A Self-Compassion and Mindfulness-Based Cognitive Mobile Intervention (Serene) for Depression, Anxiety, and Stress: Promoting Adaptive Emotional Regulation and Wisdom

Mohamed Al-Refae, Amr Al-Refae, Melanie Munroe, Nicole A Sardella, Michel Ferrari, Mohamed Al-Refae, Amr Al-Refae, Melanie Munroe, Nicole A Sardella, Michel Ferrari

Abstract

Introduction: Many individuals and families are currently experiencing a high level of COVID-19-related stress and are struggling to find helpful coping mechanisms. Mindfulness-based interventions are becoming an increasingly popular treatment for individuals experiencing depression and chronic levels of stress. The app (Serene) draws from scholarly evidence on the efficacy of mindfulness meditations and builds on the pre-existing apps by incorporating techniques that are used in some therapies such as cognitive behavioral therapy and mindfulness-based cognitive therapy. Methods: Participants were randomly assigned to a 4-week mindfulness and self-compassion-based cognitive smartphone intervention (Serene) or a wait-list control group. They were instructed to engage in self-compassion and mindfulness practices and a cognitive restructuring task. They also completed measures that evaluated their levels of depression, stress, anxiety, self-compassion, wisdom, psychological well-being, and subjective well-being. The intervention group was also instructed to track their weekly engagement with the app. Standardized effect sizes for between-group differences were calculated using Cohen's d for complete case analyses. Results: Complete case analyses from baseline to the end of this randomized controlled trial demonstrated significant moderate between-group differences for depressive symptoms (d = -0.43) and decisiveness (d = 0.34). Moderate between-group differences were also found for self-compassion (d = 0.6) such that significant improvements in self-kindness, common humanity, mindfulness and decreases in self-judgement, isolation, and overidentification were observed. A small between-group difference was found for emotional regulation (d = 0.28). Moreover, a significant moderate within-group decrease in stress (d = -0.52) and anxiety symptoms (d = -0.47) was also observed in the intervention group. Conclusions: Serene is an effective intervention that promotes increased levels of self-compassion and emotional regulation. Engaging with Serene may help reduce depressive symptoms through mindfulness, self-compassion, and cognitive restructuring which help reduce overidentification with one's negative emotions. As individuals rebalance their thinking through cognitive restructuring, they can identify the varying stressors in their life, develop action plans and engage in adaptive coping strategies to address them. Serene may promote greater self-understanding which may provide one with a more balanced perspective on their current upsetting situations to positively transform their challenges during the pandemic.

Keywords: CBT; app; depression; emotion regulation; mindfulness; self-compassion; serene; wisdom.

Conflict of interest statement

AA and MA are co-founders of the Serene App which will be commercialized. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Copyright © 2021 Al-Refae, Al-Refae, Munroe, Sardella and Ferrari.

Figures

Figure 1
Figure 1
CONSORT study flow diagram.

