DNA Variations in the Gene in Young Patients With Wilms' Tumor
17 mai 2016 mis à jour par: Children's Oncology Group
The Incidence, Inheritance, and Prognostic Significance of Polymorphisms in the RASSF1A Gene in Children With Wilms Tumors
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer.
PURPOSE: This laboratory study is looking at DNA variations in the RASSF1A gene in young patients with Wilms' tumor.
Aperçu de l'étude
Statut
Complété
Les conditions
Description détaillée
OBJECTIVES:
Primary
- Determine the presence of the A133S polymorphism in the RASSF1A tumor suppressor gene by screening germline DNAs of children with Wilms' tumor.
- Determine the inheritance pattern of the A133S polymorphism by evaluating the parents of children who carry this polymorphism.
Secondary
- Determine the differences in age at diagnosis, stage, histology, site of primary tumor, and outcome, between patients with vs without the A133S polymorphism.
- Determine whether the S131F RASSF1A variant is a true polymorphism in these patients.
- Determine the polymorphic differences in this gene between these patients based on ethnicity and sex.
OUTLINE: This is a multicenter study. Patients are stratified according to age at diagnosis, stage, histology, site of primary tumor, and outcome.
Genomic DNA samples are purified from peripheral blood of patients and controls and analyzed by polymerase chain reaction for the RASSF1A gene. DNA is also analyzed from parents of patients with the A133S polymorphism.
PROJECTED ACCRUAL: A total of 471 participants (229 Wilms' tumor patients and 200 control participants plus 42 parents) will be accrued for this study.
Type d'étude
Observationnel
Inscription (Anticipé)
471
Contacts et emplacements
Cette section fournit les coordonnées de ceux qui mènent l'étude et des informations sur le lieu où cette étude est menée.
Lieux d'étude
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New South Wales
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Randwick, New South Wales, Australie, 2031
- Sydney Children's Hospital
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Westmead, New South Wales, Australie, 2145
- Children's Hospital at Westmead
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South Australia
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North Adelaide, South Australia, Australie, 5006
- Women's and Children's Hospital
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Victoria
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Parkville, Victoria, Australie, 3052
- Royal Children's Hospital
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Western Australia
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Perth, Western Australia, Australie, 6001
- Princess Margaret Hospital for Children
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Alberta
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Calgary, Alberta, Canada, T2T 5C7
- Alberta Children's Hospital
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Edmonton, Alberta, Canada, T6G 1Z2
- Cross Cancer Institute
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British Columbia
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Vancouver, British Columbia, Canada, V6H 3V4
- British Columbia Children's Hospital
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Manitoba
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Winnipeg, Manitoba, Canada, R3E 0V9
- CancerCare Manitoba
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Newfoundland and Labrador
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St. John's, Newfoundland and Labrador, Canada, A1B 3V6
- Janeway Children's Health and Rehabilitation Centre
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Nova Scotia
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Halifax, Nova Scotia, Canada, B3J 3G9
- IWK Health Centre
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Ontario
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Hamilton, Ontario, Canada, L8S 4J9
- McMaster Children's Hospital at Hamilton Health Sciences
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London, Ontario, Canada, N6C 2V5
- Children's Hospital of Western Ontario
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Ottawa, Ontario, Canada, K1H 8L1
- Children's Hospital of Eastern Ontario
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Toronto, Ontario, Canada, M5G 1X8
- Hospital for Sick Children
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Quebec
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Montreal, Quebec, Canada, H3T 1C5
- Hopital Sainte Justine
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Montreal, Quebec, Canada, H3G 1A4
- Montreal Children's Hospital at McGill University Health Center
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Sainte Foy, Quebec, Canada, GIV 4G2
- Centre de Recherche du Centre Hospitalier de l'Universite Laval
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Saskatchewan
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Regina, Saskatchewan, Canada, S4T 7T1
- Allan Blair Cancer Centre at Pasqua Hospital
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Saskatoon, Saskatchewan, Canada, S7N 4H4
- Saskatoon Cancer Centre
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Auckland, Nouvelle-Zélande
- Starship Children's Health
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Groningen, Pays-Bas, 9700 RB
- Academisch Ziekenhuis Groningen
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San Juan, Porto Rico, 00936-5067
- Puerto Rico Cancer Center at University of Puerto Rico - Medical Sciences Campus
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Santurce, Porto Rico, 00912
- San Jorge Childrens Hospital
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Bern, Suisse, CH 3010
- Swiss Pediatric Oncology Group Bern
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Geneva, Suisse, CH 1211
- Swiss Pediatric Oncology Group Geneva
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Lausanne, Suisse, CH 1011
- Swiss Pediatric Oncology Group Lausanne
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Alabama
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Birmingham, Alabama, États-Unis, 35233
- University of Alabama at Birmingham Comprehensive Cancer Center
