Comparing motor performance, praxis, coordination, and interpersonal synchrony between children with and without Autism Spectrum Disorder (ASD)

Maninderjit Kaur, Sudha M Srinivasan, Anjana N Bhat, Maninderjit Kaur, Sudha M Srinivasan, Anjana N Bhat

Abstract

Children with Autism Spectrum Disorder (ASD) have basic motor impairments in balance, gait, and coordination as well as autism-specific impairments in praxis/motor planning and interpersonal synchrony. Majority of the current literature focuses on isolated motor behaviors or domains. Additionally, the relationship between cognition, symptom severity, and motor performance in ASD is unclear. We used a comprehensive set of measures to compare gross and fine motor, praxis/imitation, motor coordination, and interpersonal synchrony skills across three groups of children between 5 and 12 years of age: children with ASD with high IQ (HASD), children with ASD with low IQ (LASD), and typically developing (TD) children. We used the Bruininks-Oseretsky Test of Motor Proficiency and the Bilateral Motor Coordination subtest of the Sensory Integration and Praxis Tests to assess motor performance and praxis skills respectively. Children were also examined while performing simple and complex rhythmic upper and lower limb actions on their own (solo context) and with a social partner (social context). Both ASD groups had lower gross and fine motor scores, greater praxis errors in total and within various error types, lower movement rates, greater movement variability, and weaker interpersonal synchrony compared to the TD group. In addition, the LASD group had lower gross motor scores and greater mirroring errors compared to the HASD group. Overall, a variety of motor impairments are present across the entire spectrum of children with ASD, regardless of their IQ scores. Both, fine and gross motor performance significantly correlated with IQ but not with autism severity; however, praxis errors (mainly, total, overflow, and rhythmicity) strongly correlated with autism severity and not IQ. Our study findings highlight the need for clinicians and therapists to include motor evaluations and interventions in the standard-of-care of children with ASD and for the broader autism community to recognize dyspraxia as an integral part of the definition of ASD.

Keywords: Autism; Children; Coordination; Interpersonal synchrony; Motor; Praxis.

Conflict of interest statement

Conflict of Interest

The authors declare no conflict of interest regarding the presented work.

Copyright © 2017 Elsevier Ltd. All rights reserved.

Figures

Figure 1
Figure 1
A typically developing child performing (A) gross motor and fine motor actions from the standardized motor test, BOT-2, (B) action sequences from the Bilateral Motor Coordination subtest of the SIPT, and (C) simple and complex clap, march, march clap, and drum actions in solo and social contexts.
Figure 2
Figure 2
Standard/scaled scores for BOT-2 subtests in the TD, HASD, and LASD groups. Note: BOT-2 standard scores have a mean of 50 and standard deviation of 10. BOT-2 scaled scores have a mean of 15 and standard deviation of 5.
Figure 3
Figure 3
Praxis errors for SIPT-BMC in the TD, HASD, and LASD groups.
Figure 4
Figure 4
Movement variability or Coefficient of Variation for the rhythmic actions in the TD, HASD, and LASD groups.
Figure 5
Figure 5
Movement rates for the rhythmic actions in the TD, HASD, and LASD groups.
Figure 6
Figure 6
Interpersonal synchrony during the social context of rhythmic actions in the TD, HASD, and LASD groups.

References

    1. Ament K, Mejia A, Buhlman R, Erklin S, Caffo B, Mostofsky S, Wodka E. Evidence for specificity of motor impairments in catching and balance in children with autism. Journal of Autism and Developmental disorders. 2015;45:742–751.
    1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. Fifth. Arlington, VA: American Psychiatric Association; 2013.
    1. Ayres J. Sensory Integration and Praxis Tests (SIPT) Los Angeles, CA: Western Psychological Services; 1988.
    1. Bastian AJ, Martin TA, Keating JG, Thach WT. Cerebellar ataxia: Abnormal control of interaction torques across multiple joints. Journal of Neurophysiology. 1996;76(1):492–509.
    1. Barbeau EB, Meilleur AAS, Zeffiro TA, Mottron L. Comparing motor skills in autism spectrum individuals with and without speech delay. Autism Research. 2015;8(6):682–693.
    1. Barber AB, Wetherby AM, Chambers NW. Brief report: Repetitive behaviors in young children with autism spectrum disorder and developmentally similar peers: A follow up to Watt et al.(2008) Journal of autism and developmental disorders. 2012;42(9):2006–2012.