References

    1. Aldao A., Nolen-Hoeksema S., Schweizer S. (2010). Emotion-regulation strategies across psychopathology: a meta-analytic review. Clin. Psychol. Rev. 30, 217–237. 10.1016/j.cpr.2009.11.004
    1. Allen A. B., Leary M. R. (2010). Self-compassion, stress, and coping. Soc. Personal. Psychol. Compass 4, 107–118. 10.1111/j.1751-9004.2009.00246.x
    1. Antony M. M., Bieling P. J., Cox B. J., Enns M. W., Swinson R. P. (1998). Psychometric properties of the 42-item and 21-item versions of the Depression Anxiety Stress Scales in clinical groups and a community sample. Psychol. Assess 10, 176–181. 10.1037/1040-3590.10.2.176
    1. Ardelt M. (1997). Wisdom and life satisfaction in old age. J. Gerontol. 52, P15–P27. 10.1093/geronb/52B.1.P15
    1. Ardelt M. (2000). Antecedents and effects of wisdom in old age: a longitudinal perspective on aging well. Res. Aging 22, 360–394. 10.1177/0164027500224003
    1. Ardelt M. (2003). Empirical assessment of a three-dimensional wisdom scale. Res. Aging, 25, 275–324. 10.1177/0164027503025003004
    1. Ardelt M., Jeste D. V. (2018). Wisdom and hard times: the ameliorating effect of wisdom on the negative association between adverse life events and well-being. J. Gerontol. 73, 1374–1383. 10.1093/geronb/gbw137
    1. Bangen K. J., Meeks T. W., Jeste D. V. (2013). Defining and assessing wisdom: a review of the literature. Am. J. Geriatric Psychiatry 21, 1254–1266. 10.1016/j.jagp.2012.11.020
    1. Bluth K., Roberson P. N., Gaylord S. A., Faurot K. R., Grewen K. M., Arzon S., et al. . (2016). Does self-compassion protect adolescents from Stress? J. Child Fam. Stud. 25, 1098–1109. 10.1007/s10826-015-0307-3
    1. Breines J. G., McInnis C. M., Kuras Y. I., Thoma M. V., Gianferante D., Hanlin L., et al. . (2015). Self-compassionate young adults show lower salivary alpha-amylase responses to repeated psychosocial stress. Self Identity 14, 390–402. 10.1080/15298868.2015.1005659
    1. Bridges L. J., Denham S. A., Ganiban J. M. (2004). Definitional issues in emotion regulation research. Child Dev. 75, 340–345. 10.1111/j.1467-8624.2004.00675.x
    1. Brose A., Blanke E. S., Schmiedek F., Kramer A. C., Schmidt A., Neubauer A. B. (2020). Change in mental health symptoms during the COVID-19 pandemic: the role of appraisals and daily life experiences. J. Personality. 10.1111/jopy.12592. [Epub ahead of print].
    1. Brown K. W., Ryan R. M., Creswell J. D. (2007). Mindfulness: theoretical foundations and evidence for its salutary effects. Psychol. Inq. 18, 211–237. 10.1080/10478400701598298
    1. Canet-Juric L., Andrés M. L., Del Valle M., López-Morales H., Poó F., Galli J. I., et al. . (2020). A longitudinal study on the emotional impact cause by the COVID-19 pandemic quarantine on general population. Front. Psychol. 11:565688. 10.3389/fpsyg.2020.565688
    1. Chishima Y., Mizuno M., Sugawara D., Miyagawa Y. (2018). The influence of self-compassion on cognitive appraisals and coping with stressful events. Mindfulness 9, 1907–1915. 10.1007/s12671-018-0933-0
    1. Cohen J. (1977). Statistical Power Analysis for the Behavioral Sciences (Rev. ed.). Hillsdale, NJ: Lawrence Erlbaum Associates, Inc.
    1. Crews D. A., Stolz-Newton M., Grant N. S. (2016). The use of yoga to build self-compassion as a healing method for survivors of sexual violence. J. Religion Spirituality Social Work 35, 139–156. 10.1080/15426432.2015.1067583
    1. Cuijpers P., Sijbrandij M., Koole S., Huibers M., Berking M., Andersson G. (2014). Psychological treatment of generalized anxiety disorder: a meta-analysis. Clin. Psychol. Rev. 34, 130–140. 10.1016/j.cpr.2014.01.002
    1. Dawel A., Shou Y., Smithson M., Cherbuin N., Banfield M., Calear A. L., et al. . (2020). The effect of COVID-19 on mental health and wellbeing in a representative sample of Australian Adults. Front. Psychiatry 11:579985. 10.3389/fpsyt.2020.579985
    1. Diedrich A., Burger J., Kirchner M., Berking M. (2017). Adaptive emotion regulation mediates the relationship between self-compassion and depression in individuals with unipolar depression. Psychol. Psychother. 90, 247–263. 10.1111/papt.12107
