Psidium guajava: A review on its potential as an adjunct in treating periodontal disease

K Ravi, P Divyashree, K Ravi, P Divyashree

Abstract

Plants for thousands of years have been used to enhance health and for medicinal purposes. Psidium guajava is one which has an enormous wealth of medicinal value. It for long has been known for its anti-inflammatory, antimicrobial, antioxidant, antidiarrheal, antimutagenic properties. Despite of its widespread biologic uses there is a dearth of information on its therapeutic effect in the treatment of periodontal disease. Hence, this review is an attempt to highlight the potential of P. guajava in the treatment of periodontal disease. Internet databases PubMed, Google Scholar were searched and the most relevant articles were considered for review.

Keywords: Antiplaque; Psidium guajava; gingivitis; guaijaverin; periodontitis; quercetin.

Conflict of interest statement

Conflict of Interest: None declared

References

    1. Chaturvedi TP. Uses of turmeric in dentistry: An update. Indian J Dent Res. 2009;20:107–9.
    1. Powell RN. The relationship of forming and mature dental plaque to the tooth surface. J Dent Res. 1965;44:1171–5.
    1. Somu CA, Ravindra S, Ajith S, Ahamed MG. Efficacy of a herbal extract gel in the treatment of gingivitis: A clinical study. J Ayurveda Integr Med. 2012;3:85–90.
    1. Kornman KS. Mapping the pathogenesis of periodontitis: A new look. J Periodontol. 2008;79:1560–8.
    1. Kumar P, Ansari SH, Ali J. Herbal remedies for the treatment of periodontal disease: A patent review. Recent Pat Drug Deliv Formul. 2009;3:221–8.
    1. Alviano DS, Alviano CS. Plant extracts: Search for new alternatives to treat microbial diseases. Curr Pharm Biotechnol. 2009;10:106–21.
    1. Groppo FC, Bergamaschi Cde C, Cogo K, Franz-Montan M, Motta RH, de Andrade ED. Use of phytotherapy in dentistry. Phytother Res. 2008;22:993–8.
    1. Maxwell SR. Prospects for the use of antioxidant therapies. Drugs. 1995;49:345–61.
    1. Joseph B, Priya RM. Phytochemical and biopharmaceutical aspects of Psidium guajava (L.) essential oil: A review. Res J Med Plant. 2011;5:432–42.
    1. Esimone CO, Nworu CS, Ekong US, Iroha IR, Okolin CS. A case for the use of herbal extracts in oral hygiene: the efficacy of Psidium guajava-based mouthwash formulations. Res J Appl Sci. 2007;2:1143–7.
    1. Kumar A. Importance for life ‘Psidium guajava’. Int J Res Pharm Biomed Sci. 2012;3:137–3.
    1. Sanda KA, Grema HA, Geidam YA, Bukar-Kolo YM. Pharmacological aspects of Psidium guajava: An update. Int J Pharmacol. 2011;7:316–24.
    1. Gupta GK, Chahal J, Arora D. Psidium guajava Linn.: Current research and future prospects. J Pharm Res. 2011;4:42–6.
    1. Rishika D, Sharma R. An update of pharmacological activity of Psidium guajava in the management of various disorders. Int J Pharm Sci Res. 2012;3:3577–84.
    1. Barbalho SM, Farinazzi-Machado FM, de Alvares Goulart R, Brunnati AC, Ottoboni AM. Psidium guajava (Guava): A plant of multipurpose medicinal plants. Med Aromat Plants. 2012;1:104.
    1. Mittal P, Gupta V, Kaur G, Garg AK, Singh A. Phytochemistry and pharmacological activities of Psidium guajava: A review. Int J Pharm Sci Res. 2010;1:9–19.
