Carer involvement in medication adherence: carer views and experiences of facilitating medication adherence using pharmacy-filled multi-compartment medication compliance aids and other methods of adherence support-a questionnaire survey

Lieze Thielemans, Katherine Chin, Alice Hegarty, Rebekah Schiff, Lieze Thielemans, Katherine Chin, Alice Hegarty, Rebekah Schiff

Abstract

Introduction: Unpaid carers are an increasing proportion of the UK population. One of the many ways in which they help those they care for is assisting with medication adherence. Many older adults have medicines dispensed in pharmacy-filled multi-compartment medication compliance aids (pMCAs). However, evidence suggests that pMCAs may increase medication-related harm, and little is known about the interaction between the user, medication adherence systems and the carer.

Aim: To explore the views of carers supporting older adults to manage their medications with and without a pMCA.

Method: A researcher-administered questionnaire survey of carers supporting older adults to manage their medicines with or without a pMCA. Participants were recruited from inpatient wards, outpatient clinics and community services in central London. Responses were analysed by two independent researchers to identify overarching themes.

Results: Eighty-eight unpaid carers were interviewed and responses were categorised according to the medication adherence method used; 47 supported a user with a pMCA and 41 supported without a pMCA. The main themes were: Time, Responsibility and Mistakes, Waste and Sustainability, and Polypharmacy, with sub-themes of design of multi-compartment medication compliance aids, organisation and reassurance.

Conclusion: Supporting medication adherence puts considerable burden on carers regardless of whether a self- or pharmacy-filled medication compliance aid is used or not. Prescribers could alleviate this burden through regular medication review by considering the prescribing frequency and duration and medication rationalisation. Redesign of both pMCAs and systems surrounding their use could also help reduce carer's burden and environmental burden.

Keywords: carer; frailty; medication adherence; medication compliance aid; older people.

Conflict of interest statement

None.

© The Author(s) 2023. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Figures

Figure 1
Figure 1
Carer perceptions of why a pMCA was started. Total responses recorded = 42.
Figure 2
Figure 2
Themes and subthemes of carer perceptions of medication management.