    1. Bauman ML. Brief report: neuroanatomic observations of the brain in pervasive developmental disorders. Journal of autism and developmental disorders. 1996;26(2):199–203.
    1. Bauman ML, Kemper TL. Neuroanatomic observations of the brain in autism: A review and future directions. International Journal of Developmental Neuroscience. 2005;23(2–3):183–187.
    1. Becker KA. History of the Stanford-Binet intelligence scales: Content and psychometrics. Fifth. Itasca, IL: Riverside Publishing; 2003.
    1. Bedford R, Pickles A, Lord C. Early gross motor skills predict the subsequent development of language in children with autism spectrum disorder. Autism Research. 2016 In press. .
    1. Berkeley SL, Zittel LL, Pitney LV, Nichols SE. Locomotor and object control skills of children diagnosed with autism. Adapted Physical Activity Quarterly. 2001;18(4):405–416.
    1. Bhat AN, Landa RJ, Galloway JC. Current perspectives on motor functioning in infants, children, and adults with autism spectrum disorders. Physical Therapy. 2011;91:1116–1129.
    1. Bhat AN, Galloway JC, Landa RJ. Relation between early motor delay and later communication delay in infants at risk for autism. Infant Behavior and Development. 2012;35(4):838–846.
    1. Bhat AN, Srinivasan S, Woxholdt C, Shield A. Differences in praxis performance and receptive language during fingerspelling between deaf children with and without Autism Spectrum Disorder. Autism. 2016:1–12.
    1. Bhat AN, Hoffman MH, Trost SL, Culotta ML, Eilbott J, Tsuzuki D, Pelphrey KA. Cortical activation during action observation, action execution, and interpersonal synchrony in adults: A functional near-infrared spectroscopy (fNIRS) study. Frontiers in Human Neuroscience. 2017;11:431.
    1. Biscaldi M, Rauh R, Irion L, Jung NH, Mall V, Fleischhaker C, Klein C. Deficits in motor abilities and developmental fractionation of imitation performance in high-functioning autism spectrum disorders. European child & adolescent psychiatry. 2014;23(7):599–610.
    1. Boas D, Elwell C, Ferrari M, Taga G. Twenty years of functional near-infrared spectroscopy (fNIRS): introduction for the special issue. Neuroimage. 2014;85:1–5.
    1. Brass M, Bekkering H, Prinz W. Movement observation affects movement execution in a simple response task. Acta psychologica. 2001;106(1):3–22.
    1. Bruininks RH, Bruininks BD. Bruininks-Oseretsky Test of Motor Proficiency. 2nd. Minneapolis, MN: NCS Pearson; 2005.
    1. Bryson SE, Smith IM. Epidemiology of autism: Prevalence, associated characteristics, and implications for research and service delivery. Developmental Disabilities Research Reviews. 1998;4(2):97–103.
    1. Buccino G, Vogt S, Ritzl A, Fink GR, Zilles K, Freund HJ, Rizzolatti G. Neural circuits underlying imitation learning of hand actions: an event-related fMRI study. Neuron. 2004;42(2):323–334.
    1. Carmo JC, Rumiati RI, Siugzdaite R, Brambilla P. Preserved imitation of known gestures in children with high-functioning autism. ISRN Neurology. 2013:1–8.
    1. Case-Smith J, Miller H. Occupational therapy with children with pervasive developmental disorders. American Journal of Occupational Therapy. 1999;53(5):506–513.
    1. Casanova MF, El-Baz A, Mott M, Mannheim G, Hassan H, Fahmi R, Farag A. Reduced gyral window and corpus callosum size in autism: possible macroscopic correlates of a minicolumnopathy. Journal of autism and developmental disorders. 2009;39(5):751–764.
    1. Casanova MF, El-Baz A, Elnakib A, Switala AE, Williams EL, Williams DL, Conturo TE. Quantitative analysis of the shape of the corpus callosum in patients with autism and comparison individuals. Autism. 2011;15(2):223–238.
    1. Castiello U. Understanding other people’s actions: intention and attention. Journal of Experimental Psychology: Human Perception and Performance. 2003;29(2):416.
    1. Charman T, Pickles A, Simonoff E, Chandler S, Loucas T, Baird G. IQ in children with autism spectrum disorders: data from the Special Needs and Autism Project (SNAP) Psychological medicine. 2011;41(03):619–627.