    1. Diedrich A., Hofmann S. G., Cuijpers P., Berking M. (2016). Self-compassion enhances the efficacy of explicit cognitive reappraisal as an emotion regulation strategy in individuals with major depressive disorder. Behav. Res. Ther. 82, 1–10. 10.1016/j.brat.2016.04.003
    1. Diener E., Emmons R. A., Larsen R. J., Griffin S. (1985). The satisfaction with life scale. J. Pers. Assess. 49, 71–75. 10.1207/s15327752jpa4901_13
    1. Firth J., Torous J., Nicholas J., Carney R., Pratap A., Rosenbaum S., et al. . (2017a). The efficacy of smartphone-based mental health interventions for depressive symptoms: a meta-analysis of randomized controlled trials. World Psychiatry 16, 287–298. 10.1002/wps.20472
    1. Firth J., Torous J., Nicholas J., Carney R., Rosenbaum S., Sarris J. (2017b). Can smartphone mental health interventions reduce symptoms of anxiety? A meta-analysis of randomized controlled trials. J. Affective Disorders 218, 15–22. 10.1016/j.jad.2017.04.046
    1. Fortuna L. R., Vallejo Z. (2015). Treating Co-occurring Adolescent PTSD and Addiction: Mindfulness-based Cognitive Therapy for Adolescents with Trauma and Substance-Abuse Disorders. Oakland, CA: Context Press/New Harbinger Publications.
    1. Galea S., Merchant R. M., Lurie N. (2020). The mental health consequences of COVID-19 and physical distancing: the need for prevention and early intervention. JAMA Intern. Med. 180, 817–818. 10.1001/jamainternmed.2020.1562
    1. Garland E. L., Farb N. A., Goldin P., Fredrickson B. L. (2015). Mindfulness broadens awareness and builds eudaimonic meaning: a process model of mindful positive emotion regulation. Psychol. Inq. 26, 293–314. 10.1080/1047840X.2015.1064294
    1. Garnefski N., Kraaij V., Spinhoven P. (2001). Negative life events, cognitive emotion regulation and emotional problems. Pers. Individ. Dif. 30, 1311–1327. 10.1016/S0191-8869(00)00113-6
    1. Germer C. K., Neff K. D. (2013). Self-compassion in clinical practice. J. Clin. Psychol. 69, 856–867. 10.1002/jclp.22021
    1. Germer C. K., Siegel R. D. (2012). Wisdom and Compassion in Psychotherapy: Deepening Mindfulness in Clinical Practice. New York, NY: The Guilford Press.
    1. Glück J. (2021). How MORE life experience fosters wise coping, in Post-traumatic Growth to Psychological Well-being: Coping Wisely with Adversity, eds Munroe M., Ferrari M. Cham: Springer.
    1. Glück J., Bluck S. (2013). The MORE life experience model: a theory of the development of personal wisdom, in The Scientific Study of Personal Wisdom: From Contemplative Traditions to Neuroscience, eds Ferrari M., Weststrate N. M. (New York, NY: Springer; ). 10.1007/978-94-007-7987-7_4
    1. Glück J., Bluck S., Weststrate N. M. (2019). More on the MORE life experience model: what we have learned (So Far). J. Value Inq. 53, 349–370. 10.1007/s10790-018-9661-x
    1. Gratz K. L., Roemer L. (2004). Multidimensional assessment of emotion regulation and dysregulation: development, factor structure, and initial validation of the difficulties in emotion regulation scale. J. Psychopathol. Behav. Assess 26, 41–54. 10.1023/B:JOBA.0000007455.08539.94
    1. Grawe K. (2007). Counseling and psychotherapy: investigating practice from scientific, historical, and cultural perspectives, in Neuropsychotherapy: How the Neurosciences Inform Effective Psychotherapy (Hillsdale, NJ: Lawrence Erlbaum Associates Publishers; ).
    1. Grossmann I., Gerlach T. M., Denissen J. J. A. (2016). Wise reasoning in the face of everyday life challenges. Soc. Psychol. Personal. Sci. 7, 611–622. 10.1177/1948550616652206
    1. Gustavson K., Knudsen A. K., Nesvåg R., Knudsen G. P., Vollset S. E., Reichborn-Kjennerud T. (2018). Prevalence and stability of mental disorders among young adults: findings from a longitudinal study. BMC Psychiatry, 18, Article 65. 10.1186/s12888-018-1647-5
    1. Henry J. D., Crawford J. R. (2005). The short-form version of the Depression Anxiety Stress Scales (DASS-21): construct validity and normative data in a large non-clinical sample. Br. J. Clin. Psychol. 44, 227–239. 10.1348/014466505X29657
    1. Johnson D. P., Whisman M. A. (2013). Gender differences in rumination: a meta-analysis. Pers. Individ. Dif. 55, 367–374. 10.1016/j.paid.2013.03.019
