Late Complications of COVID-19; a Systematic Review of Current Evidence

SeyedAhmad SeyedAlinaghi, Amir Masoud Afsahi, Mehrzad MohsseniPour, Farzane Behnezhad, Mohammad Amin Salehi, Alireza Barzegary, Pegah Mirzapour, Esmaeil Mehraeen, Omid Dadras, SeyedAhmad SeyedAlinaghi, Amir Masoud Afsahi, Mehrzad MohsseniPour, Farzane Behnezhad, Mohammad Amin Salehi, Alireza Barzegary, Pegah Mirzapour, Esmaeil Mehraeen, Omid Dadras

No abstract available

Keywords: COVID-19; Late Onset Disorders; Long Term Adverse Effects; SARS-CoV-2; post-acute COVID-19 syndrome.

Figures

Figure 1
Figure 1
Flow diagram of the selection process of articles identified.
Figure 2
Figure 2
Frequency of identified late complications of COVID-19.

References

    1. Orlandi M, Lepri G, Bruni C, Wang Y, Bartoloni A, Zammarchi L, et al. The systemic sclerosis patient in the COVID-19 era: the challenging crossroad between immunosuppression, differential diagnosis and long-term psychological distress. Clinical Rheumatology. 2020:1.
    1. Heneka MT, Golenbock D, Latz E, Morgan D, Brown R. Immediate and long-term consequences of COVID-19 infections for the development of neurological disease. Alzheimer's research & therapy. 2020;12(1):69.
    1. Mehraeen E, Behnezhad F, Salehi MA, Noori T, Harandi H, SeyedAlinaghi S. Olfactory and gustatory dysfunctions due to the coronavirus disease (COVID-19): a review of current evidence. European Archives of Oto-Rhino-Laryngology. 2020:1–6.
    1. Mehraeen E, Hayati B, Saeidi S, Heydari M, Seyed Alinaghi S. Self-Care Instructions for People Not Requiring Hospitalization for Coronavirus Disease 2019 (COVID-19) Archives of Clinical Infectious Diseases. 2020;15(COVID-19)
    1. SeyedAlinaghi S, Ghadimi M, Hajiabdolbaghi M, Rasoolinejad M, Abbasian L, Nezhad MH, et al. Prevalence of COVID-19-like symptoms among people living with HIV, and using antiretroviral therapy for prevention and treatment. Current HIV Research. 2020
    1. Wang X, Fang X, Cai Z, Wu X, Gao X, Min J, et al. Comorbid Chronic Diseases and Acute Organ Injuries Are Strongly Correlated with Disease Severity and Mortality among COVID-19 Patients: A Systemic Review and Meta-Analysis. Research (Washington, DC). 2020;2020:2402961.
    1. Consoli L, Bendotti V, Cicchinelli S, Gaioni F, Prandolini P, Bettonagli M, et al. 2019 novel coronavirus (COVID-19) pneumonia complications: the importance of lung ultrasound. Journal of ultrasound. 2020:1–4.
    1. Asadollahi-Amin A, Hasibi M, Ghadimi F, Rezaei H, SeyedAlinaghi S. Lung involvement found on chest ct scan in a pre-symptomatic person with SARS-CoV-2 infection: a case report. Tropical medicine and infectious disease. 2020;5(2):56.
    1. Ghiasvand F, Miandoab SZ, Harandi H, Golestan FS, Alinaghi SAS. A patient with COVID-19 disease in a Referral Hospital in Iran: a typical case. Infectious disorders drug targets. 2020
    1. Wagener F, Pickkers P, Peterson SJ, Immenschuh S, Abraham NG. Targeting the Heme-Heme Oxygenase System to Prevent Severe Complications Following COVID-19 Infections. Antioxidants (Basel, Switzerland) 2020;9(6)
    1. Montalvan V, Lee J, Bueso T, De Toledo J, Rivas K. Neurological manifestations of COVID-19 and other coronavirus infections: A systematic review. Clinical Neurology and Neurosurgery. 2020;194:105921.
