Clinical review: airway hygiene in the intensive care unit

Sanja Jelic, Jennifer A Cunningham, Phillip Factor, Sanja Jelic, Jennifer A Cunningham, Phillip Factor

Abstract

Maintenance of airway secretion clearance, or airway hygiene, is important for the preservation of airway patency and the prevention of respiratory tract infection. Impaired airway clearance often prompts admission to the intensive care unit (ICU) and can be a cause and/or contributor to acute respiratory failure. Physical methods to augment airway clearance are often used in the ICU but few are substantiated by clinical data. This review focuses on the impact of oral hygiene, tracheal suctioning, bronchoscopy, mucus-controlling agents, and kinetic therapy on the incidence of hospital-acquired respiratory infections, length of stay in the hospital and the ICU, and mortality in critically ill patients. Available data are distilled into recommendations for the maintenance of airway hygiene in ICU patients.

References

    1. Kollef MH. The prevention of ventilator-associated pneumonia. New Engl J Med. 1999;340:627–634. doi: 10.1056/NEJM199902253400807.
    1. Levine SA, Niederman MS. The impact of tracheal intubation on host defenses and risks for nosocomial pneumonia. Clin Chest Med. 1991;12:523–543.
    1. Weinmeister KD, Dal Nogare AR. Buccal cell carbohydrates are altered during critical illness. Am J Respir Crit Care Med. 1994;150:131–134.
    1. Woods DE, Straus DC, Johanson WG, Jr, Bass JA. Role of fibronectin in the prevention of adherence of Pseudomonas aeruginosa to buccal cells. J Infect Dis. 1981;143:784–790.
    1. Woods DE, Straus DC, Johanson WG, Brass JA. Role of salivary protease activity in adherence of gram-negative bacilli to mammalian buccal epithelial cells in vivo. J Clin Invest. 1981;68:1435–1440. doi: 10.1172/JCI110395.
    1. American Thoracic Society Hospital-acquired pneumonia in adults: diagnosis, assessment of severity, initial antimicrobial therapy, and preventive strategies. A consensus statement, November 1995. Am J Respir Crit Care Med. 1996;153:1711–1725.
    1. Garrouste-Orgeas M, Chevret S, Arlet G, Marie O, Rouveau M, Popoff N, Schlemmer B. Oropharyngeal or gastric colonization and nosocomial pneumonia in adult intensive care unit patients. Am J Respir Crit Care Med. 1997;156:1647–1655.
    1. Bonten MJ, Gaillard CA, vanTiel FH, Smeets HG, vanderGeest S, Stobberingh EE. The stomach is not a source for colonization of the upper respiratory tract and pneumonia in ICU patients. Chest. 1994;105:878–884. doi: 10.1378/chest.105.3.878.
    1. Cardenosa Cendrero JA, Sole-Violan J, Bordes Benitez A, Noguera Catalan J, Arroyo Fernandez J, Saavedra Santana P, Rodriguez de Castro F. Role of different routes of tracheal colonization in the development of pneumonia in patients receiving mechanical ventilation. Chest. 1999;116:462–470. doi: 10.1378/chest.116.2.462.
    1. Bonten MJ, Bergmans DC, Ambergen AW, deLeeuw PW, van-derGeest S, Stobberingh EE, Gaillard CA. Risk factors for pneumonia, and colonization of respiratory tract and stomach in mechanically ventilated ICU patients. Am J Respir Crit Care Med. 1996;154:1339–1346.
    1. DeRiso AJ, Ladowski JS, Dillon TA, Justice JW, Peterson AC. Chlorhexidine gluconate 0.12% oral rinse reduces the incidence of total nosocomial respiratory infection and nonprophylactic systemic antibiotic use in patients undergoing heart surgery. Chest. 1996;109:1556–1561. doi: 10.1378/chest.109.6.1556.
    1. Genuit T, Bochicchio G, Napolitano LM, McCarter RJ, Roghman MC. Prophylactic chlorhexidine oral rinse decreases ventilator-associated pneumonia in surgical ICU patients. Surg Infect (larch mt) 2001;2(1):5–18. doi: 10.1089/109629601750185316.
    1. Houston S, Hougland P, Anderson JJ, LaRocco M, Kennedy V, Gentry LO. Effectiveness of 0.12% chlorhexidine gluconate oral rinse in reducing prevalence of nosocomial pneumonia in patients undergoing heart surgery. Am J Crit Care. 2002;11:567–570.