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Mobile, Alabama, États-Unis, 36604
- University of South Alabama Cancer Research Institute
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Arizona
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Phoenix, Arizona, États-Unis, 85016
- Phoenix Children's Hospital
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Tucson, Arizona, États-Unis, 85724
- Arizona Cancer Center at University of Arizona Health Sciences Center
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Arkansas
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Little Rock, Arkansas, États-Unis, 72205
- Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
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California
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Downey, California, États-Unis, 90242
- Southern California Permanente Medical Group
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La Jolla, California, États-Unis, 92093-0658
- Rebecca and John Moores UCSD Cancer Center
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Loma Linda, California, États-Unis, 92354
- Loma Linda University Cancer Institute at Loma Linda University Medical Center
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Long Beach, California, États-Unis, 90801-1428
- Jonathan Jaques Children's Cancer Center at Miller Children's Hospital
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Los Angeles, California, États-Unis, 90048
- Cedars-Sinai Comprehensive Cancer Center at Cedars-Sinai Medical Center
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Los Angeles, California, États-Unis, 90095-1781
- Jonsson Comprehensive Cancer Center, UCLA
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Los Angeles, California, États-Unis, 90027-0700
- Children's Hospital Los Angeles
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Madera, California, États-Unis, 93638-8762
- Children's Hospital Central California
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Oakland, California, États-Unis, 94609-1809
- Children's Hospital and Research Center at Oakland
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Orange, California, États-Unis, 92868
- Children's Hospital of Orange County
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Orange, California, États-Unis, 92868
- Chao Family Comprehensive Cancer Center at University of California Irvine Cancer Center
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Palo Alto, California, États-Unis, 94304
- Lucile Packard Children's Hospital at Stanford University Medical Center
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Sacramento, California, États-Unis, 95816
- Sutter Cancer Center
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Sacramento, California, États-Unis, 95825
- Kaiser Permanente Medical Center - Sacramento
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San Diego, California, États-Unis, 92120
- Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego
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San Diego, California, États-Unis, 92123-4282
- Children's Hospital and Health Center, San Diego
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San Francisco, California, États-Unis, 94143
- UCSF Comprehensive Cancer Center
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Santa Barbara, California, États-Unis, 93102
- Santa Barbara Cottage Hospital
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Santa Clara, California, États-Unis, 95051-5386
- Kaiser Permanente Medical Center - Santa Clara
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Travis Air Force Base, California, États-Unis, 94535
- David Grant Medical Center
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Colorado
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Denver, Colorado, États-Unis, 80218-1088
- Children's Hospital of Denver
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Denver, Colorado, États-Unis, 80218
- Presbyterian - St. Luke's Medical Center
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Connecticut
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Farmington, Connecticut, États-Unis, 06360-7106
- University of Connecticut Comprehensive Cancer Center at University of Connecticut Health Center
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New Haven, Connecticut, États-Unis, 06520-8028
- Yale Comprehensive Cancer Center
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Delaware
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Wilmington, Delaware, États-Unis, 19899
- Alfred I. DuPont Hospital for Children
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District of Columbia
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Washington, District of Columbia, États-Unis, 20007
- Lombardi Cancer Center at Georgetown University Medical Center
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Washington, District of Columbia, États-Unis, 20010-2970
- Children's National Medical Center
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Florida
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Fort Lauderdale, Florida, États-Unis, 33316
- Broward General Medical Center
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Fort Myers, Florida, États-Unis, 33908
- Children's Hospital of Southwest Florida
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Gainesville, Florida, États-Unis, 32610-0296
- Shands Cancer Center at the University of Florida Health Science Center
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Hollywood, Florida, États-Unis, 33021
- Joe DiMaggio Children's Hospital at Memorial
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Jacksonville, Florida, États-Unis, 32207
- Nemours Children's Clinic
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Miami, Florida, États-Unis, 33155
- Miami Children's Hospital
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Miami, Florida, États-Unis, 33136
- Jackson Memorial Hospital
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Miami, Florida, États-Unis, 33176-2197
- Baptist-South Miami Regional Cancer Program
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Orlando, Florida, États-Unis, 32804
- Florida Hospital Cancer Institute
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Orlando, Florida, États-Unis, 32806
