A Review on the Taxonomy, Ethnobotany, Chemistry and Pharmacology of Oroxylum indicum Vent

Harminder, V Singh, A K Chaudhary, Harminder, V Singh, A K Chaudhary

Abstract

Oroxylum indicum Vent. (O. indicum) is a tree commonly called Indian trumpet tree found in tropical countries, such as India, Japan, China, Sri Lanka, Malaysia. The chemical constituents obtained from different parts of plant include baicalein-7-O-diglucoside (Oroxylin B), baicalein-7-O-glucoside, chrysin, apegenin, prunetin, sitosterol, oroxindin, biochanin-A, ellagic acid, baicalein and its 6- and 7-glucuronides, scutellarein, tetuin, antraquinone and aloe-emodin. Various parts of the plant are used in Ayurveda and folk medicine for the treatment of different ailments such as cancer, diarrhea, fever, ulcer and jaundice. Recent in vivo and in vitro studies have indicated its antiinflammatory, antiulcer, hepatoprotective, anticancer, antioxidant, photocytotoxic, antiproliferative, antiarthritic, antimicrobial, antimutagenic and immunostimulant properties. Exhaustive literature survey reveals that there are some activities which are still not proven scientifically. This article is an attempt to compile an up-to-date and comprehensive review on O. indicum covering its traditional and folk medicinal uses, phytochemistry and pharmacology.

Keywords: Ethnomedicinal; O. indicum; ethnopharmacology; phytochemical.

Figures

Fig. 1
Fig. 1
Oroxylum indicum: (a) tree (b) leaves (c) flowers (d) wood bark
Fig. 2
Fig. 2
Chemical structure of the biologically active compounds isolated from Oroxylum indicum.

