Anethum graveolens: An Indian traditional medicinal herb and spice

S Jana, G S Shekhawat, S Jana, G S Shekhawat

Abstract

Anethum graveolens L. (dill) has been used in ayurvedic medicines since ancient times and it is a popular herb widely used as a spice and also yields essential oil. It is an aromatic and annual herb of apiaceae family. The Ayurvedic uses of dill seeds are carminative, stomachic and diuretic. There are various volatile components of dill seeds and herb; carvone being the predominant odorant of dill seed and α-phellandrene, limonene, dill ether, myristicin are the most important odorants of dill herb. Other compounds isolated from seeds are coumarins, flavonoids, phenolic acids and steroids. The main purpose of this review is to understand the significance of Anethum graveolens in ayurvedic medicines and non-medicinal purposes and emphasis can also be given to the enhancement of secondary metabolites of this medicinal plant.

Keywords: Anethum graveolens; ayurvedic uses; carvone; limonene; monoterpenes; review.

Conflict of interest statement

Conflict of Interest: None declared

Figures

Figure 1
Figure 1
(a) Seeds, (b) plants (c) inflorescence
Figure 2
Figure 2
Enzymatic pathway depicting synthesis of limonene and carvone in seeds of Anethum graveolens

References

    1. Khare CP. Indian herbal remedies. Berlin, New York: Springer; 2004. Rational western therapy, ayurvedic and other traditional usages, botany; pp. 60–1.
    1. Ravindran P, Balachandran I. Under utilized medicinal spices II, Spice India. Vol. 17. India: Publisher V K Krishnan Nair; 2005. pp. 32–6.
    1. Bailer J, Aichinger T, Hackl G, Hueber KD, Dachler M. Essential oil content and composition in commercially available dill cultivars in comparison to caraway. Indus Crops Prods. 2001;14:229–39.
    1. Quer F. Plantas Medicinales, El Dioscorides Renovado. Barcelona: Editorial labor, S A; 1981. p. 500.
    1. Pulliah T. Medicinal Plants in India. Vol. 1. New Delhi: Regency Publications New Delhi; 2002. pp. 55–6.
    1. Warrier PK, Nambiar VPK, Ramakutty C. Arya Vaidya Sala. Vol. 1. Kottakkal Madras, India: Orient Longman Limited; 1994. Indian Medicinal Plants; pp. 153–4.
    1. Carrubba A, Torre R, Saiano F, Aiello P. Sustainable production of fennel and dill by intercropping. Agro Sust Develop. 2007;28:247–56.
    1. Patt JM, Hamilton GC, Lashomb JH. Foraging success of parasitoid wasps on flowers: Interplay of insect morphology, floral architecture and searching behavior. Entomol Exp Appl. 1997;83:21–30.
    1. Wanner H, Gu H, Dorn S. Nutritional value of floral nectar sources for flight in the parasitoid wasp, Cotesia glomerata. Physiol Entomol. 2006;31:127–33.
    1. Hornok L. Cultivation and processing of medicinal plants: Academic publications. 1992:338.
    1. Sharma R. Agrotechniques of medicinal plants. New Delhi: Daya Publishing House; 2004. pp. 3–8.
    1. Duke JA. Handbooke of Medicinal Herbs. London: CRC Press; 2001. p. 42.
    1. Fleming T. PDR for Herbal Medicines. New Jersey: Medical Economics Company; 2000. p. 252.
    1. Nair R, Chanda S. Antibacterial activities of some medicinal plants of the western region of India. Turk J Biol. 2007;31:231–6.
    1. Blank I, Grosch W. Evaluation of potent odorants in dill seed anddill herb (Anethum graveolens L.) by aroma extract dilution analysis. J Food Sci. 1991;56:63–7.
    1. Huopalathi R, Linko RR. Composition and content of aroma compounds in dill, Anethum graveolens L., at three different growth stages. J Agri Food Chem. 1983;31:331–3.
    1. Lawless J. The illustrated encyclopedia of essential oils. Shaftesbury, Dorset: Element; 1995. p. 83.
    1. Chaubey MK. Insecticidal activity of Trachspermum ammi (Umbelliferae), Anethum graveolens (Umbelliferae) and Nigella sativa (Ranunculaceae) essential oils against stored-product beetle Tribolium castaneum Herbst Coleoptra: Tenebrionidae. Afrin J Agri Res. 2007;2:596–600.
    1. Kirtikar KP, Basu BD, Mahaskar C. Indian Medicinal Plants. 2nd ed. Vol. 2. Allahabad: International Book Distributors; 1987. p. 1219.
    1. Chaurasia SC, Jain PC. Antibacterial activity of essential oils of four medicinal plants. Indian J Hosp Pharm. 1978;15:166–8.
    1. Delaquis PJ, Stanich K, Girard B, Mazza G. Antimicrobial activity of individual and mixed fractions of dill, cilantro, coriander and eucalyptus essential oils. Int J Food Microbiol. 2002;74:101–9.
    1. Yazdanparast R, Alavi M. Antihyperlipidaemic and antihypercholesterolaemic effects of Anethum graveolens leaves after the removal of furocoumarins. Cytobios. 2001;105:185–91.