- Nemours Children's Clinic-Orlando
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Pensacola, Florida, États-Unis, 32504
- Sacred Heart Children's Hospital
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St. Petersburg, Florida, États-Unis, 33701
- All Children's Hospital
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Tampa, Florida, États-Unis, 33677-4227
- St. Joseph's Children's Hospital
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West Palm Beach, Florida, États-Unis, 33407
- St. Mary's Hospital
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Georgia
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Augusta, Georgia, États-Unis, 30912-4000
- MBCCOP-Medical College of Georgia Cancer Center
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Macon, Georgia, États-Unis, 31201
- Medical Center of Central Georgia
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Savannah, Georgia, États-Unis, 31405
- Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
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Hawaii
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Honolulu, Hawaii, États-Unis, 96813
- Cancer Research Center of Hawaii
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Honolulu, Hawaii, États-Unis, 96813
- MBCCOP - Hawaii
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Idaho
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Boise, Idaho, États-Unis, 83712
- Mountain States Tumor Institute - Boise
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Illinois
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Chicago, Illinois, États-Unis, 60612
- Rush University Medical Center
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Chicago, Illinois, États-Unis, 60614
- Children's Memorial Hospital - Chicago
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Chicago, Illinois, États-Unis, 60601
- University of Chicago Cancer Research Center
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Chicago, Illinois, États-Unis, 60612
- University of Illinois Medical Center
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Oak Lawn, Illinois, États-Unis, 60453
- Advocate Hope Children's Hospital
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Park Ridge, Illinois, États-Unis, 60068-1174
- Lutheran General Cancer Care Center
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Peoria, Illinois, États-Unis, 61637
- Saint Jude Midwest Affiliate
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Springfield, Illinois, États-Unis, 62794-9658
- Southern Illinois University School of Medicine
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Indiana
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Indianapolis, Indiana, États-Unis, 46202-5225
- Riley Children Cancer Center at Riley Hospital for Children
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Indianapolis, Indiana, États-Unis, 46260
- St. Vincent Hospitals and Health Care Centers
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Iowa
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Des Moines, Iowa, États-Unis, 50309
- John Stoddard Cancer Center at Iowa Methodist Medical Center
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Des Moines, Iowa, États-Unis, 50308
- Blank Children's Hospital
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Iowa City, Iowa, États-Unis, 52242-1009
- Holden Comprehensive Cancer Center at University of Iowa
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Kansas
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Wichita, Kansas, États-Unis, 67214
- Wesley Medical Center
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Kentucky
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Lexington, Kentucky, États-Unis, 40536-0284
- Markey Cancer Center at University of Kentucky Chandler Medical Center
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Louisville, Kentucky, États-Unis, 40202-3830
- Kosair Children's Hospital
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Louisiana
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New Orleans, Louisiana, États-Unis, 70121
- Ochsner Clinic Foundation
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New Orleans, Louisiana, États-Unis, 70118
- Children's Hospital of New Orleans
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New Orleans, Louisiana, États-Unis, 70112
- MBCCOP - LSU Health Sciences Center
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New Orleans, Louisiana, États-Unis, 70112
- Tulane Cancer Center at Tulane University Hospital and Clinic
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Maine
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Bangor, Maine, États-Unis, 04401
- Eastern Maine Medical Center
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Scarborough, Maine, États-Unis, 04074-9308
- Maine Children's Cancer Program
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Maryland
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Baltimore, Maryland, États-Unis, 21231-2410
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
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Baltimore, Maryland, États-Unis, 21201-1595
- Greenebaum Cancer Center at University of Maryland Medical Center
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Baltimore, Maryland, États-Unis, 21225
- Alvin and Lois Lapidus Cancer Institute at Sinai Hospital
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Silver Spring, Maryland, États-Unis, 20910
- Walter Reed Army Medical Center
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Massachusetts
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Boston, Massachusetts, États-Unis, 02115
- Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute
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Boston, Massachusetts, États-Unis, 02111
- Floating Hospital for Children
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Springfield, Massachusetts, États-Unis, 01107
- Baystate Regional Cancer Program at Baystate Medical Center
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Worcester, Massachusetts, États-Unis, 01655
- UMASS Memorial Cancer Center - University Campus
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Michigan
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Ann Arbor, Michigan, États-Unis, 48109-0914