    1. Killgore W., Taylor E. C., Cloonan S. A., Dailey N. S. (2020). Psychological resilience during the COVID-19 lockdown. Psychiatry Res. 291:113216. 10.1016/j.psychres.2020.113216
    1. Kirby J. N., Tellegen C. L., Steindl S. R. (2017). A meta-analysis of compassion-based interventions: current state of knowledge and future directions. Behav. The., 48, 778–792. 10.1016/j.beth.2017.06.003
    1. Kunzmann U. (2004). Approaches to a good life: the emotional-motivational side to wisdom, in Positive Psychology in Practice, eds Linley P. A., Joseph S. (Hoboken, NJ: John Wiley & Sons; ).
    1. Lazarus R., Folkman S. (1984). Stress, Appraisal, and Coping. New York, NY: Springer.
    1. Leary M. R., Tate E. B., Adams C. E., Batts Allen A., Hancock J. (2007). Self-compassion and reactions to unpleasant self-relevant events: the implications of treating oneself kindly. J. Pers. Soc. Psychol, 92, 887–904. 10.1037/0022-3514.92.5.887
    1. Linardon J. (2020). Can acceptance, mindfulness, and self-compassion be learned by smartphone apps? A systematic and meta-analytic review of randomized controlled trials. Behavior. Therapy 51, 646–658. 10.1016/j.beth.2019.10.002
    1. Little R. J. (1988). A test of missing completely at random for multivariate data with missing values. J. Am. Stat. Assoc. 83, 1198–1202. 10.1080/01621459.1988.10478722
    1. Lovibond P. F., Lovibond S. H. (1995a). The structure of negative emotional states: Comparison of the Depression Anxiety Stress Scales (DASS) with the beck depression and anxiety inventories. Behav. Res. Ther. 33, 335–343. 10.1016/0005-7967(94)00075-U
    1. Lovibond S. H., Lovibond P. F. (1995b). Manual for the Depression Anxiety Stress Scales, (2nd ed.). Sydney: Psychology Foundation of Australia. 10.1037/t39835-000
    1. MacBeth A., Gumley A. (2012). Exploring compassion: a meta-analysis of the association between self-compassion and psychopathology. Clin. Psychol. Rev. 32, 545–552. 10.1016/j.cpr.2012.06.003
    1. Mak W. W., Tong A. C., Yip S. Y., Lui W. W., Chio F. H., Chan A. T., et al. . (2018). Efficacy and moderation of mobile app-based programs for mindfulness-based training, self-compassion training, and cognitive behavioral psychoeducation on mental health: randomized controlled noninferiority trial. JMIR Mental Health 5:e60. 10.2196/mental.8597
    1. McRae K., Ochsner K. N., Mauss I. B., Gabrieli J., Gross J. J. (2008). Gender differences in emotion regulation: an fMRI study of cognitive reappraisal. Group Processes Intergroup Relations 11, 143–162. 10.1177/1368430207088035
    1. Mukaka M., White S. A., Terlouw D. J., Mwapasa V., Kalilani-Phiri L., Faragher E. B. (2016). Is using multiple imputation better than complete case analysis for estimating a prevalence (risk) difference in randomized controlled trials when binary outcome observations are missing? Trials 17:341. 10.1186/s13063-016-1473-3
    1. Neff K. D. (2003a). Self-compassion: an alternative conceptualization of a healthy attitude toward oneself. Self Identity 2, 85–101. 10.1080/15298860309032
    1. Neff K. D. (2003b). The development and validation of a scale to measure self-compassion. Self and Identity, 2, 223–250. 10.1080/15298860309027
    1. Neff K. D., Hsieh Y.-P., Dejitterat K. (2005). Self-compassion, achievement goals, and coping with academic failure. Self Identity 4, 263–287. 10.1080/13576500444000317
    1. Neff K. D., Kirkpatrick K. L., Rude S. S. (2007). Self-compassion and adaptive psychological functioning. J. Res. Pers. 41, 139–154. 10.1016/j.jrp.2006.03.004
    1. Okruszek Ł., Aniszewska-Stańczuk A., Piejka A., Wiśniewska M., Zurek K. (2020). Safe but lonely? Loneliness, anxiety, and depression symptoms and COVID-19. Front. Psychol. 11:579181. 10.3389/fpsyg.2020.579181
    1. Prout T. A., Zilcha-Mano S., Aafjes-van Doorn K., Békés V., Christman-Cohen I., Whistler K., et al. . (2020). Identifying predictors of psychological distress during COVID-19: a machine learning approach. Front. Psychol. 11:586202. 10.3389/fpsyg.2020.586202
    1. Ryff C. D., Keyes C. L. (1995). The structure of psychological well-being revisited. J. Pers. Soc. Psychol. 69, 719–727. 10.1037/0022-3514.69.4.719
