Blood loss from transverse versus longitudinal uterine incision in abdominal myomectomy: a randomized controlled trial

Alaa Elguindy, Hosam Hemeda, Mohamed Esmat Shawky, Mohamed Elsenity, Medhat Adel Elsayed, Ahmed Fahim, Khaled Afifi, Maii Nawara, Alaa Elguindy, Hosam Hemeda, Mohamed Esmat Shawky, Mohamed Elsenity, Medhat Adel Elsayed, Ahmed Fahim, Khaled Afifi, Maii Nawara

Abstract

Background: It is unclear whether transverse uterine incision is non-inferior to longitudinal incision during myomectomy with regard to bleeding. Our aim was to compare between transverse and longitudinal uterine incisions in myomectomy.

Methods: A parallel randomized controlled single-blinded study in a university affiliated hospital, in the period between January 2017 and April 2018, in which 52 women candidates for abdominal myomectomy were randomized into transverse uterine incision or longitudinal uterine incision groups (26 in each group). Intraoperative blood loss (estimated directly by blood volume in suction bottle and linen towels and indirectly by difference between preoperative and postoperative hematocrit), operative time and postoperative fever were analyzed.

Results: No statistically significant difference was found between transverse and longitudinal incisions regarding intraoperative blood loss (389.7 ± 98.56 ml vs 485.04 ± 230.6 ml respectively, p value = 0.07), operative time (59.96 ± 16.78 min vs 66.58 ± 17.33 min respectively, p value = 0.18), and postoperative fever (4% vs 8.33%, p value = 0.6).

Conclusion: Transverse uterine incision does not cause more blood loss than longitudinal incision and is a reasonable option during abdominal myomectomy.

Trial registration: NCT03009812 at clinicaltrials.gov, registered January 2017.

Keywords: Blood loss; Longitudinal uterine incision; Myomectomy; Randomized controlled study; Transverse uterine incision.

Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Fig. 1
Fig. 1
Transverse elliptical uterine incision
Fig. 2
Fig. 2
Transverse incision after removal of the myoma
Fig. 3
Fig. 3
Closure of transverse incision
Fig. 4
Fig. 4
Transverse incision after closure