    1. Heneka MT, Golenbock D, Latz E, Morgan D, Brown R. Immediate and long-term consequences of COVID-19 infections for the development of neurological disease. Alzheimer's Research & Therapy. 2020;12:1–3.
    1. Beghi E, Feigin V, Caso V, Santalucia P, Logroscino G. COVID-19 Infection and Neurological Complications: Present Findings and Future Predictions. Neuroepidemiology. 2020;4:1–6.
    1. Aghagoli G, Gallo Marin B, Soliman LB, Sellke FW. Cardiac involvement in COVID‐19 patients: Risk factors, predictors, and complications: A review. Journal of Cardiac Surgery. 2020
    1. Inciardi RM, Lupi L, Zaccone G, Italia L, Raffo M, Tomasoni D, et al. Cardiac involvement in a patient with coronavirus disease 2019 (COVID-19) JAMA cardiology. 2020
    1. Bandyopadhyay D, Akhtar T, Hajra A, Gupta M, Das A, Chakraborty S, et al. COVID-19 pandemic: Cardiovascular complications and future implications. American Journal of Cardiovascular Drugs. 2020:1–14.
    1. Bellastella G, Maiorino M, Esposito K. Endocrine complications of COVID-19: what happens to the thyroid and adrenal glands? Journal of Endocrinological Investigation. 2020:1.
    1. Docherty AB, Harrison EM, Green CA, Hardwick HE, Pius R, Norman L, et al. Features of 16,749 hospitalised UK patients with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol. medRxiv. 2020
    1. Singh Y, Gupta G, Kazmi I, Al‐Abbasi FA, Negi P, Chellappan D, et al. SARS CoV‐2 aggravates cellular metabolism mediated complications in COVID‐19 infection. Dermatologic therapy. 2020
    1. Coperchini F, Chiovato L, Croce L, Magri F, Rotondi M. The cytokine storm in COVID-19: an overview of the involvement of the chemokine/chemokine-receptor system. Cytokine & Growth Factor Reviews. 2020
    1. Sepehrinezhad A, Shahbazi A, Negah SS. COVID-19 virus may have neuroinvasive potential and cause neurological complications: a perspective review. Journal of neurovirology. 2020;26(3):324–9.
    1. Filatov A, Sharma P, Hindi F, Espinosa PS. Neurological complications of coronavirus disease (COVID-19): encephalopathy. Cureus. 2020;12(3)
    1. Singh Y, Gupta G, Kazmi I, Al-Abbasi FA, Negi P, Chellappan DK, et al. SARS CoV-2 aggravates cellular metabolism mediated complications in COVID-19 infection. Dermatologic therapy. :e13871.
    1. Varatharajah N, Rajah S. Microthrombotic Complications of COVID-19 Are Likely Due to Embolism of Circulating Endothelial Derived Ultralarge Von Willebrand Factor (eULVWF) Decorated-Platelet Strings. Federal practitioner : for the health care professionals of the VA, DoD, and PHS. 2020;37(6):e1–e2.
    1. Helms J, Kremer S, Merdji H, Clere-Jehl R, Schenck M, Kummerlen C, et al. Neurologic features in severe SARS-CoV-2 infection. New England Journal of Medicine. 2020
    1. Kochi AN, Tagliari AP, Forleo GB, Fassini GM, Tondo C. Cardiac and arrhythmic complications in patients with COVID-19. Journal of cardiovascular electrophysiology. 2020;31(5):1003–8.
    1. Klok FA, Kruip M, van der Meer NJM, Arbous MS, Gommers D, Kant KM, et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thrombosis research. 2020;191:145–7.
    1. Landi A, De Servi S. The burden of thrombotic complications in critically ill patients with COVID-19: charting the uncharted. Internal and emergency medicine. 2020:1–3.
    1. Nogueira MS. Optical theranostics and treatment dosimetry for COVID-19 lung complications: towards increasing the survival rate of vulnerable populations. Photodiagnosis and photodynamic therapy. 2020;31:101892.
    1. Klok FA, Kruip M, van der Meer NJM, Arbous MS, Gommers D, Kant KM, et al. Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: An updated analysis. Thrombosis research. 2020;191:148–50.