    1. Segers P, Speekenbrink RG, Ubbink DT, van Ogtrop ML, de Mol BA. Prevention of nosocomial infection in cardiac surgery by decontamination of the nasopharynx and oropharynx with chlorhexidine gluconate: a randomized controlled trial. JAMA. 2006;296:2460–2466. doi: 10.1001/jama.296.20.2460.
    1. Bergmans DC, Bonten MJ, Gaillard CA, Paling JC, vanderGeest S, vanTiel FH, Beysens AJ, deLeeuw PW, Stobberingh EE. Prevention of ventilator-associated pneumonia by oral decontamination. A prospective, randomized, double-blind, placebo-controlled study. Am J Respir Crit Care Med. 2001;164:382–388.
    1. Pugin J, Auckenthaler R, Lew DP, Suter PM. Oropharyngeal decontamination decreases incidence of ventilator-associated pneumonia. A randomized, placebo-controlled, double-blind clinical trial. JAMA. 1991;265:2704–2710. doi: 10.1001/jama.265.20.2704.
    1. Gastinne H, Wolff M, Delatour F, Faurisson F, Chevret S. A controlled trial in intensive care units of selective decontamination of the digestive tract with nonabsorbable antibiotics. New Engl J Med. 1992;326:594–599.
    1. Selective Decontamination of the Digestive Tract Trialists' Collaborative Group Meta-analysis of randomised controlled trials of selective decontamination of the digestive tract. BMJ. 1993;307:525–532.
    1. D'Amico R, Pifferi S, Leonetti C, Torri V, Tinazzi A, Liberati A. Effectiveness of antibiotic prophylaxis in critically ill adult patients: systematic review of randomised controlled trials. BMJ. 1998;316:1275–1285.
    1. Heyland DK, Cook DJ, Jaeschke R, Griffith L, Lee HN, Guyatt GH. Selective decontamination of the digestive tract. An overview. Chest. 1994;105:1221–1229. doi: 10.1378/chest.105.4.1221.
    1. Hurley JC. Prophylaxis with enteral antibiotics in ventilated patients: selective decontamination or selective cross-infection? Antimicrob Agents Chemother. 1995;39:941–947.
    1. Kollef MH. The role of selective digestive tract decontamination on mortality and respiratory tract infections. A meta-analysis. Chest. 1994;105:1101–1108. doi: 10.1378/chest.105.4.1101.
    1. Liberati A, D'Amico R, Pifferi , Torri V, Brazzi L. Antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving intensive care. Cochrane Database Syst Rev. 2004;(1):CD000022.
    1. Nathens AB, Marshall JC. Selective decontamination of the digestive tract in surgical patients: a systematic review of the evidence. Arch Surg. 1999;134:170–176. doi: 10.1001/archsurg.134.2.170.
    1. Safdar N, Said A, Lucey MR. The role of selective digestive decontamination for reducing infection in patients undergoing liver transplantation: a systematic review and meta-analysis. Liver Transpl. 2004;10:817–827. doi: 10.1002/lt.20108.
    1. Sun X, Wagner DP, Knaus WA. Does selective decontamination of the digestive tract reduce mortality for severely ill patients? Crit Care Med. 1996;24:753–755. doi: 10.1097/00003246-199605000-00005.
    1. van Saene HK, Stoutenbeek CP, Hart CA. Selective decontamination of the digestive tract (SDD) in intensive care patients: a critical evaluation of the clinical, bacteriological and epidemiological benefits. J Hosp Infect. 1991;18:261–277. doi: 10.1016/0195-6701(91)90184-A.
    1. Vandenbroucke-Grauls CM, Vandenbroucke JP. Effect of selective decontamination of the digestive tract on respiratory tract infections and mortality in the intensive care unit. Lancet. 1991;338:859–862. doi: 10.1016/0140-6736(91)91510-2.
    1. vanNieuwenhoven CA, Buskens E, Bergmans DC, vanTiel FH, Ramsay G, Bonten MJ. Oral decontamination is cost-saving in the prevention of ventilator-associated pneumonia in intensive care units. Crit Care Med. 2004;32:126–130. doi: 10.1097/01.CCM.0000104111.61317.4B.
    1. Krueger WA, Lenhart FP, Neeser G, Ruckdeschel G, Schreck-hase H, Eissner HJ, Forst H, Eckart J, Peter K, Unertl KE. Influence of combined intravenous and topical antibiotic prophylaxis on the incidence of infections, organ dysfunctions, and mortality in critically ill surgical patients: a prospective, stratified, randomized, double-blind, placebo-controlled clinical trial. Am J Respir Crit Care Med. 2002;166:1029–1037. doi: 10.1164/rccm.2105141.
