Comparison 22 Sensitivity analyses, Outcome 1 Sensitivity analysis: Excluding GTN/Placebo RCTs with very low placebo response rates (
Comparison 22 Sensitivity analyses, Outcome 2 Excluding RCT in Children with very low Placebo response rate: NON‐healing.
Comparison 22 Sensitivity analyses, Outcome 3 Excluding RCT in Adults with very low Placebo response rate: NON‐healing.
Comparison 22 Sensitivity analyses, Outcome 4 Excluding RCT with very low Placebo response rate: NON‐healing; Lignocaine.
Comparison 22 Sensitivity analyses, Outcome 5 Excluding study with
22.6. Analysis
Comparison 22 Sensitivity analyses, Outcome…
22.6. Analysis
Comparison 22 Sensitivity analyses, Outcome 6 Excluding Mishra to investigate heterogeneity, Comparison 16;…
22.6. Analysis Comparison 22 Sensitivity analyses, Outcome 6 Excluding Mishra to investigate heterogeneity, Comparison 16; Medicine vs. Surgery.
22.7. Analysis
Comparison 22 Sensitivity analyses, Outcome…
22.7. Analysis
Comparison 22 Sensitivity analyses, Outcome 7 Three Largest GTN/Placebo Studies.
22.7. Analysis Comparison 22 Sensitivity analyses, Outcome 7 Three Largest GTN/Placebo Studies.
23.1. Analysis
Comparison 23 Botox versus Botox…
23.1. Analysis
Comparison 23 Botox versus Botox Dysport, Outcome 1 Non‐healing of fissure.
23.1. Analysis Comparison 23 Botox versus Botox Dysport, Outcome 1 Non‐healing of fissure.
24.1. Analysis
Comparison 24 CCB versus LIS,…
24.1. Analysis
Comparison 24 CCB versus LIS, Outcome 1 Non‐Healing of the Fissure.
24.1. Analysis Comparison 24 CCB versus LIS, Outcome 1 Non‐Healing of the Fissure.
24.2. Analysis
Comparison 24 CCB versus LIS,…
24.2. Analysis
Comparison 24 CCB versus LIS, Outcome 2 Incontinence.
24.2. Analysis Comparison 24 CCB versus LIS, Outcome 2 Incontinence.
24.3. Analysis
Comparison 24 CCB versus LIS,…
24.3. Analysis
Comparison 24 CCB versus LIS, Outcome 3 Headache.
24.3. Analysis Comparison 24 CCB versus LIS, Outcome 3 Headache.
25.1. Analysis
Comparison 25 Minoxidil versus Lidocaine,…
25.1. Analysis
Comparison 25 Minoxidil versus Lidocaine, Outcome 1 Non‐healing of the fissure.
25.1. Analysis Comparison 25 Minoxidil versus Lidocaine, Outcome 1 Non‐healing of the fissure.
26.1. Analysis
Comparison 26 Indoramine versus placebo,…
26.1. Analysis
Comparison 26 Indoramine versus placebo, Outcome 1 Non‐healing of the fissure.
26.1. Analysis Comparison 26 Indoramine versus placebo, Outcome 1 Non‐healing of the fissure.
26.2. Analysis
Comparison 26 Indoramine versus placebo,…
26.2. Analysis
Comparison 26 Indoramine versus placebo, Outcome 2 Headache.
26.2. Analysis Comparison 26 Indoramine versus placebo, Outcome 2 Headache.
27.1. Analysis
Comparison 27 GTN Dose Comparisons,…
27.1. Analysis
Comparison 27 GTN Dose Comparisons, Outcome 1 Non‐healing of the fissure.
27.1. Analysis Comparison 27 GTN Dose Comparisons, Outcome 1 Non‐healing of the fissure.
28.1. Analysis
Comparison 28 Calcium Channel blocker…
28.1. Analysis
Comparison 28 Calcium Channel blocker (oral Nifedipine) versus Botox, Outcome 1 Non healing…
28.1. Analysis Comparison 28 Calcium Channel blocker (oral Nifedipine) versus Botox, Outcome 1 Non healing of the fissure.