- University of Michigan Comprehensive Cancer Center
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Detroit, Michigan, États-Unis, 48201
- Children's Hospital of Michigan
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Detroit, Michigan, États-Unis, 48236
- Van Elslander Cancer Center at St. John Hospital and Medical Center
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Detroit, Michigan, États-Unis, 48202
- Josephine Ford Cancer Center at Henry Ford Health System
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Flint, Michigan, États-Unis, 48503
- Hurley Medical Center
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Grand Rapids, Michigan, États-Unis, 49503
- Spectrum Health and DeVos Children's Hospital
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Kalamazoo, Michigan, États-Unis, 49007-5364
- Bronson Methodist Hospital
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Lansing, Michigan, États-Unis, 48910
- Breslin Cancer Center at Ingham Regional Medical Center
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Royal Oak, Michigan, États-Unis, 48073-6769
- CCOP - Beaumont
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Royal Oak, Michigan, États-Unis, 48073-6769
- William Beaumont Hospital - Royal Oak
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Minnesota
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Duluth, Minnesota, États-Unis, 55805
- St. Mary's - Duluth Clinic Cancer Center
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Minneapolis, Minnesota, États-Unis, 55404
- Children's Hospitals and Clinics - Minneapolis
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Rochester, Minnesota, États-Unis, 55905
- Mayo Clinic Cancer Center
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Saint Paul, Minnesota, États-Unis, 55102
- Children's Hospitals and Clinics - Minnesota
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Mississippi
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Jackson, Mississippi, États-Unis, 39216-4505
- University of Mississippi Medical Center
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Missouri
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Columbia, Missouri, États-Unis, 65212
- Ellis Fischel Cancer Center at University of Missouri - Columbia
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Kansas City, Missouri, États-Unis, 64108
- Children's Mercy Hospital
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Saint Louis, Missouri, États-Unis, 63110
- St. Louis Children's Hospital
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Saint Louis, Missouri, États-Unis, 63104
- Cardinal Glennon Children's Hospital
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Nebraska
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Omaha, Nebraska, États-Unis, 68114
- Children's Hospital of Omaha
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Omaha, Nebraska, États-Unis, 68198-2168
- UNMC Eppley Cancer Center at the University of Nebraska Medical Center
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Nevada
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Las Vegas, Nevada, États-Unis, 89109
- Sunrise Hospital and Medical Center
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New Hampshire
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Lebanon, New Hampshire, États-Unis, 03756
- Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
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New Jersey
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Hackensack, New Jersey, États-Unis, 07601
- Cancer Center at Hackensack University Medical Center
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New Brunswick, New Jersey, États-Unis, 08903
- Cancer Institute of New Jersey at Robert Wood Johnson University Hospital
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Newark, New Jersey, États-Unis, 07112-2094
- Newark Beth Israel Medical Center
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Paterson, New Jersey, États-Unis, 07503
- St. Joseph's Hospital and Medical Center
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Summit, New Jersey, États-Unis, 07901
- Valerie Fund Children's Center at Atlantic Health
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New Mexico
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Albuquerque, New Mexico, États-Unis, 87131
- University of New Mexico Cancer Research and Treatment Center
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New York
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Albany, New York, États-Unis, 12208
- Cancer Center of Albany Medical Center
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Bronx, New York, États-Unis, 10461
- Albert Einstein Clinical Cancer Center
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Brooklyn, New York, États-Unis, 11203
- SUNY Downstate Medical Center
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Brooklyn, New York, États-Unis, 11212
- Brookdale University Hospital and Medical Center
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Brooklyn, New York, États-Unis, 11201-5493
- Brooklyn Hospital Center
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Brooklyn, New York, États-Unis, 11219
- Comprehensive Cancer Center at Maimonides Medical Center
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Buffalo, New York, États-Unis, 14263-0001
- Roswell Park Cancer Institute
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New Hyde Park, New York, États-Unis, 11042
- Schneider Children's Hospital
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New York, New York, États-Unis, 10021
- Memorial Sloan-Kettering Cancer Center
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New York, New York, États-Unis, 10029
- Mount Sinai School of Medicine
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New York, New York, États-Unis, 10021
- New York Weill Cornell Cancer Center at Cornell University
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New York, New York, États-Unis, 10032
- Herbert Irving Comprehensive Cancer Center at Columbia University
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Rochester, New York, États-Unis, 14642
- James P. Wilmot Cancer Center at University of Rochester Medical Center