    1. Kamath JV, Rahul N, Ashok Kumar CK, Lakshmi SM. Psidium guajava L.: A review. Int J Green Pharm. 2008;2:9–12.
    1. Joseph B, Priya M. Review on nutritional, medicinal, and pharmacological properties of guava (Psidium Guajava Linn.) Int J Pharma Bio Sci. 2011;2:53–69.
    1. Ishikawa I. Host responses in periodontal diseases: A preview. Periodontol 2000. 2007;43:9–13.
    1. Bansal S, Rastogi S, Bajpai M. Mechanical, chemical and herbal aspects of periodontitis: a review. Int J Pharm Sci Res. 2012;3:1260–7.
    1. Fathilah AR. Piper betle L. and Psidium guajava L. in oral health maintenance. J Med Plant Res. 2011;5:156–63.
    1. Prabu GR, Gnanamani A, Sadulla S. Guaijaverin: A plant flavonoid as potential antiplaque agent against Streptococcus mutans. J Appl Microbiol. 2006;101:487–95.
    1. Ushimaru PI, Silva MT, Di Stasi LC, Barbosa L, Fernandes A., Jr Antibacterial activity of medicinal plant extracts. Braz J Microbiol. 2007;38:717–9.
    1. Joseph B, Priya RM, Helen PA, Sujatha S. Bio-active compounds in essential oil and its effects of antimicrobial, cytotoxic activity from the Psidium Guajava (L.) leaf. J Adv Biotechnol. 2010;9:10–4.
    1. Gashe F, Belete A, Gebre-Mariam T. Evaluation of antimicrobial and anti-inflammatory activities and formulation studies on the leaf extracts of Psidium guajava L. Ethiop Pharm J. 2010;28:131–42.
    1. Adeyemi OS, Akanji MA, Oguntoye SA. Ethanolic leaf extract of Psidium guajava: Phyto-chemical and trypanocidal activity in rats infected with Trypanosoma brucei. J Med Plants Res. 2009;3:420–3.
    1. Arima H, Danno G. Isolation of antimicrobial compounds from guava (Psidium guajava L.) and their structural elucidation. Biosci Biotechnol Biochem. 2002;66:1727–30.
    1. Metwally AM, Omar AA, Harraz FM, El Sohafy SM. Phytochemical investigation and antimicrobial activity of Psidium guajava L. leaves. Pharmacogn Mag. 2010;6:212–8.
    1. Tona L, Kambu K, Ntondele D, Cimanga K, Luki N. Antimicrobial activity of tannins. Fitoterapia. 1994;65:276–8.
    1. Shu Y, Liu Y, Li L, Feng J, Lou B, Zhou X, et0 al. Antibacterial activity of quercetin on oral infectious pathogens. Afr J Microbiol Res. 2011;5:5358–61.
    1. Geoghegan F, Wong RW, Rabie AB. Inhibitory effect of quercetin on periodontal pathogens in vitro. Phytother Res. 2010;24:817–20.
    1. Abdelrahim SI, Almagboul AZ, Omer ME, Elegami A. Antimicrobial activity of Psidium guajava L. Fitoterapia. 2002;73:713–5.
    1. Limsong J, Benjavongkulchai E, Kuvatanasuchati J. Inhibitory effect of some herbal extracts on adherence of Streptococcus mutans. J Ethnopharmacol. 2004;92:281–9.
    1. Brötz-Oesterhelt H, Beyer D, Kroll HP, Endermann R, Ladel C, Schroeder W, et al. Dysregulation of bacterial proteolytic machinery by a new class of antibiotics. Nat Med. 2005;11:1082–7.
    1. Fathilah AR, Rahim ZH, Othman Y, Yusoff M. Bacteriostatic effect of Piper betle and Psidium guajava extracts on dental plaque bacteria. Pak J Biol Sci. 2009;12:518–21.
    1. Nordini Hasnor WI, Fathilah AR, Rahim ZH. Plant extracts of Psidium guajava, Mangifera and Mentha sp. inhibit the growth of the population of single-species oral biofilm. Altern Integr Med. 2013;2:102.