29.1. Analysis
Comparison 29 Long Term Follow‐up…
29.1. Analysis
Comparison 29 Long Term Follow‐up (> 1 year) ; Any Operation vs. Any…
29.1. Analysis Comparison 29 Long Term Follow‐up (> 1 year) ; Any Operation vs. Any Medical Therapy, Outcome 1 Non‐healing of the fissure.
30.1. Analysis
Comparison 30 GTN vs. Patient…
30.1. Analysis
Comparison 30 GTN vs. Patient Self Dilation (vs. both), Outcome 1 Non Healing.
30.1. Analysis Comparison 30 GTN vs. Patient Self Dilation (vs. both), Outcome 1 Non Healing.
30.2. Analysis
Comparison 30 GTN vs. Patient…
30.2. Analysis
Comparison 30 GTN vs. Patient Self Dilation (vs. both), Outcome 2 Headache.
30.2. Analysis Comparison 30 GTN vs. Patient Self Dilation (vs. both), Outcome 2 Headache.
31.1. Analysis
Comparison 31 Lignocaine vs Clove…
31.1. Analysis
Comparison 31 Lignocaine vs Clove Oil, Outcome 1 NON ‐ Healing.
31.1. Analysis Comparison 31 Lignocaine vs Clove Oil, Outcome 1 NON ‐ Healing.
32.1. Analysis
Comparison 32 L‐Arginine vs Surgery,…
32.1. Analysis
Comparison 32 L‐Arginine vs Surgery, Outcome 1 NON ‐ Healing.
32.1. Analysis Comparison 32 L‐Arginine vs Surgery, Outcome 1 NON ‐ Healing.
32.2. Analysis
Comparison 32 L‐Arginine vs Surgery,…
32.2. Analysis
Comparison 32 L‐Arginine vs Surgery, Outcome 2 Headache.
32.2. Analysis Comparison 32 L‐Arginine vs Surgery, Outcome 2 Headache.
33.1. Analysis
Comparison 33 Sitz Baths vs…
33.1. Analysis
Comparison 33 Sitz Baths vs Control, Outcome 1 NON ‐ Healing.
33.1. Analysis Comparison 33 Sitz Baths vs Control, Outcome 1 NON ‐ Healing.
34.1. Analysis
Comparison 34 Sildenafil versus Placebo,…
34.1. Analysis
Comparison 34 Sildenafil versus Placebo, Outcome 1 NON ‐ Healing.
34.1. Analysis Comparison 34 Sildenafil versus Placebo, Outcome 1 NON ‐ Healing.
35.1. Analysis
Comparison 35 Nitroglycerine Topical vs…
35.1. Analysis
Comparison 35 Nitroglycerine Topical vs Intra‐anal injection, Outcome 1 NON ‐ Healing.
35.1. Analysis Comparison 35 Nitroglycerine Topical vs Intra‐anal injection, Outcome 1 NON ‐ Healing.
35.2. Analysis
Comparison 35 Nitroglycerine Topical vs…
35.2. Analysis
Comparison 35 Nitroglycerine Topical vs Intra‐anal injection, Outcome 2 Headache.
35.2. Analysis Comparison 35 Nitroglycerine Topical vs Intra‐anal injection, Outcome 2 Headache.
36.1. Analysis
Comparison 36 diltiazem vs. no…
36.1. Analysis
Comparison 36 diltiazem vs. no treatment, Outcome 1 NON ‐ Healing.
36.1. Analysis Comparison 36 diltiazem vs. no treatment, Outcome 1 NON ‐ Healing.
37.1. Analysis
Comparison 37 GTN vs ISMN,…
37.1. Analysis
Comparison 37 GTN vs ISMN, Outcome 1 NON ‐ Healing.
37.1. Analysis Comparison 37 GTN vs ISMN, Outcome 1 NON ‐ Healing.
37.2. Analysis
Comparison 37 GTN vs ISMN,…
37.2. Analysis
Comparison 37 GTN vs ISMN, Outcome 2 Headache.
