Innovative treatment using tilapia skin as a xenograft for partial thickness burns after a gunpowder explosion

Edmar Maciel Lima-Junior, Manoel Odorico de Moraes Filho, Bruno Almeida Costa, Francisco Vagnaldo Fechine, Maria Elisabete Amaral de Moraes, Francisco Raimundo Silva-Junior, Maria Flaviane Araújo do Nascimento Soares, Marina Becker Sales Rocha, Cybele Maria Philopimin Leontsinis, Edmar Maciel Lima-Junior, Manoel Odorico de Moraes Filho, Bruno Almeida Costa, Francisco Vagnaldo Fechine, Maria Elisabete Amaral de Moraes, Francisco Raimundo Silva-Junior, Maria Flaviane Araújo do Nascimento Soares, Marina Becker Sales Rocha, Cybele Maria Philopimin Leontsinis

Abstract

Tilapia skin has non-infectious microbiota, high amounts of type I collagen, and similar morphological structure to human skin, so it has been suggested as a potential xenograft for the management of burn wounds. A 23-year-old male patient, with no comorbidities, arrived at our burn treatment center after a thermal injury caused by contact with flames from a gunpowder explosion. Superficial partial thickness burns were present in his right upper limb and deep partial thickness burns were present in his left upper limb. Tilapia skin was applied to the lesions, leading to complete reepithelialization within 12 and 17 days of treatment, respectively. No dressing changes were needed and no side effects were observed. Tilapia skin carries the promise of an innovative, easy-to-apply and highly available product that can become the first nationally studied animal skin registered by the National Sanitary Surveillance Agency for use in the treatment of burns.

Figures

Figure 1:
Figure 1:
Superficial partial thickness burn in the right upper limb, after cleaning of the lesion.
Figure 2:
Figure 2:
Deep partial thickness burn in the left upper limb, after cleaning of the lesion.
Figure 3:
Figure 3:
Process of removing necrotic and fibrinous tissue from the lesion, an essential step to allow maximal contact between NTFS and the wound bed.
Figure 4:
Figure 4:
Appearance of the left upper limb after NTFS application.
Figure 5:
Figure 5:
Appearance of the dressing on the sixth day of treatment. Good adherence of NTFS to the wound bed was detected.
Figure 6:
Figure 6:
Appearance of the right upper limb lesion after removal of NTFS, with a total of 12 days required for complete reepithelialization of the SPTB.
Figure 7:
Figure 7:
Appearance of the left upper limb lesion after removal of NTFS, with a total of 17 days required for complete reepithelialization of the DPTB.

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Source: PubMed

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