Safe oxygen saturation targeting and monitoring in preterm infants: can we avoid hypoxia and hyperoxia?

Augusto Sola, Sergio G Golombek, María Teresa Montes Bueno, Lourdes Lemus-Varela, Claudia Zuluaga, Fernando Domínguez, Hernando Baquero, Alejandro E Young Sarmiento, Diego Natta, Jose M Rodriguez Perez, Richard Deulofeut, Ana Quiroga, Gabriel Lara Flores, Mónica Morgues, Alfredo García-Alix Pérez, Bart Van Overmeire, Frank van Bel, Augusto Sola, Sergio G Golombek, María Teresa Montes Bueno, Lourdes Lemus-Varela, Claudia Zuluaga, Fernando Domínguez, Hernando Baquero, Alejandro E Young Sarmiento, Diego Natta, Jose M Rodriguez Perez, Richard Deulofeut, Ana Quiroga, Gabriel Lara Flores, Mónica Morgues, Alfredo García-Alix Pérez, Bart Van Overmeire, Frank van Bel

Abstract

Oxygen is a neonatal health hazard that should be avoided in clinical practice. In this review, an international team of neonatologists and nurses assessed oxygen saturation (SpO2 ) targeting in preterm infants and evaluated the potential weaknesses of randomised clinical trials.

Conclusion: SpO2 of 85-89% can increase mortality and 91-95% can cause hyperoxia and ill effects. Neither of these ranges can be recommended, and wider intermediate targets, such as 87-94% or 88-94%, may be safer.

Keywords: Hyperoxia; Oximetry; Oxygen saturation; Premature infant; Retinopathy of prematurity.

© 2014 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.

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