    1. Hosseinzadeh H, Karimi GR, Ameri M. Effects of Anethum graveolens L. seed extracts on experimental gastric irritation models in mice. BMC Pharmacol. 2002;2:21–5.
    1. Mahran GH, Kadry HA, Thabet CK, Al-Azizi M, Liv N. GC/ MS analysis of volatile oil of fruits of Anethum graveolens. Int J Pharmacog. 1992;30:139–44.
    1. Mohele B, Heller W, Wellmann E. UV-induced biosynthesis of quercetin 3-o-beta-d-glucuronide in dill Anethum graveolens cell cultures. Phytochem. 1985;24:183–5.
    1. Naseri-Gharib MK, Heidari A. Antispasmodic effect of A. graveolens fruit extract on rat ileum. Int J Pharm. 2007;3:260–4.
    1. Yazdanparast R, Bahramikia S. Improvement of liver antioxidant status in hypercholesterolamic rats treated with A.graveolens extracts. Pharmacologyonline. 2007;3:88–94.
    1. Arora DS, Kaur JG. Antibacterial activity of some Indian medicinal plants. J Nat Med. 2007;61:313–7.
    1. Farag RS, Daw ZY, Abo-Raya SH. Influence of some spice essential oils on Aspergillus parasiticus growth and production of aflatoxin in a synthetic medium. J Food Sci. 1989;54:74–7.
    1. Aiyelaagbe OO, Osamudiamen PM. Phytochemical screening for active compounds in Mangifera indica leaves from Ibadan, Oyo state. Plant Sci Res. 2009;2:11–3.
    1. Santos AG, Figueiredo AC, Lourenco PM, Barrosa JG, Pedro LG. Hairy root cultures of Anethum graveolens (dill): Establishment, growth, time-course study of their essential oil and its comparison with parent plant oils. Biotech Lett. 2002;24:1031–6.
    1. Bonnlander B, Winterhalter P. 9-Hydroxypiperitone beta-D-glucopyranoside and other polar constituents from dill (Anethum graveolens L.) herb. J Agric Food Chem. 2000;48:4821–5.
    1. Bouwmeester HJ, Gershenzon J, Konings MC, Croteau R. Biosynthesis of the monoterpenes limonene and carvone in the fruit of caraway. I. Demonstration Of enzyme activities and their changes with development. Plant Physiol. 1998;117:901–12.
    1. Raghvan B, Abrahman KO, Koller WD, Shankarnarayanan ML. Studies on flavor changes during drying of Dill (Anethum sowa. Roxb) leaves. J Food Qual. 1994;17:457–66.
    1. Score C, Lorenzi R, Ranall P. The effect of S- (+)-carvone treatments on seed potato tuber dormancy and sprouting. Potato Res. 1997;40:155–61.
    1. Vigushin DM, Poon GK, Boody A, English J, Halbert GW, Pagonis C, et al. Phase I and pharmacokinetic study of D-limonene in patients with advanced cancer. Cancer Research Campaign Phase I/II Clinical Trials Committee. Cancer Chemother Pharmacol. 1998;42:111–7.
    1. Dhalwal K, Shinde VM, Mahadik KR. Efficient and sensitive method for quantitative determination and validation of Umbelliferone, carvone and Myristicin in Anethum graveolens and Carum carvi seeds. Chromatograph. 2008;67:163–7.
    1. Newberne P, Smith RL, Doull J, Goodman JI, Munro IC, Portoghese PS, et al. The FEMA GRAS assessment of trans-anethole used as a flavoring substance. Flavor and Extract Manufacturer's Association. Food Chem Toxicol. 1999;37:789–811.
    1. Sharma RK, Wakhlu AK, Boleria M. Micropropagation of Anethum graveolens L. through axillary shoots proliferation. J Plant Biochem Biotech. 2004;13:157–9.
    1. Sehgal CB. Differentiation of shoot buds and embryoids from inflorescence of Anethum graveolens in cultures. Phytomorphol. 1978;28:291–7.
    1. Gupta R. Studies in cultivation and improvement of dill (Anethum graveolens) in India. In: Atal CK, Kapur BM, editors. Jammu: In Cultivation and Utilization of Medicinal and Aromatic plants, Regional Research Laboratory; pp. 545–8.
    1. Stockigt J, Obitz P, Fakenghegen H, Lutterbach R, Endress S. The natural product and enzymes from plant cell culture. Plant Cell Tissue Organ Cult. 1985;43:97–109.
    1. Blank I, Sen A, Grosch W. Sensory study on the character-impact flavour compounds of dill herb (Anethum graveolens L.) Food Chem. 1992;43:337–43.
    1. Lee BK, Kim JH, Jung JW, Choi JW, Han ES, Lee SH, et al. Myristicin-induced neurotoxicity in human neuroblastoma SK-N-SH cells. Toxicol Lett. 2005;157:49–56.
    1. Shulgin AT, Sargent T. Psychotropic phenylisopropylamines derived from apiole and dillapiole. Nature. 1967;215:1494–5.
    1. Singh G, Maurya S, Lampasona MP, Catalan C. Chemical constituents, antimicrobial investigations, and antioxidative potentials of Anethum graveolens L. essential oil and acetone extract: Part 52. J Food Sci. 2005;70:208–15.

Source: PubMed

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