p62 at the crossroads of autophagy, apoptosis, and cancer
Jorge Moscat, Maria T Diaz-Meco, Jorge Moscat, Maria T Diaz-Meco
Abstract
The signaling adaptor p62 is a multidomain protein implicated in the activation of the transcription factor NF-kappaB. Recent findings link p62 activity to the extrinsic apoptosis pathway, and Mathew et al. (2009) now show that the modulation of p62 by autophagy is a key factor in tumorigenesis. These findings place p62 at critical decision points that control cell death and survival.
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Source: PubMed