New Cerebral Microbleeds and Mechanism of Post-Thrombolysis Remote Intracerebral Hemorrhage: "Red Meets White" Revisited

Ashkan Shoamanesh, Shenqiang Yan, Andreas Charidimou, Ashkan Shoamanesh, Shenqiang Yan, Andreas Charidimou

No abstract available

Keywords: acute stroke; cerebral amyloid angiopathy; cerebral microbleeds; cerebral small vessel disease; intracerebral hemorrhage; thrombolysis.

Figures

Figure 1
Figure 1
New cerebral microbleeds and remote (i.e., extra-ischemic) intracerebral hemorrhage. Meta-analysis of the association between symptomatic remote intracerebral hemorrhage (ICH) risk in patients with acute ischemic stroke treated with intravenous thrombolysis, in relation to the presence of new cerebral microbleeds (CMBs) on MRI. Moderate heterogeneity was detected across the different studies pooled in the meta-analysis. Two authors search PubMed and extracted relevant data for the analysis. We quantified the strength of the association between new CMBs and ICH using odds ratios (OR) and their corresponding 95% CIs, with the inverse variance method for weighting. We assessed statistical heterogeneity using I-squared statistics and also visually through inspection of the forest plot. We repeated all analyses using random effects models. Meta-analyses were performed using Stata 11.2 (StataCorp LP, Texas).

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Source: PubMed

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