    1. Cerda E, Abella A, de la Cal MA, Lorente JA, Garcia-Hierro P, van Saene HK, Alia I, Aranguren A. Enteral vancomycin controls methicillin-resistant Staphylococcus aureus endemicity in an intensive care burn unit: a 9-year prospective study. Ann Surg. 2007;245:397–407. doi: 10.1097/01.sla.0000250418.14359.31.
    1. de la Cal MA, Cerda E, van Saene HK, Garcia-Hierro P, Negro E, Parra ML, Arias S, Ballesteros D. Effectiveness and safety of enteral vancomycin to control endemicity of methicillin-resistant Staphylococcus aureus in a medical/surgical intensive care unit. J Hosp Infect. 2004;56:175–183. doi: 10.1016/j.jhin.2003.09.021.
    1. Kollef MH. Selective digestive decontamination should not be routinely employed. Chest. 2003;123:464S–468S. doi: 10.1378/chest.123.5_suppl.464S.
    1. Tablan OC, Anderson LJ, Arden NH, Breiman RF, Butler JC, McNeil MM. Guideline for prevention of nosocomial pneumonia. The Hospital Infection Control Practices Advisory Committee, Centers for Disease Control and Prevention. Infect Control Hosp Epidemiol. 1994;15:587–627.
    1. Kollef M, Pittet D, Sánchez García M, Chastre J, Fagon JY, Bonten M, Hyzy R, Fleming TR, Fuchs H, Bellm L, Mercat A, Mañez R, Martínez A, Eggimann P, Daguerre M, Luyt CE, Prevention of Pneumonia Study (POPS-1) Trial Group A randomized double-blind trial of iseganan in prevention of ventilator-associated pneumonia. Am J Respir Crit Care Med. 2006;173:91–97. doi: 10.1164/rccm.200504-656OC.
    1. Higgins CS, Murtough SM, Williamson E, Hiom SJ, Payne DJ, Russell AD, Walsh TR. Resistance to antibiotics and biocides among non-fermenting Gram-negative bacteria. Clin Microbiol Infect. 2001;7:308–315. doi: 10.1046/j.1198-743x.2001.00253.x.
    1. Russell AD. Biocide use and antibiotic resistance: the relevance of laboratory findings to clinical and environmental situations. Lancet Infect Dis. 2003;3:794–803. doi: 10.1016/S1473-3099(03)00833-8.
    1. Keller C, Brimacombe J. Bronchial mucus transport velocity in paralyzed anesthetized patients: a comparison of the laryngeal mask airway and cuffed tracheal tube. Anesth Analg. 1998;86:1280–1282. doi: 10.1097/00000539-199806000-00028.
    1. Konrad F, Schiener R, Marx T, Georgieff M. Ultrastructure and mucociliary transport of bronchial respiratory epithelium in intubated patients. Intensive Care Med. 1995;21:482–489. doi: 10.1007/BF01706201.
    1. Sackner MA, Hirsch JA, Epstein S, Rywlin AM. Effect of oxygen in graded concentrations upon tracheal mucous velocity. A study in anesthetized dogs. Chest. 1976;69:164–167. doi: 10.1378/chest.69.2.164.
    1. Hornick DB, Allen BL, Horn MA, Clegg S. Adherence to respiratory epithelia by recombinant Escherichia coli expressing Klebsiella pneumoniae type 3 fimbrial gene products. Infect Immun. 1992;60:1577–1588.
    1. Brodsky L, Reidy M, Stanievich JF. The effects of suctioning techniques on the distal tracheal mucosa in intubated low birth weight infants. Int J Pediatr Otorhinolaryngol. 1987;14:1–14. doi: 10.1016/0165-5876(87)90044-9.
    1. Adlkofer RM, Powaser MM. The effect of endotracheal suctioning on arterial blood gases in patients after cardiac surgery. Heart Lung. 1978;7:1011–1014.
    1. Brown SE, Stansbury DW, Merrill EJ, Linden GS, Light RW. Prevention of suctioning-related arterial oxygen desaturation. Comparison of off-ventilator and on-ventilator suctioning. Chest. 1983;83:621–627. doi: 10.1378/chest.83.4.621.
    1. Van de Leur JP, Zwaveling JH, Loef BG, Van der Schans CP. Endotracheal suctioning versus minimally invasive airway suctioning in intubated patients: a prospective randomised controlled trial. Intensive Care Med. 2003;29:426–432.
    1. Maggiore SM, Lellouche F, Pigeot J, Taille S, Deye N, Durrmeyer X, Richard JC, Mancebo J, Lemaire F, Brochard L. Prevention of endotracheal suctioning-induced alveolar derecruitment in acute lung injury. Am J Respir Crit Care Med. 2003;167:1215–1224. doi: 10.1164/rccm.200203-195OC.
