What factors are important for deprescribing in Australian long-term care facilities? Perspectives of residents and health professionals

Justin P Turner, Susan Edwards, Melinda Stanners, Sepehr Shakib, J Simon Bell, Justin P Turner, Susan Edwards, Melinda Stanners, Sepehr Shakib, J Simon Bell

Abstract

Objectives: Polypharmacy and multimorbidity are common in long-term care facilities (LTCFs). Reducing polypharmacy may reduce adverse events and maintain quality of life. Deprescribing refers to reducing medications after consideration of therapeutic goals, benefits and risks, and medical ethics. The objective was to use nominal group technique (NGT) to generate then rank factors that general medical practitioners (GPs), nurses, pharmacists and residents or their representatives perceive are most important when deciding whether or not to deprescribe medications.

Design: Qualitative research using NGT.

Setting: Participants were invited if they worked with, or resided in LTCFs across metropolitan and regional South Australia.

Participants: 11 residents/representatives, 19 GPs, 12 nurses and 14 pharmacists participated across six separate groups.

Methods: Individual groups of GPs, nurses, pharmacists and residents/representatives were convened. Using NGT each group ranked factors perceived to be most important when deciding whether or not to deprescribe. Then, using NGT, the prioritised factors from individual groups were discussed and prioritised by a multidisciplinary metropolitan and regional group comprised of resident representatives, GPs, nurses and pharmacists.

Results: No two groups had the same priorities. GPs ranked 'evidence for deprescribing' and 'communication with family/resident' as most important factors. Nurses ranked 'GP receptivity to deprescribing' and 'nurses ability to advocate for residents' as most important. Pharmacists ranked 'clinical appropriateness of therapy' and 'identifying residents' goals of care' as most important. Residents ranked 'wellbeing of the resident' and 'continuity of nursing staff' as most important. The multidisciplinary groups ranked 'adequacy of medical and medication history' and 'identifying residents' goals of care' as most important.

Conclusions: While each group prioritised different factors, common and contrasting factors emerged. Future deprescribing interventions need to consider the similarities and differences within the range of factors prioritised by residents and health professionals.

Keywords: GERIATRIC MEDICINE; PRIMARY CARE.

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Figures

Figure 1
Figure 1
Flow diagram for phase 1 and phase 2. GP, general medical practitioner.
Figure 2
Figure 2
Process of nominal group technique (NGT).