    1. Kraivaphan V, Boonyamanound L, Amornchat C, Trirantana T, Kraivaphan P. The effect of a mouthrinse containing Psidium guajava leaf extract on gingivitis. J Dent Assoc Thai. 1991;41:323–8.
    1. Fathilah AR, Yusoff M, Rahim ZH. The effect of Psidium guajava and Piper betle extracts on the morphology of dental plaque bacteria. Pak J Med Sci. 2009;25:928–33.
    1. Razak FA, Rahim ZH. The anti-adherence effect of Piper betle and Psidium guajava extracts on the adhesion of early settlers in dental plaque to saliva-coated glass surfaces. J Oral Sci. 2003;45:201–6.
    1. Razak FA, Othman RY, Rahim ZH. The effect of Piper betle and Psidium guajava extracts on the cell-surface hydrophobicity of selected early settlers of dental plaque. J Oral Sci. 2006;48:71–5.
    1. Fathilah AR, Sujata R, Norhanom AW, Adenan MI. Antiproliferative activity of aqueous extract of Piper betle L. and Psidium guajava L. on KB and HeLa cell lines. J Med Plant Res. 2010;4:987–90.
    1. John NR, Gala VC, Sawant CS. Inhibitory effects of plant extracts on multi-species dental biofilm formation in-vitro. Int J Pharm Bio Sci. 2013;4:487–95.
    1. Weni LH, Widayanti Anti-inflammatory activity of the extract of guava leaves (Psidium guajava L.) in the rat (Rattus norvegicus L.) Indonesian J Cancer Chemoprevention. 2011;2:169–72.
    1. Kavimani S, Ilango R, Vertichelvan T. Anti-inflammatory activity of volatile oil of Psidium guajava. Anc Sci Life. 1998;17:300–4.
    1. Kwamin F, Gref R, Haubek D, Johansson A. Interactions of extracts from selected chewing stick sources with Aggregatibacter actinomycetemcomitans. BMC Res Notes. 2012;5:203.
    1. Joyce OO, Chinwe ND, Kwaku JP, Tabot PD. Psidium guajava's effect on acute phase protein levels during acute inflammation. Am J PharmTech Res. 2012;2:424–33.
    1. Yamazaki K, Honda T, Oda T, Ueki-Maruyama K, Nakajima T, Yoshie H, et al. Effect of periodontal treatment on the C-reactive protein and proinflammatory cytokine levels in Japanese periodontitis patients. J Periodontal Res. 2005;40:53–8.
    1. Kaileh M, Vanden Berghe W, Boone E, Essawi T, Haegeman G. Screening of indigenous Palestinian medicinal plants for potential anti-inflammatory and cytotoxic activity. J Ethnopharmacol. 2007;113:510–6.
    1. Choi SY, Hwang JH, Park SY, Jin YJ, Ko HC, Moon SW, et al. Fermented guava leaf extract inhibits LPS-induced COX-2 and iNOS expression in Mouse macrophage cells by inhibition of transcription factor NF-kB. Phytother Res. 2008;22:1030–4.
    1. Koide M, Kinugawa S, Takahashi N, Udagawa N. Osteoclastic bone resorption induced by innate immune responses. Periodontol 2000. 2010;54:235–46.
    1. Asman B, Bergström K. Expression of Fc-gamma-RIII and fibronectin in peripheral polymorphonuclear neutrophils with increased response to Fc stimulation in patients with juvenile periodontitis. Arch Oral Biol. 1992;37:991–5.
    1. Petti S, Scully C. Polyphenols, oral health and disease: A review. J Dent. 2009;37:413–23.
    1. Diab-Ladki R, Pellat B, Chahine R. Decrease in the total antioxidant activity of saliva in patients with periodontal diseases. Clin Oral Investig. 2003;7:103–7.