References

    1. AgeUk . Briefing: Health and Care of Older People in England 2017. 2017. Available from: (ageuk ) (accessed 20 June 2023).
    1. AgeUk . New Age UK Research Finds the Numbers of UK over Age 65s Caring Unpaid Nearly Double during the Pandemic to More than 4 Million. 2021. Available from: New Age UK research finds the numbers of UK over age 65s caring unpaid nearly double during the pan to more than 4 million (accessed 20 June 2023).
    1. Whittingham K, Barnes S, Gardiner C. Tools to measure quality of life and carer burden in informal carers of heart failure patients: a narrative review. Palliat Med 2013; 27: 596–607.
    1. Trueman P, Lowson K, Blighe A. et al. . Evaluation of the Scale, Causes and Costs of Waste Medicines. Report of the DH Funded Project. London, 2010. Available from: (Accessed 20 June 2023).
    1. Bruce R, Murdoch W, Kable A. et al. . Evaluation of carer strain and carer coping with medications for people with dementia after discharge: results from the SMS dementia study. Healthcare (Basel) 2020; 8: 248. 10.3390/healthcare8030248.
    1. Smith F, Grijseels MS, Ryan P, Tobiansky R. Assisting people with dementia with their medicines: experiences of family carers. Int J Pharm Pract 2015; 23: 44–51.
    1. NICE . Medicines Adherence: Involving Patients in Decisions about Prescribed Medicines and Supporting Adherence 2009. Available from: (accessed 20 June 2023).
    1. Cross AJ, Etherton-Beer CD, Clifford RM, Potter K, Page AT. Exploring stakeholder roles in medication management for people living with dementia. Res Social Adm Pharm 2021; 17: 707–14. 10.1016/j.sapharm.2020.06.006.
    1. Lecouturier J, Cunningham B, Campbell D, Copeland R. Medication compliance aids: a qualitative study of users' views. Br J Gen Pract 2011; 61: 93–100.
    1. Bhattacharya D, Aldus CF, Barton G. et al. . The feasibility of determining the effectiveness and cost-effectiveness of medication organisation devices compared with usual care for older people in a community setting: systematic review, stakeholder focus groups and feasibility randomised controlled trial. Health Technol Assess 2016; 20: 1–250.
    1. Royal Pharmaceutical Society . Improving Patient Outcomes. The Better Use of Multi-Compartment Compliance Aids. 2013. Available from: (accessed 20 June 2023).
    1. Care Quality C . Multi-Compartment Compliance Aids (MCAs) in Adult Social Care. 2022. (accessed 20 June 2023).
    1. Braun V, Clarke V. Using thematic analysis in psychology. Qual Res Psychol 2006; 3: 77–101. 10.1191/1478088706qp063oa.
    1. Walters S, Chakravorty M, McLachlan S. et al. . Medication compliance aids unpackaged: a national survey. Br J Clin Pharmacol 2022; 88: 4595–606.
    1. Nunney J, Raynor DK, Knapp P, Closs SJ. How do the attitudes and beliefs of older people and healthcare professionals impact on the use of multi-compartment compliance aids? Drugs Aging 2011; 28: 403–14.
    1. Francis SA, Smith F, Gray N, Denham M. Partnerships between older people and their carers in the management of medication. Int J Older People Nurs 2006; 1: 201–7.
    1. Ibrahim K, Cox NJ, Stevenson JM, Lim S, Fraser SDS, Roberts HC. A systematic review of the evidence for deprescribing interventions among older people living with frailty. BMC Geriatr 2021; 21: 258. 10.1186/s12877-021-02208-8.
    1. Velde N, Minhas JS. Appropriate deprescribing in older people: a challenging necessity. Commentary to accompany themed collection on deprescribing. Age Ageing 2021; 50: 1516–9.
    1. Seppala LJ, Petrovic M, Ryg J. et al. . STOPPFall (screening tool of older persons prescriptions in older adults with high fall risk): a Delphi study by the EuGMS task and finish group on fall-risk-increasing drugs. Age Ageing 2021; 50: 1189–99.
    1. Department of Health and Social Care . Good for you, Good for us, Good for Everybody. 2021. Available from: (accessed 20 June 2023).
    1. Parekh N, Ali K, Davies JG. et al. . Medication-related harm in older adults following hospital discharge: development and validation of a prediction tool. BMJ Qual Saf 2020; 29: 142–53.
    1. NHS . NHS Discharge Medicines Service - Essential Service. Toolkit for Pharmacy Staff in Community, Primary and Secondary Care. 2921 15/01/2021. Available from: (accessed 20 June 2023).
    1. Cardwell K. Reducing medication errors and transitions of care. Age Ageing 2020; 49: 537–9.
    1. Dineen-Griffin S, Garcia-Cardenas V, Williams K, Benrimoj SI. Helping patients help themselves: a systematic review of self-management support strategies in primary health care practice. PloS One 2019; 14: e0220116. 10.1371/journal.pone.0220116.
    1. NHS . National Health Service Act 2006. 2006. Available from: (accessed 20 June 2023).
    1. Haywood A, Glass BD. Evidence of stability of medicines repackaged in compliance aids: a review. Curr Drug Saf 2016; 11: 69–77.
    1. García ER, Thalhauser S, Loscertales HR, Modamio P, Lastra CF, Mariño EL. Current evidence in the stability of medicines in dose administration aids: implications for patient safety. Expert Opin Drug Deliv 2018; 15: 577–87.
    1. Gilmartin JF, Raimi-Abraham BT, Jani Y, Smith F, Orlu-Gul M. Taking the guesswork out of supplying multicompartment compliance aids: do pharmacists require further guidance on medication stability? Int J Pharm Pract 2015; 23: 367–9.
    1. Nunney JM, Raynor D. How are multi-compartment compliance aids used in primary care? Pharm J 2001; 267: 784–9.

Source: PubMed

3
Tilaa