    1. Shim C, Fine N, Fernandez R, Williams MH., Jr Cardiac arrhythmias resulting from tracheal suctioning. Ann Intern Med. 1969;71:1149–1153.
    1. Piepmeier JM, Lehmann KB, Lane JG. Cardiovascular instability following acute cervical spinal cord trauma. Cent Nerv Syst Trauma. 1985;2:153–160.
    1. Choi JS, Jones AY. Effects of manual hyperinflation and suctioning in respiratory mechanics in mechanically ventilated patients with ventilator-associated pneumonia. Aust J Physiother. 2005;51:25–30.
    1. Mancinelli-Van Atta J, Beck SL. Preventing hypoxemia and hemodynamic compromise related to endotracheal suctioning. Am J Crit Care. 1992;1:62–79.
    1. Stiller K. Physiotherapy in intensive care: towards an evidence-based practice. Chest. 2000;118:1801–1813. doi: 10.1378/chest.118.6.1801.
    1. Ackerman MH. The effect of saline lavage prior to suctioning. Am J Crit Care. 1993;2:326–330.
    1. Ackerman MH, Mick DJ. Instillation of normal saline before suctioning in patients with pulmonary infections: a prospective randomized controlled trial. Am J Crit Care. 1998;7:261–266.
    1. Hagler DA, Traver GA. Endotracheal saline and suction catheters: sources of lower airway contamination. Am J Crit Care. 1994;3:444–447.
    1. Akgul S, Akyolcu N. Effects of normal saline on endotracheal suctioning. J Clin Nurs. 2002;11:826–830. doi: 10.1046/j.1365-2702.2002.00655.x.
    1. Kinloch D. Instillation of normal saline during endotracheal suctioning: effects on mixed venous oxygen saturation. Am J Crit Care. 1999;8:231–240.
    1. Cordero L, Sananes M, Ayers LW. A comparison of two airway suctioning frequencies in mechanically ventilated, very-low-birthweight infants. Respir Care. 2001;46:783–788.
    1. Wood CJ. Can nurses safely assess the need for endotracheal suction in short-term ventilated patients, instead of using routine techniques? Intensive Crit Care Nurs. 1998;14:170–178. doi: 10.1016/S0964-3397(98)80486-2.
    1. Deppe SA, Kelly JW, Thoi LL, Chudy JH, Longfield RN, Ducey JP, Truwit CL, Antopol MR. Incidence of colonization, nosocomial pneumonia, and mortality in critically ill patients using a Trach Care closed-suction system versus an open-suction system: prospective, randomized study. Crit Care Med. 1990;18:1389–1393. doi: 10.1097/00003246-199012000-00016.
    1. Rabitsch W, Kostler WJ, Fiebiger W, Dielacher C, Losert H, Sherif C, Staudinger T, Seper E, Koller W, Daxbock F, Schuster E, Knobl P, Burgmann H, Frass M. Closed suctioning system reduces cross-contamination between bronchial system and gastric juices. Anesth Analg. 2004;99:886–892.
    1. Combes P, Fauvage B, Oleyer C. Nosocomial pneumonia in mechanically ventilated patients, a prospective randomised evaluation of the Stericath closed suctioning system. Intensive Care Med. 2000;26:878–882. doi: 10.1007/s001340051276.
    1. Jongerden IP, Rovers MM, Grypdonck MH, Bonten MJ. Open and closed endotracheal suction systems in mechanically ventilated intensive care patients: a meta-analysis. Crit Care Med. 2007;35:260–270. doi: 10.1097/01.CCM.0000251126.45980.E8.
    1. Lorente L, Lecuona M, Martin MM, Garcia C, Mora ML, Sierra A. Ventilator-associated pneumonia using a closed versus an open tracheal suction system. Crit Care Med. 2005;33:115–119. doi: 10.1097/01.CCM.0000150267.40396.90.
    1. Zeitoun SS, de Barros AL, Diccini S. A prospective, randomized study of ventilator-associated pneumonia in patients using a closed vs. open suction system. J Clin Nurs. 2003;12:484–489. doi: 10.1046/j.1365-2702.2003.00749.x.
    1. Johnson KL, Kearney PA, Johnson SB, Niblett JB, MacMillan NL, McClain RE. Closed versus open endotracheal suctioning: costs and physiologic consequences. Crit Care Med. 1994;22:658–666. doi: 10.1097/00003246-199404000-00023.
