Pretransplantation therapy with azacitidine vs induction chemotherapy and posttransplantation outcome in patients with MDS

Aaron T Gerds, Ted A Gooley, Elihu H Estey, Frederick R Appelbaum, H Joachim Deeg, Bart L Scott, Aaron T Gerds, Ted A Gooley, Elihu H Estey, Frederick R Appelbaum, H Joachim Deeg, Bart L Scott

Abstract

Although allogeneic hematopoietic cell transplantation (HCT) has proven curative potential for myelodysplastic syndrome, relapse after HCT remains a problem. Pretransplantation cytoreduction with induction chemotherapy (IC) has been used to reduce relapse rates but is associated with significant toxicity and mortality. Hypomethylating agents may achieve cytoreduction with limited toxicity; however, data on the effect of pre-HCT hypomethylation on post-HCT outcomes are limited. We retrospectively reviewed results in 68 patients who underwent allogeneic HCT for myelodysplastic syndrome or acute myeloid leukemia transformed from MDS. Thirty-five patients had received cytoreduction with azacitidine before HCT with either a high-dose (40%) or a reduced-intensity (60%) conditioning regimen, and 33 had undergone IC before HCT with high-dose conditioning. The estimated 1-year overall survival (OS) was 57% in the azacitidine group and 36% in the IC group. The risk of post-HCT mortality (hazard ratio, 0.68; 95% confidence interval, 0.35-1.30), nonrelapse mortality (hazard ratio, 0.99; 95% confidence interval, 0.41-2.34), and relapse (hazard ratio, 0.34; 95% confidence interval, 0.41-2.34) were lower in the azacitidine group compared to the IC group, but only the hazard for relapse was significantly lower. After adjustment for cytogenetic risk, International Prognostic Scoring System, and donor, the rates of post-HCT relapse for the 2 cohorts were similar. Although the current study was retrospective and nonrandomized and needs to be interpreted in this context, the results add to the growing evidence that pre-HCT therapy with azacitidine is associated with less toxicity than IC and may allow for similar post-HCT outcomes.

Copyright © 2012 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

Figures

Figure 1
Figure 1
Overall survival following HCT according to pre-transplant therapy: azacitidine (AZA) vs. induction chemotherapy (IC). Patients were censored at the last follow up. The difference between AZA and IC was not significant at p = 0.24.
Figure 2
Figure 2
Non-relapse mortality following HCT according to pre-transplant therapy: azacitidine (AZA) vs. induction chemotherapy (IC). Patients were censored at the last follow up. The difference between AZA and IC was not significant at p = 0.98.
Figure 3
Figure 3
Relapse following HCT according to pre-transplant therapy: azacitidine (AZA) vs. induction chemotherapy (IC). Patients were censored at the last follow up. The difference between AZA and IC was significant at p = 0.04.
Figure 4
Figure 4
Relapse-free survival following HCT according to pre-transplant therapy: azacitidine (AZA) vs. induction chemotherapy (IC). Patients were censored at the last follow up. The difference between AZA and IC was not significant at p = 0.14.

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