physical activity for health from the four home countries’ Chief Medical Officer. London: Department of Health; 2011.
    1. Dobbins M, De Corby K, Robeson P, Husson H, Tirilis D. School-based physical activity programs for promoting physical activity and fitness in children and adolescents aged 6–18. Cochrane Database Syst Rev. 2009;1 CD007651.
    1. Strong WB, Malina RM, Blimkie CJ, Daniels SR, Dishman RK, Gutin B, Hergenroeder AC, Must A, Nixon PA, Pivarnik JM. Evidence based physical activity for school-age youth. J Pediatr. 2005;146(6):732–737. doi: 10.1016/j.jpeds.2005.01.055.
    1. Burgomaster KA, Howarth KR, Phillips SM, Rakobowchuk M, Macdonald MJ, McGee SL, Gibala MJ. Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans. J Physiol. 2008;586(1):151–160.
    1. Tjonna AE, Stolen TO, Bye A, Volden M, Slordahl SA, Odegard R, Skogvoll E, Wisloff U. Aerobic interval training reduces cardiovascular risk factors more than a multitreatment approach in overweight adolescents. Clin Sci. 2009;116(4):317–326. doi: 10.1042/CS20080249.
    1. Gutin B, Barbeau P, Owens S, Lemmon CR, Bauman M, Allison J, Kang HS, Litaker MS. Effects of exercise intensity on cardiovascular fitness, total body composition, and visceral adiposity of obese adolescents. Am J Clin Nutr. 2002;75(5):818–826.
    1. Babraj JA, Vollaard NB, Keast C, Guppy FM, Cottrell G, Timmons JA. Extremely short duration high intensity interval training substantially improves insulin action in young healthy males. BMC Endocr Disord. 2009;9:3. doi: 10.1186/1472-6823-9-3.
    1. Buchan DS, Ollis S, Young JD, Thomas NE, Cooper SM, Tong TK, Nie J, Malina RM, Baker JS. The effects of time and intensity of exercise on novel and established markers of CVD in adolescent youth. Am J Hum Biol. 2011;23(4):517–526. doi: 10.1002/ajhb.21166.
    1. Godin G, Desharnais R, Valois R, Lepage L, Jobin J, Bradet R. Differences in perceived barriers to exercise between high and low intenders: observations among different populations. Am J Health Promot. 1994;8(4):279–285. doi: 10.4278/0890-1171-8.4.279.
    1. Buchan DS, Ollis S, Thomas NE, Baker JS. The influence of a high intensity physical activity intervention on a selection of health related outcomes: an ecological approach. BMC Publ Health. 2010;10(1):8. doi: 10.1186/1471-2458-10-8.
    1. Buchan DS, Ollis S, Thomas NE, Buchanan N, Cooper SM, Malina RM, Baker JS. Physical activity interventions: effects of duration and intensity. Scand J Med Sci Sports. 2011;21(6):e341–e350. doi: 10.1111/j.1600-0838.2011.01303.x.
    1. Stokols D, Allen J, Bellingham RL. The social ecology of health promotion: implications for research and practice. Am J Health Promot. 1996;10(4):247–251. doi: 10.4278/0890-1171-10.4.247.
    1. King AC, Stokols D, Talen E, Brassington GS, Killingsworth R. Theoretical approaches to the promotion of physical activity: forging a transdisciplinary paradigm. Am J Prev Med. 2002;23(2 Suppl):15–25.
    1. Gillies P. Effectiveness of Alliances and Partnerships for Health Promotion. Health Promot Int. 1998;13(2):99–120. doi: 10.1093/heapro/13.2.99.
    1. Baum F, MacDougall C, Smith D. Participatory action research. J Epidemiol Community Health. 2006;60(10):854–857. doi: 10.1136/jech.2004.028662.
    1. Baker J, Ramsbottom R, Hazeldine R. Maximal shuttle running over 40 m as a measure of anaerobic performance. Br J Sports Med. 1993;27(4):228–232. doi: 10.1136/bjsm.27.4.228.
    1. Tanner JM, Whitehouse RH. Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. Arch Dis Child. 1976;51(3):170–179. doi: 10.1136/adc.51.3.170.
    1. Leger LA, Mercier D, Gadoury C, Lambert J. The multistage 20 metre shuttle run test for aerobic fitness. J Sports Sci. 1988;6(2):93–101. doi: 10.1080/02640418808729800.
    1. Draper JA, Lancaster MG. The 505 test: a test for agility in the horizontal plane. Aust J Sci Med Sport. 1985;17(1):15–18.
    1. Kowalski KC, Crocker PRE, Kowalski NP. Convergent validity of the physical activity questionnaire for adolescents. Pediatr Exerc Sci. 1997;9:342–352.
    1. Food Standards Agency. McCance and Widdowson’s the Composition of Foods. 6. Cambridge UK: Royal Society of Chemistry; 2002. pp. 29–379.