    1. Christensen DL, Baio J, van Naarden Braun K, Bilder D, Charles J, Constantino JN, Yeargin-Allsopp M. Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 8 Years — Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2012. Surveillance Summaries. 2016;65(3):1–23.
    1. Chukoskie L, Townsend J, Westerfield M. Motor skill in autism spectrum disorders: A subcortical view. International review of neurobiology. 2013;113(7):207–249.
    1. Colombi C, Liebal K, Tomasello M, Young G, Warneken F, Rogers SJ. Examining correlates of cooperation in autism Imitation, joint attention, and understanding intentions. Autism. 2009;13(2):143–163.
    1. Courchesne E. New evidence of cerebellar and brainstem hypoplasia in autistic infants, children and adolescents: the MR imaging study by Hashimoto and colleagues. Journal of autism and developmental disorders. 1995;25(1):19–22.
    1. Courchesne E. Brainstem, cerebellar and limbic neuroanatomical abnormalities in autism. Current opinion in neurobiology. 1997;7(2):269–278.
    1. Courchesne E, Campbell K, Solso S. Brain growth across the life span in autism: Age-specific changes in anatomical pathology. Brain Research. 2011;1380:138–145.
    1. Courchesne E, Karns CM, Davis HR, Ziccardi R, Carper RA, Tigue ZD, Lincoln AJ. Unusual brain growth patterns in early life in patients with autistic disorder an MRI study. Neurology. 2001;57(2):245–254.
    1. Dapretto M, Davies MS, Pfeifer JH, Scott AA, Sigman M, Bookheimer SY, Iacoboni M. Understanding emotions in others: mirror neuron dysfunction in children with autism spectrum disorders. Nature neuroscience. 2006;9(1):28–30.
    1. Dawson G, Bernier R, Ring RH. Social attention: a possible early indicator of efficacy in autism clinical trials. Journal of Neurodevelopmental Disorders. 2012;4(1):11.
    1. Decety J, Sommerville JA. Shared representations between self and other: a social cognitive neuroscience view. Trends in cognitive sciences. 2003;7(12):527–533.
    1. Dewey D. Error analysis of limb and orofacial praxis in children with developmental motor deficits. Brain and Cognition. 1993;23(2):203–221.
    1. Dewey D, Cantell M, Crawford SG. Motor and gestural performance in children with autism spectrum disorders, developmental coordination disorder, and/or attention deficit hyperactivity disorder. Journal of the International Neuropsychological Society. 2007;13(02):246–256.
    1. Dowell LR, Mahone EM, Mostofsky SH. Associations of postural knowledge and basic motor skill with dyspraxia in autism: implication for abnormalities in distributed connectivity and motor learning. Neuropsychology. 2009;23(5):563.
    1. Downey R, Rapport MJK. Motor activity in children with autism: a review of current literature. Pediatric Physical Therapy. 2012;24(1):2–20.
    1. Ewen JB, Lakshmanan BM, Hallett M, Mostofsky SH, Crone NE, Korzeniewska A. Dynamics of functional and effective connectivity within human cortical motor control networks. Clinical Neurophysiology. 2015;126(5):987–996.
    1. Fitzpatrick P, Diorio R, Richardson MJ, Schmidt RC. Dynamical methods for evaluating the time-dependent unfolding of social coordination in children with autism. Frontiers in integrative neuroscience. 2013;7
    1. Fitzpatrick P, Frazier JA, Cochran DM, Mitchell T, Coleman C, Schmidt RC. Impairments of social motor synchrony evident in autism spectrum disorder. Frontiers in Psychology. 2016;7
    1. Fitzpatrick P, Romero V, Amaral JL, Duncan A, Barnard H, Richardson MJ, Schmidt RC. Social Motor Synchronization: Insights for Understanding Social Behavior in Autism. Journal of Autism and Developmental Disorders. 2017:1–16.
    1. Flanagan JE, Landa R, Bhat A, Bauman M. Head lag in infants at risk for autism: a preliminary study. American Journal of Occupational Therapy. 2012;66(5):577–585.
    1. Fleury A, Kushki A, Tanel N, Anagnostou E, Chau T. Statistical persistence and timing characteristics of repetitive circle drawing in children with ASD. Developmental neurorehabilitation. 2013;16(4):245–254.