    1. Sculley DV, Langley-Evans SC. Periodontal disease is associated with lower antioxidant capacity in whole saliva and evidence of increased protein oxidation. Clin Sci (Lond) 2003;105:167–72.
    1. Pavlica Z, Petelin M, Nemec A, Erzen D, Skaleric U. Measurement of total antioxidant capacity in gingival crevicular fluid and serum in dogs with periodontal disease. Am J Vet Res. 2004;65:1584–8.
    1. Van der Velden U, Kuzmanova D, Chapple IL. Micronutritional approaches to periodontal therapy. J Clin Periodontol. 2011;38(Suppl 11):142–58.
    1. Battino M, Bullon P, Wilson M, Newman H. Oxidative injury and inflammatory periodontal diseases: The challenge of anti-oxidants to free radicals and reactive oxygen species. Crit Rev Oral Biol Med. 1999;10:458–76.
    1. Sculley DV, Langley-Evans SC. Salivary antioxidants and periodontal disease status. Proc Nutr Soc. 2002;61:137–43.
    1. Ritchie CS, Kinane DF. Nutrition, inflammation, and periodontal disease. Nutrition. 2003;19:475–6.
    1. Figuero E, Soory M, Cerero R, Bascones A. Oxidant/antioxidant interactions of nicotine, coenzyme Q10, pycnogenol and phytoestrogens in oral periosteal fibroblasts and MG63 osteoblasts. Steroids. 2006;71:1062–72.
    1. Carnelio S, Khan SA, Rodrigues G. Definite, probable or dubious: Antioxidants trilogy in clinical dentistry. Br Dent J. 2008;204:29–32.
    1. Fasola TR, Oloyede GK, Aponjolosun BS. Chemical composition, toxicity and antioxidant activities of essential oils of stem bark of Nigerian species of Guava (Psidium guajava Linn.) EXCLI J. 2011;10:34–43.
    1. Vyas N, Tailang M, Gavatia NP, Gupta BK. Antioxidant potential of Psidium guajava Linn. Int J PharmTech Res. 2010;2:417–9.
    1. Ogunlana OE, Ogunlana OO. In vitro assessment of the free radical scavenging activity of Psidium guajava. Res J Agric Biol Sci. 2008;4:666–71.
    1. Chen HY, Yeh GC. Antioxidant activity and free radical-scavenging capacity of extracts from guava (Psidium guajava L.) leaves. Food Chem. 2007;101:686–94.
    1. Qian H, Nihorimbere V. Antioxidant power of phytochemicals from Psidium guajava leaf. J Zhejiang Univ Sci. 2004;5:676–83.
    1. Dakappa SS, Adhikari R, Timilsina SS, Sunita S. A review on the medicinal plant Psidium guajava Linn. (Myrtaceae) J Drug Deliv Ther. 2013;3:162–8.
    1. Oguntibeju OO. The biochemical, physiological and therapeutic roles of ascorbic acid. Afr J Biotechnol. 2008;7:4700–5.
    1. Brown LA, Jones DP. The biology of ascorbic acid. In: Cadenas E, Packer L, editors. Handbook of Antioxidants. New York: Marcel Dekker, Inc; 1996. pp. 117–54.
    1. Chapple IL. Role of free radicals and antioxidants in the pathogenesis of the inflammatory periodontal diseases. Clin Mol Pathol. 1996;49:M247–55.
    1. Fernandes KP, Bussadori SK, Marques MM, Wadt NS, Bach E, Martins MD. Healing and cytotoxic effects of Psidium guajava (Myrtaceae) leaf extracts. Braz J Oral Sci. 2010;9:449–54.
    1. Rao NJ, Subash KR, Kumar KS. Role of phytotherapy in gingivitis: A review. Int J Pharmacol. 2012;1:1–5.
    1. Devi BP, Ramasubramaniaraja R. Dental caries and medicinal plants-An overview. J Pharm Res. 2009;2:1669–75.

Source: PubMed

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