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Stony Brook, New York, États-Unis, 11794
- Long Island Cancer Center at Stony Brook University Hospital
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Syracuse, New York, États-Unis, 13210
- SUNY Upstate Medical University Hospital
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Valhalla, New York, États-Unis, 10595
- New York Medical College
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North Carolina
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Asheville, North Carolina, États-Unis, 28801
- Mission Hospitals
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Chapel Hill, North Carolina, États-Unis, 27599-7295
- Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
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Charlotte, North Carolina, États-Unis, 28232-2861
- Blumenthal Cancer Center at Carolinas Medical Center
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Charlotte, North Carolina, États-Unis, 28233
- Presbyterian Healthcare
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Durham, North Carolina, États-Unis, 27710
- Duke Comprehensive Cancer Center
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Greenville, North Carolina, États-Unis, 27858-4354
- Leo W. Jenkins Cancer Center of University Health Systems of Eastern Carolina
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Winston-Salem, North Carolina, États-Unis, 27157-1081
- Comprehensive Cancer Center at Wake Forest University
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North Dakota
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Fargo, North Dakota, États-Unis, 58103-4940
- Dakota Cancer Institute at Innovis Health - Dakota Clinic
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Ohio
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Akron, Ohio, États-Unis, 44308-1062
- Children's Hospital Medical Center of Akron
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Cincinnati, Ohio, États-Unis, 45229-3039
- Cincinnati Children's Hospital Medical Center
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Cleveland, Ohio, États-Unis, 44195
- Cleveland Clinic Taussig Cancer Center
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Cleveland, Ohio, États-Unis, 44106-5065
- Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University
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Columbus, Ohio, États-Unis, 43205-2696
- Columbus Children's Hospital
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Dayton, Ohio, États-Unis, 45404
- Children's Medical Center - Dayton
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Toledo, Ohio, États-Unis, 43601
- Toledo Children's Hospital
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Toledo, Ohio, États-Unis, 43608
- St. Vincent Mercy Medical Center
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Youngstown, Ohio, États-Unis, 44501
- Forum Health-Tod Childrens Hospital
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Oklahoma
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Oklahoma City, Oklahoma, États-Unis, 73104
- Children's Hospital at Oklahoma University Medical Center
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Tulsa, Oklahoma, États-Unis, 74136
- Natalie Warren Bryant Cancer Center
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Tulsa, Oklahoma, États-Unis, 74136
- CCOP - Oklahoma
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Oregon
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Portland, Oregon, États-Unis, 97225
- CCOP - Columbia River Oncology Program
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Portland, Oregon, États-Unis, 97227
- Legacy Emanuel Hospital and Health Center & Children's Hospital
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Portland, Oregon, États-Unis, 97239-3098
- Doernbecher Children's Hospital at Oregon Health & Science University
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Pennsylvania
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Danville, Pennsylvania, États-Unis, 17822-1320
- Geisinger Medical Center
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Hershey, Pennsylvania, États-Unis, 17033
- Penn State Cancer Institute at Milton S. Hershey Medical Center
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Philadelphia, Pennsylvania, États-Unis, 19104
- Children's Hospital of Philadelphia
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Philadelphia, Pennsylvania, États-Unis, 19134-1095
- St. Christopher's Hospital for Children
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Pittsburgh, Pennsylvania, États-Unis, 15213-2583
- Children's Hospital of Pittsburgh
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Rhode Island
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Providence, Rhode Island, États-Unis, 02903
- Rhode Island Hospital
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South Carolina
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Charleston, South Carolina, États-Unis, 29425-0721
- Hollings Cancer Center at Medical University of South Carolina
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Columbia, South Carolina, États-Unis, 29203
- Palmetto Health South Carolina Cancer Center
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Greenville, South Carolina, États-Unis, 29605
- Children's Hospital of Greenville Hospital System
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South Dakota
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Sioux Falls, South Dakota, États-Unis, 57105-1080
- Avera Cancer Institute
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Sioux Falls, South Dakota, États-Unis, 57117-5039
- Sioux Valley Hospital at University of South Dakota Medical Center
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Tennessee
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Johnson City, Tennessee, États-Unis, 37614-0622
- East Tennessee State University Cancer Center at Johnson City Medical Center
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Knoxville, Tennessee, États-Unis, 37901
- East Tennessee Children's Hospital
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Memphis, Tennessee, États-Unis, 38105-2794
- St. Jude Children's Research Hospital
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Nashville, Tennessee, États-Unis, 37232-6310