    1. Pronk NP. Short term effects of exercise on plasma lipids and lipoproteins in humans. Sports Med. 1993;16(6):431–448. doi: 10.2165/00007256-199316060-00006.
    1. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18(6):499–502.
    1. Kirby SL, Greaves L, Reid C. Research Social Change: Methods Beyond the Mainstream. 2. Ontario: Broadview Press; 2006. pp. 219–254.
    1. Park I, Schutz RW. An introduction to latent growth models: analysis of repeated measures physical performance data. Res Q Exerc Sport. 2005;76(2):176–192. doi: 10.1080/02701367.2005.10599279.
    1. Cohen J. A power primer. Psychol Bull. 1992;112(1):155–159.
    1. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ. 2000;320(7244):1240–1243. doi: 10.1136/bmj.320.7244.1240.
    1. World Health Organization. Obesity and overweight fact sheet. Geneva, Switzerland: World Health Organization; 2003. Internet: (accessed 10 January 2013)
    1. American College of Sports Medicine. ACSM’s guidelines for exercise testing and prescription. Philadelphia: Lippincott, Williams & Wilkins; 2008.
    1. Clausen JP. Effect of physical training on cardiovascular adjustments to exercise in man. Physiol Rev. 1977;57(4):779–815.
    1. Cornelissen VA, Fagard RH. Effects of endurance training on blood pressure, blood pressure-regulating mechanisms, and cardiovascular risk factors. Hypertension. 2005;46(4):667–675. doi: 10.1161/01.HYP.0000184225.05629.51.
    1. Rakobowchuk M, Tanguay S, Burgomaster KA, Howarth KR, Gibala MJ, MacDonald MJ. Sprint interval and traditional endurance training induce similar improvements in peripheral arterial stiffness and flow-mediated dilation in healthy humans. Am J Physiol Regul Integr Comp Physiol. 2008;295(1):R236–R242. doi: 10.1152/ajpregu.00069.2008.
    1. Macpherson RE, Hazell TJ, Olver TD, Paterson DH, Lemon PW. Run sprint interval training improves aerobic performance but not maximal cardiac output. Med Sci Sports Exerc. 2011;43(1):115–122. doi: 10.1249/MSS.0b013e3181e5eacd.
    1. Gibala MJ, Little JP, Van Essen M, Wilkin GP, Burgomaster KA, Safdar A, Raha S, Tarnopolsky MA. Short-term sprint interval versus traditional endurance training: similar initial adaptations in human skeletal muscle and exercise performance. J Physiol. 2006;575(Pt 3):901–911.
    1. Ortega FB, Artero EG, Ruiz JR, Espana-Romero V, Jimenez-Pavon D, Vicente-Rodriguez G, Moreno LA, Manios Y, Beghin L, Ottevaere C. Physical fitness levels among European adolescents: the HELENA study. Br J Sports Med. 2011;45(1):20–29. doi: 10.1136/bjsm.2009.062679.
    1. Bogdanis GC, Nevill ME, Boobis LH, Lakomy HK. Contribution of phosphocreatine and aerobic metabolism to energy supply during repeated sprint exercise. J Appl Physiol. 1996;80(3):876–884.
    1. Spriet LL, Lindinger MI, McKelvie RS, Heigenhauser GJ, Jones NL. Muscle glycogenolysis and H+ concentration during maximal intermittent cycling. J Appl Physiol. 1989;66(1):8–13.
    1. Hazell TJ, Macpherson RE, Gravelle BM, Lemon PW. 10 or 30-s sprint interval training bouts enhance both aerobic and anaerobic performance. Eur J Appl Physiol. 2010;110(1):153–160. doi: 10.1007/s00421-010-1474-y.
    1. Baquet G, Guinhouya C, Dupont G, Nourry C, Berthoin S. Effects of a short-term interval training program on physical fitness in prepubertal children. J Strength Cond Res. 2004;18(4):708–713.
    1. Durandt J, Tee JC, Prim SK, Lambert MI. Physical fitness components associated with performance in a multiple-sprint test. Int J Sports Physiol Perform. 2006;1(2):150–160.
    1. Lionis C, Kafatos A, Vlachonikolis J, Vakaki M, Tzortzi M, Petraki A. The effects of a health education intervention program among Cretan adolescents. Prev Med. 1991;20(6):685–699. doi: 10.1016/0091-7435(91)90064-B.
    1. Manios Y, Kafatos A. Health and nutrition education in elementary schools: changes in health knowledge, nutrient intakes and physical activity over a six year period. Public Health Nutr. 1999;2(3A):445–448.
    1. Luepker RV, Perry CL, McKinlay SM, Nader PR, Parcel GS, Stone EJ, Webber LS, Elder JP, Feldman HA, Johnson CC. Outcomes of a field trial to improve children's dietary patterns and physical activity. The Child and Adolescent Trial for Cardiovascular Health. CATCH collaborative group. JAMA. 1996;275(10):768–776. doi: 10.1001/jama.1996.03530340032026.

Source: PubMed

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