    1. Fournier KA, Hass CJ, Naik SK, Lodha N, Cauraugh JH. Motor coordination in autism spectrum disorders: a synthesis and meta-analysis. Journal of autism and developmental disorders. 2010;40(10):1227–1240.
    1. Frith CD, Frith U. Interacting minds–a biological basis. Science. 1999;286(5445):1692–1695.
    1. Freitag CM, Kleser C, Schneider M, von Gontard A. Quantitative assessment of neuromotor function in adolescents with high functioning autism and Asperger syndrome. Journal of autism and developmental disorders. 2007;37(5):948–959.
    1. Fuentes CT, Mostofsky SH, Bastian AJ. Children with autism show specific handwriting impairments. Neurology. 2009;73(19):1532–1537.
    1. Gallese V. Before and below ‘theory of mind’: embodied simulation and the neural correlates of social cognition. Philosophical Transactions of the Royal Society of London B: Biological Sciences. 2007;362(1480):659–669.
    1. Gallese V. Mirror neurons and the social nature of language: The neural exploitation hypothesis. Social neuroscience. 2008;3(3–4):317–333.
    1. Gallese V, Eagle MN, Migone P. Intentional attunement: Mirror neurons and the neural underpinnings of interpersonal relations. Journal of the American psychoanalytic Association. 2007;55(1):131–175.
    1. Getchell N. Age and task-related differences in timing stability, consistency, and natural frequency of children’s rhythmic, motor coordination. Developmental psychobiology. 2006;48(8):675–685.
    1. Getchell N. Developmental aspects of perception-action coupling in multi-limb coordination: rhythmic sensorimotor synchronization. Motor control. 2007;11(1):1.
    1. Getchell N, Whitall J. How do children coordinate simultaneous upper and lower extremity tasks? The development of dual motor task coordination. Journal of Experimental Child Psychology. 2003;85(2):120–140.
    1. Ghaziuddin M, Butler E. Clumsiness in autism and Asperger syndrome: A further report. Journal of Intellectual Disability Research. 1998;42(1):43–48.
    1. Gizzonio V, Avanzini P, Campi C, Orivoli S, Piccolo B, Cantalupo G, Fabbri-Destro M. Failure in pantomime action execution correlates with the severity of social behavior deficits in children with autism: a praxis study. Journal of autism and developmental disorders. 2015;45(10):3085–3097.
    1. Glazebrook C, Gonzalez D, Hansen S, Elliott D. The role of vision for online control of manual aiming movements in persons with autism spectrum disorders. Autism. 2009;13(4):411–433.
    1. Green D, Baird G, Barnett AL, Henderson L, Huber J, Henderson SE. The severity and nature of motor impairment in Asperger’s syndrome: a comparison with specific developmental disorder of motor function. Journal of child psychology and psychiatry. 2002;43(5):655–668.
    1. Green D, Charman T, Pickles A, Chandler S, Loucas T, Simonoff E, Baird G. Impairment in movement skills of children with autistic spectrum disorders. Developmental Medicine & Child Neurology. 2009;51(4):311–316.
    1. Gowen E, Stanley J, Miall RC. Movement interference in autism-spectrum disorder. Neuropsychologia. 2008;46(4):1060–1068.
    1. Hadders-Algra M. Reduced variability in motor behaviour: an indicator of impaired cerebral connectivity? Early human development. 2008;84(12):787–789.
    1. Hallett M, Lebiedowska MK, Thomas SL, Stanhope SJ, Denckla MB, Rumsey J. Locomotion of autistic adults. Archives of Neurology. 1993;50(12):1304–1308.
    1. Ham HS, Bartolo A, Corley M, Rajendran G, Szabo A, Swanson S. Exploring the relationship between gestural recognition and imitation: Evidence of dyspraxia in autism spectrum disorders. Journal of Autism and Developmental Disorders. 2011;41(1):1–12.
    1. Ham HS, Bartolo A, Corley M, Swanson S, Rajendran G. Case report: Selective deficit in the production of intransitive gestures in an individual with autism. Cortex. 2010;46(3):407–409.
    1. Hamilton AFDC, Grafton ST. Goal representation in human anterior intraparietal sulcus. Journal of Neuroscience. 2006;26(4):1133–1137.