    1. Consoli L, Bendotti V, Cicchinelli S, Gaioni F, Prandolini P, Bettonagli M, et al. 2019 novel coronavirus (COVID-19) pneumonia complications: the importance of lung ultrasound. Journal of ultrasound. 2020:1–4.
    1. Lifelong Lung Damage: The Serious COVID-19 Complication That Can Hit People in Their 20s [Internet] Healthline. 2020. Available from: .
    1. Orsi FA, De Paula EV, Santos FO, Teruchkin MM, Campêlo DHC, Mello TT, et al. Guidance on diagnosis, prevention and treatment of thromboembolic complications in COVID-19: a position paper of the Brazilian Society of Thrombosis and Hemostasis and the Thrombosis and Hemostasis Committee of the Brazilian Association of Hematology, Hemotherapy and Cellular Therapy. Hematology, transfusion and cell therapy. 2020
    1. Lodigiani C, Iapichino G, Carenzo L, Cecconi M, Ferrazzi P, Sebastian T, et al. Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy. Thrombosis research. 2020;191:9–14.
    1. Poggiali E, Bastoni D, Ioannilli E, Vercelli A, Magnacavallo A. Deep Vein Thrombosis and Pulmonary Embolism: Two Complications of COVID-19 Pneumonia? European journal of case reports in internal medicine. 2020;7(5):001646.
    1. Yancy CW, Fonarow GC. Coronavirus Disease 2019 (COVID-19) and the Heart—Is Heart Failure the Next Chapter? JAMA cardiology. 2020
    1. Puntmann VO, Carerj ML, Wieters I, Fahim M, Arendt C, Hoffmann J, et al. Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19) JAMA cardiology. 2020
    1. Pryce-Roberts A, Talaei M, Robertson NP. Neurological complications of COVID-19: a preliminary review. Journal of neurology. 2020;267(6):1870–3.
    1. Sheraton M, Deo N, Kashyap R, Surani S. A Review of Neurological Complications of COVID-19. Cureus. 2020;12(5):e8192.
    1. Strafella C, Caputo V, Termine A, Barati S, Gambardella S, Borgiani P, et al. Analysis of ACE2 Genetic Variability among Populations Highlights a Possible Link with COVID-19-Related Neurological Complications. Genes. 2020;11(7)
    1. Varatharaj A, Thomas N, Ellul MA, Davies NWS, Pollak TA, Tenorio EL, et al. Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study. The lancet Psychiatry. 2020
    1. Paybast S, Emami A, Koosha M, Baghalha F. Novel Coronavirus Disease (COVID-19) and Central Nervous System Complications: What Neurologist Need to Know. Acta neurologica Taiwanica. 2020;29(1):24–31.
    1. Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA neurology. 2020;77(6):683–90.
    1. Kunutsor SK, Laukkanen JA. Hepatic manifestations and complications of COVID-19: A systematic review and meta-analysis. The Journal of infection. 2020
    1. Lazar HL. Commentary: Compliance with the American Association for Thoracic Surgery guidelines will prevent sternal wound infections and minimize postoperative complications in cardiac surgery patients during the COVID-19 pandemic. The Journal of thoracic and cardiovascular surgery. 2020;160(2):e44–8.
    1. Lee M, Chen CS, Ovbiagele B. Covert COVID-19 complications: Continuing the use of evidence-based drugs to minimize potentially lethal indirect effects of the pandemic in stroke patients. Journal of the neurological sciences. 2020;414:116883.
    1. Liabeuf S, Moragny J, Bennis Y, Batteux B, Brochot E, Schmit JL, et al. Association between renin-angiotensin system inhibitors and COVID-19 complications. European heart journal Cardiovascular pharmacotherapy. 2020
    1. Liu B, Qi Z. Authors' Reply to: Tocilizumab, Adipokines and Severe Complications of COVID-19. Clinical drug investigation. 2020:1–3.
