Effect of a Multidomain Lifestyle Intervention on Estimated Dementia Risk

Alina Solomon, Ron Handels, Anders Wimo, Riitta Antikainen, Tiina Laatikainen, Esko Levälahti, Markku Peltonen, Hilkka Soininen, Timo Strandberg, Jaakko Tuomilehto, Miia Kivipelto, Tiia Ngandu, Alina Solomon, Ron Handels, Anders Wimo, Riitta Antikainen, Tiina Laatikainen, Esko Levälahti, Markku Peltonen, Hilkka Soininen, Timo Strandberg, Jaakko Tuomilehto, Miia Kivipelto, Tiia Ngandu

Abstract

We investigated the effect of a multidomain lifestyle intervention on the risk of dementia estimated using the validated CAIDE risk score (post-hoc analysis). The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a 2-year randomized controlled trial among 1,260 at-risk older adults (60-77 years). Difference in the estimated mean change in CAIDE score at 2 years in the intervention compared to the control group was -0.16 (95 %CI -0.31 to 0.00) (p = 0.013), corresponding to a relative dementia risk reduction between 6.04-6.50%. This could be interpreted as a reflection of the prevention potential of the intervention.

Keywords: Clinical trial; dementia; dementia risk score; lifestyle intervention; prevention.

Conflict of interest statement

Authors’ disclosures available online (https://www.j-alz.com/manuscript-disclosures/21-0331r1).

Figures

Fig. 1
Fig. 1
Change in CAIDE Dementia Risk Score during the 2-year intervention. The figure shows estimated means of CAIDE score at baseline, 12 and 24 months (lower scores indicate lower risk for dementia). Error bars are CIs. Mixed-model repeated-measures analysis was used to assess between-group differences (randomization group×time interaction) in change from baseline to 24 months.

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Source: PubMed

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