References

    1. Stewart EA, Cookson CL, Gandolfo RA, Schulze-Rath R. Epidemiology of uterine fibroids: a systematic review. BJOG. 2017;124(10):1501–1512. doi: 10.1111/1471-0528.14640.
    1. Marret H, Fritel X, Ouldamer L, Bendifallah S, Brun JL, De Jesus I, Derrien J, Giraudet G, Kahn V, Koskas M, Legendre G, Lucot JP, Niro J, Panel P, Pelage JP, Fernandez H, CNGOF (French College of Gynecology and Obstetrics). Therapeutic management of uterine fibroid tumors: updated French guidelines. Eur J Obstet Gynecol Reprod Biol. 2012;165(2):156–64.
    1. Tinelli A, Mettler L, Malvasi A. Impact of surgical approach on blood loss during intracapsular myomectomy. Minim Invasive Ther Allied Technol. 2014;23(2):87–95. doi: 10.3109/13645706.2013.839951.
    1. Breech LL, Rock JA. Leiomyomata uteri and myomectomy. In: Rock JA, Jones HW, editors. TeLinde’s operative gynecology. 10. Philadelphia: Lippincott Williams & Wilkins; 2008. pp. 716–718.
    1. Falcone T, Drake RL, Hurd WW. Surgical anatomy of the abdomen and pelvis. In: Falcone T, Hurd WW, editors. Clinical reproductive medicine and surgery. Philadelphia: Mosby Elsevier; 2007.
    1. Discepola F, Valenti DA, Reinhold C, Tulandi T. Analysis of arterial blood vessels surrounding the myoma: relevance to myomectomy. Obstet Gynecol. 2007;110:1301. doi: 10.1097/01.AOG.0000290331.95709.26.
    1. Royal College of Obstetricians and Gynaecologists (RCOG). Birth after Previous Caesarean Birth (Green-top Guideline No. 45). London. RCOG; October 2015.
    1. Greene RA, Fitzpatrick C, Turner MJ. What are the maternal implications of a classical caesarean section? J Obstet Gynaecol. 1998;18(4):345–347. doi: 10.1080/01443619867083.
    1. Takamoto N, Leppert PC, Yu SY. Cell death and proliferation and its relation to collagen degradation in uterine involution of rat. Connect Tissue Res. 1998;37:163–175. doi: 10.3109/03008209809002436.
    1. Halperin ME, Moore DC, Hannah WJ. Classical versus low-segment transverse incision for preterm caesarean section: maternal complications and outcome of subsequent pregnancies. Br J Obstet Gynecol. 1988;95(10):990–996. doi: 10.1111/j.1471-0528.1988.tb06502.x.
    1. Parker WH. Uterine myomas: management. Fertil Steril. 2007;88:255–271. doi: 10.1016/j.fertnstert.2007.06.044.
    1. Morita M, Asakawa Y, Uchiide I, Nakakuma M, Kubo H. Surgery results using different uterine wall incision directions in laparoscopic myomectomy of the intramural myoma. Reprod Med Biol. 2004;3(1):33–37. doi: 10.1111/j.1447-0578.2004.00049.x.
    1. Celik H, Sapmaz E. Use of a single preoperative dose of misoprostol is efficacious for patients who undergo abdominal myomectomy. Fertil Steril. 2003;79(5):1207–10. doi: 10.1016/S0015-0282(03)00076-1.
    1. Al Kadri HM, Al Anazi BK, Tamim HM. Visual estimation versus gravimetric measurement of postpartum blood loss: a prospective cohort study. Arch Gynecol Obstet. 2011;283(6):1207–1213. doi: 10.1007/s00404-010-1522-1.
    1. Miller RD. Transfusion Therapy. In: RD Miller Editor. Anesthesia, Philadelphia Churchill-Livingston 5th Edition, 2000; Ch. 46: 1613–7.
    1. Vavilis D, Togaridou E, Agorastos T. Abdominal myomectomy and febrile morbidity. Int J Gynecol Obstet. 2005;88(1):61. doi: 10.1016/j.ijgo.2004.09.021.
    1. Iverson RE, Jr, Chelmow D, Strohbehn K, Waldman L, Evantash EG, Aronson MP. Myomectomy fever: testing the dogma. Fertil Steril. 1999;72(1):104–108. doi: 10.1016/s0015-0282(99)00156-9.
    1. Munro MG, Critchley HO, Broder MS, Fraser IS, and FIGO Working Group on Menstrual Disorders. FIGO classification system (PALM-COEIN) for causes of abnormal uterine bleeding in nongravid women of reproductive age. Int J Gynaecol Obstet, 2011; 113: 3–13.