References

    1. Tinetti ME, Fried TR, Boyd CM. Designing health care for the most common chronic condition—multimorbidity. JAMA 2012;307:2493–4. 10.1001/jama.2012.5265
    1. Jokanovic N, Tan EC, Dooley MJ et al. . Prevalence and factors associated with polypharmacy in long term care facilities: a systematic review. J Am Med Dir Assoc 2015;16:535.e1–12. 10.1016/j.jamda.2015.03.003
    1. Hilmer SN, Gnjidic D, Le Couteur DG. Thinking through the medication list—appropriate prescribing and deprescribing in robust and frail older patients. Aust Fam Physician 2012;41:924–8.
    1. Hajjar ER, Cafiero AC, Hanlon JT. Polypharmacy in elderly patients. Am J Geriatr Pharmacother 2007;5:345–51. 10.1016/j.amjopharm.2007.12.002
    1. Maher RL, Hanlon J, Hajjar ER. Clinical consequences of polypharmacy in elderly. Expert Opin Drug Saf 2014;13:57–65. 10.1517/14740338.2013.827660
    1. Shah BM, Hajjar ER. Polypharmacy, adverse drug reactions, and geriatric syndromes. Clin Geriatr Med 2012;28:173–86. 10.1016/j.cger.2012.01.002
    1. Tamura BK, Bell CL, Inaba M et al. . Outcomes of polypharmacy in nursing home residents. Clin Geriatr Med 2012;28:217–36. 10.1016/j.cger.2012.01.005
    1. Woodward MC, Bird M, Elliot R et al. . Deprescribing: achieving better health outcomes for older people through reducing medications. J Pharm Pract Res 2003;33:323–7.
    1. Reeve E, Turner JP. Patients’ perspectives on the brave new word ‘deprescribing’. Int J Pharm Pract 2015;23:90–1. 10.1111/ijpp.12111
    1. Hardy J, Hilmer SN. Deprescribing in the last year of life. J Pharm Pract Res 2011;41:146–51. 10.1002/j.2055-2335.2011.tb00684.x
    1. Garfinkel D, Ilhan B, Bahat G. Routine deprescribing of chronic medications to combat polypharmacy. Ther Adv Drug Saf 2015;6:212–33. 10.1177/2042098615613984
    1. Thompson W, Farrell B. Deprescribing: what is it and what does the evidence tell us? Can J Hosp Pharm 2013;66:201–2.
    1. Garfinkel D, Zur-Gil S, Ben-Israel J. The war against polypharmacy: a new cost-effective geriatric-palliative approach for improving drug therapy in disabled elderly people. Isr Med Assoc J 2007;9:430–4.
    1. Garfinkel D, Mangin D. Feasibility study of a systematic approach for discontinuation of multiple medications in older adults: addressing polypharmacy. Arch Intern Med 2010;170:1648–54. 10.1001/archinternmed.2010.355
    1. Somers M, Rose E, Simmonds D et al. . Quality use of medicines in residential aged care. Aust Fam Physician 2010;39:413–16.
    1. Rancourt C, Moisan J, Baillargeon L et al. . Potentially inappropriate prescriptions for older patients in long-term care. BMC Geriatr 2004;4:9 10.1186/1471-2318-4-9
    1. Linsky A, Simon SR, Bokhour B. Patient perceptions of proactive medication discontinuation. Patient Educ Couns 2015;98: 220–5. 10.1016/j.pec.2014.11.010
    1. Flick U, Garms-Homolová V, Röhnsch G. “And mostly they have a need for sleeping pills”: physicians’ views on treatment of sleep disorders with drugs in nursing homes. J Aging Stud 2012;26:484–94. 10.1016/j.jaging.2012.07.001
    1. Harriman K, Howard L, McCracken R. Deprescribing medication for frail elderly patients in nursing homes: a survey of Vancouver family physicians. B C Med J 2014;56:436–41.
    1. Anderson K, Stowasser D, Freeman C et al. . Prescriber barriers and enablers to minimising potentially inappropriate medications in adults: a systematic review and thematic synthesis. BMJ Open 2014;4:e006544 10.1136/bmjopen-2014-006544
    1. Reeve E, To J, Hendrix I et al. . Patient barriers to and enablers of deprescribing: a systematic review. Drugs Aging 2013;30:793–807. 10.1007/s40266-013-0106-8
    1. Lim CJ, Kwong MW, Stuart RL et al. . Antibiotic prescribing practice in residential aged care facilities—health care providers’ perspectives. Med J Aust 2014;201:98–102.
    1. Hughes CM, Lapane K, Watson MC et al. . Does organisational culture influence prescribing in care homes for older people? A new direction for research. Drugs Aging 2007;24:81–93. 10.2165/00002512-200724020-00001
    1. Halvorsen KH, Ruths S, Granas AG et al. . Multidisciplinary intervention to identify and resolve drug-related problems in Norwegian nursing homes. Scand J Prim Health Care 2010;28:82–8. 10.3109/02813431003765455
    1. Schuling J, Gebben H, Veehof LJ et al. . Deprescribing medication in very elderly patients with multimorbidity: the view of Dutch GPs. A qualitative study. BMC Fam Pract 2012;13:56 10.1186/1471-2296-13-56
    1. Reeve E, Wiese MD, Hendrix I et al. . People's attitudes, beliefs, and experiences regarding polypharmacy and willingness to deprescribe. J Am Geriatr Soc 2013;61:1508–14. 10.1111/jgs.12418
    1. Scott IA, Denaro CP, Bennett CJ et al. . Towards more effective use of decision support in clinical practice: what the guidelines for guidelines Don't tell you. Intern Med J 2004;34:492–500. 10.1111/j.1445-5994.2004.00604.x
    1. Cantrill JA, Sibbald B, Buetow S. The Delphi and nominal group techniques in health services research. Int J Pharm Pract 1996;4:67–74. 10.1111/j.2042-7174.1996.tb00844.x
    1. McMurray AR. Three decision-making aids: brainstorming, nominal group, and Delphi technique. J Nurs Staff Dev 1994;10:62–5.