    1. Lorente L, Lecuona M, Jimenez A, Mora ML, Sierra A. Tracheal suction by closed system without daily change versus open system. Intensive Care Med. 2006;32:538–544. doi: 10.1007/s00134-005-0057-6.
    1. Adams DH, Hughes M, Elliott TS. Microbial colonization of closed-system suction catheters used in liver transplant patients. Intensive Crit Care Nurs. 1997;13:72–76. doi: 10.1016/S0964-3397(97)80135-8.
    1. Zielmann S, Grote R, Sydow M, Radke J, Burchardi H. Endotracheal suctioning using a 24-hour continuous system. Can costs and waste products be reduced? Anaesthesist. 1992;41:494–498.
    1. Kollef MH, Prentice D, Shapiro SD, Fraser VJ, Silver P, Trovillion E, Weilitz P, von Harz B, St John R. Mechanical ventilation with or without daily changes of in-line suction catheters. Am J Respir Crit Care Med. 1997;156:466–472.
    1. Dezfulian C, Shojania K, Collard HR, Kim HM, Matthay MA, Saint S. Subglottic secretion drainage for preventing ventilator-associated pneumonia: a meta-analysis. Am J Med. 2005;118:11–18. doi: 10.1016/j.amjmed.2004.07.051.
    1. Girou E, Buu-Hoi A, Stephan F, Novara A, Gutmann L, Safar M, Fagon JY. Airway colonisation in long-term mechanically ventilated patients. Effect of semi-recumbent position and continuous subglottic suctioning. Intensive Care Med. 2004;30:225–233. doi: 10.1007/s00134-003-2077-4.
    1. Kollef MH, Skubas NJ, Sundt TM. A randomized clinical trial of continuous aspiration of subglottic secretions in cardiac surgery patients. Chest. 1999;116:1339–1346. doi: 10.1378/chest.116.5.1339.
    1. Mahul P, Auboyer C, Jospe R, Ros A, Guerin C, el Khouri Z, Galliez M, Dumont A, Gaudin O. Prevention of nosocomial pneumonia in intubated patients: respective role of mechanical subglottic secretions drainage and stress ulcer prophylaxis. Intensive Care Med. 1992;18:20–25. doi: 10.1007/BF01706421.
    1. Smulders K, vanderHoeven H, Weers-Pothoff I, Vandenbroucke-Grauls C. A randomized clinical trial of intermittent subglottic secretion drainage in patients receiving mechanical ventilation. Chest. 2002;121:858–862. doi: 10.1378/chest.121.3.858.
    1. Valles J, Artigas A, Rello J, Bonsoms N, Fontanals D, Blanch L, Fernandez R, Baigorri F. Continuous aspiration of subglottic secretions in preventing ventilator-associated pneumonia. Ann Intern Med. 1995;122:179–186.
    1. Berra L, Panigada M, De Marchi L, Greco G, Z-Xi Y, Baccarelli A, Pohlmann J, Costello KF, Appleton J, Mahar R, Lewandowski R, Ravitz L, Kolobow T. New approaches for the prevention of airway infection in ventilated patients. Lessons learned from laboratory animal studies at the National Institutes of Health. Minerva Anestesiol. 2003;69:342–347.
    1. Shorr AF, O'Malley PG. Continuous subglottic suctioning for the prevention of ventilator-associated pneumonia. Potential economic implications. Chest. 2001;119:228–235. doi: 10.1378/chest.119.1.228.
    1. Rau JL. Mucus-controlling agents. In: Rau JL, editor. Respiratory Care Pharmacology. St Louis: Mosby; 1994. pp. 195–222.
    1. Ackerman MH. The use of bolus normal saline instillations in artifical airways: is it useful or necessary? Heart Lung. 1985;14:505–506.
    1. Bostick J, Wendelgass ST. Normal saline instillation as part of the suctioning procedure: effects on PaO2 and amount of secretions. Heart Lung. 1987;16:532–537.
    1. Smith CM, Anderson SD. A comparison between the airway response to isocapnic hyperventilation and hypertonic saline in subjects with asthma. Eur Respir J. 1989;2:36–43.
    1. Sheffner AL, Medler EM, Jacobs LW, Sarett HP. The in vitro reduction in viscosity of human tracheobronchial secretions by acetylcysteine. Am Rev Respir Dis. 1964;90:721–729.
    1. Lawson D, Saggers BA. N.A.C. and antibiotics in cystic fibrosis. BMJ. 1965;5430:317.
    1. Parry MF, Neu HC. Effect of N-acetylcysteine on antibiotic activity and bacterial growth in vitro. J Clin Microbiol. 1977;5:58–61.