    1. Lorenzo-Villalba N, Maouche Y, Syrovatkova A, Pham F, Chahbazian JB, Pertoldi P, et al. Cutaneous Complications Secondary to Haemostasis Abnormalities in COVID-19 Infection. European journal of case reports in internal medicine. 2020;7(7):001769.
    1. Loungani RS, Rehorn MR, Newby LK, Katz JN, Klem I, Mentz RJ, et al. A care pathway for the cardiovascular complications of COVID-19: Insights from an institutional response. American heart journal. 2020;225:3–9.
    1. Long B, Brady WJ, Koyfman A, Gottlieb M. Cardiovascular complications in COVID-19. The American journal of emergency medicine. 2020;38(7):1504–7.
    1. Lopez M, Bell K, Annaswamy T, Juengst S, Ifejika N. COVID-19 Guide for the Rehabilitation Clinician: A Review of Nonpulmonary Manifestations and Complications. American journal of physical medicine & rehabilitation. 2020;99(8):669–73.
    1. Ma J, Xia P, Zhou Y, Liu Z, Zhou X, Wang J, et al. Potential effect of blood purification therapy in reducing cytokine storm as a late complication of critically ill COVID-19. Clinical Immunology (Orlando, Fla). 2020;214:108408.
    1. Ma L, Song K, Huang Y. Coronavirus Disease-2019 (COVID-19) and Cardiovascular Complications. Journal of cardiothoracic and vascular anesthesia. 2020
    1. Mauro V, Lorenzo M, Paolo C, Sergio H. Treat all COVID 19-positive patients, but do not forget those negative with chronic diseases. Internal and emergency medicine. 2020:1–4.
    1. Mendoza-Pinto C, Escárcega RO, García-Carrasco M, Bailey DJO, Gálvez-Romero JL, Cervera R. Viral infections and their relationship with catastrophic antiphospholipid syndrome: a possible pathogenic mechanism of severe COVID-19 thrombotic complications. Journal of internal medicine. 2020
    1. Nobile B, Durand M, Olié E, Guillaume S, Molès JP, Haffen E, et al. Clomipramine Could Be Useful in Preventing Neurological Complications of SARS-CoV-2 Infection. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2020:1–2.
    1. Oudkerk M, Büller HR, Kuijpers D, van Es N, Oudkerk SF, McLoud TC, et al. Diagnosis, Prevention, and Treatment of Thromboembolic Complications in COVID-19: Report of the National Institute for Public Health of the Netherlands. Radiology. 2020:201629.
    1. Palmer K, Monaco A, Kivipelto M, Onder G, Maggi S, Michel JP, et al. The potential long-term impact of the COVID-19 outbreak on patients with non-communicable diseases in Europe: consequences for healthy ageing. Aging clinical and experimental research. 2020;32(7):1189–94.
    1. Parry AH, Wani AH, Yaseen M, Dar MI. Demystifying pulmonary vascular complications in severe coronavirus disease-19 pneumonia (COVID-19) in the light of clinico-radiologic-pathologic correlation. Thrombosis research. 2020
    1. Patel VG, Zhong X, Liaw B, Tremblay D, Tsao CK, Galsky MD, et al. Does androgen deprivation therapy protect against severe complications from COVID-19? Annals of oncology : official journal of the European Society for Medical Oncology. 2020
    1. Paul P. Cardiac Troponin-I may be a predictor of complications and mortality in COVID-19 patients. Current medicine research and practice. 2020;10(3):130–1.
    1. Rey JR, Caro-Codón J, Poveda Pineda D, Merino JL, Iniesta Á M, López-Sendón JL. Arterial thrombotic complications in hospitalized patients with COVID-19. Revista espanola de cardiologia (English ed) :2020.
    1. Roche JA, Roche R. A hypothesized role for dysregulated bradykinin signaling in COVID-19 respiratory complications. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020;34(6):7265–9.
    1. Rosen RJ. Thrombotic complications in critically ill patients with COVID 19. Thrombosis research. 2020;191
    1. Saban-Ruiz J, Ly-Pen D. COVID-19: A Personalized Cardiometabolic Approach for Reducing Complications and Costs The Role of Aging Beyond Topics. The Journal of Nutrition, Health & Aging. 2020:1.
