Interleukin-6 in surgery, trauma, and critical care part II: clinical implications
Randeep S Jawa, Sergio Anillo, Kristin Huntoon, Heinz Baumann, Mahmoud Kulaylat, Randeep S Jawa, Sergio Anillo, Kristin Huntoon, Heinz Baumann, Mahmoud Kulaylat
Abstract
A variety of cytokines play a role in the inflammatory response. Interleukin-6 (IL-6)-type cytokines are released in response to tissue injury or an inflammatory stimulus, and act locally and systemically to generate a variety of physiologic responses. Interleukin-6 concentrations are elevated after surgery, trauma, and critical illness. The magnitude of IL-6 elevation correlates with the extent of tissue trauma/injury severity. Furthermore, there is an association between IL-6 elevation and adverse outcome. Interleukin-6 levels can also be used to stratify patients for therapeutic intervention.
Conflict of interest statement
Declaration of Conflicting Interests
The author(s) declared no conflicts of interest with respect to the authorship and/or publication of this article.
Source: PubMed