    1. Barton AD. Aerosolized detergents and mucolytic agents in the treatment of stable chronic obstructive pulmonary disease. Am Rev Respir Dis. 1974;110:104–110.
    1. Dueholm M, Nielsen C, Thorshauge H, Evald T, Hansen NC, Madsen HD, Maltbek N. N-acetylcysteine by metered dose inhaler in the treatment of chronic bronchitis: a multi-centre study. Respir Med. 1992;86:89–92. doi: 10.1016/S0954-6111(06)80220-9.
    1. Dorsch W, Auch E, Powerlowicz P. Adverse effects of acetylcysteine on human and guinea pig bronchial asthma in vivo and on human fibroblasts and leukocytes in vitro. Int Arch Allergy Appl Immunol. 1987;82:33–39.
    1. Mant TG, Tempowski JH, Volans GN, Talbot JC. Adverse reactions to acetylcysteine and effects of overdose. Br Med J (Clin Res Ed) 1984;289(6439):217–9.
    1. Kory RC, Hirsch SR, Giraldo J. Nebulization of N-acetylcysteine combined with a bronchodilator in patients with chronic bronchitis. A controlled study. Dis Chest. 1968;54:504–509. doi: 10.1378/chest.54.6.504.
    1. Lourenco RV, Cotromanes E. Clinical aerosols II. Therapeutic aerosols. Arch Intern Med. 1982;142:2299–2308. doi: 10.1001/archinte.142.13.2299.
    1. Lieberman J. The appropriate use of mucolytic agents. Am J Med. 1970;49:1–4. doi: 10.1016/S0002-9343(70)80107-3.
    1. Irwin RS, Thomas HD. Mucoid inpaction of the bronchus. Diagnosis and treatment. Am Rev Respir Dis. 1973;108:955–959.
    1. Urschel HC, Jr, Paulson DL, Shaw RR. Mucoid impaction of the bronchi. Ann Thorac Surg. 1966;2:1–16.
    1. Boogaard R, de Jongste JC, Merkus PJ. Pharmacotherapy of impaired mucociliary clearance in non-CF pediatric lung disease. A review of the literature. Pediatr Pulmonol. 2007;42:989–1001. doi: 10.1002/ppul.20693.
    1. Flume PA, O'Sullivan BP, Robinson KA, Goss CH, Mogayzel PJ, Jr, Willey-Courand DB, Bujan J, Finder J, Lester M, Quittell L, Rosenblatt R, Vender RL, Hazle L, Sabadosa K, Marshall B, Cystic Fibrosis Foundation, Pulmonary Therapies Committee Cystic fibrosis pulmonary guidelines: chronic medications for maintenance of lung health. Am J Respir Crit Care Med. 2007;176:957–969. doi: 10.1164/rccm.200705-664OC.
    1. Greally P. Human recombinant DNase for mucus plugging in status asthmaticus. Lancet. 1995;346:1423–1424. doi: 10.1016/S0140-6736(95)92436-1.
    1. Morris C, Mullan B. Use of dornase alfa in the management of ARDS. Anaesthesia. 2004;59:1249. doi: 10.1111/j.1365-2044.2004.04018.x.
    1. Riethmueller J, Borth-Bruhns T, Kumpf M, Vonthein R, Wiskirchen J, Stern M, Hofbeck M, Baden W. Recombinant human deoxyribonuclease shortens ventilation time in young, mechanically ventilated children. Pediatr Pulmonol. 2006;41(1):61–6. doi: 10.1002/ppul.20298.
    1. Frohock JI, Wijkstrom-Frei C, Salathe M. Effects of albuterol enantiomers on ciliary beat frequency in ovine tracheal epithelial cells. J Appl Physiol. 2002;92:2396–2402.
    1. Lafortuna CL, Fazio F. Acute effect of inhaled salbutamol on mucociliary clearance in health and chronic bronchitis. Respiration. 1984;45:111–123.
    1. Svartengren K, Philipson K, Svartengren M, Camner P. Effect of adrenergic stimulation on clearance from small ciliated airways in healthy subjects. Exp Lung Res. 1998;24:149–158.
    1. Beck-Sague C, Banerjee S, Jarvis WR. Infectious diseases and mortality among US nursing home residents. Am J Public Health. 1993;83:1739–1742.
    1. Kaneko K, Milic-Emili J, Dolovich MB, Dawson A, Bates DV. Regional distribution of ventilation and perfusion as a function of body position. J Appl Physiol. 1966;21:767–777.
    1. Raoof S, Chowdhrey N, Raoof S, Feuerman M, King A, Sriraman R, Khan FA. Effect of combined kinetic therapy and percussion therapy on the resolution of atelectasis in critically ill patients. Chest. 1999;115:1658–1666. doi: 10.1378/chest.115.6.1658.