    1. Happé F, Frith U. The weak coherence account: detail-focused cognitive style in autism spectrum disorders. Journal of autism and developmental disorders. 2006;36(1):5–25.
    1. Haswell CC, Izawa J, Dowell LR, Mostofsky SH, Shadmehr R. Representation of internal models of action in the autistic brain. Nature neuroscience. 2009;12(8):970–972.
    1. Hilton C, Graver K, LaVesser P. Relationship between social competence and sensory processing in children with high functioning autism spectrum disorders. Research in Autism Spectrum Disorders. 2007;1(2):164–173.
    1. Hilton CL, Zhang Y, Whilte MR, Klohr CL, Constantino J. Motor impairment in sibling pairs concordant and discordant for autism spectrum disorders. Autism. 2012;16(4):430–441.
    1. Hilton CL, Cumpata K, Klohr C, Gaetke S, Artner A, Johnson H, Dobbs S. Effects of exergaming on executive function and motor skills in children with autism spectrum disorder: a pilot study. American Journal of Occupational Therapy. 2014;68(1):57–65.
    1. Hollingshead A. Four factor index of social status. New Haven, CT: Yale University; 1975. Unpublished Manuscript.
    1. Iacoboni M, Dapretto M. The mirror neuron system and the consequences of its dysfunction. Nature Reviews Neuroscience. 2006;7(12):942–951.
    1. Iacoboni M, Molnar-Szakacs I, Gallese V, Buccino G, Mazziotta JC, Rizzolatti G. Grasping the intentions of others with one’s own mirror neuron system. PLoS biology. 2005;3(3):e79.
    1. Iacoboni M, Woods RP, Brass M, Bekkering H, Mazziotta JC, Rizzolatti G. Cortical mechanisms of human imitation. science. 1999;286(5449):2526–2528.
    1. Isenhower RW, Marsh KL, Richardson MJ, Helt M, Schmidt RC, Fein D. Rhythmic bimanual coordination is impaired in young children with autism spectrum disorder. Research in Autism Spectrum Disorders. 2012;6(1):25–31.
    1. Ivry RB, Spencer RM. Evaluating the role of the cerebellum in temporal processing: beware of the null hypothesis. Brain. 2004;127(8):e13–e13.
    1. Ivry R. Cerebellar timing systems. International review of neurobiology. 1997:555–573.
    1. Jackson PL, Decety J. Motor cognition: A new paradigm to study self–other interactions. Current opinion in neurobiology. 2004;14(2):259–263.
    1. Jansiewicz EM, Goldberg MC, Newschaffer CJ, Denckla MB, Landa R, Mostofsky SH. Motor signs distinguish children with high functioning autism and Asperger’s syndrome from controls. Journal of autism and developmental disorders. 2006;36(5):613–621.
    1. Jeste SS. The neurology of autism spectrum disorders. Current opinion in neurology. 2011;24(2):132.
    1. Jones V, Prior M. Motor imitation abilities and neurological signs in autistic children. Journal of autism and developmental disorders. 1985;15(1):37–46.
    1. Just M, Keller T, Malave V, Kana R, Varma S. Autism as a neural systems disorder: A theory of frontal-posterior underconnectivity. Neuroscience and Biobehavioral Reviews. 2012;36(4):1292–1313.
    1. Kaur M, Gifford T, Marsh KL, Bhat A. Effect of robot-child interactions on bilateral coordination skills of typically developing children and a child with autism spectrum disorder: A preliminary study. Journal of Motor Learning and Development. 2013;1(2):31–37.
    1. Kaur M. Doctoral dissertation. University of Delaware; 2016. Creative yoga intervention for children with Autism Spectrum Disorder.
    1. Kinsbourne M, Helt M. Entrainment, mimicry, and interpersonal synchrony. The neuropsychology of autism. 2011:339–365.
    1. Kushki A, Chau T, Anagnostou E. Handwriting difficulties in children with autism spectrum disorders: A scoping review. Journal of autism and developmental disorders. 2011;41(12):1706–1716.
    1. Koehne S, Hatri A, Cacioppo JT, Dziobek I. Perceived interpersonal synchrony increases empathy: insights from autism spectrum disorder. Cognition. 2016;146:8–15.
    1. Landa R, Garrett-Mayer E. Development in infants with autism spectrum disorders: A prospective study. Journal of Child Psychology and Psychiatry. 2006;47(6):629–638.
