Antivenom for critically ill children with neurotoxicity from scorpion stings
Leslie V Boyer, Andreas A Theodorou, Robert A Berg, Joanne Mallie, Arizona Envenomation Investigators, Ariana Chávez-Méndez, Walter García-Ubbelohde, Stephen Hardiman, Alejandro Alagón, M D Berg, P B Chase, L Esparza, J Gutierrez, R J Meyer, M Karadsheh, J T McNally, Leslie V Boyer, Andreas A Theodorou, Robert A Berg, Joanne Mallie, Arizona Envenomation Investigators, Ariana Chávez-Méndez, Walter García-Ubbelohde, Stephen Hardiman, Alejandro Alagón, M D Berg, P B Chase, L Esparza, J Gutierrez, R J Meyer, M Karadsheh, J T McNally
Abstract
Background: Clinically significant scorpion envenomation by Centruroides sculpturatus produces a dramatic neuromotor syndrome and respiratory insufficiency that often necessitate intensive supportive care. We hypothesized that a scorpion-specific F(ab')(2) antivenom would promptly resolve clinical symptoms in children with this syndrome.
Methods: In a randomized, double-blind study, the efficacy of scorpion-specific F(ab')(2) antivenom, as compared with placebo, was assessed in 15 children 6 months to 18 years of age who were admitted to a pediatric intensive care unit with clinically significant signs of scorpion envenomation. The primary end point was the resolution of the clinical syndrome within 4 hours after administration of the study drug. Secondary end points included the total dose of concomitant midazolam for sedation and quantitative plasma venom levels, before and after treatment.
Results: The clinical syndrome resolved more rapidly among recipients of the antivenom than among recipients of placebo, with a resolution of symptoms in all eight antivenom recipients versus one of seven placebo recipients within 4 hours after treatment (P=0.001). More midazolam was administered in the placebo recipients than in the antivenom recipients (mean cumulative dose, 4.61 vs. 0.07 mg per kilogram of body weight; P=0.01). Plasma venom concentrations were undetectable in all eight antivenom recipients but in only one placebo recipient 1 hour after treatment (P=0.001).
Conclusions: Among critically ill children with neurotoxic effects of scorpion envenomation, intravenous administration of scorpion-specific F(ab')(2) antivenom resolved the clinical syndrome within 4 hours, reduced the need for concomitant sedation with midazolam, and reduced the levels of circulating unbound venom. (ClinicalTrials.gov number, NCT00685230.)
2009 Massachusetts Medical Society
Source: PubMed