Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit

Cornelis P C de Jager, Paul T L van Wijk, Rejiv B Mathoera, Jacqueline de Jongh-Leuvenink, Tom van der Poll, Peter C Wever, Cornelis P C de Jager, Paul T L van Wijk, Rejiv B Mathoera, Jacqueline de Jongh-Leuvenink, Tom van der Poll, Peter C Wever

Abstract

Introduction: Absolute lymphocytopenia has been reported as a predictor of bacteremia in medical emergencies. Likewise, the neutrophil-lymphocyte count ratio (NLCR) has been shown a simple promising method to evaluate systemic inflammation in critically ill patients.

Methods: We retrospectively evaluated the ability of conventional infection markers, lymphocyte count and NLCR to predict bacteremia in adult patients admitted to the Emergency Department with suspected community-acquired bacteremia. The C-reactive protein (CRP) level, white blood cell (WBC) count, neutrophil count, lymphocyte count and NLCR were compared between patients with positive blood cultures (n = 92) and age-matched and gender-matched patients with negative blood cultures (n = 92) obtained upon Emergency Department admission.

Results: Significant differences between patients with positive and negative blood cultures were detected with respect to the CRP level (mean ± standard deviation 176 ± 138 mg/l vs. 116 ± 103 mg/l; P = 0.042), lymphocyte count (0.8 ± 0.5 × 109/l vs. 1.2 ± 0.7 × 109/l; P < 0.0001) and NLCR (20.9 ± 13.3 vs. 13.2 ± 14.1; P < 0.0001) but not regarding WBC count and neutrophil count. Sensitivity, specificity, positive and negative predictive values were highest for the NLCR (77.2%, 63.0%, 67.6% and 73.4%, respectively). The area under the receiver operating characteristic curve was highest for the lymphocyte count (0.73; confidence interval: 0.66 to 0.80) and the NLCR (0.73; 0.66 to 0.81).

Conclusions: In an emergency care setting, both lymphocytopenia and NLCR are better predictors of bacteremia than routine parameters like CRP level, WBC count and neutrophil count. Attention to these markers is easy to integrate in daily practice and without extra costs.

Figures

Figure 1
Figure 1
Receiver operating characteristic curves of five infection markers for differentiating bacteremia from nonbacteremia. Receiver operating characteristic (ROC) curves of C-reactive protein (CRP), white blood cell (WBC) count, neutrophil count, lymphocyte count and neutrophil-lymphocyte count ratio (NLCR) for differentiating bacteremia from nonbacteremia. The area under the NLCR ROC curve differed significantly from those for the CRP level, WBC count and neutrophil count. The area under the lymphocyte count ROC curve differed significantly from those for the WBC count and neutrophil count.

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