- Vanderbilt Children's Hospital
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Texas
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Amarillo, Texas, États-Unis, 79106
- Texas Tech University Health Sciences Center School of Medicine
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Austin, Texas, États-Unis, 78701
- Children's Hospital of Austin
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Dallas, Texas, États-Unis, 75230
- Medical City Dallas Hospital
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Dallas, Texas, États-Unis, 75390-9063
- Simmons Cancer Center at University of Texas Southwestern Medical Center - Dallas
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Fort Worth, Texas, États-Unis, 76104
- Cook Children's Medical Center - Fort Worth
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Galveston, Texas, États-Unis, 77555-0361
- University of Texas Medical Branch
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Houston, Texas, États-Unis, 77030
- Baylor College of Medicine
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Houston, Texas, États-Unis, 77030-4009
- University of Texas - MD Anderson Cancer Center
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Lackland Air Force Base, Texas, États-Unis, 78236
- San Antonio Military Pediatric Cancer and Blood Disorders Center
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Lubbock, Texas, États-Unis, 79410
- Covenant Children's Hospital
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San Antonio, Texas, États-Unis, 78207
- University of Texas Health Science Center at San Antonio
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San Antonio, Texas, États-Unis, 78229-3900
- MBCCOP - South Texas Pediatrics
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San Antonio, Texas, États-Unis, 78229-3902
- Methodist Cancer Center at Methodist Specialty and Transplant Hospital
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Temple, Texas, États-Unis, 76508
- CCOP - Scott and White Hospital
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Temple, Texas, États-Unis, 76508
- Center for Cancer Prevention and Care at Scott and White Clinic
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Utah
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Salt Lake City, Utah, États-Unis, 84112
- Huntsman Cancer Institute
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Vermont
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Burlington, Vermont, États-Unis, 05401-3498
- Vermont Cancer Center at University of Vermont
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Virginia
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Charlottesville, Virginia, États-Unis, 22908
- Cancer Center at the University of Virginia
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Falls Church, Virginia, États-Unis, 22042-3300
- Inova Fairfax Hospital
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Norfolk, Virginia, États-Unis, 23507
- Children's Hospital of The King's Daughters
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Portsmouth, Virginia, États-Unis, 23708-5100
- Naval Medical Center, Portsmouth
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Richmond, Virginia, États-Unis, 23298-0121
- Massey Cancer Center at Virginia Commonwealth University
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Roanoke, Virginia, États-Unis, 24029
- Carilion Medical Center for Children
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Washington
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Seattle, Washington, États-Unis, 98105
- Children's Hospital and Regional Medical Center - Seattle
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Seattle, Washington, États-Unis, 98109-1024
- Fred Hutchinson Cancer Research Center
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Seattle, Washington, États-Unis, 98112
- Group Health Central Hospital
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Spokane, Washington, États-Unis, 99210-0248
- Deaconess Medical Center
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Tacoma, Washington, États-Unis, 98431-5000
- Madigan Army Medical Center
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Tacoma, Washington, États-Unis, 98415-0299
- Mary Bridge Children's Hospital and Health Center
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West Virginia
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Charleston, West Virginia, États-Unis, 25302
- West Virginia University - Robert C. Byrd Health Sciences Center - Charleston Division
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Huntington, West Virginia, États-Unis, 25701
- Cabell Huntington Hospital
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Morgantown, West Virginia, États-Unis, 26506-9300
- West Virginia University Hospitals
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Wisconsin
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Green Bay, Wisconsin, États-Unis, 54301
- CCOP - St. Vincent Hospital Cancer Center, Green Bay
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Green Bay, Wisconsin, États-Unis, 54301
- Bellin Memorial Hospital
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Green Bay, Wisconsin, États-Unis, 54307-9070
- St. Vincent Hospital
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La Crosse, Wisconsin, États-Unis, 54601
- Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center
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Madison, Wisconsin, États-Unis, 53792-6164
- University of Wisconsin Comprehensive Cancer Center
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Marshfield, Wisconsin, États-Unis, 54449-5772
- Marshfield Clinic
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Marshfield, Wisconsin, États-Unis, 54449
- CCOP - Marshfield Clinic Research Foundation
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Milwaukee, Wisconsin, États-Unis, 53226
- Midwest Children's Cancer Center
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Critères de participation
Les chercheurs recherchent des personnes qui correspondent à une certaine description, appelée critères d'éligibilité. Certains exemples de ces critères sont l'état de santé général d'une personne ou des traitements antérieurs.
