Effects of levosimendan on occurrence of cerebral vasospasm after aneurysmal subarachnoid hemorrhage: a case-control study

Antoine Trinh-Duc, Marc-Antoine Labeyrie, Anaïs Caillard, Wagih Ben Hassen, Alexandre Mebazaa, Benjamin Glenn Chousterman, Antoine Trinh-Duc, Marc-Antoine Labeyrie, Anaïs Caillard, Wagih Ben Hassen, Alexandre Mebazaa, Benjamin Glenn Chousterman

No abstract available

Keywords: Cerebral vasospasm; Delayed cerebral ischemia; Levosimendan; Subarachnoid hemorrhage.

Conflict of interest statement

BGC was a member of an advisory board for Roche Diagnostic; AM received speaker’s honoraria from Abbott, Novartis, Orion, Roche and Servier and fees as a member of the advisory board and/or steering committee from Cardiorentis, Adrenomed, MyCartis, Neurotronik and Sphingotec. EG received research grant from Sphingotec and consultancy fees from Magnisense and Roche Diagnostics. All other authors have nothing to disclose.

Figures

Fig. 1
Fig. 1
Mean vessels diameters variations between day 1 and days 5–7 in levosimendan treated vs control patients. Quantitative analysis of cerebral arteries diameters in patients who had vessel imaging (CT or angiography) at admission and at days 5–7 in nine levosimendan-treated patients and 18 controls. Vessels narrowing was more pronounced in controls compared to levosimendan-treated patients (P = 0.004)

References

    1. Macdonald RL. Delayed neurological deterioration after subarachnoid haemorrhage. Nat Rev Neurol. 2014;10(1):44–58. doi: 10.1038/nrneurol.2013.246.
    1. Brami J, Chousterman B, Boulouis G, Dorze ML, Majlath M, Saint-Maurice J-P, et al. Delayed Cerebral Infarction is Systematically Associated with a Cerebral Vasospasm of Large Intracranial Arteries. Neurosurgery. 2019 Sep 9;nyz340.
    1. Li K, Barras CD, Chandra RV, Kok HK, Maingard JT, Carter NS, et al. A review of the management of cerebral vasospasm after aneurysmal subarachnoid hemorrhage. World Neurosurg. 2019;126:513–527. doi: 10.1016/j.wneu.2019.03.083.
    1. Busani S, Rinaldi L, Severino C, Cobelli M, Pasetto A, Girardis M. Levosimendan in cardiac failure after subarachnoid hemorrhage. J Trauma Inj Infect Crit Care. 2010;68(5):E108–E110. doi: 10.1097/TA.0b013e31817c4284.
    1. Vergouwen MDI, Vermeulen M, van Gijn J, Rinkel GJE, Wijdicks EF, Muizelaar JP, et al. Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: proposal of a multidisciplinary research group. Stroke. 2010;41(10):2391–2395. doi: 10.1161/STROKEAHA.110.589275.
    1. Zhang L, Zhang B, Qi S. Impact of echocardiographic wall motion abnormality and cardiac biomarker elevation on outcome after subarachnoid hemorrhage: a meta-analysis. Neurosurg Rev. 2020;43(1):59–68. doi: 10.1007/s10143-018-0985-6.

Source: PubMed

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