Worldwide Burden, Risk Factors, and Temporal Trends of Ovarian Cancer: A Global Study

Junjie Huang, Wing Chung Chan, Chun Ho Ngai, Veeleah Lok, Lin Zhang, Don Eliseo Lucero-Prisno 3rd, Wanghong Xu, Zhi-Jie Zheng, Edmar Elcarte, Mellissa Withers, Martin C S Wong, On Behalf Of Ncd Global Health Research Group Of Association Of Pacific Rim Universities Apru, Junjie Huang, Wing Chung Chan, Chun Ho Ngai, Veeleah Lok, Lin Zhang, Don Eliseo Lucero-Prisno 3rd, Wanghong Xu, Zhi-Jie Zheng, Edmar Elcarte, Mellissa Withers, Martin C S Wong, On Behalf Of Ncd Global Health Research Group Of Association Of Pacific Rim Universities Apru

Abstract

This study aimed to investigate the most updated worldwide incidence and mortality, risk factors, and epidemiologic trend of ovarian cancer in different countries, regions, and age groups. The Global Cancer Observatory database was used for incidence and mortality rates of ovarian cancer in 2020. Data from Cancer Incidence in Five Continents and the WHO mortality database was accessed for trend analysis. Age-standardized rates (ASRs, per 100,000 persons) were calculated for incidence and mortality. The 10-year annual average percent change (AAPC) was estimated by Joinpoint regression analysis. There was an overall decreasing trend of ovarian cancer, yet its burden has been increasing in lower-income countries and among younger females in some countries. Intensive lifestyle modifications are warranted, especially for the populations at high risk for ovarian cancer, including smoking cessation, alcohol use reduction, physical activity, weight control, and treatment of metabolic diseases.

Keywords: incidence; mortality; ovarian cancer; risk factors; temporal trends.

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Global incidence and mortality of ovarian cancer, all ages, in 2020; Data source: https://gco.iarc.fr/today (accessed on 10 May 2021).
Figure 2
Figure 2
Associations between risk factors and the incidence of ovarian cancer.
Figure 3
Figure 3
Associations between risk factors and mortality of ovarian cancer.
Figure 4
Figure 4
AAPC of incidence of ovarian cancer aged 0–85+. * Statistically significant.
Figure 5
Figure 5
AAPC of mortality of ovarian cancer aged 085+. * Statistically significant.

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