    1. Landa RJ, Holman KC, Garrett-Mayer E. Social and communication development in toddlers with early and later diagnosis of autism spectrum disorders. Archives of general psychiatry. 2007;64(7):853–864.
    1. Leary MR, Hill DA. Moving on: autism and movement disturbance. Mental retardation. 1996;34(1):39.
    1. Liu T, Breslin CM. Fine and gross motor performance of the MABC-2 by children with autism spectrum disorder and typically developing children. Research in Autism Spectrum Disorders. 2013;7(10):1244–1249.
    1. Lloyd M, MacDonald M, Lord C. Motor skills of toddlers with autism spectrum disorders. Autism. 2013;17(2):133–146.
    1. Lord C, Rutter M, DiLavore PC, Risi S, Gotham K, Bishop SL. Autism diagnostic observation schedule, (ADOS-2) manual (part 1): modules 1–4. second. Torrance, CA: Western Psychological Services; 2012.
    1. MacDonald M, Esposito P, Hauck J, Jeong I, Hornyak J, Argento A, Ulrich DA. Bicycle training for youth with Down syndrome and autism spectrum disorders. Focus on Autism and Other Developmental Disabilities. 2012;27(1):12–21.
    1. MacNeil LK, Mostofsky SH. Specificity of dyspraxia in children with autism. Neuropsychology. 2012;26(2):165.
    1. Mahajan R, Dirlikov B, Crocetti D, Mostofsky SH. Motor circuit anatomy in children with autism spectrum disorder with or without attention deficit hyperactivity disorder. Autism Research. 2016;9(1):67–81.
    1. Mari M, Castiello U, Marks D, Marraffa C, Prior M. The reach–to–grasp movement in children with autism spectrum disorder. Philosophical Transactions of the Royal Society of London B: Biological Sciences. 2003;358(1430):393–403.
    1. Martineau J, Cochin S, Magne R, Barthelemy C. Impaired cortical activation in autistic children: is the mirror neuron system involved? International journal of psychophysiology. 2008;68(1):35–40.
    1. Manjiviona J, Prior M. Comparison of Asperger syndrome and high-functioning autistic children on a test of motor impairment. Journal of autism and developmental disorders. 1995;25(1):23–39.
    1. Marsh KL, Isenhower RW, Richardson MJ, Helt M, Verbalis AD, Schmidt RC, Fein D. Autism and social disconnection in interpersonal rocking. Frontiers in integrative neuroscience. 2013;7
    1. Mayes SD, Calhoun SL. Ability profiles in children with autism: Influence of age and IQ. Autism. 2003;7(1):65–80.
    1. McPhillips M, Finlay J, Bejerot S, Hanley M. Motor Deficits in Children with Autism Spectrum Disorder: A Cross-Syndrome Study. Autism Research. 2014;7(6):664–676.
    1. Minshew NJ, Goldstein G, Siegel DJ. Neuropsychologic functioning in autism: Profile of a complex information processing disorder. Journal of the International Neuropsychological Society. 1997;3(04):303–316.
    1. Minshew NJ, Sung K, Jones BL, Furman JM. Underdevelopment of the postural control system in autism. Neurology. 2004;63(11):2056–2061.
    1. Miyahara M, Tsujii M, Hori M, Nakanishi K, Kageyama H, Sugiyama T. Brief report: motor incoordination in children with Asperger syndrome and learning disabilities. Journal of autism and developmental disorders. 1997;27(5):595–603.
    1. Montes G, Halterman JS. Association of childhood autism spectrum disorders and loss of family income. Pediatrics. 2008;121(4):821–826.
    1. Mostofsky SH, Dubey P, Jerath VK, Jansiewicz EM, Goldberg MC, Denckla MB. Developmental dyspraxia is not limited to imitation in children with autism spectrum disorders. Journal of the International Neuropsychological Society. 2006;12(03):314–326.
    1. Mostofsky SH, Newschaffer CJ, Denckla MB. Overflow movements predict impaired response inhibition in children with ADHD. Perceptual and motor skills. 2003;97(3 suppl):1315–1331.
    1. Mostofsky SH, Powell SK, Simmonds DJ, Goldberg MC, Caffo B, Pekar JJ. Decreased connectivity and cerebellar activity in autism during motor task performance. Brain. 2009;132(9):2413–2425.
    1. Mostofsky SH, Ewen JB. Altered connectivity and action model formation in autism is autism. The Neuroscientist. 2011;17(4):437–448.
