Vancomycin cerebrospinal fluid pharmacokinetics in children with cerebral ventricular shunt infections

Abstract

This study described the cerebrospinal fluid (CSF) exposure of vancomycin in 8 children prescribed intravenous vancomycin therapy for cerebral ventricular shunt infection. Vancomycin CSF concentrations ranged from 0.06 to 9.13 mg/L and the CSF: plasma ratio ranged from 0 to 0.66. Two of 3 children with a staphylococcal CSF infection had CSF concentrations greater than minimal inhibitory concentration at the end of the dosing interval.

Figures

Figure 1. Vancomycin concentrations over time

CSF, cerebrospinal fluid Two cerebrospinal fluid concentrations at 5 and 10 h are not paired with a predicted serum concentration. These concentrations are from the child who was excluded from the pharmacokinetic analysis due to insufficient serum sampling.