    1. Segal Z. V., Williams J. M. G., Teasdale J. D. (2013). Mindfulness-Based Cognitive Therapy for Depression (2nd ed.). New York City, NY: The Guilford Press.
    1. Sharma A., Dewangan R. L. (2017). Can wisdom be fostered: time to test the model of wisdom. Cogent Psychology 4:1381456. 10.1080/23311908.2017.1381456
    1. Shikatani B., Antony M. M., Kuo J. R., Cassin S. E. (2014). The impact of cognitive restructuring and mindfulness strategies on postevent processing and affect in social anxiety disorder. J. Anxiety Disord. 28, 570–579. 10.1016/j.janxdis.2014.05.012
    1. Substance Abuse Mental Health Services Administration (2020). Key substance use and mental health indicators in the United States: Results from the 2019 National Survey on Drug Use and Health (HHS Publication No. PEP20-07-01-001). Available online at: (accessed December 26, 2020).
    1. Taylor J., McLean L., Korner A., Stratton E., Glozier N. (2020). Mindfulness and yoga for psychological trauma: systematic review and meta-analysis. J. Trauma Dissociation. 21, 536–573. 10.1080/15299732.2020.1760167
    1. Thomas M. L., Bangen K. J., Ardelt M., Jeste D. V. (2017). Development of a 12-item abbreviated Three-Dimensional Wisdom Scale (3D-WS-12): item selection and psychometric properties. Assessment 24, 71–82. 10.1177/1073191115595714
    1. Thomas M. L., Bangen K. J., Palmer B. W., Sirkin Martin A., Avanzino J. A., Depp C. A., et al. . (2019). A new scale for assessing wisdom based on common domains and a neurobiological model: the San Diego Wisdom Scale (SD-WISE). J. Psychiatr. Res. 108, 40–47. 10.1016/j.jpsychires.2017.09.005
    1. Treleaven D. A. (2018). Trauma-Sensitive Mindfulness: Practices for Safe and Transformative Healing. New York, NY: W.W. Norton & Co.
    1. Van Dam N. T., Hobkirk A. L., Sheppard S. C., Aviles-Andrews R., Earleywine M. (2014). How does mindfulness reduce anxiety, depression, and stress? An exploratory examination of change processes in wait-list controlled mindfulness meditation training. Mindfulness 5, 574–588. 10.1007/s12671-013-0229-3
    1. Wahbeh H., Svalina M. N., Oken B. S. (2014). Group, one-on-one, or internet? Preferences for mindfulness meditation delivery format and their predictors. Open Med. J. 1, 66–74. 10.2174/1874220301401010066
    1. Wasil A. R., Venturo-Conerly K. E., Shingleton R. M., Weisz J. R. (2019). A review of popular smartphone apps for depression and anxiety: assessing the inclusion of evidence-based content. Behav. Res. Ther. 123:103498. 10.1016/j.brat.2019.103498
    1. Watkins E. R., Roberts H. (2020). Reflecting on rumination: consequences, causes, mechanisms and treatment of rumination. Behav. Res. Ther. 127:103573. 10.1016/j.brat.2020.103573
    1. Webster J. D. (2007). Measuring the character strength of wisdom. Int. J. Aging Hum. Dev. 65, 163–183. 10.2190/AG.65.2.d
    1. Weisel K. K., Fuhrmann L. M., Berking M., Baumeister H., Cuijpers P., Ebert D. D. (2019). Standalone smartphone apps for mental health-a systematic review and meta-analysis. NPJ Digital Med. 2:118. 10.1038/s41746-019-0188-8
    1. Weststrate N. M., Glück J. (2017). Hard-earned wisdom: exploratory processing of difficult life experience is positively associated with wisdom. Dev. Psychol. 53, 800–814. 10.1037/dev0000286
    1. Wong C. C. Y., Yeung N. C. Y. (2017). Self-compassion and posttraumatic growth: cognitive processes as mediators. Mindfulness 8, 1078–1087. 10.1007/s12671-017-0683-4
    1. Xu C., Xu Y., Xu S., Zhang Q., Liu X., Shao Y., et al. . (2020). Cognitive reappraisal and the association between perceived stress and anxiety symptoms in COVID-19 isolated people. Front. Psychiatry 11:858. 10.3389/fpsyt.2020.00858
    1. Zeller M., Yuval K., Nitzan-Assayag Y., Bernstein A. (2015). Self-compassion in recovery following potentially traumatic stress: longitudinal study of at-risk youth. J. Abnorm. Child Psychol. 43, 645–653. 10.1007/s10802-014-9937-y
    1. Zhang H., Watson-Singleton N. N., Pollard S. E., Pittman D. M., Lamis D. A., Fischer N. L., et al. . (2019). Self-criticism and depressive symptoms: mediating role of self-compassion. Omega 80, 202–223. 10.1177/0030222817729609

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