    1. Nayate A, Tonge BJ, Bradshaw JL, McGinley JL, Iansek R, Rinehart NJ. Differentiation of high-functioning autism and Asperger’s disorder based on neuromotor behaviour. Journal of autism and developmental disorders. 2012;42(5):707–717.
    1. Nebel MB, Eloyan A, Nettles CA, Sweeney KL, Ament K, Ward RE, Mostofsky SH. Intrinsic visual-motor synchrony correlates with social deficits in autism. Biological psychiatry. 2016;79(8):633–641.
    1. Nebel MB, Joel SE, Muschelli J, Barber AD, Caffo BS, Pekar JJ, Mostofsky SH. Disruption of functional organization within the primary motor cortex in children with autism. Human brain mapping. 2014;35(2):567–580.
    1. Noterdaeme M, Mildenberger K, Minow F, Amorosa H. Evaluation of neuromotor deficits in children with autism and children with a specific speech and language disorder. European child & adolescent psychiatry. 2002;11(5):219–225.
    1. Oberman LM, Hubbard EM, McCleery JP, Altschuler EL, Ramachandran VS, Pineda JA. EEG evidence for mirror neuron dysfunction in autism spectrum disorders. Cognitive brain research. 2005;24(2):190–198.
    1. Oberman LM, Ramachandran VS. The simulating social mind: the role of the mirror neuron system and simulation in the social and communicative deficits of autism spectrum disorders. Psychological bulletin. 2007;133(2):310.
    1. Ozonoff S, Young GS, Goldring S, Greiss-Hess L, Herrera AM, Steele J, Rogers SJ. Gross motor development, movement abnormalities, and early identification of autism. Journal of autism and developmental disorders. 2008;38(4):644–656.
    1. Pan CY, Chu CH, Tsai CL, Sung MC, Huang CY, Ma WY. The impacts of physical activity intervention on physical and cognitive outcomes in children with autism spectrum disorder. Autism. 2017;21(2):190–202.
    1. Piek JP, Dyck MJ. Sensory-motor deficits in children with developmental coordination disorder, attention deficit hyperactivity disorder and autistic disorder. Human movement science. 2004;23(3):475–488.
    1. Provost B, Heimerl S, Lopez BR. Levels of gross and fine motor development in young children with autism spectrum disorder. Physical & Occupational Therapy in Pediatrics. 2007;27(3):21–36.
    1. Provost B, Lopez BR, Heimerl S. A comparison of motor delays in young children: autism spectrum disorder, developmental delay, and developmental concerns. Journal of autism and developmental disorders. 2007;37(2):321–328.
    1. Rinehart NJ, Tonge BJ, Iansek R, McGinley J, Brereton AV, Enticott PG, Bradshaw JL. Gait function in newly diagnosed children with autism: cerebellar and basal ganglia related motor disorder. Developmental Medicine & Child Neurology. 2006;48(10):819–824.
    1. Rizzolatti G, Fogassi L, Gallese V. Neurophysiological mechanisms underlying the understanding and imitation of action. Nature reviews neuroscience. 2001;2(9):661–670.
    1. Rizzolatti G, Craighero L. The mirror-neuron system. Annu Rev Neurosci. 2004;27:169–192.
    1. Rogers SJ, Bennetto L, McEvoy R, Pennington BF. Imitation and pantomime in high-functioning adolescents with autism spectrum disorders. Child development. 1996;67(5):2060–2073.
    1. Sacrey LAR, Germani T, Bryson SE, Zwaigenbaum L. Reaching and grasping in autism spectrum disorder: a review of recent literature. Frontiers in neurology. 2014;5
    1. Salowitz NM, Eccarius P, Karst J, Carson A, Schohl K, Stevens S, Scheidt RA. Brief report: visuo-spatial guidance of movement during gesture imitation and mirror drawing in children with autism spectrum disorders. Journal of autism and developmental disorders. 2013;43(4):985–995.
    1. Smith IM, Bryson SE. Imitation and action in autism: a critical review. Psychological bulletin. 1994;116(2):259–273.
    1. Srinivasan SM, Lynch KA, Bubela DJ, Gifford TD, Bhat AN. Effect of interactions between a child and a robot on the imitation and praxis performance of typically developing children and a child with autism: A preliminary study. Perceptual and motor skills. 2013;116(3):885–904.
