Clinical utility of urinary antigen detection for diagnosis of community-acquired, travel-associated, and nosocomial legionnaires' disease
Jürgen H Helbig, Søren A Uldum, Sverker Bernander, Paul Christian Lück, Günther Wewalka, Bill Abraham, Valeria Gaia, Timothy G Harrison, Jürgen H Helbig, Søren A Uldum, Sverker Bernander, Paul Christian Lück, Günther Wewalka, Bill Abraham, Valeria Gaia, Timothy G Harrison
Abstract
The clinical utility of Legionella urinary antigen assays for the diagnosis of Legionnaires' disease was assessed by using samples from 317 culture-proven cases. The sensitivities of the Binax enzyme immunoassay (EIA) and Biotest EIA were found to be 93.7 and 94.4% for travel-associated infection and 86.5 and 76.0% for community-acquired infection but only 44.2 and 45.7% for nosocomially acquired infection, respectively.
Figures
Distribution of MAb 3/1 (MAb 2)-positive and negative L. pneumophila serotypes depending on the category of infection.
Source: PubMed