HIV incidence among men who have sex with men in Beijing: a prospective cohort study

Dongliang Li, Shuming Li, Yingjie Liu, Yanjie Gao, Mingrun Yu, Xueying Yang, Qingchun Li, Shulin Jiang, Zhenhai Zhou, Zheng Zhang, Li Yan, Guiyan Jiang, Dong Xiao, Stephen W Pan, Fengji Luo, Yuhua Ruan, Yiming Shao, Dongliang Li, Shuming Li, Yingjie Liu, Yanjie Gao, Mingrun Yu, Xueying Yang, Qingchun Li, Shulin Jiang, Zhenhai Zhou, Zheng Zhang, Li Yan, Guiyan Jiang, Dong Xiao, Stephen W Pan, Fengji Luo, Yuhua Ruan, Yiming Shao

Abstract

Objectives: (1) To assess the HIV incidence rate among men who have sex with men (MSM) in a large cohort study in Beijing, China and (2) to identify sociodemographic and behavioural risk factors of HIV seroconversion among MSM in Beijing, China.

Design: A prospective cohort study.

Setting: Baseline and follow-up visits were conducted among MSM in Beijing, China.

Participants: A cohort of 797 HIV-seronegative MSM was recruited from August to December 2009, with follow-up occurring after 6 and 12 months.

Primary and secondary outcome measures: At baseline and follow-up visits, participants reported sociodemographic and sexual behaviour information, and were tested for HIV, herpes simplex virus-2 (HSV-2) and syphilis with whole blood specimens. Cox regression analysis was used to identify factors associated with HIV seroconversion.

Results: Most study participants (86.8%) were retained by the 12-month follow-up. The HIV, HSV-2 and syphilis incidence rates were 8.09 (95% CI 6.92 to 9.26), 5.92 (95% CI 5.44 to 6.40) and 8.06 (95% CI 7.56 to 8.56) cases per 100 person-years, respectively. HIV seroconversion was significantly associated with being <25 years old, having <12 years of education, having >1 male sex partner in the past 6 months, and being syphilis positive or HSV-2 positive.

Conclusions: The HIV incidence among MSM in Beijing is serious. Interventions and treatment of sexually transmitted diseases (STD) should be combined with HIV control and prevention measures among MSM.

References

    1. Ministry of Health of the People's Republic of China, UNAIDS, WHO National report for HIV/AIDS estimation in China, 2011. Beijing: Chinese Center for Disease Control and Prevention, 2011
    1. Ruan Y, Jia Y, Zhang X, et al. Incidence of HIV-1, syphilis, hepatitis B, and hepatitis C virus infections and predictors associated with retention in a 12-month follow-up study among men who have sex with men in Beijing, China. J Acquir Immune Defic Syndr 2009;52:604–10
    1. Yang H, Hao C, Huan X, et al. HIV incidence and associated factors in a cohort of men who have sex with men in Nanjing, China. Sex Transm Dis 2010;37:208–13
    1. Xu J, Zhang M, Brown K, et al. Syphilis and HIV seroconversion among a 12-month prospective cohort of men who have sex with men in Shenyang, China. Sex Transm Dis 2010;37:432–9
    1. Li S, Zhang X, Li X, et al. Detection of recent HIV-1 infections among men who have sex with men in Beijing during 2005–2006. Chin Med J (Engl) 2008;121:1105–8
    1. Li S, Zhou Z, Jiang S, et al. [Incidence and risk factors of HIV and syphilis seroconversion among men who have sex with men in Bejing] (in Chinese). Zhonghua Yu Fang Yi Xue Za Zhi 2011;45:118–22.
    1. Dukers NHTM, Fennema HSa, van der Snoek EM, et al. HIV incidence and HIV testing behavior in men who have sex with men: using three incidence sources, The Netherlands, 1984–2005. AIDS 2007;21:491–9
    1. Li H, Peng R, Li J, et al. HIV incidence among men who have sex with men in China: a meta-analysis of published studies. PloS One 2011;6:e23431.
    1. Prejean J, Song R, Hernandez A, et al. Estimated HIV incidence in the United States, 2006–2009. PloS One 2011;6:e17502.
    1. Ma X, Zhang Q, He X, et al. Trends in prevalence of HIV, syphilis, hepatitis C, hepatitis B, and sexual risk behavior among men who have sex with men. J Acquir Immune Defic Syndr 2007;45:581–7
    1. Li D, Jia Y, Ruan Y, et al. Correlates of incident infections for HIV, syphilis, and hepatitis B virus in a cohort of men who have sex with men in Beijing. AIDS Patient Care STDs 2010;24:595–602
    1. Ruan Y, Qin G, Yin L, et al. Incidence of HIV, hepatitis C and hepatitis B viruses among injection drug users in southwestern China: a 3-year follow-up study. AIDS 2007;21(Suppl 8):S39–46
    1. Zhang Y, Shan H, Trizzino J, et al. HIV incidence, retention rate, and baseline predictors of HIV incidence and retention in a prospective cohort study of injection drug users in Xinjiang, China. Int J Infect Dis 2007;11:318–23
    1. Wei L, Chen J, Rodolph M, et al. HIV incidence, retention, and changes of high-risk behaviors among rural injection drug users in Guangxi, China. Substance Abuse 2006;27:53–62
    1. Ruan Y, Qin G, Liu S, et al. HIV incidence and factors contributed to retention in a 12-month follow-up study of injection drug users in Sichuan Province, China. J Acquir Immune Defic Syndr 2005;39:459–63
    1. Freeman EE, Weiss Ha, Glynn JR, et al. Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and meta-analysis of longitudinal studies. AIDS 2006;20:73–83
    1. Zhu J, Hladik F, Woodward A, et al. Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition. Nat Med 2009;15:886–92
    1. Celum C, Wald A, Hughes J, et al. Effect of aciclovir on HIV-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: a randomised, double-blind, placebo-controlled trial. Lancet 2008;371:2109–19
    1. Knussen C, Flowers P, McDaid LM, et al. HIV-related sexual risk behaviour between 1996 and 2008, according to age, among men who have sex with men (Scotland). Sex Transm Infect 2011;87:257–9
    1. Hampton MC, Halkitis PN, Storholm ED, et al. Sexual risk taking in relation to sexual identification, age, and education in a diverse sample of African American men who have sex with men (MSM) in New York City. AIDS Behav Published Online First: 2 Feb 2012.doi:
    1. Li Q, Liu Y, Zhou Z, et al. Online sex-seeking behaviors among men who have sex with men: implications for investigation and intervention. AIDS Behav 2011;16:1690–8.

Source: PubMed

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