References

    1. Nakahara K, Roy MK, Alzoreky NS, Thalang V, Trakoontivakorn G. Inventory of indigenous plants and minor crops in Thailand based on bioactivities. 9th JIRCAS International Symposium- Value addition to Agricultural Product. 2002:135–9.
    1. Chauhan NS. Medicinal and Aromatic plants of Himachal Pradesh. 1st ed. New Delhi: Indus Publishing; 1999. Oroxylum indicum; pp. 96–298.
    1. Warrier PK, Nambiar VP, Ramankutty C, Vasudevan R, editors. Indian Medicinal Plants: A compendium of 500 species. 1st ed. Chennai: Orient Longmam Private Ltd; 1995. Oroxylum indicum; pp. 186–90.
    1. Khare CP. Oroxylum indicum. In: Khare CP, editor. Indian Herbal Remedies: Rational Western Therapy, Ayurvedic and other traditional usage, Botany. 4th ed. New York: Springer-Verlag Berlin Heidelberg; 2004. pp. 340–1.
    1. Jayaram K, Prasad MN. Genetic diversity in Oroxylum indicum (L.) Vent. (Bignoniaceae), a vulnerable medicinal plant by random amplified polymorphic DNA marker. Afr J Biotech. 2008;7:254–62.
    1. Qiang G, Luo H, Zheng W, Liu Z, Huang Y. Pseudonocardia oroxyli sp. nov., a novel actinomycete isolated from surface-sterilized Oroxylum indicum root. Int J Syst Evol Microbiol. 2006;56:2193–7.
    1. Dalal NV, Rai VR. In vitro propagation of Oroxylum indicum Vent. a medicinally important forest tree. J For Res. 2004;9:61–5.
    1. Nakahara K, Trakoontivakorn G, Alzoreky NS, Ono H, Onishi-Kameyama M, Yoshida M. Anti-mutagenicity activity of some edible Thai plants, and a bioactive carbazole alkaloid, mahanine, isolated from Micromelum minutun. J Agri Food Chem. 2002;50:4796–802.
    1. Yoganarasimhan SN. Vol. 1. Bangalore: Interline Publishing; 1996. Medicinal plants of India: Karnataka; pp. 366–7.
    1. Bhattacharje SK. Use of flavours and fragrances. In: Bhattacharje SK, editor. Handbook of aromatic plants. 2nd ed. Jaipur: Pointer Publishers; 2005.
    1. Zaveri M, Khandhar A, Jain S. Quantification of Baicalein, Chrysin, Biochanin-A and Ellagic acid in root bark of Oroxylum indicum by RP-HPLC with UV detection. Eurasian J Anal Chem. 2008;3:245–57.
    1. Jabbar S, Khan MT, Choudhuri MS, Sil BK. Bioactivity studies of the individual ingredients of the Dashamularishta. Pak J Pharm Sci. 2004;17:9–17.
    1. Chen LJ, Games DE, Jones J. Isolation and identification of four flavonoids constituents from the seeds of Oroxylum indicum by high-speed counter-current chromatography. J Chromatogr A. 2003;988:95–105.
    1. Chen LJ, Song H, Lan XQ, Games DE, Sutherland IA. Comparisons of high speed counter-current chromatography instruments for the separation of the extracts of the seeds of Oroxylum indicum. J Chromatogr A. 2005;1063:241–5.
    1. Dey AK, Mukherjee A, Das PC, Chatterjee A. Occurrence of aloe-emodin in the leaves of Oroxylum indicum Vent. Indian J Chem. 1978;16B:1042.
    1. Yuan Y, Hou W, Tang M, Luo H, Chen LJ, Guan YH, et al. Separation of flavonoids from the leaves of Oroxylum indicum by HSCCC. Chromatographia. 2008;68:885–92.
    1. Yuan Y, Houding L, Lijuan C. Linear scale-up of the separation of active components from Oroxylum indicum using high speed counter current chromatography. Chinese J Chromatogr. 2008;26:489–93.
    1. Subramaniam SS, Nair AG. Flavonoids of the stem bark of Oroxylum indicum. Curr Sci. 1972;41:62–3.
    1. Kawsar U, Sayeed A, Islam A, Rahman AA, Ali A, Khan AM, et al. Biological activities of extracts and two flavanoids from Oroxylum indicum Vent. J Biol Sci. 2003;3:371–5.
    1. Roy MK, Nakahara K, Trakoontivakorn G, Takenaka M, Isobe S, Tsushida T. Baicalein, a flavanoid extracts from a methanolic extract of Oroxylum indicum inhibits proliferation of a cancer cell line in vitro via induction of apoptosis. Pharmazie. 2007;62:149–53.
    1. Tomimori T, Imoto Y, Ishida M, Kizu H, Namba T. Studies on the Nepalese crude drug.VIII. On the flavonoid constituents of the seed of Oroxylum indicum. Shoyakugaku Zasshi. 1988;42:98–101.
    1. Bhattacharje AK, Das AK. Phytochemical screening of some Indian plants. QJ Crude Drug Res. 1969;9:1408.
    1. Kapoor LD. 1st ed. Florida: CRC press Inc; 2001. Handbook of Ayurvedic Medicinal Plants: Herbal reference library; p. 252.
    1. Subramaniam SS, Nair AG. Flavonoids of leaves of Oroxylum indicum and Pajanelia longifolia. Phytochem. 1972;11:439–70.
    1. Laupattarakasem P, Houghton PJ, Hoult JR, Itharat A. An evaluation of the activity related to inflammation of four plants used in Thailand to treat arthritis. J Ethnopharmacol. 2003;85:207–15.
    1. Kandaswami C, Lee LT, Lee PP, Hwang JJ, Ke FC, Huang YT, et al. The antitumor activities of flavonoids. In vivo. 2005;19:895–909.
    1. Ren W, Qiao Z, Wang H, Zhu L, Zhang L. Flavonoids: promising anticancer agents. Med Res Rev. 2003;23:519–34.
    1. Kao YC, Zhou C, Sherman M, Laughton CA, Chen S. Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A Site-directed Mutagenesis Study. Environ Health Perspect. 1998;106:85–92.
