A high-fat diet decreases GABA concentration in the frontal cortex and hippocampus of rats

Cuauhtemoc Sandoval-Salazar, Joel Ramírez-Emiliano, Aurora Trejo-Bahena, Cecilia I Oviedo-Solís, Martha Silvia Solís-Ortiz, Cuauhtemoc Sandoval-Salazar, Joel Ramírez-Emiliano, Aurora Trejo-Bahena, Cecilia I Oviedo-Solís, Martha Silvia Solís-Ortiz

Abstract

Background: It has been proposed that the γ-aminobutyric acid (GABA) plays a key role in the regulation of food intake and body weight by controlling the excitability, plasticity and the synchronization of neuronal activity in the frontal cortex (FC). It has been also proposed that the high-fat diet (HFD) could disturb the metabolism of glutamate and consequently the GABA levels, but the mechanism is not yet clearly understood. Therefore, the aim of this study was to investigate the effect of a HFD on the GABA levels in the FC and hippocampus of rats.

Results: The HFD significantly increased weight gain and blood glucose levels, whereas decreased the GABA levels in the FC and hippocampus compared with standard diet-fed rats.

Conclusions: HFD decreases GABA levels in the FC and hippocampus of rat, which likely disrupts the GABAergic inhibitory processes, underlying feeding behavior.

Figures

Fig. 1
Fig. 1
Effect of high-fat diet on body weight gain. SD, standard diet (n = 10); HFD, high-fat diet (n = 10). Data are given as the mean ± standard error of the mean (SEM)
Fig. 2
Fig. 2
Effect of high-fat diet on GABA levels in frontal cortex and hippocampus. SD, standard diet (n = 10); HFD, high-fat diet (n = 10). Data are given as the mean ± standard error of the mean (SEM)

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