Clinical utility and reproducibility of visceral adipose tissue measurements derived from dual-energy X-ray absorptiometry in White and African American adults

Peter T Katzmarzyk, Frank L Greenway, Steven B Heymsfield, Claude Bouchard, Peter T Katzmarzyk, Frank L Greenway, Steven B Heymsfield, Claude Bouchard

Abstract

Objective: The purpose of this study was to determine reproducibility and clinical thresholds for DXA-derived visceral adipose tissue (VAT).

Design and methods: The sample included 2317 white and African American adults 18-74 years of age. VAT areas (cm(2) ) were measured using a Hologic DXA scanner equipped with APEX 4.0 software. Reproducibility was assessed using repeated measurements on 101 participants scanned 14 days apart. Receiver Operating Characteristic (ROC) curves were used to assess clinical utility and select thresholds that identified elevated cardiometabolic risk, defined as the presence of ≥2 risk factors.

Results: Reproducibility of DXA-VAT was 8.1%. The areas under the ROC curves ranged from 0.754 in African American men to 0.807 in white women. The thresholds were higher in white men (154 cm(2) ) and women (143 cm(2) ) compared to African American men (101 cm(2) ) and women (114 cm(2) ).

Conclusion: The results demonstrated that DXA VAT is a useful clinical marker of cardiometabolic risk; however, further research is required to determine associations with health outcomes using longitudinal studies.

Copyright © 2013 The Obesity Society.

References

    1. Cornier MA, Despres JP, Davis N, et al. Assessing adiposity: a scientific statement from the American Heart Association. Circulation. 2011;124:1996–2019.
    1. Despres JP, Lemieux I, Bergeron J, et al. Abdominal obesity and the metabolic syndrome: Contribution to global and cardiometabolic risk. Arterioscler Thromb Vasc Biol. 2008;28:1039–1049.
    1. Kaul S, Rothney MP, Peters DM, et al. Dual-energy X-ray absorptiometry for quantification of visceral fat. Obesity. 2012;20:1313–1318.
    1. Micklesfield LK, Goedecke JH, Punyanitya M, Wilson KE, Kelly TL. Dual-energy x-ray performs as well as clinical computed tomography for the measurement of visceral fat. Obesity. 2012;20:1109–1114.
    1. Despres JP, Lamarche B. Effects of diet and physical activity on adiposity and body fat distribution: Implications for the prevention of cardiovascular disease. Nutr Res Rev. 1993;6:137–159.
    1. Hunter GR, Snyder SW, Kekes-Szabo T, Nicholson C, Berland L. Intra-abdominal adipose tissue values associated with risk of possessing elevated blood lipids and blood pressure. Obes Res. 1994;2:563–568.
    1. Pickhardt PJ, Jee Y, O'Connor SD, Del Rio AM. Visceral adiposity and hepatic steatosis at abdominal CT: Association with the metabolic syndrome. AJR Am J Roentgenol. 2012;198:1100–1107.
    1. von Eyben FE, Mouritsen E, Holm J, Dimcevski G, Montvilas P, Suciu G. Computed tomography scans of intra-abdominal fat, anthropometric measurements, and 3 nonobese metabolic risk factors. Metabolism. 2006;55:1337–1343.
    1. Williams MJ, Hunter GR, Kekes-Szabo T, et al. Intra-abdominal adipose tissue cut-points related to elevated cardiovascular risk in women. Int J Obes Relat Metab Disord. 1996;20:613–617.
    1. Katzmarzyk PT, Heymsfield SB, Bouchard C. Clinical utility of visceral adipose tissue for the identification of cardiometabolic risk in white and African AMerican adults. Am J Clin Nutr. 2013;97:480–486.
    1. Alberti KG, Eckel RH, Grundy SM, et al. Harmonizing the Metabolic Syndrome. A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120:1640–1645.
    1. Ulijaszek SJ, Kerr DA. Anthropometric measurement error and the assessment of nutritional status. Br J Nutr. 1999;82:165–177.
    1. Staten MA, Totty WG, Kohrt WM. Measurement of fat distribution by magnetic resonance imaging. Invest Radiol. 1989;24:345–349.
    1. Thaete FL, Colberg SR, Burke T, Kelley DE. Reproducibility of computed tomography measurement of visceral adipose tissue area. Int J Obes. 1995;19:464–467.
    1. Kumar R, Indrayan A. Receiver operating characteristic (ROC) curve for medical researchers. Indian Pediatrics. 2011;48:277–287.
    1. Zou KH, O'Malley J, Mauri L. Receiver-operating characteristic analysis for evaluating diagnostic tests and predictive models. Circulation. 2007;115:654–657.
    1. Bouchard C. BMI, fat mass, abdominal adiposity and visceral fat: where is the 'beef'? Int J Obes Relat Metab Disord. 2007;31:1552–1553.
    1. Pouliot MC, Despres JP, Lemieux S, et al. Waist circumference and abdominal sagittal diameter: best simple anthropometric indexes of abdominal visceral adipose tissue accumulation and related cardiovascular risk in men and women. Am J Cardiol. 1994;73:460–468.
    1. Rankinen T, Kim SY, Perusse L, Despres JP, Bouchard C. The prediction of abdominal visceral fat level from body composition and anthropometry: ROC analysis. Int J Obes Relat Metab Disord. 1999;23:801–809.

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