A natural mineral supplement provides relief from knee osteoarthritis symptoms: a randomized controlled pilot trial

Joy L Frestedt, Melanie Walsh, Michael A Kuskowski, John L Zenk, Joy L Frestedt, Melanie Walsh, Michael A Kuskowski, John L Zenk

Abstract

Background: This small, pilot study evaluated the impact of treatment with a natural multi-mineral supplement from seaweed (Aquamin) on walking distance, pain and joint mobility in subjects with moderate to severe osteoarthritis of the knee.

Methods: Subjects (n = 70) with moderate to severe osteoarthritis of the knee were randomized to four double-blinded treatments for 12 weeks: (a) Glucosamine sulfate (1500 mg/d); (b) Aquamin (2400 mg/d); (c) Combined treatment composed of Glucosamine sulfate (1500 mg/d) plus Aquamin (2400 mg/d) and (d) Placebo. Primary outcome measures were WOMAC scores and 6 Minute Walking Distances (6 MWD). Laboratory based blood tests were used as safety measures.

Results: Fifty subjects completed the study and analysis of the data showed significant differences between the groups for changes in WOMAC pain scores over time (p = 0.009 ANCOVA); however, these data must be reviewed with caution since significant differences were found between the groups at baseline for WOMAC pain and stiffness scores (p = 0.0039 and p = 0.013, respectively, ANOVA). Only the Aquamin and Glucosamine groups demonstrated significant improvements in symptoms over the course of the study. The combination group (like the placebo group) did not show any significant improvements in OA symptoms in this trial. Within group analysis demonstrated significant improvements over time on treatment for the WOMAC pain, activity, composite and stiffness (Aquamin only) scores as well as the 6 minute walking distances for subjects in the Aquamin and Glucosamine treatment groups. The Aquamin and Glucosamine groups walked 101 feet (+7%) and 56 feet (+3.5%) extra respectively. All treatments were well tolerated and the adverse events profiles were not significantly different between the groups.

Conclusion: This small preliminary study suggested that a multi mineral supplement (Aquamin) may reduce the pain and stiffness of osteoarthritis of the knee over 12 weeks of treatment and warrants further study.

Trial registration: ClinicalTrials.gov number: NCT00452101.

Figures

Figure 1
Figure 1
Trial flow chart.
Figure 2
Figure 2
Percent change in WOMAC scores from baseline over 12 weeks of treatment.

References

    1. Nussmeier NA, Whelton AA, Brown MT, Langford RM, Hoeft A, Parlow JL, Boyce SW, Verburg KM. Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery. The New England journal of medicine. 2005;352:1081–1091. doi: 10.1056/NEJMoa050330.
    1. Ray WA, Griffin MR, Stein CM. Cardiovascular toxicity of valdecoxib. The New England journal of medicine. 2004;351:2767. doi: 10.1056/NEJMc045711.
    1. Towheed TE, Maxwell L, Anastassiades TP, Shea B, Houpt J, Robinson V, Hochberg MC, Wells G. Glucosamine therapy for treating osteoarthritis. Cochrane database of systematic reviews (Online) 2005:CD002946.
    1. Poolsup N, Suthisisang C, Channark P, Kittikulsuth W. Glucosamine long-term treatment and the progression of knee osteoarthritis: systematic review of randomized controlled trials. The Annals of pharmacotherapy. 2005;39:1080–1087. doi: 10.1345/aph.1E576.
    1. Clegg DO, Reda DJ, Harris CL, Klein MA, O'Dell JR, Hooper MM, Bradley JD, Bingham CO, 3rd, Weisman MH, Jackson CG, Lane NE, Cush JJ, Moreland LW, Schumacher HR, Jr., Oddis CV, Wolfe F, Molitor JA, Yocum DE, Schnitzer TJ, Furst DE, Sawitzke AD, Shi H, Brandt KD, Moskowitz RW, Williams HJ. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. The New England journal of medicine. 2006;354:795–808. doi: 10.1056/NEJMoa052771.
    1. Zenk JL HTR., Kuskowski MA The effects of milk protein concentrate on the symptoms of osteoarthritis in adults: an exploratory, randomised, double-bline, placebo-controlled trial. Curr Ther Res. 2002;63:430–442. doi: 10.1016/S0011-393X(02)80049-2.
    1. Kim LS, Axelrod LJ, Howard P, Buratovich N, Waters RF. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2006;14:286–294. doi: 10.1016/j.joca.2005.10.003.
    1. Cho SH, Jung YB, Seong SC, Park HB, Byun KY, Lee DC, Song EK, Son JH. Clinical efficacy and safety of Lyprinol, a patented extract from New Zealand green-lipped mussel (Perna Canaliculus) in patients with osteoarthritis of the hip and knee: a multicenter 2-month clinical trial. Allergie et immunologie. 2003;35:212–216.
    1. Biegert C, Wagner I, Ludtke R, Kotter I, Lohmuller C, Gunaydin I, Taxis K, Heide L. Efficacy and safety of willow bark extract in the treatment of osteoarthritis and rheumatoid arthritis: results of 2 randomized double-blind controlled trials. The Journal of rheumatology. 2004;31:2121–2130.
    1. Miller MJ, Mehta K, Kunte S, Raut V, Gala J, Dhumale R, Shukla A, Tupalli H, Parikh H, Bobrowski P, Chaudhary J. Early relief of osteoarthritis symptoms with a natural mineral supplement and a herbomineral combination: a randomized controlled trial [ISRCTN38432711] Journal of inflammation (London, England) 2005;2:11.
    1. Shakibaei M, Kociok K, Forster C, Vormann J, Gunther T, Stahlmann R, Merker HJ. Comparative evaluation of ultrastructural changes in articular cartilage of ofloxacin-treated and magnesium-deficient immature rats. Toxicologic pathology. 1996;24:580–587.
    1. King DE, Mainous AG, 3rd, Geesey ME, Woolson RF. Dietary magnesium and C-reactive protein levels. Journal of the American College of Nutrition. 2005;24:166–171.
    1. Henrotin Y, Kurz B, Aigner T. Oxygen and reactive oxygen species in cartilage degradation: friends or foes? Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2005;13:643–654. doi: 10.1016/j.joca.2005.04.002.
    1. Kurz B, Jost B, Schunke M. Dietary vitamins and selenium diminish the development of mechanically induced osteoarthritis and increase the expression of antioxidative enzymes in the knee joint of STR/1N mice. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2002;10:119–126. doi: 10.1053/joca.2001.0489.
    1. Sasaki S, Iwata H, Ishiguro N, Habuchi O, Miura T. Low-selenium diet, bone, and articular cartilage in rats. Nutrition (Burbank, Los Angeles County, Calif. 1994;10:538–543.
    1. Gaby AR. Natural treatments for osteoarthritis. Altern Med Rev. 1999;4:330–341.
    1. Roos EM, Roos HP, Lohmander LS, Ekdahl C, Beynnon BD. Knee Injury and Osteoarthritis Outcome Score (KOOS)--development of a self-administered outcome measure. The Journal of orthopaedic and sports physical therapy. 1998;28:88–96.
    1. Muller-Fassbender H, Bach GL, Haase W, Rovati LC, Setnikar I. Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 1994;2:61–69. doi: 10.1016/S1063-4584(05)80007-X.

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