Gamma Entrainment Binds Higher-Order Brain Regions and Offers Neuroprotection
Chinnakkaruppan Adaikkan, Steven J Middleton, Asaf Marco, Ping-Chieh Pao, Hansruedi Mathys, David Nam-Woo Kim, Fan Gao, Jennie Z Young, Ho-Jun Suk, Edward S Boyden, Thomas J McHugh, Li-Huei Tsai, Chinnakkaruppan Adaikkan, Steven J Middleton, Asaf Marco, Ping-Chieh Pao, Hansruedi Mathys, David Nam-Woo Kim, Fan Gao, Jennie Z Young, Ho-Jun Suk, Edward S Boyden, Thomas J McHugh, Li-Huei Tsai
Abstract
Neuronal and synaptic loss is characteristic in many neurodegenerative diseases, such as frontotemporal dementia and Alzheimer's disease. Recently, we showed that inducing gamma oscillations with visual stimulation (gamma entrainment using sensory stimuli, or GENUS) reduced amyloid plaques and phosphorylated tau in multiple mouse models. Whether GENUS can affect neurodegeneration or cognitive performance remains unknown. Here, we demonstrate that GENUS can entrain gamma oscillations in the visual cortex, hippocampus, and prefrontal cortex in Tau P301S and CK-p25 mouse models of neurodegeneration. Tau P301S and CK-p25 mice subjected to chronic, daily GENUS from the early stages of neurodegeneration showed a preservation of neuronal and synaptic density across multiple brain areas and modified cognitive performance. Our transcriptomic and phosphoproteomic data suggest that chronic GENUS shifts neurons to a less degenerative state, improving synaptic function, enhancing neuroprotective factors, and reducing DNA damage in neurons while also reducing inflammatory response in microglia.
Conflict of interest statement
DECLARATION OF INTEREST
L.-H.T. and E.S.B are scientific co-founders and serve on the scientific advisory board of Cognito Therapeutics.
Copyright © 2019 Elsevier Inc. All rights reserved.
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Source: PubMed