Increased duration of mechanical ventilation is associated with decreased diaphragmatic force: a prospective observational study

Greet Hermans, Anouk Agten, Dries Testelmans, Marc Decramer, Ghislaine Gayan-Ramirez, Greet Hermans, Anouk Agten, Dries Testelmans, Marc Decramer, Ghislaine Gayan-Ramirez

Abstract

Introduction: Respiratory muscle weakness is an important risk factor for delayed weaning. Animal data show that mechanical ventilation itself can cause atrophy and weakness of the diaphragm, called ventilator-induced diaphragmatic dysfunction (VIDD). Transdiaphragmatic pressure after magnetic stimulation (TwPdi BAMPS) allows evaluation of diaphragm strength. We aimed to evaluate the repeatability of TwPdi BAMPS in critically ill, mechanically ventilated patients and to describe the relation between TwPdi and the duration of mechanical ventilation.

Methods: This was a prospective observational study in critically ill and mechanically ventilated patients, admitted to the medical intensive care unit of a university hospital. Nineteen measurements were made in a total of 10 patients at various intervals after starting mechanical ventilation. In seven patients, measurements were made on two or more occasions, with a minimum interval of 24 hours.

Results: The TwPdi was 11.5 ± 3.9 cm H2O (mean ± SD), indicating severe respiratory muscle weakness. The between-occasion coefficient of variation of TwPdi was 9.7%, comparable with data from healthy volunteers. Increasing duration of mechanical ventilation was associated with a logarithmic decline in TwPdi (R = 0.69; P = 0.038). This association was also found for cumulative time on pressure control (R = 0.71; P = 0.03) and pressure-support ventilation (P = 0.05; R = 0.66) separately, as well as for cumulative dose of propofol (R = 0.66; P = 0.05) and piritramide (R = 0.79; P = 0.01).

Conclusions: Duration of mechanical ventilation is associated with a logarithmic decline in diaphragmatic force, which is compatible with the concept of VIDD. The observed decline may also be due to other potentially contributing factors such as sedatives/analgesics, sepsis, or others.

Figures

Figure 1
Figure 1
Tracheal, esophageal, and abdominal pressure tracings on bilateral magnetic stimulation. Ptr, tracheal pressure; Pes, esophageal pressure; Pabd, abdominal pressure; Pdi, transdiaphragmatic pressure (which was obtained by electronic subtraction of Pabd and Pes).
Figure 2
Figure 2
Patient disposition.
Figure 3
Figure 3
Regression analysis for TwPdi and total duration of mechanical ventilation; cumulative duration of BIPAP/ASB, PSV, and IPPV at the time of measurement; and cumulative dose of piritramide and propofol. All data concern values up to the time of measurement of TwPdi. TwPdi, twitch transdiaphragmatic pressure; BIPAP/ASB, bilevel positive airway pressure with assisted spontaneous breathing; PSV, pressure-support ventilation; IPPV, intermittent positive-pressure ventilation.

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