Changes in biomarkers of bone resorption over the first six months after pediatric hematopoietic cell transplantation

Abstract

Bone loss has been observed within the first six months after HCT in both children and adults. While there is some evidence that bone formation may be reduced in children after HCT, it is currently unknown whether bone resorption is increased. The objective of this prospective study was to evaluate changes in markers of bone resorption over the first six months after pediatric HCT. Twenty-six participants (eight females) aged 10.9 ± 3.4 yr entered the study prior to HCT. Bone resorption was measured by urine DPD and PYD, and by plasma NTX and CTX. Seventeen participants who completed day +30 visit and either day +100 or +180 visits were included in the analysis. DPD increased between days +30 and +100 (mean change, 11.3 nmol/nmol creatinine; p = 0.012) and between days +30 and +180 (13.7 nmol/nmol creatinine; p = 0.036). PYD increased between days +30 and +100 (32 nmBCE/L; p = 0.019). CTX increased between baseline and day +100 (5.9 μg/L; p = 0.012). Changes in NTX levels were not statistically significant. This study shows that markers of bone resorption increase in children after HCT, suggesting that increased resorption may be a contributing factor to the pathophysiology of bone loss after pediatric HCT.

© 2012 John Wiley & Sons A/S.

Figures

Fig. 1

Changes in mean bone resorption for urine pyridinolines (PYD), urine deoxypyridinoline (DPD), serum N-telopeptide (NTX), and C-telopeptide (CTX). Data for each individual is plotted with individual trajectories in grey, dotted lines are used only when the value at day +100 was missing and points were connected between day +30 and +180, diamonds are means at each time point, which are connected with a black line and have bars representing 95% confidence intervals. The number of measurements at each time point is presented below the axis.