    1. deBoisblanc BP, Castro M, Everret B, Grender J, Walker CD, Summer WR. Effect of air-supported, continuous, postural oscillation on the risk of early ICU pneumonia in nontraumatic critical illness. Chest. 1993;103:1543–1547. doi: 10.1378/chest.103.5.1543.
    1. Fink MP, Helsmoortel CM, Stein KL, Lee PC, Cohn SM. The efficacy of an oscillating bed in the prevention of lower respiratory tract infection in critically ill victims of blunt trauma. A prospective study. Chest. 1990;97:132–137. doi: 10.1378/chest.97.1.132.
    1. Kirschenbaum L, Azzi E, Sfeir T, Tietjen P, Astiz M. Effect of continuous lateral rotational therapy on the prevalence of ventilator-associated pneumonia in patients requiring long-term ventilatory care. Crit Care Med. 2002;30:1983–1986. doi: 10.1097/00003246-200209000-00006.
    1. Summer WR, Curry P, Haponik EF, Nelson S, Elston R. Continuous mechanical turning of intensive care unit patients shortens length of stay in some diagnostic-related groups. J Crit Care. 1989;4:45–53. doi: 10.1016/0883-9441(89)90091-9.
    1. Whiteman K, Nachtmann L, Kramer D, Sereika S, Bierman M. Effects of continuous lateral rotation therapy on pulmonary complications in liver transplant patients. Am J Crit Care. 1995;4:133–139.
    1. Gentilello L, Thompson DA, Tonnesen AS, Hernandez D, Kapadia AS, Allen SJ, Houtchens BA, Miner ME. Effect of a rotating bed on the incidence of pulmonary complications in critically ill patients. Crit Care Med. 1988;16:783–786. doi: 10.1097/00003246-198808000-00010.
    1. Traver GA, Tyler ML, Hudson LD, Sherrill DL, Quan SF. Continuous oscillation: outcome in critically ill patients. J Crit Care. 1995;10:97–103. doi: 10.1016/0883-9441(95)90000-4.
    1. Kelley RE, Bell LK, Mason RL. Cost analysis of kinetic therapy in the prevention of complications of stroke. South Med J. 1990;83:433–434.
    1. Mackenzie CF, Shin B. Cardiorespiratory function before and after chest physiotherapy in mechanically ventilated patients with post-traumatic respiratory failure. Crit Care Med. 1985;13:483–486. doi: 10.1097/00003246-198506000-00009.
    1. Marini JJ, Pierson DJ, Hudson LD. Acute lobar atelectasis: a prospective comparison of fiberoptic bronchoscopy and respiratory therapy. Am Rev Respir Dis. 1979;119:971–978.
    1. Stiller K, Geake T, Taylor J, Grant R, Hall B. Acute lobar atelectasis. A comparison of two chest physiotherapy regimens. Chest. 1990;98:1336–1340. doi: 10.1378/chest.98.6.1336.
    1. MacLean D, Drummond G, Macpherson C, McLaren G, Prescott R. Maximum expiratory airflow during chest physiotherapy on ventilated patients before and after the application of an abdominal binder. Intensive Care Med. 1989;15:396–399. doi: 10.1007/BF00261500.
    1. Hall JC, Tarala RA, Tapper J, Hall JL. Prevention of respiratory complications after abdominal surgery: a randomised clinical trial. BMJ. 1996;312:148–152.
    1. Lawrence VA, Cornell JE, Smetana GW. Strategies to reduce postoperative pulmonary complications after noncardiothoracic surgery: systematic review for the American College of Physicians. Ann Intern Med. 2006;144:596–608.
    1. Lederer DH, Van de Water JM, Indech RB. Which deep breathing device should the postoperative patient use? Chest. 1980;77:610–613. doi: 10.1378/chest.77.5.610.
    1. Van De Water JM. Preoperative and postoperative techniques in the prevention of pulmonary complications. Surg Clin North Am. 1980;60:1339–1348.
    1. Overend TJ, Anderson CM, Lucy SD, Bhatia C, Jonsson BI, Timmermans C. The effect of incentive spirometry on postoperative pulmonary complications: a systematic review. Chest. 2001;120:971–978. doi: 10.1378/chest.120.3.971.
    1. Pasquina P, Tramer MR, Granier JM, Walder B. Respiratory physiotherapy to prevent pulmonary complications after abdominal surgery: a systematic review. Chest. 2006;130:1887–1899. doi: 10.1378/chest.130.6.1887.
