Prevalence of Nontuberculous Mycobacterial Pulmonary Disease, Germany, 2009-2014

Felix C Ringshausen, Dirk Wagner, Andrés de Roux, Roland Diel, David Hohmann, Lennart Hickstein, Tobias Welte, Jessica Rademacher, Felix C Ringshausen, Dirk Wagner, Andrés de Roux, Roland Diel, David Hohmann, Lennart Hickstein, Tobias Welte, Jessica Rademacher

Abstract

We analyzed routine statutory health insurance claim data to determine prevalence of nontuberculous mycobacterial pulmonary disease in Germany. Documented prevalence rates of this nonnotifiable disease increased from 2.3 to 3.3 cases/100,000 population from 2009 to 2014. Prevalence showed a strong association with advanced age and chronic obstructive pulmonary disease.

Keywords: Atypical mycobacterial infection; COPD; Germany; Mycobacterium avium complex; NTM-PD; bronchiectasis; chronic obstructive pulmonary disease; cystic fibrosis; international classification of diseases; nontuberculous mycobacteria; pulmonary; respiratory infections; tuberculosis.

Figures

Figure 1
Figure 1
Trends in annual prevalence of nontuberculous mycobacterial pulmonary disease by sex and year, Germany, 2009–2014. Solid trend line indicates overall prevalence; dotted linear trend line, male prevelance; dashed linear trend line, female prevalence.
Figure 2
Figure 2
Prevalence rates of nontuberculous mycobacterial pulmonary disease, by age group, sex, and year, Germany, 2009–2014.

References

    1. Griffith DE, Aksamit T, Brown-Elliott BA, Catanzaro A, Daley C, Gordin F, et al. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med. 2007;175:367–416. 10.1164/rccm.200604-571ST
    1. Thomson RM. Changing epidemiology of pulmonary nontuberculous mycobacteria infections. Emerg Infect Dis. 2010;16:1576–83. 10.3201/eid1610.091201
    1. Hoefsloot W, van Ingen J, Andrejak C, Angeby K, Bauriaud R, Bemer P, et al. The geographic diversity of nontuberculous mycobacteria isolated from pulmonary samples: an NTM-NET collaborative study. Eur Respir J. 2013;42:1604–13. 10.1183/09031936.00149212
    1. Prevots DR, Shaw PA, Strickland D, Jackson LA, Raebel MA, Blosky MA, et al. Nontuberculous mycobacterial lung disease prevalence at four integrated health care delivery systems. Am J Respir Crit Care Med. 2010;182:970–6. 10.1164/rccm.201002-0310OC
    1. Adjemian J, Olivier KN, Seitz AE, Holland SM, Prevots DR. Prevalence of nontuberculous mycobacterial lung disease in U.S. Medicare beneficiaries. Am J Respir Crit Care Med. 2012;185:881–6. 10.1164/rccm.201111-2016OC
    1. Ringshausen FC, Apel RM, Bange FC, de Roux A, Pletz MW, Rademacher J, et al. Burden and trends of hospitalisations associated with pulmonary non-tuberculous mycobacterial infections in Germany, 2005–2011. BMC Infect Dis. 2013;13:231. 10.1186/1471-2334-13-231
    1. German Federal Statistical Office. Facts & figures–state & society–Federal Statistical Office (Destatis). 2015. Sep 19 [cited 2015 Sep 19].
    1. Andersohn F, Walker J. Characteristics and external validity of the German Health Risk Institute (HRI) Database. Pharmacoepidemiol Drug Saf. 2016;25:106–9. 10.1002/pds.3895
    1. Dean AG, Sullivan KM, Soe MM, Mir RA. OpenEpi: Open source epidemiologic statistics for public health, version 3.03a. 2015. May 4 [cited 2015 Sept 19].
    1. Wagner D, van Ingen J, Adjemian J, Lange C, Prevots DR, Griffith D, et al. Annual Prevalence and Treatment Estimates for Nontuberculous Mycobacterial Pulmonary Disease in Europe: A NTM-NET Collaborative Study. Eur Respir J. 2014;44(Suppl 58):1067 .
    1. European Commission. Policy—European Commission. 2016. [cited 2016 Feb 21].
    1. World Health Organization. Global Health Observatory Data Repository. 2015. [cited 2016 Feb 21].
    1. Andréjak C, Nielsen R, Thomsen VO, Duhaut P, Sorensen HT, Thomsen RW. Chronic respiratory disease, inhaled corticosteroids and risk of non-tuberculous mycobacteriosis. Thorax. 2013;68:256–62. 10.1136/thoraxjnl-2012-201772
    1. van Ingen J, Adjemian J, Morimoto K, Wagner D, Lange C, Haworth C, et al. Comparison of treatment practices for nontuberculous mycobacterial pulmonary disease in Japan, Europe, and the United States. Eur Respir J. 2014;44(Suppl 58):1066.
    1. Aksamit TR, Carretta E, Daley CL, O’Donnell AE, Thomashow B, Dominik R, et al. The Bronchiectasis Research Registry: a collaborative research cohort for non-cystic fibrosis bronchiectasis [abstract]. Am J Respir Crit Care Med. 2012;185:A3654.

Source: PubMed

3
Tilaa