    1. Qais N, Rahman MM, Rashid MA, Koshino H, Nagasawa K, Nakata T. Antibacterial flavonoids from Desmos chinensis. Fitoterapia. 1996;67:554–5.
    1. Hecker M, Preiss C, Klemm P, Busse R. Inhibition by antioxidants of nitric oxide synthase expression in murine. Br J Pharmacol. 1996;118:2178.
    1. Fishkin RJ, Winslow JT. Endotoxin-induced reduction of social investigation by mice: interaction with amphetamine and antiinflammatory drugs. Psychopharmacology (Berl) 1997;132:335–41.
    1. Pearce FL, Befs AD, Bienenstock J. Mucosal mast cells. III. Effect of quercitin and other flavonoids on antigen-induced histamine secretion from rat intestinal mast cells. J Allergy Clin Immunol. 1984;73:819–23.
    1. Habtemariam S. Flavonoids as inhibitors or enhancers of the cytotoxicity of tumor necrosis factor-alpha in L-929 tumor cells. J Nat Prod. 1997;60:775–8.
    1. Wolfman C, Viola H, Paladini A, Dajas F, Medina JH. Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passifloara coerulea. Pharmacol Biochem Behav. 1994;47:1–4.
    1. Kubo I, Kinst-Hori I, Choudhuri SK, Kubo Y, Sanchez Y, Ogura T. Flovonols from Heterothesca inuloides: tyrosinase inhibitory activity and structural criteria. Bioorg Med Chem Lett. 2000;8:1749–55.
    1. Suresh CT, Leena S, Sari M, Risto S. Inhibition of 17β-estradiol formation by isoflavonoids and flavonoids in cultured JEG-3 cells: Search for aromatase-targeting dietary compounds. J Med Food. 1999;2:235–8.
    1. Liu Y, Ho DK, Cassady JM, Cook VM, Baird WM. Isolation of potential anticancer chemopreventive agents from Eriodictyon californicum. J Nat Prod. 1992;55:357–63.
    1. Babu KS, Babu TH, Srinivas PV, Kishore KH, Murthy US, Rao JM. Synthesis and biological evaluation of novel C (7) modified chrysin analogues as antibacterial agents. Bioorg Med Chem Lett. 2006;16:221–4.
    1. Chen YC, Yang LL, Lee TJ. Oroxylin A inhibition of lipopolysaccharide-induced iNOS and cox-2 gene expression via suppression of nuclear factor-kb activation. Biochem Pharmacol. 2000;59:1445–57.
    1. You KM, Jong HG, Kim HP. Inhibition of cyclooxygenase/lipooxygenase from human platelets by polyhydroxylated/methoxylated flavonoids isolated from medicinal plants. Arch Pharmacol Res. 1999;22:18–24.
    1. Ryu SH, Ahn BZ, Pack MY. The cytotoxic principle of Scutellariae radix against L1210 cell. Planta Med. 1995;4:335.
    1. Ali RM, Houghton PJ, Hoult JRS. Antimicrobial and antiinflammatory activities of extracts and constituents of Oroxylum indicum (L.) Vent Phytomed. 1998;5:375–81.
    1. Rasadah MA, Houghton PJ. Anti-microbial activity of some species of Bignoniaceae. ASEAN Review of Biodiversity and Environmental Conservation (ARBEC) 1998;3:1–3.
    1. Kimura Y, Okuda Y, Taira Z, Shoji N, Takemoto T, Arichi S. Studies on Scutellariae radix. IX. New component inhibiting lipid peroxidation in rat liver. Planta Med. 1984;50:290–5.
    1. Nakahara K, Onishi-Kameyama M, Ona H, Yoshida M, Trakoontivakorn G. Antimutagenic activity against Trp-P-1 of the edible Thai plant, Oroxylum indicum Vent. Biosci Biotechnol Biochem. 2001;65:2358–60.
    1. Babu KS, Babu TH, Srinivas PV, Sastry BS, Kishore KH, Murty US, et al. Synthesis and in vitro study of novel 7-O-acyl derivatives of Oroxylin A as antibacterial agents. Bioorg Med Chem Lett. 2005;15:3953–6.
    1. Upaganlawar AB, Tende CR, Yeole PG. Antiinflammatory activity of aqueous extract of Oroxylum indicum Vent.leaves extract-preliminary study. Pharmacology online. 2009;1:22–6.
    1. Khandhar M, Shah M, Santani D, Jain S. Antiulcer activity of the root bark of Oroxylum indicum against experimental gastric ulcers. Pharm Bio. 2006;44:363–70.
    1. Chopade VV, Upaganlawar AB, Yeole PG. Antimicrobial activity of Oroxylum indicum. Antiseptic. 2008;105:146–7.
    1. Upaganlawar AB, Tende CR. In vitro antioxidant activity of leaves of Oroxylum indicum Vent. Biomed. 2007;2:300.
    1. Ong CY, Ling SK, Ali RM, Chee CF, Samah ZA, Ho AS, et al. Systemic analysis of in vitro photo-cytotoxic activity in extracts from terrestrial plants in Peninsula Malaysia for photodynamic therapy. J Photochem Photobiol B. 2009;96:216–22.
    1. Zaveri M, Gohil P, Jain S. Immunostimulant activity of n-butanol fraction of root bark of Oroxylum indicum Vent. J Immunotoxicol. 2006;3:83–99.
    1. Lambertini E, Piva R, Khan MT, Lampronti I, Bianchi N, Borgatti M, et al. Effects of extracts from Bangladeshi medicinal plants on in vitro proliferation of human breast cancer cell lines and expression of estrogen receptor alpha gene. Int J Oncol. 2004;24:419–23.
    1. Zaveri M, Jain S. Hepatoprotective effect of root bark of Oroxylum indicum on carbon tetrachloride (CCl4)-induced hepatotoxicity in experimental animals. [Last updated on 2009 Aug 08]. Available from: .

Source: PubMed

Sponsorit ja yhteistyökumppanit

Sairaudet

Huumeiden interventiot

3
Tilaa