    1. Morran CG, Finlay IG, Mathieson M, McKay AJ, Wilson N, McArdle CS. Randomized controlled trial of physiotherapy for postoperative pulmonary complications. Br J Anaesth. 1983;55:1113–1117. doi: 10.1093/bja/55.11.1113.
    1. Ntoumenopoulos G, J PJ, M> M, Cade JF. Chest physiotherapy for the prevention of ventilator-associated pneumonia. Intensive Care Med. 2002;28:850–856. doi: 10.1007/s00134-002-1342-2.
    1. Ntoumenopoulos G, Gild A, Cooper DJ. The effect of manual lung hyperinflation and postural drainage on pulmonary complications in mechanically ventilated trauma patients. Anaesth Intensive Care. 1998;26:492–496.
    1. Hammon WE, Connors AF, McCaffree DR. Cardiac arrhythmias during postural drainage and chest percussion of critically ill patients. Chest. 1992;102:1836–1841. doi: 10.1378/chest.102.6.1836.
    1. Selsby DS. Chest physiotherapy. BMJ. 1989;298:541–542.
    1. Templeton M, Palazzo MG. Chest physiotherapy prolongs duration of ventilation in the critically ill ventilated for more than 48 hours. Intensive Care Med. 2007;33:1938–1945. doi: 10.1007/s00134-007-0762-4.
    1. Kang SW, Kang YS, Moon JH, Yoo TW. Assisted cough and pulmonary compliance in patients with Duchenne muscular dystrophy. Yonsei Med J. 2005;46:233–238.
    1. Newth CJ, Amsler B, Anderson GP, Morley J. The effects of varying inflation and deflation pressures on the maximal expiratory deflation flow-volume relationship in anesthetized rhesus monkeys. Am Rev Respir Dis. 1991;144:807–813.
    1. Marchant WA, Fox R. Postoperative use of a cough-assist device in avoiding prolonged intubation. Br J Anaesth. 2002;89:644–647. doi: 10.1093/bja/aef227.
    1. Whitman J, VanBeusekom R, Olson S, Worm M, Indihar F. Preliminary evaluation of high-frequency chest compression for secretion clearance in mechanically ventilated patients. Respir Care. 1993;38:1081–1087.
    1. Laurikka JO, Toivio I, Tarkka MR. Effects of a novel pneumatic vest on postoperative pain and lung function after coronary artery bypass grafting. Scand Cardiovasc J. 1998;32:141–144. doi: 10.1080/14017439850140094.
    1. Tobin M. Principles and Practices of Mechanical Ventilation. 2. New York: Mc-Graw Hill; 2006.
    1. Kerwin AJ, Croce MA, Timmons SD, Maxwell RA, Malhotra AK, Fabian TC. Effects of fiberoptic bronchoscopy on intracranial pressure in patients with brain injury: a prospective clinical study. J Trauma. 2000;48:878–882.
    1. Lindholm CE, Ollman B, Snyder JV, Millen EG, Grenvik A. Cardiorespiratory effects of flexible fiberoptic bronchoscopy in critically ill patients. Chest. 1978;74:362–368. doi: 10.1378/chest.74.4.362.
    1. Snow N, Lucas AE. Bronchoscopy in the critically ill surgical patient. Am Surg. 1984;50:441–445.
    1. Trouillet JL, Guiguet M, Gibert C, Fagon JY, Dreyfuss D, Blanchet F, Chastre J. Fiberoptic bronchoscopy in ventilated patients. Evaluation of cardiopulmonary risk under midazolam sedation. Chest. 1990;97:927–933. doi: 10.1378/chest.97.4.927.
    1. Kreider ME, Lipson DA. Bronchoscopy for atelectasis in the ICU: a case report and review of the literature. Chest. 2003;124:344–350. doi: 10.1378/chest.124.1.344.
    1. Lindholm CE, Ollman B, Snyder J, Millen E, Grenvik A. Flexible fiberoptic bronchoscopy in critical care medicine. Diagnosis, therapy and complications. Crit Care Med. 1974;2:250–261.
    1. Olopade CO, Prakash UB. Bronchoscopy in the critical-care unit. Mayo Clin Proc. 1989;64:1255–1263.
    1. Stevens RP, Lillington GA, Parsons GH. Fiberoptic bronchoscopy in the intensive care unit. Heart Lung. 1981;10:1037–1045.
    1. Weinstein HJ, Bone RC, Ruth WE. Pulmonary lavage in patients treated with mechanical ventilation. Chest. 1977;72:583–587. doi: 10.1378/chest.72.5.583.

Source: PubMed

3
Tilaa