    1. Siguret V, Voicu S, Neuwirth M, Delrue M, Gayat E, Stépanian A, et al. Are antiphospholipid antibodies associated with thrombotic complications in critically ill COVID-19 patients? Thrombosis Research. 2020
    1. Silingardi R, Gennai S, Migliari M, Covic T, Leone N. Acute limb ischemia in COVID-19 patients: Could Aortic Floating Thrombus be the source of embolic complications? Journal of vascular surgery. 2020
    1. Silverman DA, Lin C, Tamaki A, Puram SV, Carrau RL, Seim NB, et al. Respiratory and pulmonary complications in head and neck cancer patients: Evidence‐based review for the COVID‐19 era. Head & Neck. 2020;42(6):1218–26.
    1. Stevens DV, Tran AQ, Kim E. Complications of Orbital Emphysema in a COVID-19 Patient. Ophthalmology. 2020
    1. Tian D, Ye Q. Hepatic complications of COVID-19 and its treatment. Journal of medical virology. 2020
    1. Thomas W, Varley J, Johnston A, Symington E, Robinson M, Sheares K, et al. Thrombotic complications of patients admitted to intensive care with COVID-19 at a teaching hospital in the United Kingdom. Thrombosis Research. 2020;191:76–7.
    1. Terpos E, Ntanasis‐Stathopoulos I, Elalamy I, Kastritis E, Sergentanis TN, Politou M, et al. Hematological findings and complications of COVID‐19. American journal of hematology. 2020
    1. Zhu H, Rhee J-W, Cheng P, Waliany S, Chang A, Witteles RM, et al. Cardiovascular complications in patients with COVID-19: consequences of viral toxicities and host immune response. Current cardiology reports. 2020;22:1–9.
    1. Abboud H, Abboud FZ, Kharbouch H, Arkha Y, El Abbadi N, El Ouahabi A. COVID-19 and SARS-Cov-2 Infection: Pathophysiology and Clinical Effects on the Nervous System. World Neurosurg. 2020;140:49–53.
    1. Ahmed SI, Khan S. Coagulopathy and Plausible Benefits of Anticoagulation Among COVID-19 Patients. Curr Probl Cardiol. 2020;45(9):100648.
    1. Khandait H, Gandotra G, Sachdeva S, Kramer CA, Nye D, Golamari R, et al. COVID-19 and Hematology-What Do We Know So Far? SN Compr Clin Med. 2020:1–6.
    1. Msigwa SS, Wang Y, Li Y, Cheng X. The neurological insights of the emerging coronaviruses. J Clin Neurosci. 2020;78:1–7.
    1. Sheikh AB, Shekhar R, Javed N, Upadhyay S. Inferior Wall Myocardial Infarction in Severe COVID-19 Infection: A Case Report. Am J Case Rep. 2020;21:e926101.
    1. Siripanthong B, Nazarian S, Muser D, Deo R, Santangeli P, Khanji MY, et al. Recognizing COVID-19-related myocarditis: The possible pathophysiology and proposed guideline for diagnosis and management. Heart Rhythm. 2020;17(9):1463–71.
    1. Vonck K, Garrez I, De Herdt V, Hemelsoet D, Laureys G, Raedt R, et al. Neurological manifestations and neuro-invasive mechanisms of the severe acute respiratory syndrome coronavirus type 2. Eur J Neurol. 2020;27(8):1578–87.
    1. Wijeratne T, Sales C, Karimi L, Crewther SG. Acute Ischemic Stroke in COVID-19: A Case-Based Systematic Review. Front Neurol. 2020;11:1031.
    1. Yachou Y, El Idrissi A, Belapasov V, Ait Benali S. Neuroinvasion, neurotropic, and neuroinflammatory events of SARS-CoV-2: understanding the neurological manifestations in COVID-19 patients. Neurol Sci. 2020;41(10):2657–69.
    1. Zaim S, Chong JH, Sankaranarayanan V, Harky A. COVID-19 and Multiorgan Response. Curr Probl Cardiol. 2020;45(8):100618.

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