    1. Farrer-Brown G, Beilby JO, Tarbit MH. The blood supply of the uterus: 1. Arterial vasculature. BJOG Int J Obstet Gynaecol. 1970;77(8):673–81. doi: 10.1111/j.1471-0528.1970.tb03592.x.
    1. Sampson JA. The influence of myomata on the blood supply of the uterus, with special reference to abdominal uterine bleeding. Surg Gynecol Obstet. 1913;16:144–180.
    1. Faulkner RL. An injection study of uterine blood vessels. Am J Obstet Gynecol. 1945;49:1–9. doi: 10.1016/0002-9378(45)90094-9.
    1. Igarashi M. Value of myomectomy in the treatment of infertility [letter] Fertil Steril. 1993;59:1331. doi: 10.1016/S0015-0282(16)56003-8.
    1. Farrer-Brown G, Beilby JO, Tarbit MH. The vascular patterns in myomatous uteri. J Obstet Gynaecol Br Commonw. 1970;77:967–975. doi: 10.1111/j.1471-0528.1970.tb03439.x.
    1. Tinelli A, Mettler L, Malvasi A, Hurst B, Catherino W, Mynbaev OA, Guido M, Alkatout I, Schollmeyer T. Impact of surgical approach on blood loss during intracapsular myomectomy. Minim Invasive Ther Allied Technol. 2014;23(2):87–95. doi: 10.3109/13645706.2013.839951.
    1. D'Silva EC, Muda AM, Safiee AI, Ghazali WAHW. Five-year lapsed: review of laparoscopic myomectomy versus open myomectomy in putrajaya hospital. Gynecol Minim Invasive Ther. 2018;7(4):161–166. doi: 10.4103/GMIT.GMIT_38_18.
    1. Tinelli A, Hurst BS, Hudelist G, Tsin DA, Stark M, Mettler L, Guido M, Malvasi A. Laparoscopic myomectomy focusing on the myoma pseudocapsule: technical and outcome reports. Hum Reprod. 2012;27(2):427–435. doi: 10.1093/humrep/der369.
    1. Tinelli A, Malvasi A, Hurst BS, Tsin DA, Davila F, Dominguez G, Dell'edera D, Cavallotti C, Negro R, Gustapane S, Teigland CM. Surgical management of neurovascular bundle in uterine fibroid pseudocapsule. JSLS. 2012;16(1):119. doi: 10.4293/108680812X13291597716302.
    1. Kho KA, Thompson MJ. Minimally invasive surgery. In: Hoffman BL, Schorge JO, Bradshaw KD, Halvorson LM, Schaffer JI, Corton MM, editors. Williams gynecology. New York: Mc-Graw Hill Professional; 2016. p. 1024.
    1. Hurst BS, Matthews ML, Marshburn PB. Laparoscopic myomectomy for symptomatic uterine myomas. Fertil Steril. 2005;83(1):1–23. doi: 10.1016/j.fertnstert.2004.09.011.
    1. Parker WH. Techniques to reduce blood loss during abdominal or laparoscopic myomectomy. In: Falk SJ (ed) UpToDate. Retrieved February 2019.
    1. Shokeir T, Shalaby H, Nabil H, Barakat R. Reducing blood loss at abdominal myomectomy with preoperative use of dinoprostone intravaginal suppository: a randomized placebo-controlled pilot study. Eur J Obstet Gynecol Reprod Biol. 2013;166:61–64. doi: 10.1016/j.ejogrb.2012.09.014.
    1. Sawin SW, Pilevsky ND, Berlin JA, Barnhart KT. Comparability of perioperative morbidity between abdominal myomectomy and hysterectomy for women with uterine leiomyomas. Am J Obstet Gynecol. 2000;183(6):1448. doi: 10.1067/mob.2000.107730.
    1. Holzer A, Jirecek ST, Illievich UM, Huber J, Wenzl RJ. Laparoscopic versus open myomectomy: a double-blind study to evaluate postoperative pain. Anesth Analg. 2006;102(5):1480–1484. doi: 10.1213/01.ane.0000204321.85599.0d.
    1. Seracchioli R, Rossi S, Govoni F, Rossi E, Venturoli S. Efficacy of laparoscopic myomectomy in cases of large myoma(s): randomized comparison with laparotomic myomectomy. Hum Reprod. 1999;14:274. doi: 10.1093/humrep/14.Suppl_3.274.
    1. Schüring AN, Garcia-Rocha GJ, Schlösser HW, Gerb RR, Kiesel L, Schippert C. Perioperative complications in conventional and microsurgical abdominal myomectomy. Arch Gynecol Obstet. 2011;284:137–144. doi: 10.1007/s00404-010-1622-y.
    1. Dubuisson JB, Chavet X, Chapron C, Gregorakis SS, Morice P. Uterine rupture during pregnancy after laparoscopic myomectomy. Hum Reprod. 1995;10:1475–1477.

Source: PubMed

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