    1. Delbecq AL, Van de Ven AH. A group process model for problem identification and program planning. J Appl Behav Sci 1971;7:466–92. 10.1177/002188637100700404
    1. Campbell SM, Cantrill JA. Consensus methods in prescribing research. J Clin Pharm Ther 2001;26:5–14. 10.1046/j.1365-2710.2001.00331.x
    1. Dening KH, Jones L, Sampson EL. Preferences for end-of-life care: a nominal group study of people with dementia and their family carers. Palliat Med 2013;27:409–17. 10.1177/0269216312464094
    1. Van de Ven AH, Delbecq AL. The nominal group as a research instrument for exploratory health studies. Am J Public Health 1972;62:337–42. 10.2105/AJPH.62.3.337
    1. van Teijlingen E, Pitchforth E, Bishop C et al. . Delphi method and nominal group technique in family planning and reproductive health research. J Fam Plann Reprod Health Care 2006;32:249–52. 10.1783/147118906778586598
    1. Gallagher M, Hares T, Spencer J et al. . The nominal group technique: a research tool for general practice? Fam Pract 1993;10:76–81. 10.1093/fampra/10.1.76
    1. Drennan V, Walters K, Lenihan P et al. . Priorities in identifying unmet need in older people attending general practice: a nominal group technique study. Fam Pract 2007;24:454–60. 10.1093/fampra/cmm034
    1. Romagnoli KM, Handler SM, Ligons FM et al. . Home-care nurses’ perceptions of unmet information needs and communication difficulties of older patients in the immediate post-hospital discharge period. BMJ Qual Saf 2013;22:324–32. 10.1136/bmjqs-2012-001207
    1. Pitkälä KH, Juola AL, Kautiainen H et al. . Education to reduce potentially harmful medication use among residents of assisted living facilities: a randomized controlled trial. J Am Med Dir Assoc 2014;15:892–8. 10.1016/j.jamda.2014.04.002
    1. Farrell B, Tsang C, Raman-Wilms L et al. . What are priorities for deprescribing for elderly patients? Capturing the voice of practitioners: a modified delphi process. PLoS ONE 2015;10:e0122246 10.1371/journal.pone.0122246
    1. Anthierens S, Tansens A, Petrovic M et al. . Qualitative insights into general practitioners views on polypharmacy. BMC Fam Pract 2010;11:65 10.1186/1471-2296-11-65
    1. Gnjidic D, Le Couteur DG, Kouladjian L et al. . Deprescribing trials: methods to reduce polypharmacy and the impact on prescribing and clinical outcomes. Clin Geriatr Med 2012;28:237–53. 10.1016/j.cger.2012.01.006
    1. Castle NG. The influence of consistent assignment on nursing home deficiency citations. Gerontologist 2011;51:750–60. 10.1093/geront/gnr068
    1. Koren MJ. Person-centered care for nursing home residents: the culture-change movement. Health Aff (Millwood) 2010;29:312–17. 10.1377/hlthaff.2009.0966
    1. Roberts T, Nolet K, Bowers B. Consistent assignment of nursing staff to residents in nursing homes: A critical review of conceptual and methodological issues. Gerontologist 2015;55:434–47. 10.1093/geront/gnt101
    1. Rahman A, Straker JK, Manning L. Staff assignment practices in nursing homes: review of the literature. J Am Med Dir Assoc 2009;10:4–10. 10.1016/j.jamda.2008.08.010
    1. Iyer S, Naganathan V, McLachlan AJ et al. . Medication withdrawal trials in people aged 65 years and older: a systematic review. Drugs Aging 2008;25:1021–31. 10.2165/0002512-200825120-00004
    1. Beer C, Loh PK, Peng YG et al. . A pilot randomized controlled trial of deprescribing. Ther Adv Drug Saf 2011;2:37–43. 10.1177/2042098611400332
    1. Dalleur O, Boland B, Losseau C et al. . Reduction of potentially inappropriate medications using the STOPP criteria in frail older inpatients: a randomised controlled study. Drugs Aging 2014;31:291–8. 10.1007/s40266-014-0157-5
    1. Nelson MR, Reid CM, Krum H et al. . Predictors of normotension on withdrawal of antihypertensive drugs in elderly patients: prospective study in second Australian national blood pressure study cohort. BMJ 2002;325:815 10.1136/bmj.325.7368.815
    1. Tannenbaum C, Martin P, Tamblyn R et al. . Reduction of inappropriate benzodiazepine prescriptions among older adults through direct patient education: the EMPOWER cluster randomized trial. JAMA Intern Med 2014;174:890–8. 10.1001/jamainternmed.2014.949
    1. Van Spall HG, Toren A, Kiss A et al. . Eligibility criteria of randomized controlled trials published in high-impact general medical journals: a systematic sampling review. JAMA 2007;297:1233–40. 10.1001/jama.297.11.1233
    1. Iden KR, Hjørleifsson S, Ruths S. Treatment decisions on antidepressants in nursing homes: a qualitative study. Scand J Prim Health Care 2011;29:252–6. 10.3109/02813432.2011.628240
    1. Schmidt I, Claesson CB, Westerholm B et al. . The impact of regular multidisciplinary team interventions on psychotropic prescribing in Swedish nursing homes. J Am Geriatr Soc 1998;46:77–82. 10.1111/j.1532-5415.1998.tb01017.x
    1. Crotty M, Halbert J, Rowett D et al. . An outreach geriatric medication advisory service in residential aged care: a randomised controlled trial of case conferencing. Age Ageing 2004;33:612–17. 10.1093/ageing/afh213
    1. Bain KT, Holmes HM, Beers MH et al. . Discontinuing medications: a novel approach for revising the prescribing stage of the medication-use process. J Am Geriatr Soc 2008;56: 1946–52. 10.1111/j.1532-5415.2008.01916.x

Source: PubMed

3
Tilaa