Effect of thoracic paravertebral nerve block on the early postoperative rehabilitation in patients undergoing thoracoscopic radical lung cancer surgery

Kang Kang, Xing Meng, Bing Li, Jingli Yuan, Erhu Tian, Jiaqiang Zhang, Wei Zhang, Kang Kang, Xing Meng, Bing Li, Jingli Yuan, Erhu Tian, Jiaqiang Zhang, Wei Zhang

Abstract

Objective: To evaluate the effect of thoracic paravertebral nerve block on early postoperative rehabilitation in patients undergoing radical thoracoscopic surgery for lung cancer.

Methods: Ninety patients scheduled for elective video-assisted thoracoscopic lobectomy of lung cancer were divided into 2 groups: the general anesthesia group (GA group, n = 45) and the TPVB group (TP group, n = 45). The primary outcome was the decline rate of the 6-min walking test (6MWT); the second outcomes were as follows: absolute value and the completion rate of 6MWT, postoperative analgesia deficiency and pain scores, oxycodone consumption, sleep quality, the incidence of postoperative pulmonary complications, and the hospital stay.

Results: Compared with the GA group, the TP group had a lower decline rate of the 6MWT on POD1 and POD2. The walking distance on POD1 and POD2 in the TP group was significantly longer than that in the GA group; the completion rate at POD1 in the TP group was higher than that in the GA group. The pain scores and oxycodone consumption at POD1 in the TP group were lower than the GA group. The sleep quality in the TP group was higher than the GA group.

Conclusions: TPVB can significantly improve postoperative rehabilitation in patients undergoing thoracoscopic radical lung cancer surgery, which is helpful for promoting the early recovery of patients.

Trial registration: Chinese Clinical Trial Registry, ChiCTR1900026213. Registered 26 Sept. 2019, http://www.chictr.org.cn/showproj.aspx?proj=43733 .

Keywords: 6-min walking test; Lung cancer; Surgery; Thoracic paravertebral nerve block.

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Study flow diagram
Fig. 2
Fig. 2
Results of the 6MWT in the two groups. Comparison of 6MWT between the two groups. a The decline rate of 6MWT in the two groups at different time points. Compared with GA group, TP group had a lower decline rate of 6MWT on the POD1 and POD2. b The absolute value of 6MWT at different time points between the two groups. The 6MWT distance on the POD1 and POD2 was significantly greater in the TP group than that GA group. c The completion rate of 6MWT between the two groups. The completion rate on POD1 was higher in the TP group than the GA group. *p < 0.05, compared with the GA group

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