Critère d'éligibilité
Âges éligibles pour étudier
Pas plus vieux que 18 ans (Enfant, Adulte)
Accepte les volontaires sains
Oui
Sexes éligibles pour l'étude
Tout
Méthode d'échantillonnage
Échantillon non probabiliste
Population étudiée
Diagnosis of Wilms' tumor or control participants matched for race, sex, and age.
La description
DISEASE CHARACTERISTICS:
- Diagnosis of Wilms' tumor OR
Control participants matched for race, sex, and age
- No prior or concurrent history of cancer OR
- Parents of children involved in the study
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified
Plan d'étude
Cette section fournit des détails sur le plan d'étude, y compris la façon dont l'étude est conçue et ce que l'étude mesure.
Comment l'étude est-elle conçue ?
Détails de conception
Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
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Presence of the A133S polymorphism of the RASSF1A tumor suppressor gene in germline DNAs of children with Wilms' tumor
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Inheritance pattern of the A133S polymorphism in the parents of children who carry this polymorphism
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Mesures de résultats secondaires
Mesure des résultats |
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Differences in age at diagnosis, stage, histology, site of primary tumor, and outcome between patients with vs without the A133S polymorphism
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Whether the S131F RASSF1A variant is a true polymorphism
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Polymorphic differences in this gene based on ethnicity and sex
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Collaborateurs et enquêteurs
C'est ici que vous trouverez les personnes et les organisations impliquées dans cette étude.
Parrainer
Collaborateurs
Les enquêteurs
- Chaise d'étude: Gail E. Tomlinson, MD, PhD, Simmons Cancer Center
Dates d'enregistrement des études
Ces dates suivent la progression des dossiers d'étude et des soumissions de résultats sommaires à ClinicalTrials.gov. Les dossiers d'étude et les résultats rapportés sont examinés par la Bibliothèque nationale de médecine (NLM) pour s'assurer qu'ils répondent à des normes de contrôle de qualité spécifiques avant d'être publiés sur le site Web public.
Dates principales de l'étude
Début de l'étude
1 août 2004
Achèvement primaire (Réel)
1 mai 2016
Dates d'inscription aux études
Première soumission
4 août 2004
Première soumission répondant aux critères de contrôle qualité
4 août 2004
Première publication (Estimation)
5 août 2004
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Estimation)
19 mai 2016
Dernière mise à jour soumise répondant aux critères de contrôle qualité
17 mai 2016
Dernière vérification
1 mai 2016
Plus d'information
Termes liés à cette étude
Mots clés
Termes MeSH pertinents supplémentaires
Autres numéros d'identification d'étude
- AREN04B1
- COG-AREN04B1 (Autre identifiant: Children's Oncology Group)
- UTSMC-0390080
- CDR0000366933 (Autre identifiant: Clinical Trials.gov)
- NCI-2009-00417 (Identificateur de registre: CTRP (Clinical Trial Reporting Program))
Ces informations ont été extraites directement du site Web clinicaltrials.gov sans aucune modification. Si vous avez des demandes de modification, de suppression ou de mise à jour des détails de votre étude, veuillez contacter register@clinicaltrials.gov. Dès qu'un changement est mis en œuvre sur clinicaltrials.gov, il sera également mis à jour automatiquement sur notre site Web .