    1. Staples KL, Reid G. Fundamental movement skills and autism spectrum disorders. Journal of autism and developmental disorders. 2010;40(2):209–217.
    1. Srinivasan SM, Kaur M, Park IK, Gifford TD, Marsh KL, Bhat AN. The effects of rhythm and robotic interventions on the imitation/praxis, interpersonal synchrony, and motor performance of children with autism spectrum disorder (ASD): a pilot randomized controlled trial. Autism research and treatment. 2015 2015.
    1. Srinivasan SM, Park IK, Neelly LB, Bhat AN. A comparison of the effects of rhythm and robotic interventions on repetitive behaviors and affective states of children with Autism Spectrum Disorder (ASD) Research in autism spectrum disorders. 2015;18:51–63.
    1. Srinivasan SM, Eigsti IM, Gifford T, Bhat AN. The effects of embodied rhythm and robotic interventions on the spontaneous and responsive verbal communication skills of children with Autism Spectrum Disorder (ASD): A further outcome of a pilot randomized controlled trial. Research in autism spectrum disorders. 2016;27:73–87.
    1. Srinivasan SM, Eigsti IM, Neelly L, Bhat AN. The effects of embodied rhythm and robotic interventions on the spontaneous and responsive social attention patterns of children with autism spectrum disorder (ASD): A pilot randomized controlled trial. Research in autism spectrum disorders. 2016;27:54–72.
    1. Sutera S, Pandey J, Esser EL, Rosenthal MA, Wilson LB, Barton M, Fein D. Predictors of optimal outcome in toddlers diagnosed with autism spectrum disorders. Journal of autism and developmental disorders. 2007;37(1):98–107.
    1. Teitelbaum P, Teitelbaum O, Nye J, Fryman J, Maurer RG. Movement analysis in infancy may be useful for early diagnosis of autism. Proceedings of the National Academy of Sciences. 1998;95(23):13982–13987.
    1. Teitelbaum O, Benton T, Shah PK, Prince A, Kelly JL, Teitelbaum P. Eshkol–Wachman movement notation in diagnosis: The early detection of Asperger’s syndrome. Proceedings of the National Academy of Sciences of the United States of America. 2004;101(32):11909–11914.
    1. Théoret H, Halligan E, Kobayashi M, Fregni F, Tager-Flusberg H, Pascual-Leone A. Impaired motor facilitation during action observation in individuals with autism spectrum disorder. Current Biology. 2005;15(3):R84–R85.
    1. Turner K, Frost L, Linsenbardt D, McIlroy J, Müller R. Atypically diffuse functional connectivity between caudate nuclei and cerebral cortex in autism. Behavioral and Brain Functions. 2006;2(34) doi: 10.1186/1744-9081-2-34.
    1. Vanvuchelen M, Roeyers H, De Weerdt W. Nature of motor imitation problems in school-aged boys with autism A motor or a cognitive problem? Autism. 2007;11(3):225–240.
    1. Vilensky JA, Damasio AR, Maurer RG. Gait disturbances in patients with autistic behavior: a preliminary study. Archives of neurology. 1981;38(10):646–649.
    1. Von Hofsten C. Action in development. Developmental science. 2007;10(1):54–60.
    1. Wapner S, Cirillo L. Imitation of a model’s hand movements: Age changes in transposition of left-right relations. Child development. 1968;39(3):887–894.
    1. Wheaton LA, Hallett M. Ideomotor apraxia: a review. Journal of the neurological sciences. 2007;260(1):1–10.
    1. Whyatt CP, Craig CM. Motor skills in children aged 7–10 years, diagnosed with autism spectrum disorder. Journal of autism and developmental disorders. 2012;42(9):1799–1809.
    1. Whyatt C, Craig C. Sensory-motor problems in Autism. Frontiers in integrative neuroscience. 2013;7
    1. Whyatt C, Craig CM. Interceptive skills in children aged 9–11 years, diagnosed with Autism Spectrum Disorder. Research in Autism Spectrum Disorders. 2013;7(5):613–623.
    1. Williams JH, Waiter GD, Gilchrist A, Perrett DI, Murray AD, Whiten A. Neural mechanisms of imitation and ‘mirror neuron’functioning in autistic spectrum disorder. Neuropsychologia. 2006;44(4):610–621.

Source: PubMed

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