37.2. Analysis Comparison 37 GTN vs ISMN, Outcome 2 Headache.
38.1. Analysis
Comparison 38 ISMN vs Placebo,…
38.1. Analysis
Comparison 38 ISMN vs Placebo, Outcome 1 NON ‐ Healing.
38.1. Analysis Comparison 38 ISMN vs Placebo, Outcome 1 NON ‐ Healing.
38.2. Analysis
Comparison 38 ISMN vs Placebo,…
38.2. Analysis
Comparison 38 ISMN vs Placebo, Outcome 2 Headache.
38.2. Analysis Comparison 38 ISMN vs Placebo, Outcome 2 Headache.
39.1. Analysis
Comparison 39 "Healer cream" vs…
39.1. Analysis
Comparison 39 "Healer cream" vs Lignocaine, Outcome 1 NON ‐ healing.
39.1. Analysis Comparison 39 "Healer cream" vs Lignocaine, Outcome 1 NON ‐ healing.
39.2. Analysis
Comparison 39 "Healer cream" vs…
39.2. Analysis
Comparison 39 "Healer cream" vs Lignocaine, Outcome 2 Headache.
39.2. Analysis Comparison 39 "Healer cream" vs Lignocaine, Outcome 2 Headache.
40.1. Analysis
Comparison 40 "Healer Cream" vs…
40.1. Analysis
Comparison 40 "Healer Cream" vs GTN, Outcome 1 NON ‐ Healing.
40.1. Analysis Comparison 40 "Healer Cream" vs GTN, Outcome 1 NON ‐ Healing.
40.2. Analysis
Comparison 40 "Healer Cream" vs…
40.2. Analysis
Comparison 40 "Healer Cream" vs GTN, Outcome 2 Headache.
40.2. Analysis Comparison 40 "Healer Cream" vs GTN, Outcome 2 Headache.
41.1. Analysis
Comparison 41 Lignocaine + Botox…
41.1. Analysis
Comparison 41 Lignocaine + Botox vs Lignocaine + GTN, Outcome 1 NON ‐…
41.1. Analysis Comparison 41 Lignocaine + Botox vs Lignocaine + GTN, Outcome 1 NON ‐ Healing.
41.2. Analysis
Comparison 41 Lignocaine + Botox…
41.2. Analysis
Comparison 41 Lignocaine + Botox vs Lignocaine + GTN, Outcome 2 Headache.
41.2. Analysis Comparison 41 Lignocaine + Botox vs Lignocaine + GTN, Outcome 2 Headache.
42.1. Analysis
Comparison 42 Botox vs Botox…
42.1. Analysis
Comparison 42 Botox vs Botox + GTN, Outcome 1 NON ‐ Healing.
42.1. Analysis Comparison 42 Botox vs Botox + GTN, Outcome 1 NON ‐ Healing.
42.2. Analysis
Comparison 42 Botox vs Botox…
42.2. Analysis
Comparison 42 Botox vs Botox + GTN, Outcome 2 Minor incontinence.
42.2. Analysis Comparison 42 Botox vs Botox + GTN, Outcome 2 Minor incontinence.
43.1. Analysis
Comparison 43 GTN vs GTN…
43.1. Analysis
Comparison 43 GTN vs GTN + cryothermal dilators, Outcome 1 NON ‐ Healing.
43.1. Analysis Comparison 43 GTN vs GTN + cryothermal dilators, Outcome 1 NON ‐ Healing.
43.2. Analysis
Comparison 43 GTN vs GTN…
43.2. Analysis
Comparison 43 GTN vs GTN + cryothermal dilators, Outcome 2 Headache.
43.2. Analysis Comparison 43 GTN vs GTN + cryothermal dilators, Outcome 2 Headache.
44.1. Analysis
Comparison 44 Botox injection site…
44.1. Analysis
Comparison 44 Botox injection site location, Outcome 1 Non healing of the fissure.
44.1. Analysis Comparison 44 Botox injection site location, Outcome 1 Non healing of the fissure.